Gene Symbol: ci
Description: cubitus interruptus
Alias: CG2125, CID, Ci/GLI, Ci/Gli, Ci155, CiD, Ci[D], Dmel\CG2125, Gli, Siah, ci-D, ci155, ciD, ci[D], l(4)102ABc, l(4)13, l(4)17, cubitus interruptus, CG2125-PA, CG2125-PB, CG2125-PC, cell, ci-PA, ci-PB, ci-PC, cubitis interruptus, cubitus interuptus, cubitus-interruptus, cubitus-interruptus-Dominant
Species: fruit fly
Products:     ci

Top Publications

  1. Zhang Y, Kalderon D. Regulation of cell proliferation and patterning in Drosophila oogenesis by Hedgehog signaling. Development. 2000;127:2165-76 pubmed
    ..First, excess Hh signaling in somatic stem cells stimulates somatic cell over-proliferation...
  2. Wang G, Amanai K, Wang B, Jiang J. Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev. 2000;14:2893-905 pubmed
    ..In Drosophila, Hh acts by preventing the formation of a truncated repressor form of Cubitus interruptus (Ci) and stimulating the transcriptional activity of full-length Ci...
  3. Kugler S, Nagel A. putzig is required for cell proliferation and regulates notch activity in Drosophila. Mol Biol Cell. 2007;18:3733-40 pubmed
    We have identified the gene putzig (pzg) as a key regulator of cell proliferation and of Notch signaling in Drosophila...
  4. Khaliullina H, Panàkovà D, Eugster C, Riedel F, Carvalho M, Eaton S. Patched regulates Smoothened trafficking using lipoprotein-derived lipids. Development. 2009;136:4111-21 pubmed publisher
    ..We propose that Ptc normally regulates Smo degradation by changing the lipid composition of endosomes through which Smo passes, and that the presence of Hh on lipoproteins inhibits utilization of their lipids by Ptc. ..
  5. Zhou Q, Kalderon D. Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev Cell. 2011;20:802-14 pubmed publisher
    In flies and mammals, extracellular Hedgehog (Hh) molecules alter cell fates and proliferation by regulating the levels and activities of Ci/Gli family transcription factors...
  6. Su Y, Ospina J, Zhang J, Michelson A, Schoen A, Zhu A. Sequential phosphorylation of smoothened transduces graded hedgehog signaling. Sci Signal. 2011;4:ra43 pubmed publisher
  7. Nussbaumer U, Halder G, Groppe J, Affolter M, Montagne J. Expression of the blistered/DSRF gene is controlled by different morphogens during Drosophila trachea and wing development. Mech Dev. 2000;96:27-36 pubmed
    ..Hence, each of the three characterized enhancers constitutes a molecular link between a specific territory induced by a morphogen signal and the localized expression of a gene required for the final differentiation of this territory. ..
  8. Firth L, Baker N. Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell. 2005;8:541-51 pubmed
    Spatially and temporally choreographed cell cycles accompany the differentiation of the Drosophila retina...
  9. Yao S, Lum L, Beachy P. The ihog cell-surface proteins bind Hedgehog and mediate pathway activation. Cell. 2006;125:343-57 pubmed

More Information

Publications105 found, 100 shown here

  1. Ogden S, Fei D, Schilling N, Ahmed Y, Hwa J, Robbins D. G protein Galphai functions immediately downstream of Smoothened in Hedgehog signalling. Nature. 2008;456:967-70 pubmed publisher
    ..the Kinesin related protein Costal2 (Cos2), the protein kinase Fused (Fu) and the transcription factor Cubitus interruptus (Ci)...
  2. Alves G, Limbourg Bouchon B, Tricoire H, Brissard Zahraoui J, Lamour Isnard C, Busson D. Modulation of Hedgehog target gene expression by the Fused serine-threonine kinase in wing imaginal discs. Mech Dev. 1998;78:17-31 pubmed
    ..In wing imaginal discs, the Hh signal induces Cubitus interruptus (Ci) accumulation and activates patched (ptc) and decapentaplegic (dpp) expression along the anterior/..
  3. Denef N, Neubüser D, Perez L, Cohen S. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell. 2000;102:521-31 pubmed
    ..Hedgehog binding causes removal of Patched from the cell surface...
  4. Østerlund T, Kogerman P. Hedgehog signalling: how to get from Smo to Ci and Gli. Trends Cell Biol. 2006;16:176-80 pubmed
    ..Here, we discuss this evidence and its importance for investigations of the pathway and related biology, as well as for the development of drugs targeting components of the pathway for treatment of associated pathologies. ..
  5. Zhao Y, Tong C, Jiang J. Transducing the Hedgehog signal across the plasma membrane. Fly (Austin). 2007;1:333-6 pubmed
    b>Cell signaling mediated by the Hedgehog (Hh) family of secreted proteins is essential for metazoan development and its malfunction causes congenital disorders and cancer...
  6. Johnson R, Scott M. New players and puzzles in the Hedgehog signaling pathway. Curr Opin Genet Dev. 1998;8:450-6 pubmed
    Members of the Hedgehog (Hh) family of signaling proteins control cell fates and proliferation during animal development in part by regulating the transcription of specific genes...
  7. Chen C, von Kessler D, Park W, Wang B, Ma Y, Beachy P. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell. 1999;98:305-16 pubmed
    Transcriptional activation of Hedgehog (Hh) target genes requires Cubitus interruptus, a 155 kDa cytoplasmic zinc finger protein (Ci155), which in the absence of Hh signaling is processed to form a nuclear repressor (Ci75)...
  8. Stegman M, Vallance J, Elangovan G, Sosinski J, Cheng Y, Robbins D. Identification of a tetrameric hedgehog signaling complex. J Biol Chem. 2000;275:21809-12 pubmed
    ..Here, we show that three members of this complex, Costal2 (Cos2), Fused (Fu), and Cubitus interruptus (Ci), bind each other directly to form a trimeric complex...
  9. Kiger J, O SHEA C. Genetic evidence for a protein kinase A/cubitus interruptus complex that facilitates processing of cubitus interruptus in Drosophila. Genetics. 2001;158:1157-66 pubmed
    Hedgehog (Hh) activates a signal transduction pathway regulating Cubitus interruptus (Ci). In the absence of Hh, full-length Ci (Ci-155) is bound in a complex that includes Costal2 (Cos2) and Fused (Fu)...
  10. Noureddine M, Donaldson T, Thacker S, Duronio R. Drosophila Roc1a encodes a RING-H2 protein with a unique function in processing the Hh signal transducer Ci by the SCF E3 ubiquitin ligase. Dev Cell. 2002;2:757-70 pubmed
    ..Further, while the F box protein Slimb is required for Cubitus interruptus (Ci) and Armadillo/beta-catenin (Arm) proteolysis, Roc1a mutant cells hyperaccumulate Ci but not Arm...
  11. Goriaux C, Desset S, Renaud Y, Vaury C, Brasset E. Transcriptional properties and splicing of the flamenco piRNA cluster. EMBO Rep. 2014;15:411-8 pubmed publisher initiator motif (Inr) and downstream promoter element (DPE) and requires the transcription factor, Cubitus interruptus. We show that the flamenco precursor transcript undergoes differential alternative splicing to generate ..
  12. Capdevila J, Johnson R. Hedgehog signaling in vertebrate and invertebrate limb patterning. Cell Mol Life Sci. 2000;57:1682-94 pubmed
    ..Here we highlight the similarities and differences between the use of Hedgehog signaling in these two systems. ..
  13. Bai J, Montell D. Eyes absent, a key repressor of polar cell fate during Drosophila oogenesis. Development. 2002;129:5377-88 pubmed
    ..Although specification of these three somatic cell types is important for normal oogenesis and subsequent embryogenesis, the molecular basis for establishment of ..
  14. Ruel L, Rodriguez R, Gallet A, Lavenant Staccini L, Therond P. Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog. Nat Cell Biol. 2003;5:907-13 pubmed
    ..We have shown previously that the transcriptional mediator Cubitus interruptus (Ci) is associated in a protein complex with at least two other proteins, the kinesin-like Costal2 (Cos2) ..
  15. Callejo A, Torroja C, Quijada L, Guerrero I. Hedgehog lipid modifications are required for Hedgehog stabilization in the extracellular matrix. Development. 2006;133:471-83 pubmed that in the receiving cells of the Drosophila wing imaginal disc, lipid-unmodified Hh spreads across many more cell diameters than the wild type and this spreading leads to the activation of low but not high threshold responses...
  16. Biehs B, Kechris K, Liu S, Kornberg T. Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling. Development. 2010;137:3887-98 pubmed publisher
    ..We mapped chromatin binding sites for Cubitus interruptus (Ci), the transcription factor that mediates outputs of Hh signal transduction, and we analyzed ..
  17. Han C, Yan D, Belenkaya T, Lin X. Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc. Development. 2005;132:667-79 pubmed
    ..We propose that Wg establishes its concentration gradient by a restricted diffusion mechanism involving Dally and Dlp in the wing disc. ..
  18. Yavari A, Nagaraj R, Owusu Ansah E, Folick A, Ngo K, Hillman T, et al. Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev Cell. 2010;19:54-65 pubmed publisher
    ..Taken together, our results suggest a model in which Ptc directly or indirectly functions to suppress the accumulation of PI4P. Binding of Hh to Ptc derepresses the levels of PI4P, which, in turn, promotes Smo activation. ..
  19. Methot N, Basler K. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell. 1999;96:819-31 pubmed
    ..The Gli homolog Cubitus interruptus (Ci) is involved in controlling the transcription of Hh target genes...
  20. Chen Y, Cardinaux J, Goodman R, Smolik S. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling. Development. 1999;126:3607-16 pubmed
    ..b>cubitus interruptus (ci) encodes a transcription factor responsible for transducing the hh signal in the nucleus and activating ..
  21. Wang Q, Holmgren R. Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development. 2000;127:3131-9 pubmed
    The Hedgehog (Hh) signal is transduced via Cubitus interruptus (Ci) to specify cell fates in the Drosophila wing. In the absence of Hh, the 155 kDa full-length form of Ci is cleaved into a 75 kDa repressor...
  22. Jia H, Liu Y, Yan W, Jia J. PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation. Development. 2009;136:307-16 pubmed publisher
    ..We further find that PP4 regulates the Hh-induced Smo cell-surface accumulation. Mechanistically, we show that Hh downregulates Smo-PP4 interaction that is mediated by Cos2...
  23. Wicking C, Smyth I, Bale A. The hedgehog signalling pathway in tumorigenesis and development. Oncogene. 1999;18:7844-51 pubmed
    ..This cascade is regulated at the cell surface by the opposing actions of the patched and smoothened molecules which together form a receptor complex for ..
  24. Suh G, Poeck B, Chouard T, Oron E, Segal D, Chamovitz D, et al. Drosophila JAB1/CSN5 acts in photoreceptor cells to induce glial cells. Neuron. 2002;33:35-46 pubmed
    ..Conversely, R cells promote glial cell development including migration of glial cells into the target region...
  25. Alexandre C, Lecourtois M, Vincent J. Wingless and Hedgehog pattern Drosophila denticle belts by regulating the production of short-range signals. Development. 1999;126:5689-98 pubmed
    ..of individual denticle types and polarity suggesting that contact-dependent signaling modulates individual cell fates. Attributes of a morphogen can be ascribed to Hedgehog in this system...
  26. Dussillol Godar F, Brissard Zahraoui J, Limbourg Bouchon B, Boucher D, Fouix S, Lamour Isnard C, et al. Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs. Dev Biol. 2006;291:53-66 pubmed
    ..These effects were all enhanced in a fu mutant context and were suppressed by cubitus interruptus (Ci) overexpression...
  27. Escudero L, Freeman M. Mechanism of G1 arrest in the Drosophila eye imaginal disc. BMC Dev Biol. 2007;7:13 pubmed
    Most differentiating cells are arrested in G1-phase of the cell cycle and this proliferative quiescence appears important to allow differentiation programmes to be executed...
  28. Casso D, Liu S, Iwaki D, Ogden S, Kornberg T. A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Genetics. 2008;178:1399-413 pubmed publisher
    ..Characterization of newly isolated alleles indicates that swm is a negative regulator of Hh signaling and is essential for cell polarity.
  29. Baker N, Bhattacharya A, Firth L. Regulation of Hh signal transduction as Drosophila eye differentiation progresses. Dev Biol. 2009;335:356-66 pubmed publisher
    ..Roadkill, is expressed posterior to the furrow and targets the Hedgehog signal transduction component Cubitus interruptus for degradation by Cullin-3 and the proteosome...
  30. Christiansen A, Ding T, Bergmann A. Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila. Mech Dev. 2012;129:98-108 pubmed publisher
    ..Hh) signaling pathway is associated with the development of human cancer including medullobastoma and basal cell carcinoma. Loss of Patched or activation of Smoothened in mouse models increases the occurrence of tumors...
  31. Gieseler K, Wilder E, Mariol M, Buratovitch M, Berenger H, Graba Y, et al. DWnt4 and wingless elicit similar cellular responses during imaginal development. Dev Biol. 2001;232:339-50 pubmed
    ..We also show that both genes are transcribed in overlapping domains in imaginal discs, suggesting that DWnt4 may cooperate with wg during limb patterning. ..
  32. Ruel L, Gallet A, Raisin S, Truchi A, Staccini Lavenant L, Cervantes A, et al. Phosphorylation of the atypical kinesin Costal2 by the kinase Fused induces the partial disassembly of the Smoothened-Fused-Costal2-Cubitus interruptus complex in Hedgehog signalling. Development. 2007;134:3677-89 pubmed
    ..of the Hh signal from the transmembrane protein Smoothened (Smo) to the transcriptional mediator Cubitus interruptus (Ci)...
  33. Brankatschk M, Eaton S. Lipoprotein particles cross the blood-brain barrier in Drosophila. J Neurosci. 2010;30:10441-7 pubmed publisher
    ..Furthermore, lipid-linkage may be an efficient method to transport therapeutic molecules across the BBB. ..
  34. Jia H, Liu Y, Xia R, Tong C, Yue T, Jiang J, et al. Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. J Biol Chem. 2010;285:37218-26 pubmed publisher
    ..that CK2 plays an additional positive role downstream of Smo by regulating the stability of full-length Cubitus interruptus (Ci). CK2? RNAi promotes Ci degradation whereas coexpressing CK2? and CK2? increases the half-life of Ci...
  35. Thérond P, Limbourg Bouchon B, Gallet A, Dussilol F, Pietri T, van den Heuvel M, et al. Differential requirements of the fused kinase for hedgehog signalling in the Drosophila embryo. Development. 1999;126:4039-51 pubmed anterior, wingless-expressing cells we could show that the Hedgehog signalling components Smoothened and Cubitus interruptus are required in cells posterior to Hedgehog domain to maintain patched expression whereas Fused is not ..
  36. Huangfu D, Anderson K. Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development. 2006;133:3-14 pubmed
    ..Drosophila and vertebrates in the way signals are transduced from the membrane protein Smoothened (Smo) to the Ci/Gli transcription factors. For example, Smo structure and the roles of fused and Suppressor of fused have diverged...
  37. Tanimoto H, Itoh S, ten Dijke P, Tabata T. Hedgehog creates a gradient of DPP activity in Drosophila wing imaginal discs. Mol Cell. 2000;5:59-71 pubmed
    ..We suggest that regulation of tkv by HH is a key part of the mechanism that controls the level and distribution of DPP. ..
  38. Zhang Y, Kalderon D. Hedgehog acts as a somatic stem cell factor in the Drosophila ovary. Nature. 2001;410:599-604 pubmed
    ..Although Hedgehog proteins most commonly affect cell fate, they can also stimulate cell proliferation...
  39. Zhang Q, Zhang L, Wang B, Ou C, Chien C, Jiang J. A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. Dev Cell. 2006;10:719-29 pubmed
    The Ci/Gli family of transcription factors mediates Hedgehog (Hh) signaling in many key developmental processes. Here we identify a Hh-induced MATH and BTB domain containing protein (HIB) as a negative regulator of the Hh pathway...
  40. Zhang Y, Mao F, Lu Y, Wu W, Zhang L, Zhao Y. Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus. Cell Res. 2011;21:1436-51 pubmed publisher
    ..of the cell response to a Hh gradient by translating Smo phosphorylation information to Fu dimerization and Cubitus interruptus (Ci) nuclear localization information...
  41. Aza Blanc P, Kornberg T. Ci: a complex transducer of the hedgehog signal. Trends Genet. 1999;15:458-62 pubmed
    Recent progress has unveiled Cubitus interruptus (Ci) as a complex transcription factor whose diverse activities as an activator and repressor are regulated by its proteolysis, localization and concentration...
  42. Kalderon D. Transducing the hedgehog signal. Cell. 2000;103:371-4 pubmed
  43. Briscoe J, Chen Y, Jessell T, Struhl G. A hedgehog-insensitive form of patched provides evidence for direct long-range morphogen activity of sonic hedgehog in the neural tube. Mol Cell. 2001;7:1279-91 pubmed
    b>Cell pattern in the ventral neural tube is organized by Sonic hedgehog (Shh) secreted by floor plate cells...
  44. Amanai K, Jiang J. Distinct roles of Central missing and Dispatched in sending the Hedgehog signal. Development. 2001;128:5119-27 pubmed
    ..Finally, we show that cmn mutations bear molecular lesions in CG11495, which encodes a putative membrane bound acyltransferase related to Porcupine, a protein implicated in regulating the secretion of Wingless (Wg) signal. ..
  45. Pappu K, Chen R, Middlebrooks B, Woo C, Heberlein U, Mardon G. Mechanism of hedgehog signaling during Drosophila eye development. Development. 2003;130:3053-62 pubmed alleviate repression of eya and decapentaplegic (dpp) expression by the zinc-finger transcription factor Cubitus interruptus (Ci(rep))...
  46. Han C, Belenkaya T, Khodoun M, Tauchi M, Lin X, Lin X. Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation. Development. 2004;131:1563-75 pubmed
    ..Our results also suggest that HSPGs have two distinct roles in Wg morphogen distribution and signalling...
  47. Kim H, Kim S, Shim S, Park E, Kim C, Kim K, et al. Drosophila homolog of APP-BP1 (dAPP-BP1) interacts antagonistically with APPL during Drosophila development. Cell Death Differ. 2007;14:103-15 pubmed
    ..APPL overexpression is shown to inhibit the NEDD8 conjugation pathway. APPL-induced apoptosis is rescued by overexpression of dAPP-BP1. Our data suggest that APPL and dAPP-BP1 interact antagonistically during Drosophila development. ..
  48. Smith Bolton R, Worley M, Kanda H, Hariharan I. Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc. Dev Cell. 2009;16:797-809 pubmed publisher altered expression of patterning genes and growth regulators as well as a temporary loss of markers of cell fate commitment. Wingless and Myc are induced by tissue damage and are important for regenerative growth...
  49. Kuwabara P, Labouesse M. The sterol-sensing domain: multiple families, a unique role?. Trends Genet. 2002;18:193-201 pubmed
    ..This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis.
  50. Price M, Kalderon D. Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1. Cell. 2002;108:823-35 pubmed
    ..Hedgehog regulates gene expression in target cells in part by preventing proteolysis of the full-length Cubitus interruptus (Ci-155) transcriptional activator to the Ci-75 repressor form...
  51. Jia J, Zhang L, Zhang Q, Tong C, Wang B, Hou F, et al. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell. 2005;9:819-30 pubmed
    Hedgehog (Hh) proteins govern animal development by regulating the Gli/Ci family of transcription factors. In Drosophila, Hh signaling blocks proteolytic processing of full-length Ci to generate a truncated repressor form...
  52. Farzan S, Ascano M, Ogden S, Sanial M, Brigui A, Plessis A, et al. Costal2 functions as a kinesin-like protein in the hedgehog signal transduction pathway. Curr Biol. 2008;18:1215-20 pubmed publisher
    ..recruits and transports other components of the Hh signaling pathway, including the transcription factor Cubitus interruptus (Ci)...
  53. Chen Y, Jiang J. Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res. 2013;23:186-200 pubmed publisher
    ..Smo acts through intracellular signaling complexes to convert the latent transcription factor Cubitus interruptus (Ci)/Gli from a truncated repressor to a full-length activator, leading to derepression/activation of Hh ..
  54. Torroja C, Gorfinkiel N, Guerrero I. Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction. Development. 2004;131:2395-408 pubmed
  55. Christiansen A, Ding T, Fan Y, Graves H, Herz H, Lindblad J, et al. Non-cell autonomous control of apoptosis by ligand-independent Hedgehog signaling in Drosophila. Cell Death Differ. 2013;20:302-11 pubmed publisher
    ..Ligand-independent, deregulated Hh signaling caused by loss of negative regulators such as Patched causes excessive cell proliferation, leading to overgrowth in Drosophila and tumors in humans, including basal-cell carcinoma and ..
  56. Price M, Kalderon D. Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. Development. 1999;126:4331-9 pubmed
    ..signaling regulates transcription of target genes by modifying the activity of the DNA-binding protein Cubitus interruptus (Ci)...
  57. Brumby A, Richardson H. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 2003;22:5769-79 pubmed
    ..We have used the MARCM system to generate mutant clones of the apical-basal cell polarity tumor suppressor gene, scribble, in the context of normal tissue...
  58. Lum L, Beachy P. The Hedgehog response network: sensors, switches, and routers. Science. 2004;304:1755-9 pubmed
    The Hedgehog (Hh) signaling pathway is intimately linked to cell growth and differentiation, with normal roles in embryonic pattern formation and adult tissue homeostasis and pathological roles in tumor initiation and growth...
  59. Merabet S, Hombria J, Hu N, Pradel J, Graba Y. Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis. Development. 2005;132:3093-102 pubmed
    ..These changes in expression patterns confer axial specificity to otherwise reiteratively used segmental patterning cues, linking intrasegmental polarity and acquisition of segment identity. ..
  60. Gallet A, Staccini Lavenant L, Therond P. Cellular trafficking of the glypican Dally-like is required for full-strength Hedgehog signaling and wingless transcytosis. Dev Cell. 2008;14:712-25 pubmed publisher
    Hedgehog (Hh) and Wingless (Wg) morphogens specify cell fate in a concentration-dependent manner in the Drosophila wing imaginal disc...
  61. Sisson B, Ziegenhorn S, Holmgren R. Regulation of Ci and Su(fu) nuclear import in Drosophila. Dev Biol. 2006;294:258-70 pubmed
    ..studies have linked Su(fu) to the cytoplasmic sequestration of the zinc finger transcription factor, Cubitus interruptus (Ci), while other studies suggest a role in modulating target gene expression...
  62. Seong K, Akimaru H, Dai P, Nomura T, Okada M, Ishii S. Inhibition of the nuclear import of cubitus interruptus by roadkill in the presence of strong hedgehog signal. PLoS ONE. 2010;5:e15365 pubmed publisher
    Hedgehog (Hh) signalling plays an important role in various developmental processes by activating the Cubitus interruptus (Ci)/Glioblastoma (Gli) family of transcription factors...
  63. Crozatier M, Glise B, Vincent A. Connecting Hh, Dpp and EGF signalling in patterning of the Drosophila wing; the pivotal role of collier/knot in the AP organiser. Development. 2002;129:4261-9 pubmed
    ..phenotypes to col requirement for the local upregulation of both emc and N, two genes involved in the control of cell proliferation, the EGFR ligand Vein and the intervein determination gene blistered...
  64. Micchelli C, The I, Selva E, Mogila V, Perrimon N. Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling. Development. 2002;129:843-51 pubmed
    ..Our results suggest that Rasp-dependent acylation is necessary to generate a fully active Hh protein. ..
  65. Takeo S, Akiyama T, Firkus C, Aigaki T, Nakato H. Expression of a secreted form of Dally, a Drosophila glypican, induces overgrowth phenotype by affecting action range of Hedgehog. Dev Biol. 2005;284:204-18 pubmed
    Glypicans, a family of heparan sulfate proteoglycans attached to the cell surface via a glycosylphosphatidylinositol (GPI)-anchor, play essential roles in morphogen signaling and distributions...
  66. Malpel S, Claret S, Sanial M, Brigui A, Piolot T, Daviet L, et al. The last 59 amino acids of Smoothened cytoplasmic tail directly bind the protein kinase Fused and negatively regulate the Hedgehog pathway. Dev Biol. 2007;303:121-33 pubmed
    ..We propose that FU could act as a switch, activator in presence of HH signal or inhibitor in absence of HH. ..
  67. Raisin S, Ruel L, Ranieri N, Staccini Lavenant L, Thérond P. Dynamic phosphorylation of the kinesin Costal-2 in vivo reveals requirement of fused kinase activity for all levels of hedgehog signalling. Dev Biol. 2010;344:119-28 pubmed publisher
    ..Therefore, we propose that the extracellular Hh information is conveyed to an intracellular signal through graded Fu kinase activity. ..
  68. Ranieri N, Ruel L, Gallet A, Raisin S, Therond P. Distinct phosphorylations on kinesin costal-2 mediate differential hedgehog signaling strength. Dev Cell. 2012;22:279-94 pubmed publisher
    ..In Drosophila, associations between Smo and the Fused (Fu)/Costal-2 (Cos2)/Cubitus Interruptus (Ci) cytoplasmic complex lead to pathway activation, but it remains unclear how the cytoplasmic complex ..
  69. Greenwood S, Struhl G. Progression of the morphogenetic furrow in the Drosophila eye: the roles of Hedgehog, Decapentaplegic and the Raf pathway. Development. 1999;126:5795-808 pubmed
  70. Alexandre C, Vincent J. Requirements for transcriptional repression and activation by Engrailed in Drosophila embryos. Development. 2003;130:729-39 pubmed
    ..We suggest that, like Exd, Ubx and Abd-A could help En recognize target genes or activate the expression of factors that do so. ..
  71. Mistry H, Wilson B, Roberts I, O Kane C, Skeath J. Cullin-3 regulates pattern formation, external sensory organ development and cell survival during Drosophila development. Mech Dev. 2004;121:1495-507 pubmed
    ..and have been implicated in degradation of key regulatory molecules including Cyclin E, beta-catenin and Cubitus interruptus. Here, we describe the genetic identification and molecular characterisation of the Drosophila Cullin-3 ..
  72. Wang Y, Price M. A unique protection signal in Cubitus interruptus prevents its complete proteasomal degradation. Mol Cell Biol. 2008;28:5555-68 pubmed publisher
    The limited proteolysis of Cubitus interruptus (Ci), the transcription factor for the developmentally and medically important Hedgehog (Hh) signaling pathway, triggers a critical switch between transcriptional repressor and activator ..
  73. Vervoort M, Crozatier M, Valle D, Vincent A. The COE transcription factor Collier is a mediator of short-range Hedgehog-induced patterning of the Drosophila wing. Curr Biol. 1999;9:632-9 pubmed
    ..serum response factor (D-SRF), the activity of which is required for the adoption and maintenance of the intervein cell fate. Furthermore, col is allelic to knot, a gene involved in the formation of the central part of the wing...
  74. Suzuki T, Saigo K. Transcriptional regulation of atonal required for Drosophila larval eye development by concerted action of eyes absent, sine oculis and hedgehog signaling independent of fused kinase and cubitus interruptus. Development. 2000;127:1531-40 pubmed
    ..Sine oculis act downstream of or in parallel with Hedgehog signaling and (3) the Hedgehog signaling pathway required for Bolwig's organ development is a new type and lacks Fused kinase and Cubitus interruptus as downstream components.
  75. Jia J, Amanai K, Wang G, Tang J, Wang B, Jiang J. Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus. Nature. 2002;416:548-52 pubmed
    ..In Drosophila, Hh acts both by blocking the proteolytic processing of full-length Cubitus interruptus, Ci (Ci155), to generate a truncated repressor form (Ci75), and by stimulating the activity of accumulated ..
  76. Ou C, Lin Y, Chen Y, Chien C. Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes Dev. 2002;16:2403-14 pubmed
    ..In Drosophila Nedd8 and Cul1 mutants, protein levels of the signal transduction effectors, Cubitus interruptus (Ci) and Armadillo (Arm), and the cell cycle regulator, Cyclin E (CycE), are highly accumulated, suggesting ..
  77. Smelkinson M, Kalderon D. Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb. Curr Biol. 2006;16:110-6 pubmed
    ..In the absence of Hh, the sole Drosophila Gli homolog, Cubitus interruptus (Ci), undergoes partial proteolysis to Ci-75, which represses key Hh target genes ...
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