Gene Symbol: Chc
Description: Clathrin heavy chain
Alias: CG9012, CHC, CLH, Cla, Clh, D-Chc, Dmel\CG9012, chc, chc1, dCHC, l(1)13Fb, l(1)G0438, l(1)VI, clathrin heavy chain, CG9012-PA, CG9012-PB, CG9012-PC, CG9012-PD, CG9012-PE, CG9012-PF, CG9012-PG, Chc-PA, Chc-PB, Chc-PC, Chc-PD, Chc-PE, Chc-PF, Chc-PG, clathrin, clathrin hc, clathrin heavy-chain
Species: fruit fly
Products:     Chc

Top Publications

  1. Devergne O, Ghiglione C, Noselli S. The endocytic control of JAK/STAT signalling in Drosophila. J Cell Sci. 2007;120:3457-64 pubmed
    ..Surprisingly, blocking trafficking in distinct endosomal compartments using mutants affecting either Clathrin heavy chain, rab5, Hrs or deep orange led to an inhibition of the JAK/STAT pathway, whereas this pathway was unchanged ..
  2. Cadavid A, Ginzel A, Fischer J. The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis. Development. 2000;127:1727-36 pubmed
    ..The liquid facets locus encodes epsin, a vertebrate protein associated with the clathrin endocytosis complex...
  3. Peng Y, Yang W, Lin W, Lai T, Chien C. Nak regulates Dlg basal localization in Drosophila salivary gland cells. Biochem Biophys Res Commun. 2009;382:108-13 pubmed publisher
    ..Therefore, Nak regulates the transition of Dlg distribution likely through endocytosis of Dlg from the apical membrane domain and transcytosis of Dlg to the basolateral membrane domain during the maturation of SGs development. ..
  4. Abdallah A, Zhou X, Kim C, Shah K, Hogden C, Schoenherr J, et al. Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis. Dev Biol. 2013;378:141-53 pubmed publisher
    ..Ack associates predominantly with endocytic clathrin sites in spermatocytes, but disruption of Ack function has no apparent effect on clathrin localization and ..
  5. Zhou X, Fabian L, Bayraktar J, Ding H, Brill J, Chang H. Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis. Development. 2011;138:1111-20 pubmed publisher
    ..Like partial loss-of-function Clathrin heavy chain (Chc) mutants, aux mutant males are sterile and produce no mature sperm...
  6. Windler S, Bilder D. Endocytic internalization routes required for delta/notch signaling. Curr Biol. 2010;20:538-43 pubmed publisher
    ..Here we use null mutations in Drosophila dynamin, clathrin, and AP-2 adaptor subunits to analyze internalization requirements for the Delta ligand and its receptor, Notch...
  7. Kametaka S, Sawada N, Bonifacino J, Waguri S. Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster. J Cell Sci. 2010;123:460-71 pubmed publisher
    Targeting of proteins to their final destination is a prerequisite for living cells to maintain their homeostasis. Clathrin functions as a coat that forms transport carriers called clathrin-coated vesicles (CCVs) at the plasma membrane ..
  8. Hirst J, Sahlender D, Choma M, Sinka R, Harbour M, Parkinson M, et al. Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells. Traffic. 2009;10:1696-710 pubmed
    ..ARF (ADP ribosylation factor)-binding proteins] and the AP-1 (adaptor protein-1) complex are both adaptors for clathrin-mediated intracellular trafficking, but their relationship to each other is unclear...
  9. Vanzo N, Oprins A, Xanthakis D, Ephrussi A, Rabouille C. Stimulation of endocytosis and actin dynamics by Oskar polarizes the Drosophila oocyte. Dev Cell. 2007;12:543-55 pubmed
    ..We propose that Oskar maintains its localization at the posterior pole through dual functions in regulating endocytosis and F-actin dynamics. ..

More Information


  1. Eun S, Lea K, Overstreet E, Stevens S, Lee J, Fischer J. Identification of genes that interact with Drosophila liquid facets. Genetics. 2007;175:1163-74 pubmed
    ..Mutant alleles of clathrin heavy chain, Rala, split ends, and auxilin were identified as enhancers...
  2. Banks S, Cho B, Eun S, Lee J, Windler S, Xie X, et al. The functions of auxilin and Rab11 in Drosophila suggest that the fundamental role of ligand endocytosis in notch signaling cells is not recycling. PLoS ONE. 2011;6:e18259 pubmed publisher
    ..we find that much of the requirement for auxilin in Notch signaling was bypassed by overexpression of both clathrin heavy chain and epsin...
  3. Wingen C, Stümpges B, Hoch M, Behr M. Expression and localization of clathrin heavy chain in Drosophila melanogaster. Gene Expr Patterns. 2009;9:549-54 pubmed publisher
    ..Basic components of the vesicle coat are clathrin heavy chain (Chc) and clathrin light chain molecules...
  4. Sommer B, Oprins A, Rabouille C, Munro S. The exocyst component Sec5 is present on endocytic vesicles in the oocyte of Drosophila melanogaster. J Cell Biol. 2005;169:953-63 pubmed
    ..that in Drosophila melanogaster oocytes the majority of the exocyst component Sec5 is unexpectedly present in clathrin-coated pits and vesicles at the plasma membrane...
  5. Bazinet C, Katzen A, Morgan M, Mahowald A, Lemmon S. The Drosophila clathrin heavy chain gene: clathrin function is essential in a multicellular organism. Genetics. 1993;134:1119-34 pubmed
    The clathrin heavy chain (HC) is the major structural polypeptide of the cytoplasmic surface lattice of clathrin-coated pits and vesicles...
  6. Kasprowicz J, Kuenen S, Miskiewicz K, Habets R, Smitz L, Verstreken P. Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake. J Cell Biol. 2008;182:1007-16 pubmed publisher
    ..We test clathrin function during synaptic endocytosis using clathrin heavy chain (chc) mutants combined with chc photoinactivation to circumvent early embryonic lethality associated with ..
  7. Zhang B, Koh Y, Beckstead R, Budnik V, Ganetzky B, Bellen H. Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis. Neuron. 1998;21:1465-75 pubmed
    b>Clathrin-mediated endocytosis is thought to involve the activity of the clathrin adaptor protein AP180. However, the role of this protein in endocytosis in vivo remains unknown...
  8. van der Bliek A, Meyerowitz E. Dynamin-like protein encoded by the Drosophila shibire gene associated with vesicular traffic. Nature. 1991;351:411-4 pubmed
    ..In light of the shibire phenotype, we suggest that these proteins provide the motor for vesicular transport during endocytosis. ..
  9. Venken K, Kasprowicz J, Kuenen S, Yan J, Hassan B, Verstreken P. Recombineering-mediated tagging of Drosophila genomic constructs for in vivo localization and acute protein inactivation. Nucleic Acids Res. 2008;36:e114 pubmed publisher
    ..fluorescein-assisted light inactivation and we provide proof of concept by demonstrating that acute loss of clathrin heavy chain function in the fly eye leads to synaptic transmission defects in photoreceptors...
  10. Eun S, Banks S, Fischer J. Auxilin is essential for Delta signaling. Development. 2008;135:1089-95 pubmed publisher
    ..Here, we show in Drosophila that Auxilin, an endocytic factor that regulates Clathrin dynamics, is also essential for Notch signaling...
  11. Gonzalez Gaitan M, Jackle H. The range of spalt-activating Dpp signalling is reduced in endocytosis-defective Drosophila wing discs. Mech Dev. 1999;87:143-51 pubmed
    ..The data suggest that clathrin-mediated endocytosis, a cellular process necessary for membrane recycling and vesicular trafficking, participates ..
  12. Vazquez Pianzola P, Adam J, Haldemann D, Hain D, Urlaub H, Suter B. Clathrin heavy chain plays multiple roles in polarizing the Drosophila oocyte downstream of Bic-D. Development. 2014;141:1915-26 pubmed publisher
    ..b>Clathrin heavy chain (Chc) co-immunopurifies with Bic-D in embryos and ovaries, and a fraction of Chc colocalizes with Bic-D...
  13. Behr M, Wingen C, Wolf C, Schuh R, Hoch M. Wurst is essential for airway clearance and respiratory-tube size control. Nat Cell Biol. 2007;9:847-53 pubmed publisher
    ..Wurst is essential for clathrin-mediated endocytosis, which is required for size determination and lumen clearance of the airways...
  14. Kametaka S, Kametaka A, Yonekura S, Haruta M, Takenoshita S, Goto S, et al. AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. J Cell Sci. 2012;125:634-48 pubmed publisher
    b>Clathrin adaptor protein complex-1 (AP-1) and its accessory proteins play a role in the sorting of integral membrane proteins at the trans-Golgi network and endosomes...
  15. Kitazawa D, Yamaguchi M, Mori H, Inoue Y. COPI-mediated membrane trafficking is required for cytokinesis in Drosophila male meiotic divisions. J Cell Sci. 2012;125:3649-60 pubmed
    ..Thus, we propose that COPI plays an important role in Drosophila male meiosis, not only through vesicle transport to the cleavage furrow region, but also through the formation of ER-based structures. ..
  16. Zhang L, Ten Hagen K. Dissecting the biological role of mucin-type O-glycosylation using RNA interference in Drosophila cell culture. J Biol Chem. 2010;285:34477-84 pubmed publisher
    ..Our work provides new information regarding the biological roles of O-glycosylation and illustrates a new platform for interrogating the cellular and subcellular effects of this form of post-translational modification. ..
  17. Lawrence P. Wingless signalling: more about the Wingless morphogen. Curr Biol. 2001;11:R638-9 pubmed
    ..Recent work on pattern formation in the Drosophila embryo reveals a new mechanism which shapes the gradient of the secreted morphogen, Wingless: Wingless protein is degraded more rapidly on one side of its source than on the other. ..
  18. Rodal A, Littleton J. Synaptic endocytosis: illuminating the role of clathrin assembly. Curr Biol. 2008;18:R259-61 pubmed publisher
    Acute photo-inactivation of clathrin in Drosophila synapses sheds new light on a 35-year-old debate over mechanisms of synaptic-vesicle endocytosis: clathrin is essential for reformation of functional synaptic vesicles, but not for bulk ..
  19. Xie X, Cho B, Fischer J. Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules. Dev Biol. 2012;363:399-412 pubmed publisher
    Epsin is an endocytic protein that binds Clathrin, the plasma membrane, Ubiquitin, and also a variety of other endocytic proteins through well-characterized motifs...
  20. Kuromi H, Honda A, Kidokoro Y. Ca2+ influx through distinct routes controls exocytosis and endocytosis at drosophila presynaptic terminals. Neuron. 2004;41:101-11 pubmed
    ..In shibire(ts1), a dynamin mutant, flunarizine or La(3+) inhibited assembly of clathrin at the plasma membrane during stimulation without affecting dynamin function.
  21. Iwanami N, Nakamura Y, Satoh T, Liu Z, Satoh A. Rab6 Is Required for Multiple Apical Transport Pathways but Not the Basolateral Transport Pathway in Drosophila Photoreceptors. PLoS Genet. 2016;12:e1005828 pubmed publisher
    ..However, basolateral cargos are sorted and exported from the trans-Golgi network in a Rab6-independent manner. ..
  22. Stimson D, Estes P, Rao S, Krishnan K, Kelly L, Ramaswami M. Drosophila stoned proteins regulate the rate and fidelity of synaptic vesicle internalization. J Neurosci. 2001;21:3034-44 pubmed
    ..plasma membrane but do not alter the levels or distribution of endocytosis proteins, dynamin, alpha-adaptin, and clathrin. In addition, stn(8P1) mutants exhibit depletion and enlargement of synaptic vesicles...
  23. Richard D, Gilbert M, Crum B, Hollinshead D, Schelble S, Scheswohl D. Yolk protein endocytosis by oocytes in Drosophila melanogaster: immunofluorescent localization of clathrin, adaptin and the yolk protein receptor. J Insect Physiol. 2001;47:715-723 pubmed Drosophila melanogaster has been investigated by immunofluorescent localization of the endocytosis proteins, clathrin, alpha-adaptin and the putative yolk protein receptor (YP receptor)...
  24. Cherry S, Perrimon N. Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis. Nat Immunol. 2004;5:81-7 pubmed
    ..We infected Drosophila melanogaster cells and adults with drosophila C virus and found that the clathrin-mediated endocytotic pathway is essential for both infection and pathogenesis...
  25. Kawasaki F, Iyer J, Posey L, Sun C, Mammen S, Yan H, et al. The DISABLED protein functions in CLATHRIN-mediated synaptic vesicle endocytosis and exoendocytic coupling at the active zone. Proc Natl Acad Sci U S A. 2011;108:E222-9 pubmed publisher
    ..are known to play a conserved role in endocytic trafficking of cell surface receptors by functioning as monomeric CLATHRIN-associated sorting proteins that recruit cargo proteins into endocytic vesicles...
  26. Tsarouhas V, Senti K, Jayaram S, Tiklová K, Hemphälä J, Adler J, et al. Sequential pulses of apical epithelial secretion and endocytosis drive airway maturation in Drosophila. Dev Cell. 2007;13:214-25 pubmed
    ..The coordination of luminal matrix secretion and endocytosis may be a general mechanism in tubular organ morphogenesis and maturation. ..
  27. Zhu J, Vereshchagina N, Sreekumar V, Burbulla L, Costa A, Daub K, et al. Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model. PLoS ONE. 2013;8:e83714 pubmed publisher
  28. Sechi S, Colotti G, Belloni G, Mattei V, Frappaolo A, Raffa G, et al. GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster. PLoS Genet. 2014;10:e1004305 pubmed publisher
    ..Because cytokinesis failures have been associated with premalignant disease and cancer, our studies suggest novel insight into molecular circuits involving the oncogene GOLPH3 in cytokinesis. ..
  29. Yan Y, Denef N, Schupbach T. The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila. Dev Cell. 2009;17:387-402 pubmed publisher
    ..Our results demonstrate that Rbcn-3 affects Notch signaling and trafficking through regulating V-ATPase function, which implies that the acidification of an intracellular compartment in the receiving cells is crucial for signaling. ..
  30. Gruber J, Long A. Cis-regulatory variation is typically polyallelic in Drosophila. Genetics. 2009;181:661-70 pubmed publisher
    ..If standing cis-regulatory variation is actually slightly deleterious, the true mutational target size is larger. ..
  31. Scott M. Signalling and endocytosis: Wnt breaks down on back roads. Nat Cell Biol. 2001;3:E185-6 pubmed
  32. Peralta S, Gómez Y, González Gaitán M, Moya F, Vinós J. Notch down-regulation by endocytosis is essential for pigment cell determination and survival in the Drosophila retina. Mech Dev. 2009;126:256-69 pubmed publisher
    The clathrin heavy chain is a fundamental element in endocytosis and therefore, in the internalization of several cell-surface receptors through which cells interact with their environment...
  33. Watts R, Hoopfer E, Luo L. Axon pruning during Drosophila metamorphosis: evidence for local degeneration and requirement of the ubiquitin-proteasome system. Neuron. 2003;38:871-85 pubmed
    ..Our findings suggest that some forms of axon pruning during development may share similarities with degeneration of axons in response to injury. ..
  34. Thomson T, Schneemann A, Johnson J. Oocyte destruction is activated during viral infection. Genesis. 2012;50:453-65 pubmed publisher
    ..As expected, mutants in genes known to be involved in virus internalization and trafficking [Clathrin heavy chain (chc) and synaptotagmin] survive longer during infection...
  35. Katzen A, Bishop J. myb provides an essential function during Drosophila development. Proc Natl Acad Sci U S A. 1996;93:13955-60 pubmed
    ..Examination of the mutant phenotype revealed that Drosophila myb is important for both embryonic and imaginal development and that myb serves a role in the development of many tissues and during oogenesis. ..
  36. Tiklová K, Senti K, Wang S, Gräslund A, Samakovlis C. Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila. Nat Cell Biol. 2010;12:1071-7 pubmed publisher
    ..Mouse MTf complements the defects of Drosophila MTf mutants. Drosophila provides the first genetic model for the functional dissection of MTf in epithelial junction assembly and morphogenesis. ..
  37. Vidal O, Stec W, Bausek N, Smythe E, Zeidler M. Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking. J Cell Sci. 2010;123:3457-66 pubmed publisher
    ..We show that Dome is trafficked through clathrin-mediated endocytosis and a directed RNAi screen identified several components of the endocytic machinery as ..
  38. Liu G, Sanghavi P, Bollinger K, Perry L, Marshall B, Roon P, et al. Efficient Endocytic Uptake and Maturation in Drosophila Oocytes Requires Dynamitin/p50. Genetics. 2015;201:631-49 pubmed publisher
    ..Yolk proteins are internalized into the oocyte via clathrin-mediated endocytosis, trafficked through the endocytic pathway, and stored in condensed yolk granules...
  39. Ho Y, Lien M, Lin C, Wei S, Chang L, Hsu J. Echinoid regulates Flamingo endocytosis to control ommatidial rotation in the Drosophila eye. Development. 2010;137:745-54 pubmed publisher
    ..adherens junction-associated cell adhesion molecule, and Flamingo (Fmi), a PCP determinant, are endocytosed via a clathrin-mediated pathway in ICs...
  40. Bao H, Berlanga M, Xue M, Hapip S, Daniels R, Mendenhall J, et al. The atypical cadherin flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila. Mol Cell Neurosci. 2007;34:662-78 pubmed
    ..These findings shed new light on a possible role for Flamingo in progressive neurodegenerative diseases. ..
  41. Yang W, Peng Y, Li H, Lin H, Lin Y, Lai T, et al. Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. Neuron. 2011;72:285-99 pubmed publisher
    ..Here, we show that Nak, a clathrin adaptor-associated kinase, promotes higher-order dendrite growth through endocytosis...
  42. Oshima K, Fehon R. Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large. J Cell Sci. 2011;124:2861-71 pubmed publisher
    ..These results indicate that formation of a stable SJ core complex is separable from its proper subcellular localization, and provide new insights into the complex processes that regulate epithelial polarity and assembly of the SJ. ..
  43. Burgess J, Jauregui M, Tan J, Rollins J, Lallet S, Leventis P, et al. AP-1 and clathrin are essential for secretory granule biogenesis in Drosophila. Mol Biol Cell. 2011;22:2094-105 pubmed publisher
    ..b>Clathrin and the clathrin adaptor protein complex 1 (AP-1) are necessary for maturation of exocrine, endocrine, and ..
  44. Bronk P, Wenniger J, Dawson Scully K, Guo X, Hong S, Atwood H, et al. Drosophila Hsc70-4 is critical for neurotransmitter exocytosis in vivo. Neuron. 2001;30:475-88 pubmed
    Previous in vitro studies of cysteine-string protein (CSP) imply a potential role for the clathrin-uncoating ATPase Hsc70 in exocytosis...
  45. Ulvila J, Parikka M, Kleino A, Sormunen R, Ezekowitz R, Kocks C, et al. Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells. J Biol Chem. 2006;281:14370-5 pubmed RNAi in Drosophila: DEAD-box RNA helicase Belle, 26 S proteasome regulatory subunit 8 (Pros45), and clathrin heavy chain, a component of the endocytic machinery...
  46. Jaspers M, Nolde K, Behr M, Joo S, Plessmann U, Nikolov M, et al. The claudin Megatrachea protein complex. J Biol Chem. 2012;287:36756-65 pubmed publisher
    ..Also, our findings suggest that clathrin-coated vesicles may regulate Megatrachea turnover at the plasma membrane similar to human claudins...
  47. Parfitt K, Reist N, Li J, Burgess R, Deitcher D, DiAntonio A, et al. Drosophila genetics and the functions of synaptic proteins. Cold Spring Harb Symp Quant Biol. 1995;60:371-7 pubmed
  48. Zang Y, Wan M, Liu M, Ke H, Ma S, Liu L, et al. Plasma membrane overgrowth causes fibrotic collagen accumulation and immune activation in Drosophila adipocytes. elife. 2015;4:e07187 pubmed publisher
    ..Our work indicates that traffic imbalances and PM topology may contribute to fibrosis. It also places fibrotic deposits both downstream and upstream of immune signaling, consistent with the chronic character of fibrotic diseases. ..
  49. Fabian Fine R, Verstreken P, Hiesinger P, Horne J, Kostyleva R, Zhou Y, et al. Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals. J Neurosci. 2003;23:10732-44 pubmed
    ..They therefore rely heavily on vesicle regeneration. Null mutations in endophilin (endo) block clathrin-mediated endocytosis at the Drosophila neuromuscular junction, where previous analysis of hypomorphic mutations ..
  50. Chen W, Shih H, Liu K, Liu K, Shih Z, Chen L, et al. Intellectual disability-associated dBRWD3 regulates gene expression through inhibition of HIRA/YEM-mediated chromatin deposition of histone H3.3. EMBO Rep. 2015;16:528-38 pubmed publisher
    ..Our work thus establishes a previously unknown negative regulation of H3.3 and advances our understanding of BRWD3-dependent intellectual disability. ..
  51. Kasprowicz J, Kuenen S, Swerts J, Miskiewicz K, Verstreken P. Dynamin photoinactivation blocks Clathrin and ?-adaptin recruitment and induces bulk membrane retrieval. J Cell Biol. 2014;204:1141-56 pubmed publisher
    ..Bulk membrane retrieval has also been seen upon Clathrin photoinactivation, and superresolution imaging indicated that acute Dynamin photoinactivation blocked Clathrin ..
  52. Fang X, Zhou J, Liu W, Duan X, Gala U, Sandoval H, et al. Dynamin Regulates Autophagy by Modulating Lysosomal Function. J Genet Genomics. 2016;43:77-86 pubmed publisher
    ..shi encodes a dynamin protein required for fission of clathrin-coated vesicles from the plasma membrane during endocytosis...
  53. Gautier J, Lomakina M, Bouslama Oueghlani L, Derivery E, Beilinson H, Faigle W, et al. Clathrin is required for Scar/Wave-mediated lamellipodium formation. J Cell Sci. 2011;124:3414-27 pubmed publisher
    ..This screen identified Clathrin heavy chain (CHC) as a protein that binds to the SWC and whose depletion affects lamellipodium formation...
  54. Hardie R. Phototransduction: shedding light on translocation. Curr Biol. 2003;13:R775-7 pubmed
    ..New work has identified a phosphoinositide lipid binding domain in Drosophila arrestin and implicates PIP(3) in control of arrestin translocation. ..
  55. Li X, Kuromi H, Briggs L, Green D, Rocha J, Sweeney S, et al. Bicaudal-D binds clathrin heavy chain to promote its transport and augments synaptic vesicle recycling. EMBO J. 2010;29:992-1006 pubmed publisher
    ..b>Clathrin heavy chain (Chc), a major constituent of coated pits and vesicles, is the most abundant protein co-precipitated with ..
  56. Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, et al. LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron. 2012;75:1008-21 pubmed publisher
  57. Jha A, Watkins S, Traub L. The apoptotic engulfment protein Ced-6 participates in clathrin-mediated yolk uptake in Drosophila egg chambers. Mol Biol Cell. 2012;23:1742-64 pubmed publisher
    b>Clathrin-mediated endocytosis and phagocytosis are both selective surface internalization processes but have little known mechanistic similarity or interdependence...
  58. Roos J, Kelly R. Dap160, a neural-specific Eps15 homology and multiple SH3 domain-containing protein that interacts with Drosophila dynamin. J Biol Chem. 1998;273:19108-19 pubmed
    ..We suggest that Dap160 is a scaffolding protein that helps anchor proteins required for endocytosis at sites where they are needed in the Drosophila nerve terminal. ..
  59. Georgiou M, Marinari E, Burden J, Baum B. Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability. Curr Biol. 2008;18:1631-8 pubmed publisher
  60. Dubois L, Lecourtois M, Alexandre C, Hirst E, Vincent J. Regulated endocytic routing modulates wingless signaling in Drosophila embryos. Cell. 2001;105:613-24 pubmed
  61. Fabrizio J, Hime G, Lemmon S, Bazinet C. Genetic dissection of sperm individualization in Drosophila melanogaster. Development. 1998;125:1833-43 pubmed
    ..The structure of the individualization complex in a male-sterile clathrin heavy chain (Chc) mutant is observed to be reduced or disrupted relative to wild-type, consistent with the ..