CG16941

Summary

Gene Symbol: CG16941
Description: uncharacterized protein
Alias: Dmel\CG16941, SF3a1, SF3a120, Sf3a1, l(2)SH3 146, l(3)SH146, sf3a1, uncharacterized protein, CG16941-PA, lethal (3) SH146, splicing factor 3a, subunit 1
Species: fruit fly

Top Publications

  1. Lin C, Mount S, Jarmołowski A, Makałowski W. Evolutionary dynamics of U12-type spliceosomal introns. BMC Evol Biol. 2010;10:47 pubmed publisher
    ..Loss of U12 introns or the genes containing them is more common than conversion to the U2-type. The degeneracy of U12-type terminal dinucleotides among natural U12-type introns is higher than previously thought. ..
  2. Praveen K, Wen Y, Matera A. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep. 2012;1:624-31 pubmed publisher
    ..These findings have major implications for SMA etiology because they show that SMN's role in snRNP biogenesis can be uncoupled from the organismal viability and locomotor defects. ..
  3. Lotti F, Imlach W, Saieva L, Beck E, Hao L, Li D, et al. An SMN-dependent U12 splicing event essential for motor circuit function. Cell. 2012;151:440-54 pubmed publisher
    ..These findings directly link defective splicing of critical neuronal genes induced by SMN deficiency to motor circuit dysfunction, establishing a molecular framework for the selective pathology of SMA. ..
  4. Wu H, Sun L, Wen Y, Liu Y, Yu J, Mao F, et al. Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans. Proc Natl Acad Sci U S A. 2016;113:4134-9 pubmed publisher