Cep135

Summary

Gene Symbol: Cep135
Description: Centrosomal protein 135kDa
Alias: Bld-10, Bld10, Bld10p, CEP135, CG17081, DCep135, DCep135/Bld10, DmBLD10, Dmel\CG17081, bld10, dbld10, centrosomal protein 135kDa, CG17081-PA, CG17081-PB, CG17081-PC, Cep135-PA, Cep135-PB, Cep135-PC
Species: fruit fly

Top Publications

  1. Blachon S, Cai X, Roberts K, Yang K, Polyanovsky A, Church A, et al. A proximal centriole-like structure is present in Drosophila spermatids and can serve as a model to study centriole duplication. Genetics. 2009;182:133-44 pubmed publisher
    ..Second, the centriolar proteins SAS-6, Ana1, and Bld10p/Cep135 are in the PCL. Third, PCL formation depends on SAK/PLK4 and SAS-6...
  2. Stevens N, Dobbelaere J, Brunk K, Franz A, Raff J. Drosophila Ana2 is a conserved centriole duplication factor. J Cell Biol. 2010;188:313-23 pubmed publisher
    ..We propose that members of the SAS-5/Ana2/STIL family of proteins are key conserved components of the centriole duplication machinery. ..
  3. Blachon S, Gopalakrishnan J, Omori Y, Polyanovsky A, Church A, Nicastro D, et al. Drosophila asterless and vertebrate Cep152 Are orthologs essential for centriole duplication. Genetics. 2008;180:2081-94 pubmed publisher
    ..The clear absence of several centriolar markers in mecD mutants suggests that Asl is critical early in centriole duplication...
  4. Fu J, Glover D. Structured illumination of the interface between centriole and peri-centriolar material. Open Biol. 2012;2:120104 pubmed publisher
    ..Although they occupy different spatial compartments on the G2 centriole, Cnn, Spd-2 and ?-tubulin become diminished at the centriole upon entry into meiosis to become part of PCM clouds...
  5. Mottier Pavie V, Megraw T. Drosophila bld10 is a centriolar protein that regulates centriole, basal body, and motile cilium assembly. Mol Biol Cell. 2009;20:2605-14 pubmed publisher
    ..Here we show that Drosophila Bld10, the ortholog of Chlamydomonas reinhardtii Bld10p and human Cep135, is a ubiquitous centriolar protein that also localizes to the spermatid basal body...
  6. Carvalho Santos Z, Machado P, Branco P, Tavares Cadete F, Rodrigues Martins A, Pereira Leal J, et al. Stepwise evolution of the centriole-assembly pathway. J Cell Sci. 2010;123:1414-26 pubmed publisher
    ..cohesive and ancestral module, which we term UNIMOD and is defined by three components (SAS6, SAS4/CPAP and BLD10/CEP135), that correlates with the occurrence of CBBs...
  7. Dzhindzhev N, Yu Q, Weiskopf K, Tzolovsky G, Cunha Ferreira I, Riparbelli M, et al. Asterless is a scaffold for the onset of centriole assembly. Nature. 2010;467:714-8 pubmed publisher
    ..Our findings identify independent functions for Asl as a scaffold for Plk4 and Sas-4 that facilitates self-assembly and duplication of the centriole and organization of pericentriolar material...
  8. Carvalho Santos Z, Machado P, Alvarez Martins I, Gouveia S, Jana S, Duarte P, et al. BLD10/CEP135 is a microtubule-associated protein that controls the formation of the flagellum central microtubule pair. Dev Cell. 2012;23:412-24 pubmed publisher
    ..BLD10/CEP135, a conserved player in centriole and flagella biogenesis, can bind and stabilize MTs and is required for the early ..
  9. Roque H, Wainman A, Richens J, Kozyrska K, Franz A, Raff J. Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation. J Cell Sci. 2012;125:5881-6 pubmed publisher
    b>Cep135/Bld10 is a conserved centriolar protein required for the formation of the central cartwheel, an early intermediate in centriole assembly...

More Information

Publications21

  1. Galletta B, Fagerstrom C, Schoborg T, McLamarrah T, Ryniawec J, Buster D, et al. A centrosome interactome provides insight into organelle assembly and reveals a non-duplication role for Plk4. Nat Commun. 2016;7:12476 pubmed publisher
    ..We show that Plk4 phosphorylates Cep135 to properly position the essential centriole component Asterless...
  2. Saurya S, Roque H, Novak Z, Wainman A, Aydogan M, Volanakis A, et al. Drosophila Ana1 is required for centrosome assembly and centriole elongation. J Cell Sci. 2016;129:2514-25 pubmed publisher
    ..It has recently been shown that Cep135 (also known as Bld10) initially recruits Ana1 to newly formed centrioles, and that Ana1 then recruits Asl (known ..
  3. Dzhindzhev N, Tzolovsky G, Lipinszki Z, Schneider S, Lattao R, Fu J, et al. Plk4 phosphorylates Ana2 to trigger Sas6 recruitment and procentriole formation. Curr Biol. 2014;24:2526-32 pubmed publisher
  4. Zheng X, Gooi L, Wason A, Gabriel E, Mehrjardi N, Yang Q, et al. Conserved TCP domain of Sas-4/CPAP is essential for pericentriolar material tethering during centrosome biogenesis. Proc Natl Acad Sci U S A. 2014;111:E354-63 pubmed publisher
    ..Hence, we provide possible insights into how centrosomal protein defects result in human MCPH and how Sas-4 proteins act as a vehicle to tether PCM complexes to centrioles independent of its well-known role in centriole duplication. ..
  5. Franz A, Roque H, Saurya S, Dobbelaere J, Raff J. CP110 exhibits novel regulatory activities during centriole assembly in Drosophila. J Cell Biol. 2013;203:785-99 pubmed publisher
    ..Finally, and unexpectedly, CP110 suppresses centriole overduplication induced by the overexpression of centriole duplication proteins. These studies identify novel and surprising functions for CP110 in vivo in flies. ..
  6. Nguyen M, Stone M, Rolls M. Microtubules are organized independently of the centrosome in Drosophila neurons. Neural Dev. 2011;6:38 pubmed publisher
    ..We conclude that the centrosome is not a major site of microtubule nucleation in Drosophila neurons, and is not required for maintenance of neuronal microtubule organization in these cells. ..
  7. Singh P, Ramdas Nair A, Cabernard C. The centriolar protein Bld10/Cep135 is required to establish centrosome asymmetry in Drosophila neuroblasts. Curr Biol. 2014;24:1548-55 pubmed publisher
    ..Here, we report that the centriolar protein Bld10, the fly ortholog of Cep135, is required to establish centrosome asymmetry in Drosophila neuroblasts through shedding of Polo from the mother ..
  8. Fu J, Lipinszki Z, Rangone H, Min M, Mykura C, Chao Chu J, et al. Conserved molecular interactions in centriole-to-centrosome conversion. Nat Cell Biol. 2016;18:87-99 pubmed publisher
    ..Here we show that centriole-to-centrosome conversion requires sequential loading of Cep135, Ana1 (Cep295) and Asterless (Cep152) onto daughter centrioles during mitotic progression in both Drosophila ..
  9. Galletta B, Jacobs K, Fagerstrom C, Rusan N. Asterless is required for centriole length control and sperm development. J Cell Biol. 2016;213:435-50 pubmed publisher
    ..Insights into the role of Asl/Cep152 beyond centriole duplication could help shed light on how Cep152 mutations lead to the development of microcephaly. ..
  10. Blachon S, Khire A, Avidor Reiss T. The origin of the second centriole in the zygote of Drosophila melanogaster. Genetics. 2014;197:199-205 pubmed publisher
    ..These observations demonstrate that the PCL is the origin for the second centriole in the Drosophila zygote and that a paternal centriole precursor, without centriolar proteins, is transmitted to the egg during fertilization. ..
  11. Chen J, Kao L, Jana S, Sivan Loukianova E, Mendonça S, Cabrera O, et al. Rootletin organizes the ciliary rootlet to achieve neuron sensory function in Drosophila. J Cell Biol. 2015;211:435-53 pubmed publisher
    ..Ectopically expressed Root resides at the base of mother centrioles in spermatocytes and localizes asymmetrically to mother centrosomes in neuroblasts, both requiring Bld10, a basal body protein with varied functions.
  12. Zheng Y, Mennella V, Marks S, Wildonger J, Elnagdi E, Agard D, et al. The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in Drosophila. Mol Biol Cell. 2016;27:1740-52 pubmed publisher
    ..Although it is not essential, our data suggest that Nin plays a supportive role in centrosomal and extracentrosomal microtubule organization and asymmetric stem cell division. ..