CecC

Summary

Gene Symbol: CecC
Description: Cecropin C
Alias: BcDNA:RH33561, CG1373, Cec, Cec-C, Dmel\CG1373, cec, cecC, cecropin C, CG1373-PA, CecC-PA, Cecropin-C, Cecropin-C precursor, cecropin
Species: fruit fly

Top Publications

  1. Ryu J, Kim S, Lee H, Bai J, Nam Y, Bae J, et al. Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila. Science. 2008;319:777-82 pubmed publisher
    ..These results reveal that a specific genetic deficiency within a host can profoundly influence the gut commensal microbial community and host physiology...
  2. Kim L, Choi U, Cho H, Lee J, Lee W, Kim J, et al. Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. PLoS Biol. 2007;5:e238 pubmed
    ..We conclude that an inhibitory effect of AP-1 and STAT on NF-kappaB is required for properly balanced immune responses and appears to be evolutionarily conserved. ..
  3. Rutschmann S, Jung A, Zhou R, Silverman N, Hoffmann J, Ferrandon D. Role of Drosophila IKK gamma in a toll-independent antibacterial immune response. Nat Immunol. 2000;1:342-7 pubmed
    ..Thus, in contrast to the vertebrate inflammatory response, IKK gamma is required for the activation of only one immune signaling pathway in Drosophila. ..
  4. Gottar M, Gobert V, Michel T, Belvin M, Duyk G, Hoffmann J, et al. The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature. 2002;416:640-4 pubmed
    ..The data on PGRP-SA with respect to the response to Gram-positive infections, together with the present report, indicate that the PGRP family has a principal role in sensing microbial infections in Drosophila. ..
  5. Verleyen P, Baggerman G, D Hertog W, Vierstraete E, Husson S, Schoofs L. Identification of new immune induced molecules in the haemolymph of Drosophila melanogaster by 2D-nanoLC MS/MS. J Insect Physiol. 2006;52:379-88 pubmed
    ..Many of the identified peptides are post-translationally modified by an N-terminal pyroglutamic acid and/or a C-terminal amide. Haemolymph of control larvae was treated in the same way and revealed only one peptide. ..
  6. Obata F, Kuranaga E, Tomioka K, Ming M, Takeishi A, Chen C, et al. Necrosis-driven systemic immune response alters SAM metabolism through the FOXO-GNMT axis. Cell Rep. 2014;7:821-33 pubmed publisher
    ..We propose that the dFoxO-Gnmt axis is essential for the maintenance of organismal SAM metabolism and energy homeostasis. ..
  7. Petersen A, Rimkus S, Wassarman D. ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila. Proc Natl Acad Sci U S A. 2012;109:E656-64 pubmed publisher
  8. Flatt T, Heyland A, Rus F, Porpiglia E, Sherlock C, Yamamoto R, et al. Hormonal regulation of the humoral innate immune response in Drosophila melanogaster. J Exp Biol. 2008;211:2712-24 pubmed publisher
    ..Our results suggest that 20E and JH play major roles in the regulation of gene expression in response to immune challenge. ..
  9. Gordon M, Ayres J, Schneider D, Nusse R. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. PLoS Pathog. 2008;4:e1000111 pubmed publisher
    ..These results are consistent with a model in which the regulation of host factors, including edin, must be tightly controlled to avoid the detrimental consequences of having too much or too little activity...

More Information

Publications42

  1. Ren C, Webster P, Finkel S, Tower J. Increased internal and external bacterial load during Drosophila aging without life-span trade-off. Cell Metab. 2007;6:144-52 pubmed
  2. Tryselius Y, Samakovlis C, Kimbrell D, Hultmark D. CecC, a cecropin gene expressed during metamorphosis in Drosophila pupae. Eur J Biochem. 1992;204:395-9 pubmed
    Cecropins are antibacterial peptides, induced in insects in response to bacterial infections. In Drosophila, three cecropin genes have previously been characterized, CecA1, CecA2, and CecB, in a dense cluster at 99E on the third ..
  3. Radyuk S, Michalak K, Klichko V, Benes J, Orr W. Peroxiredoxin 5 modulates immune response in Drosophila. Biochim Biophys Acta. 2010;1800:1153-63 pubmed publisher
    ..Molecular and epistatic analyses identified dPrx5 as a negative regulator in the dTak1-JNK arm of immune signaling. Our findings suggest that peroxiredoxins play an important modulatory role in the Drosophila immune response. ..
  4. Abdelsadik A, Roeder T. Chronic activation of the epithelial immune system of the fruit fly's salivary glands has a negative effect on organismal growth and induces a peculiar set of target genes. BMC Genomics. 2010;11:265 pubmed publisher
  5. Sackton T, Clark A. Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing. BMC Genomics. 2009;10:259 pubmed publisher
    ..virilis hemolymph and validate our transcriptional data. These results suggest that the acquisition of novel components of the immune system, and particularly novel effector proteins, may be a common evolutionary phenomenon. ..
  6. Matova N, Anderson K. Rel/NF-kappaB double mutants reveal that cellular immunity is central to Drosophila host defense. Proc Natl Acad Sci U S A. 2006;103:16424-9 pubmed
  7. Clark A, Wang L. Molecular population genetics of Drosophila immune system genes. Genetics. 1997;147:713-24 pubmed
    ..mauritiana, including Andropin; cecropin genes CecA1, CecA2, CecB, and CecC; and Diptericin...
  8. Zhao H, Zhou D, Nizet V, Haddad G. Experimental selection for Drosophila survival in extremely high O2 environments. PLoS ONE. 2010;5:e11701 pubmed publisher
    ..Thus our study provides a molecular basis for understanding the mechanisms of hyperoxia tolerance. ..
  9. Date Ito A, Kasahara K, Sawai H, Chigusa S. Rapid evolution of the male-specific antibacterial protein andropin gene in Drosophila. J Mol Evol. 2002;54:665-70 pubmed publisher
    Andropin, which encodes an antibacterial protein, is closely linked to the Cecropin gene cluster of D. melanogaster. Andropin and Cecropins are considered to have originated from one common ancestor...
  10. Hoffmann J, Kafatos F, Janeway C, Ezekowitz R. Phylogenetic perspectives in innate immunity. Science. 1999;284:1313-8 pubmed
    ..In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity. ..
  11. Kadalayil L, Petersen U, Engstr m Y. Adjacent GATA and kappa B-like motifs regulate the expression of a Drosophila immune gene. Nucleic Acids Res. 1997;25:1233-9 pubmed
    ..for the direct participation of a GATA motif in the expression of the Drosophila antibacterial peptide gene Cecropin A1 . Previously we have shown that a kappaB-like site is necessary for Cecropin A1 gene expression...
  12. Ramos Onsins S, Aguad M. Molecular evolution of the Cecropin multigene family in Drosophila. functional genes vs. pseudogenes. Genetics. 1998;150:157-71 pubmed
    Approximately 4 kb of the Cecropin cluster region have been sequenced in nine lines of Drosophila melanogaster and one line of the sibling species D. simulans, D. mauritiana, and D. sechellia...
  13. Varma D, Bülow M, Pesch Y, Loch G, Hoch M. Forkhead, a new cross regulator of metabolism and innate immunity downstream of TOR in Drosophila. J Insect Physiol. 2014;69:80-8 pubmed publisher
  14. Costa A, Jan E, Sarnow P, Schneider D. The Imd pathway is involved in antiviral immune responses in Drosophila. PLoS ONE. 2009;4:e7436 pubmed publisher
    ..Our data show that antiviral innate immune responses in flies infected with CrPV depend upon hemocytes and signaling through the Imd pathway. ..
  15. Dantoft W, Davis M, Lindvall J, Tang X, Uvell H, Junell A, et al. The Oct1 homolog Nubbin is a repressor of NF-?B-dependent immune gene expression that increases the tolerance to gut microbiota. BMC Biol. 2013;11:99 pubmed publisher
    ..We suggest that Nub protein plays an ancient role, shared with mammalian Oct/POU transcription factors, to moderate responses to immune challenge, thereby increasing the tolerance to biotic stress. ..
  16. Zhou X, Nguyen T, Kimbrell D. Identification and characterization of the Cecropin antibacterial protein gene locus in Drosophila virilis. J Mol Evol. 1997;44:272-81 pubmed
    b>Cecropin is a type of antibacterial peptide that is synthesized in response to infection and has been characterized in many insect species and one mammal...
  17. Samakovlis C, Asling B, Boman H, Gateff E, Hultmark D. In vitro induction of cecropin genes--an immune response in a Drosophila blood cell line. Biochem Biophys Res Commun. 1992;188:1169-75 pubmed
    ..The mbn-2 cells respond to microbial substances by the activation of cecropin genes, coding for bactericidal peptides...
  18. Han Z, Enslen H, Hu X, Meng X, Wu I, Barrett T, et al. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol Cell Biol. 1998;18:3527-39 pubmed
    ..The results revealed that one of the functions of D-p38 is to attenuate antimicrobial peptide gene expression following exposure to lipopolysaccharide. ..
  19. Meng X, Khanuja B, Ip Y. Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor. Genes Dev. 1999;13:792-7 pubmed
    ..These results reveal that individual members of the NF-kappaB family in Drosophila have distinct roles in immunity and development. ..
  20. Zhou R, Silverman N, Hong M, Liao D, Chung Y, Chen Z, et al. The role of ubiquitination in Drosophila innate immunity. J Biol Chem. 2005;280:34048-55 pubmed
    ..These studies reveal an evolutionarily conserved role of ubiquitination in IKK activation, and provide new insights into the hierarchy of signaling components in the Drosophila antibacterial immunity pathway. ..
  21. Hoffmann J, Hetru C, Reichhart J. The humoral antibacterial response of Drosophila. FEBS Lett. 1993;325:63-6 pubmed
    ..We argue that the Drosophila host defense is homologous to the mammalian acute phase response. ..
  22. Rancès E, Ye Y, Woolfit M, McGraw E, O Neill S. The relative importance of innate immune priming in Wolbachia-mediated dengue interference. PLoS Pathog. 2012;8:e1002548 pubmed publisher
  23. Liu F, Baggerman G, D Hertog W, Verleyen P, Schoofs L, Wets G. In silico identification of new secretory peptide genes in Drosophila melanogaster. Mol Cell Proteomics. 2006;5:510-22 pubmed
    ..This bioinformatic study opens perspectives for the genome-wide analysis of peptide genes in other eukaryotic model organisms. ..
  24. Moule M, Monack D, Schneider D. Reciprocal analysis of Francisella novicida infections of a Drosophila melanogaster model reveal host-pathogen conflicts mediated by reactive oxygen and imd-regulated innate immune response. PLoS Pathog. 2010;6:e1001065 pubmed publisher
    ..Our work suggests that there may be more to learn about the fly immune system, as not all of the phenotypes we observe can be readily explained by its interactions with known immune responses. ..
  25. Becker T, Loch G, Beyer M, Zinke I, Aschenbrenner A, Carrera P, et al. FOXO-dependent regulation of innate immune homeostasis. Nature. 2010;463:369-73 pubmed publisher
    ..The sparse production of AMPs in epithelial tissues in response to FOXO may help modulating the defence reaction without harming the host tissues, in particular when animals are suffering from energy shortage or stress. ..
  26. Ligoxygakis P, Bulet P, Reichhart J. Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila. EMBO Rep. 2002;3:666-73 pubmed
    ..18-Wheeler does not qualify as a pattern recognition receptor of Gram-negative bacteria. ..
  27. Overend G, Cabrero P, Guo A, Sebastian S, Cundall M, Armstrong H, et al. The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. Peptides. 2012;34:209-18 pubmed publisher
    ..Thus, the principal-cell localized NPLP1-VQQ/Gyc76C cGMP pathway acts to signal environmental (salt) stress to the whole organism. ..
  28. Hultmark D. Immune reactions in Drosophila and other insects: a model for innate immunity. Trends Genet. 1993;9:178-83 pubmed
    ..The induction of this system, which lacks clonally selected receptors like those of vertebrate B and T cells, may provide a model for innate immune reactions in other animals, including vertebrates. ..
  29. Chen H, Zheng X, Zheng Y. Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia. Cell. 2014;159:829-43 pubmed publisher
    ..paperflick: ..
  30. Vonkavaara M, Pavel S, Hölzl K, Nordfelth R, Sjostedt A, Stoven S. Francisella is sensitive to insect antimicrobial peptides. J Innate Immun. 2013;5:50-9 pubmed publisher
    ..We demonstrate that Francisella is sensitive to specific fly AMPs, i.e. Attacin, Cecropin, Drosocin and Drosomycin...
  31. Mathey Prevot B, Perrimon N. Mammalian and Drosophila blood: JAK of all trades?. Cell. 1998;92:697-700 pubmed
  32. Persson C, Oldenvi S, Steiner H. Peptidoglycan recognition protein LF: a negative regulator of Drosophila immunity. Insect Biochem Mol Biol. 2007;37:1309-16 pubmed
    ..Furthermore, following immune stimulation of S2 cells overexpressing PGRP-LF, we noticed a reduced up-regulation of expression of antimicrobial peptide genes, in consonance with an immune suppressive role for PGRP-LF. ..
  33. Craig C, Fink J, Yagi Y, Ip Y, Cagan R. A Drosophila p38 orthologue is required for environmental stress responses. EMBO Rep. 2004;5:1058-63 pubmed
    ..These phenotypes only partially overlap those caused by mutations in D-MEKK1 and dTAK1, suggesting that the D-p38a gene is required to mediate some, but not all, of the functions ascribed to p38 signalling. ..