CecB

Summary

Gene Symbol: CecB
Description: Cecropin B
Alias: CG1878, Cec, Cec B, Dmel\CG1878, cec, cecB, cedcB, crpB, cecropin B, CG1878-PA, CecB-PA, Cecropin-B, Cecropin-B precursor, cecropin, cercropin B
Species: fruit fly

Top Publications

  1. Gottar M, Gobert V, Michel T, Belvin M, Duyk G, Hoffmann J, et al. The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature. 2002;416:640-4 pubmed
    ..The data on PGRP-SA with respect to the response to Gram-positive infections, together with the present report, indicate that the PGRP family has a principal role in sensing microbial infections in Drosophila. ..
  2. Verleyen P, Baggerman G, D Hertog W, Vierstraete E, Husson S, Schoofs L. Identification of new immune induced molecules in the haemolymph of Drosophila melanogaster by 2D-nanoLC MS/MS. J Insect Physiol. 2006;52:379-88 pubmed
    ..Many of the identified peptides are post-translationally modified by an N-terminal pyroglutamic acid and/or a C-terminal amide. Haemolymph of control larvae was treated in the same way and revealed only one peptide. ..
  3. Rutschmann S, Jung A, Zhou R, Silverman N, Hoffmann J, Ferrandon D. Role of Drosophila IKK gamma in a toll-independent antibacterial immune response. Nat Immunol. 2000;1:342-7 pubmed
    ..Thus, in contrast to the vertebrate inflammatory response, IKK gamma is required for the activation of only one immune signaling pathway in Drosophila. ..
  4. Tryselius Y, Samakovlis C, Kimbrell D, Hultmark D. CecC, a cecropin gene expressed during metamorphosis in Drosophila pupae. Eur J Biochem. 1992;204:395-9 pubmed
    Cecropins are antibacterial peptides, induced in insects in response to bacterial infections. In Drosophila, three cecropin genes have previously been characterized, CecA1, CecA2, and CecB, in a dense cluster at 99E on the third ..
  5. Sackton T, Clark A. Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing. BMC Genomics. 2009;10:259 pubmed publisher
    ..virilis hemolymph and validate our transcriptional data. These results suggest that the acquisition of novel components of the immune system, and particularly novel effector proteins, may be a common evolutionary phenomenon. ..
  6. Clark A, Wang L. Molecular population genetics of Drosophila immune system genes. Genetics. 1997;147:713-24 pubmed
    ..mauritiana, including Andropin; cecropin genes CecA1, CecA2, CecB, and CecC; and Diptericin...
  7. An S, Dong S, Wang Q, Li S, Gilbert L, Stanley D, et al. Insect neuropeptide bursicon homodimers induce innate immune and stress genes during molting by activating the NF-?B transcription factor Relish. PLoS ONE. 2012;7:e34510 pubmed publisher
    ..From these data we infer that CNS-generated bursicon homodimers mediate innate prophylactic immunity to both stress and infection during the vulnerable molting cycle. ..
  8. Petersen A, Rimkus S, Wassarman D. ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila. Proc Natl Acad Sci U S A. 2012;109:E656-64 pubmed publisher
  9. Ren C, Webster P, Finkel S, Tower J. Increased internal and external bacterial load during Drosophila aging without life-span trade-off. Cell Metab. 2007;6:144-52 pubmed

More Information

Publications45

  1. Flatt T, Heyland A, Rus F, Porpiglia E, Sherlock C, Yamamoto R, et al. Hormonal regulation of the humoral innate immune response in Drosophila melanogaster. J Exp Biol. 2008;211:2712-24 pubmed publisher
    ..Our results suggest that 20E and JH play major roles in the regulation of gene expression in response to immune challenge. ..
  2. Abdelsadik A, Roeder T. Chronic activation of the epithelial immune system of the fruit fly's salivary glands has a negative effect on organismal growth and induces a peculiar set of target genes. BMC Genomics. 2010;11:265 pubmed publisher
  3. Gordon M, Ayres J, Schneider D, Nusse R. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. PLoS Pathog. 2008;4:e1000111 pubmed publisher
    ..These results are consistent with a model in which the regulation of host factors, including edin, must be tightly controlled to avoid the detrimental consequences of having too much or too little activity...
  4. Pletcher S, Macdonald S, Marguerie R, Certa U, Stearns S, Goldstein D, et al. Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol. 2002;12:712-23 pubmed
    ..Caloric restriction extends life span by slowing down the rate of normal aging. Transcription levels of genes from a wide variety of biological functions and processes are impacted by age and dietary conditions. ..
  5. Fedorka K, Linder J, Winterhalter W, Promislow D. Post-mating disparity between potential and realized immune response in Drosophila melanogaster. Proc Biol Sci. 2007;274:1211-7 pubmed
    ..Thus, estimates of immunity based on gene expression do not appear to reflect an actual ability to defend against pathogens in the hours following copulation. We discuss the possible mechanisms that may account for this pattern. ..
  6. Kadalayil L, Petersen U, Engstr m Y. Adjacent GATA and kappa B-like motifs regulate the expression of a Drosophila immune gene. Nucleic Acids Res. 1997;25:1233-9 pubmed
    ..for the direct participation of a GATA motif in the expression of the Drosophila antibacterial peptide gene Cecropin A1 . Previously we have shown that a kappaB-like site is necessary for Cecropin A1 gene expression...
  7. Ramos Onsins S, Aguad M. Molecular evolution of the Cecropin multigene family in Drosophila. functional genes vs. pseudogenes. Genetics. 1998;150:157-71 pubmed
    Approximately 4 kb of the Cecropin cluster region have been sequenced in nine lines of Drosophila melanogaster and one line of the sibling species D. simulans, D. mauritiana, and D. sechellia...
  8. Kylsten P, Samakovlis C, Hultmark D. The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection. EMBO J. 1990;9:217-24 pubmed
    ..step towards a molecular study of the induction of this response, we have isolated genomic clones that cover the cecropin locus in Drosophila melanogaster...
  9. Costa A, Jan E, Sarnow P, Schneider D. The Imd pathway is involved in antiviral immune responses in Drosophila. PLoS ONE. 2009;4:e7436 pubmed publisher
    ..Our data show that antiviral innate immune responses in flies infected with CrPV depend upon hemocytes and signaling through the Imd pathway. ..
  10. Winterhalter W, Fedorka K. Sex-specific variation in the emphasis, inducibility and timing of the post-mating immune response in Drosophila melanogaster. Proc Biol Sci. 2009;276:1109-17 pubmed publisher
    ..Our results suggest that variation in the effectiveness of the immune response between the sexes may be driven by differences in emphasis rather than overall investment. ..
  11. Kleino A, Myllymäki H, Kallio J, Vanha aho L, Oksanen K, Ulvila J, et al. Pirk is a negative regulator of the Drosophila Imd pathway. J Immunol. 2008;180:5413-22 pubmed
    ..Furthermore, pirk-overexpressing flies were more susceptible to Gram-negative bacterial infection than wild-type flies. We conclude that Pirk is a negative regulator of the Imd pathway. ..
  12. Ekengren S, Hultmark D. Drosophila cecropin as an antifungal agent. Insect Biochem Mol Biol. 1999;29:965-72 pubmed
    ..Andropin is less fungicidal than the cecropins, and Drosophila cecropin A is somewhat more potent than cecropin B. Even dense cultures of Saccharomyces cerevisiae can be cleared by micromolar concentrations of cecropin, ..
  13. Hoffmann J, Kafatos F, Janeway C, Ezekowitz R. Phylogenetic perspectives in innate immunity. Science. 1999;284:1313-8 pubmed
    ..In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity. ..
  14. Zhao H, Zhou D, Nizet V, Haddad G. Experimental selection for Drosophila survival in extremely high O2 environments. PLoS ONE. 2010;5:e11701 pubmed publisher
    ..Thus our study provides a molecular basis for understanding the mechanisms of hyperoxia tolerance. ..
  15. Hoffmann J, Hetru C, Reichhart J. The humoral antibacterial response of Drosophila. FEBS Lett. 1993;325:63-6 pubmed
    ..We argue that the Drosophila host defense is homologous to the mammalian acute phase response. ..
  16. Jacobs C, van der Zee M. Immune competence in insect eggs depends on the extraembryonic serosa. Dev Comp Immunol. 2013;41:263-9 pubmed publisher
    ..Drosophila eggs and serosa-less Tribolium eggs, however, show little to no upregulation of any of the tested immune genes. We conclude that the extraembryonic serosa is crucial for the early immune competence of the Tribolium egg...
  17. Marshall K, Sinclair B. Repeated stress exposure results in a survival-reproduction trade-off in Drosophila melanogaster. Proc Biol Sci. 2010;277:963-9 pubmed publisher
    ..Given that many environments are not static, this trade-off indicates that investigating the effects of repeated stress exposure is important for understanding and predicting physiological responses in the wild. ..
  18. Moule M, Monack D, Schneider D. Reciprocal analysis of Francisella novicida infections of a Drosophila melanogaster model reveal host-pathogen conflicts mediated by reactive oxygen and imd-regulated innate immune response. PLoS Pathog. 2010;6:e1001065 pubmed publisher
    ..Our work suggests that there may be more to learn about the fly immune system, as not all of the phenotypes we observe can be readily explained by its interactions with known immune responses. ..
  19. Rancès E, Ye Y, Woolfit M, McGraw E, O Neill S. The relative importance of innate immune priming in Wolbachia-mediated dengue interference. PLoS Pathog. 2012;8:e1002548 pubmed publisher
  20. Zhou R, Silverman N, Hong M, Liao D, Chung Y, Chen Z, et al. The role of ubiquitination in Drosophila innate immunity. J Biol Chem. 2005;280:34048-55 pubmed
    ..These studies reveal an evolutionarily conserved role of ubiquitination in IKK activation, and provide new insights into the hierarchy of signaling components in the Drosophila antibacterial immunity pathway. ..
  21. Ryu J, Kim S, Lee H, Bai J, Nam Y, Bae J, et al. Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila. Science. 2008;319:777-82 pubmed publisher
    ..These results reveal that a specific genetic deficiency within a host can profoundly influence the gut commensal microbial community and host physiology...
  22. Liu F, Baggerman G, D Hertog W, Verleyen P, Schoofs L, Wets G. In silico identification of new secretory peptide genes in Drosophila melanogaster. Mol Cell Proteomics. 2006;5:510-22 pubmed
    ..This bioinformatic study opens perspectives for the genome-wide analysis of peptide genes in other eukaryotic model organisms. ..
  23. Meng X, Khanuja B, Ip Y. Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor. Genes Dev. 1999;13:792-7 pubmed
    ..These results reveal that individual members of the NF-kappaB family in Drosophila have distinct roles in immunity and development. ..
  24. Samakovlis C, Asling B, Boman H, Gateff E, Hultmark D. In vitro induction of cecropin genes--an immune response in a Drosophila blood cell line. Biochem Biophys Res Commun. 1992;188:1169-75 pubmed
    ..The mbn-2 cells respond to microbial substances by the activation of cecropin genes, coding for bactericidal peptides...
  25. Han Z, Enslen H, Hu X, Meng X, Wu I, Barrett T, et al. A conserved p38 mitogen-activated protein kinase pathway regulates Drosophila immunity gene expression. Mol Cell Biol. 1998;18:3527-39 pubmed
    ..The results revealed that one of the functions of D-p38 is to attenuate antimicrobial peptide gene expression following exposure to lipopolysaccharide. ..
  26. Date A, Satta Y, Takahata N, Chigusa S. Evolutionary history and mechanism of the Drosophila cecropin gene family. Immunogenetics. 1998;47:417-29 pubmed
    ..b>Cecropin is one such antibacterial protein which is also found in vertebrates...
  27. Zhou X, Nguyen T, Kimbrell D. Identification and characterization of the Cecropin antibacterial protein gene locus in Drosophila virilis. J Mol Evol. 1997;44:272-81 pubmed
    b>Cecropin is a type of antibacterial peptide that is synthesized in response to infection and has been characterized in many insect species and one mammal...
  28. Samakovlis C, Kylsten P, Kimbrell D, Engstrom A, Hultmark D. The andropin gene and its product, a male-specific antibacterial peptide in Drosophila melanogaster. EMBO J. 1991;10:163-9 pubmed
    In our study of the cecropin locus in Drosophila we have found a gene for a new peptide, andropin, with antibacterial properties...
  29. Persson C, Oldenvi S, Steiner H. Peptidoglycan recognition protein LF: a negative regulator of Drosophila immunity. Insect Biochem Mol Biol. 2007;37:1309-16 pubmed
    ..Furthermore, following immune stimulation of S2 cells overexpressing PGRP-LF, we noticed a reduced up-regulation of expression of antimicrobial peptide genes, in consonance with an immune suppressive role for PGRP-LF. ..
  30. Samakovlis C, Kimbrell D, Kylsten P, Engstrom A, Hultmark D. The immune response in Drosophila: pattern of cecropin expression and biological activity. EMBO J. 1990;9:2969-76 pubmed
    ..We have used the cloned Drosophila cecropin genes CecA1, A2 and B as probes to study the developmental and tissue specific regulation of this response...
  31. Chen H, Zheng X, Zheng Y. Age-associated loss of lamin-B leads to systemic inflammation and gut hyperplasia. Cell. 2014;159:829-43 pubmed publisher
    ..paperflick: ..
  32. Craig C, Fink J, Yagi Y, Ip Y, Cagan R. A Drosophila p38 orthologue is required for environmental stress responses. EMBO Rep. 2004;5:1058-63 pubmed
    ..These phenotypes only partially overlap those caused by mutations in D-MEKK1 and dTAK1, suggesting that the D-p38a gene is required to mediate some, but not all, of the functions ascribed to p38 signalling. ..
  33. Ligoxygakis P, Bulet P, Reichhart J. Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila. EMBO Rep. 2002;3:666-73 pubmed
    ..18-Wheeler does not qualify as a pattern recognition receptor of Gram-negative bacteria. ..
  34. Mathey Prevot B, Perrimon N. Mammalian and Drosophila blood: JAK of all trades?. Cell. 1998;92:697-700 pubmed
  35. Hultmark D. Immune reactions in Drosophila and other insects: a model for innate immunity. Trends Genet. 1993;9:178-83 pubmed
    ..The induction of this system, which lacks clonally selected receptors like those of vertebrate B and T cells, may provide a model for innate immune reactions in other animals, including vertebrates. ..
  36. Vonkavaara M, Pavel S, Hölzl K, Nordfelth R, Sjostedt A, Stoven S. Francisella is sensitive to insect antimicrobial peptides. J Innate Immun. 2013;5:50-9 pubmed publisher
    ..We demonstrate that Francisella is sensitive to specific fly AMPs, i.e. Attacin, Cecropin, Drosocin and Drosomycin...