Cdk5

Summary

Gene Symbol: Cdk5
Description: Cyclin-dependent kinase 5
Alias: CDK5, CG8203, DmCdk5, Dmel\CG8203, cdk5, Cyclin-dependent kinase 5, CG8203-PA, Cdk5-PA
Species: fruit fly

Top Publications

  1. Chau K, Chan W, Shaw P, Chan H. Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila. Biochem Biophys Res Commun. 2006;346:150-9 pubmed
    ..Tau protein was phosphorylated by endogenous protein kinases in flies, and overexpression of either GSK3beta or Cdk5 enhanced tau-induced toxicity...
  2. Trunova S, Baek B, Giniger E. Cdk5 regulates the size of an axon initial segment-like compartment in mushroom body neurons of the Drosophila central brain. J Neurosci. 2011;31:10451-62 pubmed publisher
    ..We further show that Cdk5/p35 kinase regulates the formation and maintenance of the putative AIS by controlling the position of its distal ..
  3. Connell Crowley L, Le Gall M, Vo D, Giniger E. The cyclin-dependent kinase Cdk5 controls multiple aspects of axon patterning in vivo. Curr Biol. 2000;10:599-602 pubmed
    Cyclin-dependent kinase 5 (Cdk5) is one of a subfamily of Cdks involved in the control of cell differentiation and morphology rather than cell division...
  4. Kissler A, Pettersson N, Frölich A, Sigrist S, Suter B. Drosophila cdk5 is needed for locomotive behavior and NMJ elaboration, but seems dispensable for synaptic transmission. Dev Neurobiol. 2009;69:365-77 pubmed publisher
    Cyclin-dependent kinase 5 (Cdk5) functions in postmitotic neuronal cells and play roles in cell differentiation, cell migration, axonal guidance, and synaptic function...
  5. Chatterjee S, Sang T, Lawless G, Jackson G. Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model. Hum Mol Genet. 2009;18:164-77 pubmed publisher
    ..include the proline-directed kinases glycogen synthase kinase-3beta (GSK-3beta) and cyclin-dependent kinase 5 (Cdk5), as well as nonproline-directed kinases such as microtubule affinity-regulating kinase (MARK)/PAR-1; however, ..
  6. Connell Crowley L, Vo D, Luke L, Giniger E. Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Mech Dev. 2007;124:341-9 pubmed
    The cyclin-dependent kinase Cdk5 has attracted a great deal of attention both because of its roles in cell migration and axon patterning, and the extensive data implicating it in adult-onset neurodegeneration in mammals...
  7. Hellmich M, Kennison J, Hampton L, Battey J. Cloning and characterization of the Drosophila melanogaster CDK5 homolog. FEBS Lett. 1994;356:317-21 pubmed
    The D. melanogaster homolog of mammalian CDK5 has been cloned and its chromosomal location determined. The gene for Cdk5 consists of 4 exons separated by 3 short introns ranging in size from 61-160 bp...
  8. Prithviraj R, Trunova S, Giniger E. Ex vivo culturing of whole, developing Drosophila brains. J Vis Exp. 2012;: pubmed publisher
    ..the axon initial segment (AIS)(2), was shown genetically to depend on the neuron-specific cyclin-dependent kinase, Cdk5. We show here that ex vivo treatment of wild-type Drosophila larval brains with the Cdk5-specific pharmacological ..
  9. Liman J, Deeg S, Voigt A, Vo feldt H, Dohm C, Karch A, et al. CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration. J Neurochem. 2014;129:1013-23 pubmed publisher
    ..Since cyclin-dependent kinase-5 (CDK5) has been shown to exert beneficial effects on aggregate formation and cell death in various polyglutamine diseases,..

More Information

Publications29

  1. Lin H, Lin T, Juang J. Abl deregulates Cdk5 kinase activity and subcellular localization in Drosophila neurodegeneration. Cell Death Differ. 2007;14:607-15 pubmed
    Although Abl functions in mature neurons, work to date has not addressed Abl's role on Cdk5 in neurodegeneration...
  2. Zhong J, Zhang H, Stanyon C, Tromp G, Finley R. A strategy for constructing large protein interaction maps using the yeast two-hybrid system: regulated expression arrays and two-phase mating. Genome Res. 2003;13:2691-9 pubmed
    ..We also present a three-dimensional pooling scheme to further increase the efficiency of large-scale two-hybrid analyses. ..
  3. Demay Y, Perochon J, Szuplewski S, Mignotte B, Gaumer S. The PERK pathway independently triggers apoptosis and a Rac1/Slpr/JNK/Dilp8 signaling favoring tissue homeostasis in a chronic ER stress Drosophila model. Cell Death Dis. 2014;5:e1452 pubmed publisher
    ..Thanks to a novel chronic ER stress model, these results establish a new pathway that both participates in tissue homeostasis and triggers apoptosis through an original regulation. ..
  4. Ryoo H. Drosophila as a model for unfolded protein response research. BMB Rep. 2015;48:445-53 pubmed
    ..The fact that the basic UPR pathways are conserved, together with the availability of many human disease models in this organism, makes Drosophila a powerful tool for studying human disease mechanisms. ..
  5. Rincon Limas D, Jensen K, Fernandez Funez P. Drosophila models of proteinopathies: the little fly that could. Curr Pharm Des. 2012;18:1108-22 pubmed
    ..To remain relevant in this competitive environment, Drosophila models will need to expand their flexible, innovative, and multidisciplinary approaches to find new discoveries and translational applications. ..
  6. Nannapaneni K, Ben Shahar Y, Keen H, Welsh M, Casavant T, Scheetz T. Computational identification of operon-like transcriptional loci in eukaryotes. Comput Biol Med. 2013;43:738-43 pubmed publisher
    ..elegans and some instances in Drosophila. We identify several candidate operons in Drosophila melanogaster of which two have been subsequently molecularly validated. ..
  7. Lin T, Huang C, Chou W, Juang J. Abi enhances Abl-mediated CDC2 phosphorylation and inactivation. J Biomed Sci. 2004;11:902-10 pubmed
    ..Furthermore, coexpression of Abl and Abi in Drosophila S2 cells led to suppression of cell growth. These data suggest that Abl signaling may be involved in the downregulation of Cdc2 kinase in cell cycle control. ..
  8. Choksi D, Roy B, Chatterjee S, Yusuff T, Bakhoum M, Sengupta U, et al. TDP-43 Phosphorylation by casein kinase I? promotes oligomerization and enhances toxicity in vivo. Hum Mol Genet. 2014;23:1025-35 pubmed publisher
    ..TDP-43 in the fly is specific for DBT, as it is not observed using the validated tau kinases GSK-3?, PAR-1/MARK2 or CDK5. Coexpression of DBT with TDP-43(Q331K) enhances the formation of high-molecular weight oligomeric species ..
  9. Jauffred B, Llense F, Sommer B, Wang Z, Martin C, Bellaiche Y. Regulation of centrosome movements by numb and the collapsin response mediator protein during Drosophila sensory progenitor asymmetric division. Development. 2013;140:2657-68 pubmed publisher
  10. Rascle A, Stowers R, Garza D, Lepesant J, Hogness D. L63, the Drosophila PFTAIRE, interacts with two novel proteins unrelated to cyclins. Mech Dev. 2003;120:617-28 pubmed
    ..Interaction between L63 and PIF-1B was confirmed in vitro and in vivo. The role of this interaction remains to be demonstrated, but our data suggest that PIF-1B might serve as a regulator of L63. ..
  11. Lin C, Tsai P, Wu R, Chien C. LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß. J Neurosci. 2010;30:13138-49 pubmed publisher
    ..G2019S increases the recruitment of autoactivated Sgg, thus inducing hyperphosphorylation and mislocalization of tau with resultant dendrite degeneration. ..
  12. Smith Trunova S, Prithviraj R, Spurrier J, Kuzina I, Gu Q, Giniger E. Cdk5 regulates developmental remodeling of mushroom body neurons in Drosophila. Dev Dyn. 2015;244:1550-63 pubmed publisher
    ..We show here that the neuronal cyclin-dependent kinase, Cdk5, regulates the timing and rate of mushroom body remodeling: reduced Cdk5 activity causes a delay in pruning of MB ..
  13. Kang M, Chung J, Ryoo H. CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model. Nat Cell Biol. 2012;14:409-15 pubmed publisher
    ..Here, we report the identification of a signalling pathway mediated by cdk5 and mekk1 required for ER-stress-induced apoptosis...
  14. Sauer K, Weigmann K, Sigrist S, Lehner C. Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase. Mol Biol Cell. 1996;7:1759-69 pubmed
    ..comparisons suggest that the four putative kinases represent the Drosophila homologues of vertebrate cdk4/6, cdk5, PCTAIRE, and PITSLRE kinases...
  15. Trunova S, Giniger E. Absence of the Cdk5 activator p35 causes adult-onset neurodegeneration in the central brain of Drosophila. Dis Model Mech. 2012;5:210-9 pubmed publisher
    Altered function of Cdk5 kinase is associated with many forms of neurodegenerative disease in humans...
  16. Choe E, Liao L, Zhou J, Cheng D, Duong D, Jin P, et al. Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1. J Neurosci. 2007;27:9503-12 pubmed
    ..such as casein kinase II, MARK (microtubule affinity regulating kinase)/PAR1, and cyclin-dependent kinase 5 (CDK5)...
  17. Liu J, Kipreos E. Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): differential conservation of CAKs in yeast and metazoa. Mol Biol Evol. 2000;17:1061-74 pubmed
  18. Kolonin M, Finley R. Targeting cyclin-dependent kinases in Drosophila with peptide aptamers. Proc Natl Acad Sci U S A. 1998;95:14266-71 pubmed
    ..Combined, our results demonstrate that peptide aptamers generated by yeast two-hybrid methods can serve as inhibitory reagents to target specific proteins in vivo. ..
  19. Ben Shahar Y, Nannapaneni K, Casavant T, Scheetz T, Welsh M. Eukaryotic operon-like transcription of functionally related genes in Drosophila. Proc Natl Acad Sci U S A. 2007;104:222-7 pubmed
    ..These data reveal eukaryotic operon-like transcription of functionally related genes in Drosophila. The results also suggest that operon-based transcription may be more common in eukaryotes than previously appreciated. ..
  20. Chow C, Kelsey K, Wolfner M, Clark A. Candidate genetic modifiers of retinitis pigmentosa identified by exploiting natural variation in Drosophila. Hum Mol Genet. 2016;25:651-9 pubmed publisher
    ..This study demonstrates the utility of studying a pathogenic mutation across a wide range of genetic backgrounds. These candidate modifiers provide new avenues of inquiry that may reveal new RP disease mechanisms and therapies. ..