Gene Symbol: Cdk12
Description: Cyclin-dependent kinase 12
Alias: AC017581, CDK12, CG7597, Dmel\CG7597, anon-WO0140519.165, cg7597, dCDK12, gi24668141, Cyclin-dependent kinase 12, CG7597-PA, CG7597-PB, CG7597-PC, Cdk12-PA, Cdk12-PB, Cdk12-PC
Species: fruit fly
Bartkowiak B, Liu P, Phatnani H, Fuda N, Cooper J, Price D, et al
. CDK12 is a transcription elongation-associated CTD kinase, the metazoan ortholog of yeast Ctk1. Genes Dev. 2010;24:2303-16 pubmed publisher
..Using Drosophila, we demonstrate that dCDK12 (CG7597) is a transcription-associated CTD kinase, the ortholog of yCtk1...
Li X, Chatterjee N, Spirohn K, Boutros M, Bohmann D. Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes. Sci Rep. 2016;6:21455 pubmed publisher
..This paper describes the identification and characterization of the RNA polymerase II (Pol II) kinase Cdk12 as a factor that is required for Nrf2 target gene expression in cell culture and in vivo...
Liu J, Kipreos E. Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): differential conservation of CAKs in yeast and metazoa. Mol Biol Evol. 2000;17:1061-74 pubmed
Rodrigues F, Thuma L, Klämbt C. The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity. Development. 2012;139:1765-76 pubmed publisher
..This approach identified Cyclin-dependent kinase 12 (Cdk12) and the splicesosomal component Prp40 as major determinants in regulating HOW-dependent splicing of Neurexin IV...
Schaaf C, Kwak H, Koenig A, Misulovin Z, Gohara D, Watson A, et al
. Genome-wide control of RNA polymerase II activity by cohesin. PLoS Genet. 2013;9:e1003382 pubmed publisher
..The multiple transcriptional roles of cohesin revealed by these studies likely underlie the growth and developmental deficits caused by minor changes in cohesin activity. ..
Pan L, Xie W, Li K, Yang Z, Xu J, Zhang W, et al
. Heterochromatin remodeling by CDK12 contributes to learning in Drosophila. Proc Natl Acad Sci U S A. 2015;112:13988-93 pubmed publisher
..Here, we report that cyclin-dependent kinase 12 (CDK12), a transcription elongation-associated RNA polymerase II (RNAPII) kinase, antagonizes heterochromatin enrichment ..