Cdc42

Summary

Gene Symbol: Cdc42
Description: Cdc42
Alias: CDC42, CG12530, Cdc42Dm, D-CDC42, D-Cdc42, D-cdc42, DCDC42, DCdc42, Dcdc42, Dm Cdc42, DmCDC42, Dmcdc42, Dmel\CG12530, P40793, cdc42, Cdc42, CG12530-PA, CG12530-PC, CG12530-PD, Cdc42-PA, Cdc42-PC, Cdc42-PD, Cdc42-like
Species: fruit fly
Products:     Cdc42

Top Publications

  1. Luo L, Liao Y, Jan L, Jan Y. Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev. 1994;8:1787-802 pubmed
    ..We have cloned Drosophila homologs of rac and CDC42, Drac1, and Dcdc42. They share 70% amino acid sequence identity with each other, and both are highly expressed in the nervous system ..
  2. Larson D, Liberman Z, Cagan R. Cellular behavior in the developing Drosophila pupal retina. Mech Dev. 2008;125:223-32 pubmed publisher
    ..Based upon our live visualization of the P120-Catenin mutant as well as genetic data, we conclude that P120-Catenin is acting to stabilize E-cadherin and adherens junction integrity during eye development. ..
  3. Chen G, Gajowniczek P, Settleman J. Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis. Curr Biol. 2004;14:309-13 pubmed
    ..genetic interactions with several Rho pathway components in the formation of adult structures, but not with Rac or Cdc42. In cultured SL2 cells, inhibition of Rho, F-actin assembly, or SRF blocks the transcriptional response to ..
  4. Atwood S, Chabu C, Penkert R, Doe C, Prehoda K. Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC. J Cell Sci. 2007;120:3200-6 pubmed
    b>Cdc42 recruits Par-6-aPKC to establish cell polarity from worms to mammals...
  5. Philips J, Rubin E, Perrimon N. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science. 2005;309:1251-3 pubmed
    ..fortuitum, which suggests a conserved role for class B SRs in pattern recognition and innate immunity...
  6. Williams M, Habayeb M, Hultmark D. Reciprocal regulation of Rac1 and Rho1 in Drosophila circulating immune surveillance cells. J Cell Sci. 2007;120:502-11 pubmed
    ..Finally, though dominant negative Rac1 is able to block filopodia formation in the overexpression experiments, only Rac2 is necessary for filopodia formed by hemocytes after parasitization. ..
  7. Georgiou M, Marinari E, Burden J, Baum B. Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability. Curr Biol. 2008;18:1631-8 pubmed publisher
    ..role of actin cytoskeletal regulators in the developing Drosophila notum, we have identified a critical role for Cdc42-aPKC-Par6 in the maintenance of AJ organization...
  8. Kim M, Kamiyama D, Kolodziej P, Hing H, Chiba A. Isolation of Rho GTPase effector pathways during axon development. Dev Biol. 2003;262:282-93 pubmed
    The Rho GTPases Rac1 and Cdc42 have been implicated in the regulation of axon outgrowth and guidance...
  9. Nahm M, Lee M, Baek S, Yoon J, Kim H, Lee Z, et al. Drosophila RhoGEF4 encodes a novel RhoA-specific guanine exchange factor that is highly expressed in the embryonic central nervous system. Gene. 2006;384:139-44 pubmed
    ..In this study, the DH-PH motif is shown to enhance the dissociation of GDP from either RhoA or Rac1 but not from Cdc42 in vitro...

More Information

Publications81

  1. Noselli S. JNK signaling and morphogenesis in Drosophila. Trends Genet. 1998;14:33-8 pubmed
  2. Ryabinina O, Subbian E, Iordanov M. D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells. BMC Cell Biol. 2006;7:7 pubmed
    ..D-MEKK1, the fly orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediates the activation of D-JNK by cadmium and arsenite. ..
  3. Jhaveri D, Saharan S, Sen A, Rodrigues V. Positioning sensory terminals in the olfactory lobe of Drosophila by Robo signaling. Development. 2004;131:1903-12 pubmed
    ..The location of sensory arbors at distinct positions within the lobe allows short-range interactions with projection neurons leading to formation of the glomeruli. ..
  4. Hu H, Li M, Labrador J, McEwen J, Lai E, Goodman C, et al. Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion. Proc Natl Acad Sci U S A. 2005;102:4613-8 pubmed
    ..Dosage-sensitive genetic interactions among CrGAP, Robo, and Rac support a model in which CrGAP transduces signals downstream of Robo receptor to regulate Rac-dependent cytoskeletal changes. ..
  5. Barrett K, Leptin M, Settleman J. The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation. Cell. 1997;91:905-15 pubmed
    ..Together, these results establish a Rho-mediated signaling pathway that is essential for the major morphogenetic events in Drosophila gastrulation. ..
  6. Eaton S. Planar polarization of Drosophila and vertebrate epithelia. Curr Opin Cell Biol. 1997;9:860-6 pubmed
    ..Advances in our understanding of the Frizzled pathway, which coordinates planar polarization in Drosophila, are moving the field closer to understanding the links between signal transduction and polarized cytoskeletal reorganization. ..
  7. Wood W, Jacinto A, Grose R, Woolner S, Gale J, Wilson C, et al. Wound healing recapitulates morphogenesis in Drosophila embryos. Nat Cell Biol. 2002;4:907-12 pubmed
    ..Modulating the activities of the small GTPases Rho and Cdc42 demonstrates that these actin-dependent elements have differing cellular functions, but that either alone can ..
  8. Winter C, Wang B, Ballew A, Royou A, Karess R, Axelrod J, et al. Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Cell. 2001;105:81-91 pubmed
    ..Drosophila myosin VIIA, the homolog of the human Usher Syndrome 1B gene, also functions in conjunction with this newly defined portion of the Fz/Dsh signaling pathway to regulate the actin cytoskeleton. ..
  9. Georgiou M, Baum B. Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions. J Cell Sci. 2010;123:1089-98 pubmed publisher
    ..Bazooka/Par3 acts upstream of the RacGEF Sif/TIAM1 to limit filopodia to the basal domain, whereas Cdc42, aPKC and Par6 are required for normal protrusion morphology and dynamics...
  10. Agaisse H, Burrack L, Philips J, Rubin E, Perrimon N, Higgins D. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science. 2005;309:1248-51 pubmed
    ..monocytogenes. ..
  11. Bashaw G, Hu H, Nobes C, Goodman C. A novel Dbl family RhoGEF promotes Rho-dependent axon attraction to the central nervous system midline in Drosophila and overcomes Robo repulsion. J Cell Biol. 2001;155:1117-22 pubmed
    The key role of the Rho family GTPases Rac, Rho, and CDC42 in regulating the actin cytoskeleton is well established (Hall, A. 1998. Science. 279:509-514)...
  12. Ng J, Luo L. Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron. 2004;44:779-93 pubmed
    ..Genetic data provide evidence that Rho or Rac/Cdc42, via effector kinases Rok or Pak, respectively, activate LIM kinase to inhibit axon growth...
  13. Scott E, Reuter J, Luo L. Small GTPase Cdc42 is required for multiple aspects of dendritic morphogenesis. J Neurosci. 2003;23:3118-23 pubmed
    ..Using VS neurons as a model system, we show here using loss-of-function mutations that endogenous Cdc42, a member of Rho family of small GTPases, is required for multiple aspects of dendritic morphogenesis...
  14. Harris K, Tepass U. Cdc42 and Par proteins stabilize dynamic adherens junctions in the Drosophila neuroectoderm through regulation of apical endocytosis. J Cell Biol. 2008;183:1129-43 pubmed publisher
    ..We investigated the function of Cdc42 in maintaining adherens junctions (AJs) and apical polarity in the Drosophila melanogaster neuroectodermal ..
  15. Abreu Blanco M, Verboon J, Parkhurst S. Coordination of Rho family GTPase activities to orchestrate cytoskeleton responses during cell wound repair. Curr Biol. 2014;24:144-55 pubmed publisher
    ..We find that Rho, Rac, and Cdc42 rapidly accumulate around the wound and segregate into dynamic, partially overlapping zones...
  16. Denholm B, Brown S, Ray R, Ruiz Gomez M, Skaer H, Hombria J. crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis. Development. 2005;132:2389-400 pubmed
  17. Qin Q, Pei J, Ancona V, Shaw B, Ficht T, de Figueiredo P. RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1alpha in supporting Brucella replication. PLoS Pathog. 2008;4:e1000110 pubmed publisher
    ..Finally, we propose a model in which IRE1alpha, and other ER-associated genes uncovered in our screen, mediate Brucella replication by promoting autophagosome biogenesis. ..
  18. Knust E, Bossinger O. Composition and formation of intercellular junctions in epithelial cells. Science. 2002;298:1955-9 pubmed
    ..Comparisons between fly, worm, and vertebrate epithelia reveal marked similarities with respect to the molecules used, and pronounced differences in the organization of the junctions themselves. ..
  19. Newsome T, Schmidt S, Dietzl G, Keleman K, Asling B, Debant A, et al. Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila. Cell. 2000;101:283-94 pubmed
    ..We propose that distinct signals transduced via Trio and Dock act combinatorially to activate Pak in spatially restricted domains within the growth cone, thereby controlling the direction of axon extension. ..
  20. Sanny J, Chui V, Langmann C, Pereira C, Zahedi B, Harden N. Drosophila RhoGAP68F is a putative GTPase activating protein for RhoA participating in gastrulation. Dev Genes Evol. 2006;216:543-50 pubmed
    The Rho family small GTPases Rho, Rac, and Cdc42 regulate cell shape and motility through the actin cytoskeleton...
  21. Govek E, Newey S, Van Aelst L. The role of the Rho GTPases in neuronal development. Genes Dev. 2005;19:1-49 pubmed
    ..This review will focus on the role of the Rho GTPases and their associated signaling molecules throughout neuronal development and discuss how perturbations in Rho GTPase signaling may lead to cognitive disorders. ..
  22. Grosshans J, Wenzl C, Herz H, Bartoszewski S, Schnorrer F, Vogt N, et al. RhoGEF2 and the formin Dia control the formation of the furrow canal by directed actin assembly during Drosophila cellularisation. Development. 2005;132:1009-20 pubmed
    ..Our results support a model in which RhoGEF2 and dia control position, shape and stability of the forming furrow canal by spatially restricted assembly of actin filaments required for the proper infolding of the plasma membrane. ..
  23. Fricke R, Gohl C, Dharmalingam E, Grevelhörster A, Zahedi B, Harden N, et al. Drosophila Cip4/Toca-1 integrates membrane trafficking and actin dynamics through WASP and SCAR/WAVE. Curr Biol. 2009;19:1429-37 pubmed publisher
    ..Here, we present the functional analysis of the Drosophila F-BAR protein Cip4/Toca1 (Cdc42-interacting protein 4/transducer of Cdc42-dependent actin assembly 1)...
  24. van Impel A, Schumacher S, Draga M, Herz H, Grosshans J, Müller H. Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula. Development. 2009;136:813-22 pubmed publisher
    ..Furthermore, gain-of-function and rescue experiments suggest an important regulatory role of the C-terminal tail of Pbl for the selective activation of Rho1-versus Rac-dependent pathways...
  25. Fanto M, Weber U, Strutt D, Mlodzik M. Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Curr Biol. 2000;10:979-88 pubmed
    ..Rac is specifically required downstream of Dsh in the Fz pathway. It functions upstream or in parallel to RhoA and both signal to the nucleus, through distinct effectors, to establish planar polarity in the Drosophila eye. ..
  26. Fan X, Labrador J, Hing H, Bashaw G. Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline. Neuron. 2003;40:113-27 pubmed
    ..These results provide a direct physical link between the Robo receptor and an important cytoskeletal regulatory protein complex and suggest that Rac can function in both attractive and repulsive axon guidance. ..
  27. Baron M, O Leary V, Evans D, Hicks M, Hudson K. Multiple roles of the Dcdc42 GTPase during wing development in Drosophila melanogaster. Mol Gen Genet. 2000;264:98-104 pubmed
    ..To investigate the functions of the Drosophila Cdc42 GTPase (Dcdc42), we generated phenotypes during wing development, by expression of the dominant-negative N17 and L89 mutants of ..
  28. Sepp K, Auld V. RhoA and Rac1 GTPases mediate the dynamic rearrangement of actin in peripheral glia. Development. 2003;130:1825-35 pubmed
    ..We hypothesized that the small GTPases Rho, Rac and Cdc42 are involved in Actin cytoskeletal rearrangements that underlie peripheral glial migration and nerve ensheathement...
  29. Prokopenko S, Brumby A, O KEEFE L, Prior L, He Y, Saint R, et al. A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev. 1999;13:2301-14 pubmed
    ..pbl interacts genetically with Rho1, but not with Rac1 or Cdc42, and Pbl and Rho1 proteins interact in vivo in yeast...
  30. Colinet D, Schmitz A, Depoix D, Crochard D, Poirié M. Convergent use of RhoGAP toxins by eukaryotic parasites and bacterial pathogens. PLoS Pathog. 2007;3:e203 pubmed publisher
  31. Muyskens J, Guillemin K. Helicobacter pylori CagA disrupts epithelial patterning by activating myosin light chain. PLoS ONE. 2011;6:e17856 pubmed publisher
    ..Therefore, in our transgenic system, CagA is targeted by EPIYA motifs to a specific apical region of the epithelium where it efficiently activates MLC to disrupt epithelial integrity. ..
  32. Eaton S, Auvinen P, Luo L, Jan Y, Simons K. CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. J Cell Biol. 1995;131:151-64 pubmed
    ..b>Dcdc42, on the other hand, is required for processes that involve polarized cell shape changes during both pupal and ..
  33. Hacker U, Perrimon N. DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes Dev. 1998;12:274-84 pubmed
  34. Jhaveri D, Rodrigues V. Sensory neurons of the Atonal lineage pioneer the formation of glomeruli within the adult Drosophila olfactory lobe. Development. 2002;129:1251-60 pubmed
    ..Furthermore, correct sensory innervation is necessary for the arborization of projection neurons into glomeruli and for the elaboration of processes of central glial cells into the lobe. ..
  35. Riesgo Escovar J, Jenni M, Fritz A, Hafen E. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev. 1996;10:2759-68 pubmed
    ..Dorsal closure can also be blocked by dominant negative Drosophila cdc42, which has been shown to act upstream of JNKK in vertebrates...
  36. Harden N, Lee J, Loh H, Ong Y, Tan I, Leung T, et al. A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures. Mol Cell Biol. 1996;16:1896-908 pubmed
    ..DPAK, of the serine/threonine kinase PAK, a protein which is a target of the Rho subfamily proteins Rac and Cdc42. Rac, Cdc42, and PAK have previously been implicated in signaling by c-Jun amino-terminal kinases...
  37. Schneeberger D, Raabe T. Mbt, a Drosophila PAK protein, combines with Cdc42 to regulate photoreceptor cell morphogenesis. Development. 2003;130:427-37 pubmed
    ..revealed that the Mbt kinase domain and the GTPase binding domain, which specifically interacts with GTP-loaded Cdc42, are important for Mbt function...
  38. Hu H, Marton T, Goodman C. Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling. Neuron. 2001;32:39-51 pubmed
  39. Kamiyama D, Chiba A. Endogenous activation patterns of Cdc42 GTPase within Drosophila embryos. Science. 2009;324:1338-40 pubmed publisher
    ..With the use of a genetically encoded A-probe (activation bioprobe), we revealed that Cdc42 guanosine triphosphatase (GTPase) remains inactive within Drosophila embryos during the first two-thirds of ..
  40. Magie C, Pinto Santini D, Parkhurst S. Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila. Development. 2002;129:3771-82 pubmed
    ..Our observations suggest that alpha-catenin and p120(ctn) are key players in a mechanism of recruiting Rho1 to its sites of action. ..
  41. Sato D, Sugimura K, Satoh D, Uemura T. Crossveinless-c, the Drosophila homolog of tumor suppressor DLC1, regulates directional elongation of dendritic branches via down-regulating Rho1 activity. Genes Cells. 2010;15:485-500 pubmed publisher
    ..Cv-c was required cell-autonomously for the A-P-oriented growth, and Cv-c elevated the GTPase activity of Rho1 and Cdc42 in a cell-free assay. Our analysis of genetic interactions suggested that Rho1 was the target of Cv-c in vivo...
  42. Harden N, Ricos M, Ong Y, Chia W, Lim L. Participation of small GTPases in dorsal closure of the Drosophila embryo: distinct roles for Rho subfamily proteins in epithelial morphogenesis. J Cell Sci. 1999;112 ( Pt 3):273-84 pubmed
    ..We now show that two other Rho subfamily proteins, Dcdc42 and RhoA, as well as Ras1 are also required for dorsal closure...
  43. Nahm M, Long A, Paik S, Kim S, Bae Y, Broadie K, et al. The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signaling. J Cell Biol. 2010;191:661-75 pubmed publisher
    ..In this study, we show that Drosophila Rich (dRich), a conserved Cdc42-selective guanosine triphosphatase-activating protein (GAP), inhibits the Cdc42-Wsp pathway to stimulate ..
  44. Neisch A, Speck O, Stronach B, Fehon R. Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. J Cell Biol. 2010;189:311-23 pubmed publisher
    ..Together, these results suggest that Rho1 functions at the cell cortex to regulate JNK activity and implicate Rho1 and Moe in epithelial cell survival. ..
  45. Nahm M, Kim S, Paik S, Lee M, Lee S, Lee Z, et al. dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal. J Neurosci. 2010;30:8138-50 pubmed publisher
    ..Here, we provide evidence that Drosophila Cdc42-interacting protein 4 (dCIP4) functions postsynaptically to inhibit synaptic growth...
  46. Hutterer A, Betschinger J, Petronczki M, Knoblich J. Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Dev Cell. 2004;6:845-54 pubmed
    ..Apical localization of Par-6 requires its interaction with activated Cdc42 and dominant-active or dominant-negative Cdc42 disrupt epithelial polarity, suggesting that activation of this ..
  47. Chen W, White M, Cobb M. Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. J Biol Chem. 2002;277:49105-10 pubmed
    ..On the other hand, sorbitol requires expression of four MAP3Ks to cause maximal JNK activation. Thus, we demonstrate that specific stimuli use different mechanisms to recruit distinct MAP3Ks to regulate the JNK pathway. ..
  48. Genova J, Jong S, Camp J, Fehon R. Functional analysis of Cdc42 in actin filament assembly, epithelial morphogenesis, and cell signaling during Drosophila development. Dev Biol. 2000;221:181-94 pubmed
    b>Cdc42, a member of the Rho family of GTP binding proteins, functions in the formation of polarized actin structures, in elongation of cell shape, and in cell signaling...
  49. Lesch C, Jo J, Wu Y, Fish G, Galko M. A targeted UAS-RNAi screen in Drosophila larvae identifies wound closure genes regulating distinct cellular processes. Genetics. 2010;186:943-57 pubmed publisher
  50. Walther R, Pichaud F. Crumbs/DaPKC-dependent apical exclusion of Bazooka promotes photoreceptor polarity remodeling. Curr Biol. 2010;20:1065-74 pubmed publisher
    ..depends on Baz phosphorylation by DaPKC at the conserved serine 980 and on the activity of the small GTPase Cdc42 associated with Par6...
  51. Jacinto A, Wood W, Balayo T, Turmaine M, Martinez Arias A, Martin P. Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure. Curr Biol. 2000;10:1420-6 pubmed
    ..When the assembly of these actin-based protrusions was blocked (by interfering with the activities of Cdc42 and Jun N-terminal kinase signalling), the adhesion and fusion of opposing epithelial cells was prevented and ..
  52. Dorsten J, Kolodziej P, VanBerkum M. Frazzled regulation of myosin II activity in the Drosophila embryonic CNS. Dev Biol. 2007;308:120-32 pubmed
    ..Midline crossing errors induced by expressing activated Cdc42(v12) or Rac(v12) are suppressed by a heterozygous loss of fra(4) signaling but, in a Fra(wt) gain-of-function ..
  53. Fletcher G, Lucas E, Brain R, Tournier A, Thompson B. Positive feedback and mutual antagonism combine to polarize Crumbs in the Drosophila follicle cell epithelium. Curr Biol. 2012;22:1116-22 pubmed publisher
    ..follicle cell epithelium, apical membranes are specified by Crumbs (Crb), Stardust (Sdt), and the aPKC-Par6-cdc42 complex. Basolateral membranes are specified by Lethal giant larvae (Lgl), Discs large (Dlg), and Scribble (Scrib)...
  54. Lundström A, Gallio M, Englund C, Steneberg P, Hemphälä J, Aspenstrom P, et al. Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axons. Genes Dev. 2004;18:2161-71 pubmed
    ..These results together with genetic interaction experiments with robo, vilse, and rac mutants suggest a mechanism whereby Robo repulsion is mediated by the localized inactivation of Rac through Vilse. ..
  55. Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T. Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell. 2011;20:315-28 pubmed publisher
    ..Our data indicate that JNK-mediated cell engulfment could be an evolutionarily conserved intrinsic tumor-suppression mechanism that eliminates premalignant cells from epithelia. ..
  56. Brumby A, Richardson H. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 2003;22:5769-79 pubmed
  57. Baek S, Kwon Y, Lee H, Choe K. Rho-family small GTPases are required for cell polarization and directional sensing in Drosophila wound healing. Biochem Biophys Res Commun. 2010;394:488-92 pubmed publisher
    ..Here, we use myosin localization to demonstrate that Rac1, Cdc42, and Rho1 are each required for cell polarization and directional sensing of the wound...
  58. Warner S, Longmore G. Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension. J Cell Biol. 2009;187:119-33 pubmed publisher
    ..Using mosaic clonal analysis in the Drosophila melanogaster pupal eye, we find that Cdc42 is critical for limiting apical cell tension by antagonizing Rho activity at AJs...
  59. Pagliarini R, Xu T. A genetic screen in Drosophila for metastatic behavior. Science. 2003;302:1227-31 pubmed
    ..These findings suggest that the oncogenic background of tissues makes a distinct contribution toward metastatic development. ..
  60. Murphy A, Montell D. Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis. J Cell Biol. 1996;133:617-30 pubmed
    ..We report the discovery of a new member of the Rho family, named RhoL, which is equally similar to Rac, Rho, and Cdc42. Expression of a dominant-negative RhoL transgene in the Drosophila ovary caused nurse cells to collapse and fuse ..
  61. Warner S, Longmore G. Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epithelia. J Cell Biol. 2009;185:1111-25 pubmed publisher
    ..of Rho1 to maintain AJs; instead, Rho1 maintains AJs by inhibiting Drosophila epithelial cadherin endocytosis in a Cdc42/Par6-dependent manner...
  62. Fritz J, VanBerkum M. Regulation of rho family GTPases is required to prevent axons from crossing the midline. Dev Biol. 2002;252:46-58 pubmed
    ..of Rho GTPases in midline guidance, dominant negative (dn) and constitutively active (ct) forms of Rho, Drac1, and Dcdc42 are expressed in the Drosophila CNS...
  63. Rørth P. Initiating and guiding migration: lessons from border cells. Trends Cell Biol. 2002;12:325-31 pubmed
    ..This article discusses the implications of these studies and compares (invasive) migration through a tissue with what is known about cells crawling on a flat substratum. ..
  64. Chang H, Ready D. Rescue of photoreceptor degeneration in rhodopsin-null Drosophila mutants by activated Rac1. Science. 2000;290:1978-80 pubmed
    ..Thus, rhodopsin appears to organize the actin cytoskeleton through Drac1, contributing a structural support essential for photoreceptor morphogenesis. ..
  65. Somers W, Saint R. A RhoGEF and Rho family GTPase-activating protein complex links the contractile ring to cortical microtubules at the onset of cytokinesis. Dev Cell. 2003;4:29-39 pubmed
  66. Boutros M, Paricio N, Strutt D, Mlodzik M. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell. 1998;94:109-18 pubmed
    ..Our results indicate that different Wnt/Fz signals activate distinct intracellular pathways, and Dishevelled discriminates among them by distinct domain interactions. ..
  67. Avet Rochex A, Bergeret E, Attree I, Meister M, Fauvarque M. Suppression of Drosophila cellular immunity by directed expression of the ExoS toxin GAP domain of Pseudomonas aeruginosa. Cell Microbiol. 2005;7:799-810 pubmed
    ..Directed expression of the ExoS GAP domain (ExoSGAP) during fly eye morphogenesis inhibited Rac1-, Cdc42- and Rho-dependent signalling, demonstrating for the first time its activity on RhoGTPases in a whole organism...
  68. Agnes F, Suzanne M, Noselli S. The Drosophila JNK pathway controls the morphogenesis of imaginal discs during metamorphosis. Development. 1999;126:5453-62 pubmed
    ..Furthermore, we show that the small GTPase Dcdc42, but not Drac1, is an activator of puc expression in a hep-dependent manner in imaginal discs...
  69. Fehon R, Oren T, LaJeunesse D, Melby T, McCartney B. Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method. Genetics. 1997;146:245-52 pubmed
    ..in Drosophila homologues of two well-studied genes, the human Neurofibromatosis 2 tumor suppressor and the yeast CDC42 gene...
  70. Tepass U, Harris K. Adherens junctions in Drosophila retinal morphogenesis. Trends Cell Biol. 2007;17:26-35 pubmed
    ..Adherens junctions are involved in the organization of simple cellular patterns, and more complex cell shape changes and cell movements that depend on the dynamic modulation of adherens junctions. ..
  71. Montell D. The genetics of cell migration in Drosophila melanogaster and Caenorhabditis elegans development. Development. 1999;126:3035-46 pubmed
    ..New types of genetic screens promise to fill in some of these gaps in the near future. ..
  72. Paladi M, Tepass U. Function of Rho GTPases in embryonic blood cell migration in Drosophila. J Cell Sci. 2004;117:6313-26 pubmed
    ..We use both Gal4 lines to express dominantnegative and constitutively active isoforms of the Rho GTPases Rac1, Cdc42, Rho1 and RhoL in macrophages, and complement these experiments by analyzing embryos mutant for Rho GTPases...