Cct1

Summary

Gene Symbol: Cct1
Description: CTP:phosphocholine cytidylyltransferase 1
Alias: CCT1, CG1049, CT41283, Cct, Dmel\CG1049, cct1, CTP:phosphocholine cytidylyltransferase 1, CG1049-PA, CG1049-PB, CG1049-PC, CG1049-PD, CG1049-PE, CG1049-PF, CTP-phosphocholine cytidylyltransferase, CTP:phosphocholine cytidylyltransferase, Cct1-PA, Cct1-PB, Cct1-PC, Cct1-PD, Cct1-PE, Cct1-PF, cytidylyltransferase 1, phosphocholine cytidylyltransferase
Species: fruit fly

Top Publications

  1. Gupta T, Schupbach T. Cct1, a phosphatidylcholine biosynthesis enzyme, is required for Drosophila oogenesis and ovarian morphogenesis. Development. 2003;130:6075-87 pubmed
    ..Through this analysis, we have identified tandem Drosophila genes homologous to CTP: phosphocholine cytidylyltransferase (CCT), the second of three enzymes in the CDP-choline pathway, which is used to synthesize ..
  2. Helmink B, Friesen J. Characterization of a lipid activated CTP:phosphocholine cytidylyltransferase from Drosophila melanogaster. Biochim Biophys Acta. 2004;1683:78-88 pubmed
    CTP:phosphocholine cytidylyltransferase (CCT) is an enzyme critical for cellular phosphatidylcholine (PC) synthesis, converting phosphocholine and cytidine 5'-triphosphate (CTP) to CDP-choline...
  3. Tilley D, Evans C, Larson T, Edwards K, Friesen J. Identification and characterization of the nuclear isoform of Drosophila melanogaster CTP:phosphocholine cytidylyltransferase. Biochemistry. 2008;47:11838-46 pubmed publisher
    CTP:phosphocholine cytidylyltransferase (CCT) catalyzes the conversion of phosphocholine and cytidine 5'-triphosphate (CTP) to CDP-choline for the eventual synthesis of phosphatidylcholine (PC)...
  4. Weber U, Eroglu C, Mlodzik M. Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. Dev Cell. 2003;5:559-70 pubmed
    ..Phosphatidylcholine (PC) is a main component of the plasma membrane. Mutants in the Drosophila phosphocholine cytidylyltransferase 1 (CCT1), the rate-limiting enzyme in PC biosynthesis, show an altered phospholipid composition ..
  5. Castorena K, Stapleford K, Miller D. Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication. BMC Genomics. 2010;11:183 pubmed publisher
    ..In particular, we found that downregulation of Cct1 or Cct2, which encode essential enzymes for phosphatidylcholine biosynthesis, suppressed FHV RNA replication...
  6. Kory N, Thiam A, Farese R, Walther T. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Dev Cell. 2015;34:351-63 pubmed publisher
    ..Moreover, the LD binding affinity determines protein localization during lipolysis. Our findings identify protein crowding as an important principle in determining LD protein composition. ..
  7. Lee H, Peng Y, Guo Y. Analysis of lipid droplet dynamics and functions in Drosophila melanogaster. Methods Cell Biol. 2013;116:53-69 pubmed publisher
  8. Arnold C, Gerlach D, Stelzer C, Boryń Ł, Rath M, Stark A. Genome-wide quantitative enhancer activity maps identified by STARR-seq. Science. 2013;339:1074-7 pubmed publisher
    ..STARR-seq can be used to identify and quantify enhancer activity in other eukaryotes, including humans. ..
  9. Grillet M, Dominguez Gonzalez B, Sicart A, Pöttler M, Cascalho A, Billion K, et al. Torsins Are Essential Regulators of Cellular Lipid Metabolism. Dev Cell. 2016;38:235-47 pubmed publisher
    ..These findings identify that torsins are essential regulators of cellular lipid metabolism and implicate disturbed lipid biology in childhood-onset DYT1 dystonia. ..

More Information

Publications17

  1. Remolina S, Chang P, Leips J, Nuzhdin S, Hughes K. Genomic basis of aging and life-history evolution in Drosophila melanogaster. Evolution. 2012;66:3390-403 pubmed publisher
    ..More generally, we argue that hitchhiking mapping can be a powerful tool for uncovering the molecular bases of quantitative genetic variation. ..
  2. Wilfling F, Wang H, Haas J, Krahmer N, Gould T, Uchida A, et al. Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell. 2013;24:384-99 pubmed publisher
    ..Our results explain how TG synthesis is coupled with LD growth and identify two distinct LD subpopulations based on their capacity for localized TG synthesis. ..
  3. Landis G, Bhole D, Tower J. A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes. Genome Biol. 2003;4:R8 pubmed
    ..four wheel drive (fwd) encodes a phosphatidylinositol-4-kinase (PI 4-kinase) and CTP:phosphocholine cytidylyltransferase-l (Cctl) encodes the rate-limiting enzyme in phosphatidylcholine synthesis...
  4. Sánchez Alvarez M, Zhang Q, Finger F, Wakelam M, Bakal C. Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis. Open Biol. 2015;5:150093 pubmed publisher
    ..We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth. ..
  5. Landis G, Abdueva D, Skvortsov D, Yang J, Rabin B, Carrick J, et al. Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2004;101:7663-8 pubmed
    ..Immune reporter expression in young flies was partially predictive of remaining life span, suggesting their potential as biomonitors of aging. ..
  6. Tian Y, Bi J, Shui G, Liu Z, Xiang Y, Liu Y, et al. Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. PLoS Genet. 2011;7:e1001364 pubmed publisher
    ..In summary, we have demonstrated a tissue-autonomous role of dSeipin in ectopic lipid storage in lipodystrophy. ..
  7. Dobrosotskaya I, Seegmiller A, Brown M, Goldstein J, Rawson R. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Science. 2002;296:879-83 pubmed
  8. Krahmer N, Guo Y, Wilfling F, Hilger M, Lingrell S, Heger K, et al. Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metab. 2011;14:504-15 pubmed publisher
    ..by the Kennedy pathway, which is activated by reversible targeting of the rate-limiting enzyme, CTP:phosphocholine cytidylyltransferase (CCT), to growing LD surfaces...