Gene Symbol: Ccs
Description: Copper chaperone for superoxide dismutase
Alias: CCD, CCS, CG-17753, CG17753, DmCCS, Dmel\CG17753, anon-EST:Posey231, dCCS, l(2)03221, copper chaperone for superoxide dismutase, CCS, CG17753-PB, CG17753-PC, Ccs-PB, Ccs-PC, Cu-chaperone for superoxide dismutase
Species: fruit fly

Top Publications

  1. Landis G, Tower J. Superoxide dismutase evolution and life span regulation. Mech Ageing Dev. 2005;126:365-79 pubmed
    ..manganese-containing form (Sod2), Drosophila melanogaster is found to contain a putative copper chaperone (CCS), an extracellular Cu/Zn enzyme (Sod3), and an extracellular protein distantly related to the Cu/Zn forms (Sodq). C...
  2. Ebner A, Kiefer F, Ribeiro C, Petit V, Nussbaumer U, Affolter M. Tracheal development in Drosophila melanogaster as a model system for studying the development of a branched organ. Gene. 2002;287:55-66 pubmed
    ..We also identified a Sulfotransferase and a Multiple Inositol Polyphosphate phosphatase that are strongly upregulated in tracheal cells and discuss their possible involvement in tracheal development. ..
  3. Southon A, Burke R, Norgate M, Batterham P, Camakaris J. Copper homoeostasis in Drosophila melanogaster S2 cells. Biochem J. 2004;383:303-9 pubmed
    ..orthologues of the mammalian Cu chaperones, ATOX1 (a human orthologue of yeast ATX1), CCS (copper chaperone for superoxide dismutase), COX17 (a human orthologue of yeast COX17), and SCO1 and SCO2, did not significantly respond ..
  4. Norgate M, Lee E, Southon A, Farlow A, Batterham P, Camakaris J, et al. Essential roles in development and pigmentation for the Drosophila copper transporter DmATP7. Mol Biol Cell. 2006;17:475-84 pubmed
    ..DmATP7 displays a dynamic and unexpected expression pattern in the developing embryo, implying novel functions for this copper pump and the lethality observed in DmATP7 mutant flies is the earliest seen for any copper homeostasis gene. ..
  5. Kirby K, Jensen L, Binnington J, Hilliker A, Ulloa J, Culotta V, et al. Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone. J Biol Chem. 2008;283:35393-401 pubmed publisher
    Copper,zinc superoxide dismutase (SOD1) in mammals is activated principally via a copper chaperone (CCS) and to a lesser degree by a CCS-independent pathway of unknown nature...
  6. Creagh E, Brumatti G, Sheridan C, Duriez P, Taylor R, Cullen S, et al. Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival. PLoS ONE. 2009;4:e5055 pubmed publisher
    ..These data suggest that bicaudal/betaNAC is essential for cell survival and is a conserved target of caspases from flies to man. ..