Gene Symbol: CCKLR-17D1
Description: Cholecystokinin-like receptor at 17D1
Alias: CCKLR, CCKLR-D1, CG42301, CG6857, DSK-R2, Dm CG6857, Dmel\CG42301, Dmel_CG6857, DskR-2, SK-R, anon-WO0170980.61, anon-WO0170980.62, Cholecystokinin-like receptor at 17D1, CCK-like receptor at 17D1, CCKLR-17D1-PA, CG42301-PA, cholecystokinin-like receptor
Species: fruit fly

Top Publications

  1. Kubiak T, Larsen M, Burton K, Bannow C, Martin R, Zantello M, et al. Cloning and functional expression of the first Drosophila melanogaster sulfakinin receptor DSK-R1. Biochem Biophys Res Commun. 2002;291:313-20 pubmed
    ..To our knowledge, the cloned DSK-R1 receptor is the first functionally active Drosophila sulfakinin receptor reported to date. ..
  2. Chen X, Ganetzky B. A neuropeptide signaling pathway regulates synaptic growth in Drosophila. J Cell Biol. 2012;196:529-43 pubmed publisher
    ..Here, we demonstrate that cholecystokinin-like receptor (CCKLR) and drosulfakinin (DSK), its predicted ligand, are strong positive growth regulators of the Drosophila ..
  3. Chen X, Peterson J, Nachman R, Ganetzky B. Drosulfakinin activates CCKLR-17D1 and promotes larval locomotion and escape response in Drosophila. Fly (Austin). 2012;6:290-7 pubmed publisher
    ..We provide biochemical evidence that sulfated DSK-1 and DSK-2 activate the CCKLR-17D1 receptor in a cell culture assay...
  4. Nässel D, Williams M. Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling. Front Endocrinol (Lausanne). 2014;5:219 pubmed publisher
    ..Activity in the DSK-producing neurons is regulated by octopamine. We discuss mechanisms behind CCK function in satiety, aggression, and locomotion in some detail and highlight similarities to mammalian CCK signaling. ..
  5. Rasmussen M, Leander M, Ons S, Nichols R. Conserved molecular switch interactions in modeled cardioactive RF-NH2 peptide receptors: Ligand binding and activation. Peptides. 2015;71:259-67 pubmed publisher
    ..AKH receptor motifs were not representative of a RF-NH2 subfamily. The motifs and interactions of switches in the RFa-Rs were consistent with receptor activation and ligand-specific binding. ..
  6. Bendena W, Campbell J, Zara L, Tobe S, Chin Sang I. Select Neuropeptides and their G-Protein Coupled Receptors in Caenorhabditis Elegans and Drosophila Melanogaster. Front Endocrinol (Lausanne). 2012;3:93 pubmed publisher
    ..melanogaster and C. elegans and the behaviors that have been uncovered through genetic manipulation. ..
  7. Kiss B, Szlanka T, Zvara A, Zurovec M, Sery M, Kakaš S, et al. Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster. Gen Comp Endocrinol. 2013;191:137-45 pubmed publisher
    ..effects were found in three other combinations (Fmrf-RNAi/elav-Gal4; FR-RNAi/+, Dms-RNAi/ elav-Gal4;DmsR-2-RNAi/+, CCKLR-17D1-RNAi/elav-Gal4; CCKLR-17D3-RNAi/+), and weak effect in DmsR-2-RNAi/elav-Gal4; DmsR-1-RNAi/+...
  8. Bass C, Katanski C, Maynard B, Zurro I, Mariane E, Matta M, et al. Conserved residues in RF-NH? receptor models identify predicted contact sites in ligand-receptor binding. Peptides. 2014;53:278-85 pubmed publisher
    ..Our novel results predicted conserved residues as RF-NH2 ligand-receptor contact sites and identified unique and classic structural features. These discoveries will aid antagonist design to modulate RF-NH2 signaling. ..
  9. Walker J, Bernards A. A Drosophila screen identifies neurofibromatosis-1 genetic modifiers involved in systemic and synaptic growth. Rare Dis. 2014;2:e28341 pubmed publisher
    ..activating ligand, two other genes involved in Ras/ERK signal transduction, the synaptic scaffold Dap160 and the CCKLR-17D1 drosulfakinin receptor. Additional modifiers include several genes involved in cAMP/PKA signaling...

More Information


  1. Mohammad F, Aryal S, Ho J, Stewart J, Norman N, Tan T, et al. Ancient Anxiety Pathways Influence Drosophila Defense Behaviors. Curr Biol. 2016;26:981-6 pubmed publisher
    ..The presence of conserved neurogenetic pathways in the insect brain identifies Drosophila as an attractive genetic model for the study of anxiety and anxiety-related disorders, complementing existing rodent systems. ..
  2. Leander M, Heimonen J, Brocke T, Rasmussen M, Bass C, Palmer G, et al. The 5-amino acid N-terminal extension of non-sulfated drosulfakinin II is a unique target to generate novel agonists. Peptides. 2016;83:49-56 pubmed publisher