Gene Symbol: CCHa2
Alias: BcDNA:RE10132, CCH2, CCM, CG14375, Dm-CCHa2, Dmel\CG14375, CCHamide-2, CCHa2-PA, CCHa2-PB, CCHa2-PC, CCHamide, CCHamide 2, CG14375-PA, CG14375-PB, CG14375-PC, Drm-CCHamide-2
Species: fruit fly
Hansen K, Hauser F, Williamson M, Weber S, Grimmelikhuijzen C. The Drosophila genes CG14593 and CG30106 code for G-protein-coupled receptors specifically activated by the neuropeptides CCHamide-1 and CCHamide-2. Biochem Biophys Res Commun. 2011;404:184-9 pubmed publisher
Recently, a novel neuropeptide, CCHamide, was discovered in the silkworm Bombyx mori (L. Roller et al., Insect Biochem. Mol. Biol. 38 (2008) 1147-1157)...
Reiher W, Shirras C, Kahnt J, Baumeister S, Isaac R, Wegener C. Peptidomics and peptide hormone processing in the Drosophila midgut. J Proteome Res. 2011;10:1881-92 pubmed publisher
..The identification of enteroendocrine peptides in the fruit fly provides a platform to address functions of gut peptide hormones in the regulation of feeding and metabolism. ..
Li S, Torre Muruzabal T, Søgaard K, Ren G, Hauser F, Engelsen S, et al
. Expression patterns of the Drosophila neuropeptide CCHamide-2 and its receptor may suggest hormonal signaling from the gut to the brain. PLoS ONE. 2013;8:e76131 pubmed publisher
The insect neuropeptides CCHamide-1 and -2 are recently discovered peptides that probably occur in all arthropods...
Sano H, Nakamura A, Texada M, Truman J, Ishimoto H, Kamikouchi A, et al
. The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster. PLoS Genet. 2015;11:e1005209 pubmed publisher
..Here, we show that the peripheral tissue-derived peptide hormone CCHamide-2 (CCHa2) acts as a nutrient-dependent regulator of Drosophila insulin-like peptides (Dilps)...
Ren G, Hauser F, Rewitz K, Kondo S, Engelbrecht A, Didriksen A, et al
. CCHamide-2 Is an Orexigenic Brain-Gut Peptide in Drosophila. PLoS ONE. 2015;10:e0133017 pubmed publisher
The neuroendocrine peptides CCHamide-1 and -2, encoded by the genes ccha1 and -2, are produced by endocrine cells in the midgut and by neurons in the brain of Drosophila melanogaster...
Sano H. Coupling of growth to nutritional status: The role of novel periphery-to-brain signaling by the CCHa2 peptide in Drosophila melanogaster. Fly (Austin). 2015;9:183-7 pubmed publisher
..We recently demonstrated that a small peptide, CCHamide-2 (CCHa2), expressed in the fat body and gut, directly stimulates its receptor (CCHa2-R) in the brain, leading to ..
Zhang D, Wang D, Sun F. Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. Chromosoma. 2011;120:97-108 pubmed publisher
..Overall, this study argues that HP1b counteracts HP1a function both in heterochromatin formation and in the transcriptional regulation of euchromatic genes. ..
Veenstra J, Ida T. More Drosophila enteroendocrine peptides: Orcokinin B and the CCHamides 1 and 2. Cell Tissue Res. 2014;357:607-21 pubmed publisher
Antisera to orcokinin B, CCHamide 1, and CCHamide 2 recognize enteroendocrine cells in the midgut of the fruitfly Drosophila melanogaster and its larvae...