Gene Symbol: CBP
Description: sarcoplasmic calcium-binding protein
Alias: BcDNA.GH12350, BcDNA:GH12350, CG1435, Dmel\CG1435, cbp, dCBP, sarcoplasmic calcium-binding protein, CBP-PA, CBP-PB, CBP-PC, CG1435-PA, CG1435-PB, CG1435-PC, Ca2+ - binding protein, calcium binding protein
Species: fruit fly

Top Publications

  1. Johnson R, Seppa M, Cagan R. The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning. J Cell Biol. 2008;180:1191-204 pubmed publisher
    ..Together, these data demonstrate that Cindr is involved in dynamic cell rearrangement in an emerging epithelium. ..
  2. Ghosh S, Missra A, Gilmour D. Negative elongation factor accelerates the rate at which heat shock genes are shut off by facilitating dissociation of heat shock factor. Mol Cell Biol. 2011;31:4232-43 pubmed publisher
    ..from hsp70 and hsp26, and a similar delay was observed when cells were depleted of the histone acetyltransferase CBP. CBP has been reported to associate with Pol II, and acetylation of HSF by CBP has been implicated in inhibiting ..
  3. de Haro M, Al Ramahi I, de Gouyon B, Ukani L, Rosa A, Faustino N, et al. MBNL1 and CUGBP1 modify expanded CUG-induced toxicity in a Drosophila model of myotonic dystrophy type 1. Hum Mol Genet. 2006;15:2138-45 pubmed
    ..Perhaps more importantly, they also provide proof of the principle that CUG-induced muscle toxicity can be suppressed. ..
  4. Berkey C, Blow N, Watnick P. Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection. Cell Microbiol. 2009;11:461-74 pubmed publisher
  5. Michno K, Knight D, Campusano J, Campussano J, van de Hoef D, Boulianne G. Intracellular calcium deficits in Drosophila cholinergic neurons expressing wild type or FAD-mutant presenilin. PLoS ONE. 2009;4:e6904 pubmed publisher
    ..Our data support a model whereby presenilin plays a role in regulating intracellular calcium stores and demonstrate that Drosophila can be used to study the link between presenilin and calcium deregulation. ..
  6. Huen N, Chan H. Dynamic regulation of molecular chaperone gene expression in polyglutamine disease. Biochem Biophys Res Commun. 2005;334:1074-84 pubmed
    ..Altogether, we propose that transcriptional malfunctioning of molecular chaperone gene expression contributes to the late-onset and progressive nature of polyglutamine toxicity. ..
  7. Tie F, Banerjee R, Stratton C, Prasad Sinha J, Stepanik V, Zlobin A, et al. CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing. Development. 2009;136:3131-41 pubmed publisher
    ..The Trithorax protein (TRX), which associates with the histone acetyltransferase CBP, is required for maintenance of transcriptionally active states and antagonizes Polycomb silencing, although the ..
  8. Boyles R, Lantz K, Poertner S, Georges S, Andres A. Presenilin controls CBP levels in the adult Drosophila central nervous system. PLoS ONE. 2010;5:e14332 pubmed publisher
    ..b>CBP (CREB-binding protein) is a haplo-insufficient transcriptional co-activator with histone acetly-transferase (HAT) ..
  9. Wang S, Meyer H, Ochoa Espinosa A, Buchwald U, Onel S, Altenhein B, et al. GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis. J Cell Sci. 2012;125:461-72 pubmed publisher
    ..The fact that homologues of Garz are present in every annotated metazoan genome indicates that secretion processes mediated by the GBF-type ArfGEFs play a universal role in animal development. ..

More Information


  1. Brenman J, Gao F, Jan L, Jan Y. Sequoia, a tramtrack-related zinc finger protein, functions as a pan-neural regulator for dendrite and axon morphogenesis in Drosophila. Dev Cell. 2001;1:667-77 pubmed
  2. Merabet S, Catala F, Pradel J, Graba Y. A green fluorescent protein reporter genetic screen that identifies modifiers of Hox gene function in the Drosophila embryo. Genetics. 2002;162:189-202 pubmed
    ..Five of them encode products acting in or in connection with signal transduction pathways, which suggests an extensive use of signaling in the control of Hox gene function. ..
  3. Lim C, Lee J, Choi C, Kim J, Doh E, Choe J. Functional role of CREB-binding protein in the circadian clock system of Drosophila melanogaster. Mol Cell Biol. 2007;27:4876-90 pubmed
    ..Here, using transgenic fly models, we show that CREB-binding protein (CBP) participates in the transcriptional regulation of the Drosophila CLOCK/CYCLE (dCLK/CYC) heterodimer...