capt

Summary

Gene Symbol: capt
Description: capulet
Alias: Acap, BcDNA:LD24380, CAP, CG33979, CG5061, CG5074, Cap, Capt, Dcap, Dmel\CG33979, acu, cap, capping protein, cyclase-associated protein, l(2)06955, punc, capulet, Act up, CG33979-PA, CG33979-PB, CG33979-PC, Cyclase-associated protein, adenylyl cyclase-associated protein, capt-PA, capt-PB, capt-PC, cyclase associated protein capulet, punctate
Species: fruit fly
Products:     capt

Top Publications

  1. Baum B, Li W, Perrimon N. A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr Biol. 2000;10:964-73 pubmed
    ..for Drosophila oocyte polarity, we isolated a Drosophila homologue of the yeast cyclase-associated protein, CAP. Here we show that CAP preferentially accumulates in the oocyte, where it inhibits actin polymerisation...
  2. Wills Z, Emerson M, Rusch J, Bikoff J, Baum B, Perrimon N, et al. A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron. 2002;36:611-22 pubmed
    We demonstrate that Drosophila capulet (capt), a homolog of the adenylyl cyclase-associated protein that binds and regulates actin in yeast, associates with Abl in Drosophila cells, suggesting a functional relationship in vivo...
  3. Medina P, Worthen R, Forsberg L, Brenman J. The actin-binding protein capulet genetically interacts with the microtubule motor kinesin to maintain neuronal dendrite homeostasis. PLoS ONE. 2008;3:e3054 pubmed publisher
    ..From a Drosophila forward genetic screen, we identified a mutation in capulet--encoding a conserved actin-binding protein--that causes abnormal aggregates of actin within dendrites...
  4. Baum B, Perrimon N. Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Nat Cell Biol. 2001;3:883-90 pubmed
    ..We find that profilin and cofilin regulate actin-filament formation throughout the cell cortex. In contrast, CAP-a Drosophila homologue of Adenylyl Cyclase Associated Proteins-functions specifically to limit actin-filament ..
  5. Sansores Garcia L, Bossuyt W, Wada K, Yonemura S, Tao C, Sasaki H, et al. Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J. 2011;30:2325-35 pubmed publisher
    ..Thus, regulators of F-actin, and in particular Capping proteins, are essential for proper growth control by affecting Hippo signalling. ..
  6. Kucherenko M, Marrone A, Rishko V, Magliarelli H, Shcherbata H. Stress and muscular dystrophy: a genetic screen for dystroglycan and dystrophin interactors in Drosophila identifies cellular stress response components. Dev Biol. 2011;352:228-42 pubmed publisher
  7. Medina P, Swick L, Andersen R, Blalock Z, Brenman J. A novel forward genetic screen for identifying mutations affecting larval neuronal dendrite development in Drosophila melanogaster. Genetics. 2006;172:2325-35 pubmed
    ..In a fortuitous observation, we observed that the structure of dendritic arborization (da) neuron dendritic filopodia changes in response to a changing environment. ..
  8. Fernández B, Gaspar P, Bras Pereira C, Jezowska B, Rebelo S, Janody F. Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development. 2011;138:2337-46 pubmed publisher
    ..Here, we report that the actin-Capping Protein ?? heterodimer, which regulates actin polymerization, also functions to suppress inappropriate tissue growth ..
  9. Major R, Irvine K. Influence of Notch on dorsoventral compartmentalization and actin organization in the Drosophila wing. Development. 2005;132:3823-33 pubmed
    ..Finally, we identify a distinct requirement for a regulator of actin polymerization, capulet, in DV compartmentalization...

More Information

Publications28

  1. Benlali A, Draskovic I, Hazelett D, Treisman J. act up controls actin polymerization to alter cell shape and restrict Hedgehog signaling in the Drosophila eye disc. Cell. 2000;101:271-81 pubmed
    ..We have isolated mutations in a novel gene, act up (acu), that is required for this shape change...
  2. Baer M, Bilstein A, Leptin M. A clonal genetic screen for mutants causing defects in larval tracheal morphogenesis in Drosophila. Genetics. 2007;176:2279-91 pubmed
    ..In particular we found a range of defects in terminal cells, including failure in lumen formation and reduced or extensive branching. Other mutations affect cell growth, cell shape, and cell migration. ..
  3. Lin C, Lin P, Li Y, Hsu J. Capulet and Slingshot share overlapping functions during Drosophila eye morphogenesis. J Biomed Sci. 2012;19:46 pubmed publisher
    CAP/Capulet (Capt), Slingshot (Ssh) and Cofilin/Twinstar (Tsr) are actin-binding proteins that restrict actin polymerization...
  4. Marrone A, Kucherenko M, Rishko V, Shcherbata H. New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye. BMC Neurosci. 2011;12:93 pubmed publisher
    ..Since the function of the DGC in the brain and nervous system has not been fully defined, we have here continued to analyze the DGC modifiers' function in the developing Drosophila brain and eye...
  5. Meisel R. Evolutionary dynamics of recently duplicated genes: Selective constraints on diverging paralogs in the Drosophila pseudoobscura genome. J Mol Evol. 2009;69:81-93 pubmed publisher
    ..Therefore, the relative position of paralogs and the mechanism of duplication indirectly affect whether a duplicated gene is retained or pseudogenized. ..
  6. Herranz H, Milan M. Notch and affinity boundaries in Drosophila. Bioessays. 2006;28:113-6 pubmed
    ..The second report analyzes the differential requirements of Notch and the transcription factor Suppressor of Hairless in generating the affinity boundary. ..
  7. Stevenson V, Theurkauf W. Actin cytoskeleton: putting a CAP on actin polymerization. Curr Biol. 2000;10:R695-7 pubmed
    Two recent studies have identified a Drosophila homolog of cyclase-associated protein (CAP) as a developmentally important negative regulator of actin polymerization that may also directly mediate signal transduction.
  8. Menut L, Vaccari T, Dionne H, Hill J, Wu G, Bilder D. A mosaic genetic screen for Drosophila neoplastic tumor suppressor genes based on defective pupation. Genetics. 2007;177:1667-77 pubmed
    ..The isolation of additional loci that affect hyperplastic as well as neoplastic growth indicates the utility of this screening strategy for studying epithelial growth control. ..
  9. Baum B. Drosophila oogenesis: generating an axis of polarity. Curr Biol. 2002;12:R835-7 pubmed
    ..New studies of moesin function during Drosophila oogenesis show that Dmoesin tethers actin to the oocyte membrane. Interestingly, Dmoesin and an intact cortex are also required to stabilise ooycte polarity. ..
  10. Paunola E, Mattila P, Lappalainen P. WH2 domain: a small, versatile adapter for actin monomers. FEBS Lett. 2002;513:92-7 pubmed
    ..beta-thymosins, ciboulot, WASP (Wiskott Aldrich syndrome protein), verprolin/WIP (WASP-interacting protein), Srv2/CAP (adenylyl cyclase-associated protein) and several uncharacterized proteins...
  11. Jodoin J, Coravos J, Chanet S, Vasquez C, Tworoger M, Kingston E, et al. Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover. Dev Cell. 2015;35:685-97 pubmed publisher
    ..Our work identifies a critical role for F-actin turnover in connecting actomyosin to intercellular junctions, defining a dynamic process required for the stability of force balance across intercellular contacts in tissues. ..
  12. Janody F, Treisman J. Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium. Development. 2006;133:3349-57 pubmed
    ..We have found that Capping protein alpha (Cpa) and Capping protein beta (Cpb), which prevent extension of the barbed ends of actin filaments, ..
  13. DeVido S, Kwon D, Brown J, Kassis J. The role of Polycomb-group response elements in regulation of engrailed transcription in Drosophila. Development. 2008;135:669-76 pubmed publisher
    ..Our data are consistent with the model that engrailed PREs bring chromatin together, allowing both positive and negative regulatory interactions between distantly located DNA fragments. ..
  14. Minakhina S, Myers R, Druzhinina M, Steward R. Crosstalk between the actin cytoskeleton and Ran-mediated nuclear transport. BMC Cell Biol. 2005;6:32 pubmed
    ..We show that in chic mutants, as in Sd-RanGAP, nuclear export is impaired. Our data suggest that Profilin and the organization of the actin cytoskeleton play an important role in nuclear trafficking. ..
  15. Lee H, Engel U, Rusch J, Scherrer S, Sheard K, Van Vactor D. The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance. Neuron. 2004;42:913-26 pubmed
    ..These and other data suggest a model where Abl acts as a central signaling node to coordinate actin and microtubule dynamics downstream of guidance receptors. ..
  16. Otani T, Oshima K, Onishi S, Takeda M, Shinmyozu K, Yonemura S, et al. IKK? regulates cell elongation through recycling endosome shuttling. Dev Cell. 2011;20:219-32 pubmed publisher
    ..Our results establish an evolutionarily conserved function of IKK-related kinases in regulating recycling endosome dynamics and point to a key role of endosome dynamics in cell morphogenesis. ..
  17. Yamazaki H, Nusse R. Identification of DCAP, a drosophila homolog of a glucose transport regulatory complex. Mech Dev. 2002;119:115-9 pubmed
    ..Through alternative splicing, the DCAP gene generates a set of five different proteins with unique N-terminal sequences and a common C-terminal SH3 domain...
  18. Demontis F, Piccirillo R, Goldberg A, Perrimon N. Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech. 2013;6:1339-52 pubmed publisher
  19. Gaspar P, Holder M, Aerne B, Janody F, Tapon N. Zyxin antagonizes the FERM protein expanded to couple F-actin and Yorkie-dependent organ growth. Curr Biol. 2015;25:679-689 pubmed publisher
    ..interaction with the actin-associated protein Enabled (Ena) via a conserved LPPPP motif and is antagonized by Capping Protein (CP)...