Gene Symbol: CAP D2
Description: CAP-D2 condensin subunit
Alias: CAP-D2, CG1911, CapD2, DmCAP-D2, Dmel\CG1911, dCap-D2, CAP-D2 condensin subunit, CG1911-PA, Cap-D2-PA, dCap-D2
Species: fruit fly

Top Publications

  1. Savvidou E, Cobbe N, Steffensen S, Cotterill S, Heck M. Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatids. J Cell Sci. 2005;118:2529-43 pubmed
  2. Oliveira R, Coelho P, Sunkel C. The condensin I subunit Barren/CAP-H is essential for the structural integrity of centromeric heterochromatin during mitosis. Mol Cell Biol. 2005;25:8971-84 pubmed
    ..Taken together, our data suggest that the condensin I complex is required not only to promote sister chromatid resolution but also to maintain the structural integrity of centromeric heterochromatin during mitosis. ..
  3. Longworth M, Herr A, Ji J, Dyson N. RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. Genes Dev. 2008;22:1011-24 pubmed publisher
    ..These results uncover an unexpected link between pRB/RBF1 and chromatin condensation, providing a mechanism by which the functional inactivation of RB family members in human tumor cells may contribute to genome instability. ..
  4. Ono T, Losada A, Hirano M, Myers M, Neuwald A, Hirano T. Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Cell. 2003;115:109-21 pubmed
    ..We propose that the two condensin complexes make distinct mechanistic contributions to mitotic chromosome architecture in vertebrate cells. ..
  5. Pek J, Kai T. A role for vasa in regulating mitotic chromosome condensation in Drosophila. Curr Biol. 2011;21:39-44 pubmed publisher
    ..Our results suggest that Vas functions during mitosis and may link the piRNA pathway to mitotic chromosome condensation in Drosophila. ..
  6. Herzog S, Nagarkar Jaiswal S, Urban E, Riemer A, Fischer S, Heidmann S. Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I. PLoS Genet. 2013;9:e1003463 pubmed publisher
    ..As condensin II-specific subunits are also not found associated with SMC2, our results question the existence of a soluble condensin II complex in Drosophila. ..
  7. Carter S, Sjögren C. The SMC complexes, DNA and chromosome topology: right or knot?. Crit Rev Biochem Mol Biol. 2012;47:1-16 pubmed publisher
    ..This review focuses on the details of the relationship between the SMC complexes and topology. It also discusses the possibility that the SMC complexes are united by a capability to sense the geometrical chirality of DNA crossings. ..
  8. Hirano T. Condensins: universal organizers of chromosomes with diverse functions. Genes Dev. 2012;26:1659-78 pubmed publisher
    ..Future studies on condensins will not only enhance our understanding of chromosome architecture and dynamics, but also help address a previously underappreciated yet profound set of questions in chromosome biology. ..
  9. Buster D, Daniel S, Nguyen H, Windler S, Skwarek L, Peterson M, et al. SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2. J Cell Biol. 2013;201:49-63 pubmed publisher
    ..Therefore, SCF(Slimb)-mediated down-regulation of condensin II is required to maintain proper organization and morphology of the interphase nucleus. ..

More Information


  1. Beck E, Llopart A. Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup. Sci Rep. 2015;5:17197 pubmed publisher
  2. Schuster A, Sarvepalli K, Murphy E, Longworth M. Condensin II subunit dCAP-D3 restricts retrotransposon mobilization in Drosophila somatic cells. PLoS Genet. 2013;9:e1003879 pubmed publisher
    ..These findings identify a novel role for the anti-pairing activities of dCAP-D3/Condensin II and uncover a new way in which dCAP-D3/Condensin II influences local chromatin structure to help maintain genome stability. ..
  3. Pek J, Kai T. Non-coding RNAs enter mitosis: functions, conservation and implications. Cell Div. 2011;6:6 pubmed publisher
    ..We also highlight relevant studies implicating mitotic roles for RNAs and/or nuage in other model systems and their implications for cancer development. ..
  4. Pek J, Kai T. DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. Proc Natl Acad Sci U S A. 2011;108:12007-12 pubmed publisher
    ..Our results suggest that the RNA helicase Belle/DDX3 and the RNA interference pathway perform a common role in regulating chromosome segregation in Drosophila and human somatic cells. ..
  5. Lancaster O, Breuer M, Cullen C, Ito T, Ohkura H. The meiotic recombination checkpoint suppresses NHK-1 kinase to prevent reorganisation of the oocyte nucleus in Drosophila. PLoS Genet. 2010;6:e1001179 pubmed publisher
    ..Therefore we propose that NHK-1 is a crucial regulator of meiosis and that the meiotic checkpoint suppresses NHK-1 activity to prevent oocyte nuclear reorganisation until DNA breaks are repaired. ..
  6. Krishnan B, Thomas S, Yan R, Yamada H, Zhulin I, McKee B. Sisters unbound is required for meiotic centromeric cohesion in Drosophila melanogaster. Genetics. 2014;198:947-65 pubmed publisher
    ..In conclusion, our data show that SUNN is an essential meiosis-specific Drosophila cohesion protein. ..
  7. Nikalayevich E, Ohkura H. The NuRD nucleosome remodelling complex and NHK-1 kinase are required for chromosome condensation in oocytes. J Cell Sci. 2015;128:566-75 pubmed
    ..We further show that NHK-1 is important for chromosome condensation during mitosis as well as in oocytes. ..
  8. D Avino P, Archambault V, Przewloka M, Zhang W, Laue E, Glover D. Isolation of protein complexes involved in mitosis and cytokinesis from Drosophila cultured cells. Methods Mol Biol. 2009;545:99-112 pubmed publisher
    ..Although this method has proven very successful in isolating mitotic and cytokinetic complexes, it can also be used to characterise protein complexes involved in many other cellular processes. ..