Gene Symbol: CanB2
Description: Calcineurin B2
Alias: CG11217, CS2-1, Dmel\CG11217, canB2, dCNB2, dCnB2, calcineurin B2, CG11217-PA, CG11217-PB, CanB2-PA, CanB2-PB, calcineurin suppressor, chromosome 2, group 1
Species: fruit fly

Top Publications

  1. Lee T, Yu L, Wolf M, Rockman H. Galactokinase is a novel modifier of calcineurin-induced cardiomyopathy in Drosophila. Genetics. 2014;198:591-603 pubmed publisher
  2. Ha E, Lee K, Seo Y, Kim S, Lim J, Oh B, et al. Coordination of multiple dual oxidase-regulatory pathways in responses to commensal and infectious microbes in drosophila gut. Nat Immunol. 2009;10:949-57 pubmed publisher
    ..Thus, the coordinated regulation of DUOX enables the host to achieve gut-microbe homeostasis by efficiently combating infection while tolerating commensal microbes. ..
  3. Warren W, Phillips A, Howells A. Drosophila melanogaster contains both X-linked and autosomal homologues of the gene encoding calcineurin B. Gene. 1996;177:149-53 pubmed
    ..Northern blot analyses indicate that Dm pupae and adults express two different CnB-encoding transcripts that are differentially regulated. ..
  4. Takeo S, Swanson S, Nandanan K, Nakai Y, Aigaki T, Washburn M, et al. Shaggy/glycogen synthase kinase 3? and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis. Proc Natl Acad Sci U S A. 2012;109:6382-9 pubmed publisher
    ..Our findings suggest a mechanism in which Shaggy/GSK-3? activates calcineurin through Sarah phosphorylation on egg activation in Drosophila. ..
  5. Chang K, MIN K. Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function. Nat Neurosci. 2005;8:1577-85 pubmed
    ..These results identify nebula/DSCR1 as a regulator of mitochondrial function and integrity and further suggest that an increased level of DSCR1 may contribute to the mitochondrial dysfunction seen in Down syndrome. ..
  6. Takeo S, Tsuda M, Akahori S, Matsuo T, Aigaki T. The calcineurin regulator sra plays an essential role in female meiosis in Drosophila. Curr Biol. 2006;16:1435-40 pubmed
    ..To our knowledge, this is the first unambiguous demonstration that the regulation of calcineurin signaling by MCIPs plays a critical role in a defined biological process. ..
  7. Takeo S, Hawley R, Aigaki T. Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila. Dev Biol. 2010;344:957-67 pubmed publisher
    ..Oocytes from germline clones lacking CanB2, a calcineurin regulatory subunit B, failed to complete meiosis after egg activation, and laid eggs exhibited a ..
  8. Fontenele M, Carneiro K, Agrellos R, Oliveira D, Oliveira Silva A, Vieira V, et al. The Ca2+-dependent protease Calpain A regulates Cactus/I kappaB levels during Drosophila development in response to maternal Dpp signals. Mech Dev. 2009;126:737-51 pubmed publisher
    ..This mechanism may allow coordination of Toll, BMP and Ca(2+) signals, conferring precision to Dorsal-target expression domains. ..
  9. Nakai Y, Horiuchi J, Tsuda M, Takeo S, Akahori S, Matsuo T, et al. Calcineurin and its regulator sra/DSCR1 are essential for sleep in Drosophila. J Neurosci. 2011;31:12759-66 pubmed publisher
    ..of knock-out mutants for all Drosophila CN genes: CanA-14F, Pp2B-14D, and CanA1 (catalytic subunits), and CanB and CanB2 (regulatory subunits)...

More Information


  1. Deng H, Gerencser A, Jasper H. Signal integration by Ca(2+) regulates intestinal stem-cell activity. Nature. 2015;528:212-7 pubmed publisher
    ..We propose that the dynamic regulation of intracellular Ca(2+) levels allows effective integration of diverse mitogenic signals in ISCs to adapt their proliferative activity to the needs of the tissue. ..
  2. Tomita J, Mitsuyoshi M, Ueno T, Aso Y, Tanimoto H, Nakai Y, et al. Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster. J Neurosci. 2011;31:13137-46 pubmed publisher
    ..These results indicate a role for Cn and calcium-dependent signal transduction in sleep and memory regulation and may bring insight into the relationship between them. ..
  3. Watanabe Y, Takahashi A, Itoh M, Takano Shimizu T. Molecular spectrum of spontaneous de novo mutations in male and female germline cells of Drosophila melanogaster. Genetics. 2009;181:1035-43 pubmed publisher
    ..The high occurrence of NAHR that we observed has important consequences for genome evolution through the production of segmental duplications. ..
  4. Krauchunas A, Sackton K, Wolfner M. Phospho-regulation pathways during egg activation in Drosophila melanogaster. Genetics. 2013;195:171-80 pubmed publisher
    ..Nuclei, Young Arrest, Spindly, and Vap-33-1-as molecular markers, we showed that the egg activation genes sarah, CanB2, and cortex are required for the phospho-regulation of multiple proteins...
  5. Eeken J, Romeijn R, de Jong A, Pastink A, Lohman P. Isolation and genetic characterisation of the Drosophila homologue of (SCE)REV3, encoding the catalytic subunit of DNA polymerase zeta. Mutat Res. 2001;485:237-53 pubmed
    ..This phenotype of the Drosophila mus205 mutant is strikingly different from the phenotype of the yeast rev3 mutant, which is hypomutable after UV, X-rays, NQO and alkylating agents. ..
  6. Gajewski K, Wang J, Schulz R. Calcineurin function is required for myofilament formation and troponin I isoform transition in Drosophila indirect flight muscle. Dev Biol. 2006;289:17-29 pubmed
    Mutations in the Drosophila calcineurin B2 gene cause the collapse of indirect flight muscles during mid stages of pupal development...
  7. Schulz R, Yutzey K. Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Dev Biol. 2004;266:1-16 pubmed
  8. Singh K, Ju J, Walsh M, Diiorio M, Hart A. Deep conservation of genes required for both Drosphila melanogaster and Caenorhabditis elegans sleep includes a role for dopaminergic signaling. Sleep. 2014;37:1439-51 pubmed publisher
    ..Quantitative analysis of various components of quiescence suggests that interdependent or identical cellular and molecular mechanisms are likely to regulate both arousal and sleep entry. ..
  9. Warren W, Palmer S, Howells A. Molecular characterization of the cinnabar region of Drosophila melanogaster: identification of the cinnabar transcription unit. Genetica. 1996;98:249-62 pubmed
    ..The predicted cn protein contains several sequence motifs common to aromatic monooxygenases and is consistent with the assignment of cn as encoding the structural gene for kynurenine 3-monooxygenase. ..
  10. Gajewski K, Wang J, Molkentin J, Chen E, Olson E, Schulz R. Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila. Proc Natl Acad Sci U S A. 2003;100:1040-5 pubmed
    ..Here, we demonstrate that a mutation in the canB2 gene, which encodes a regulatory subunit of Drosophila calcineurin, can suppress a pupal developmental arrest ..