Gene Symbol: Cals
Alias: CALS, CG11059, CT30877, Cad102F, DCad102F, Dmel\CG11059, cals, Calsyntenin-1, CG11059-PA, CG11059-PB, CG11059-PC, CG11059-PD, Cals-PA, Cals-PB, Cals-PC, Cals-PD, calsyntenin-1, calsyntenin-1-like
Species: fruit fly
Tepass U, Truong K, Godt D, Ikura M, Peifer M. Cadherins in embryonic and neural morphogenesis. Nat Rev Mol Cell Biol. 2000;1:91-100 pubmed
..Cadherins may also contribute to neurite outgrowth and pathfinding, and to synaptic specificity and modulation in the central nervous system. ..
Roos J, DiGregorio P, Yeromin A, Ohlsen K, Lioudyno M, Zhang S, et al
. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 2005;169:435-45 pubmed
..We propose that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels. ..
Fung S, Wang F, Chase M, Godt D, Hartenstein V. Expression profile of the cadherin family in the developing Drosophila brain. J Comp Neurol. 2008;506:469-88 pubmed
..We conclude from this analysis that cadherins are likely to play a role in 'generic' neural functions, such as neurite fasciculation, branching, and synapse formation. ..
Vogt L, Schrimpf S, Meskenaite V, Frischknecht R, Kinter J, Leone D, et al
. Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. Mol Cell Neurosci. 2001;17:151-66 pubmed
..Thus, calsyntenin-1 may link extracellular proteolysis in the synaptic cleft and postsynaptic Ca2+ signaling. ..
Hill E, Broadbent I, Chothia C, Pettitt J. Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster. J Mol Biol. 2001;305:1011-24 pubmed
..Each organism also has a approximately 980 residue protein (CDH-11 and CG11059) with two cadherin domains and whose sequences match well over their entire length two proteins from human brain...
Zhang S, Yeromin A, Zhang X, Yu Y, Safrina O, Penna A, et al
. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A. 2006;103:9357-62 pubmed
Zartman J, Kanodia J, Yakoby N, Schafer X, Watson C, Schlichting K, et al
. Expression patterns of cadherin genes in Drosophila oogenesis. Gene Expr Patterns. 2009;9:31-6 pubmed publisher
..Of particular note is the complex patterning of the region of the follicular epithelium that gives rise to the dorsal appendages, which are tubular structures that serve as respiratory organs for the developing embryo. ..
Hong X, Hammell M, Ambros V, Cohen S. Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. Proc Natl Acad Sci U S A. 2009;106:15085-90 pubmed publisher
..This study reveals a complex relationship among different features in miRNA-target recognition and poses a new challenge for computational prediction. ..
Sato Miyata Y, Muramatsu K, Funakoshi M, Tsuda M, Aigaki T. Overexpression of dilp2 causes nutrient-dependent semi-lethality in Drosophila. Front Physiol. 2014;5:147 pubmed publisher
..Our results suggest that excess insulin/IGF signaling impairs the physiology of animals, which can be ameliorated by controlling the nutritional balance between proteins and carbohydrates, at least in flies. ..