Gene Symbol: Calr
Description: Calreticulin
Alias: CG9429, Clr, Crc, Dmel\CG9429, anon-EST:Liang-2.11, anon-EST:Liang-2.17, anon-EST:fe3D7, chr3R:5454619..5454778, clone 2.11, clone 2.17, crc, eth, potp, calreticulin, CG9429-PA, CG9429-PB, Calr-PA, Calr-PB, anon-fast-evolving-3D7, pot pourri, potpourri
Species: fruit fly

Top Publications

  1. Harbison S, Sehgal A. Quantitative genetic analysis of sleep in Drosophila melanogaster. Genetics. 2008;178:2341-60 pubmed publisher
    ..The large mutational target that we observed implicates genes functioning in a variety of biological processes, suggesting that sleep may serve a number of different functions rather than a single purpose. ..
  2. Kuraishi T, Manaka J, Kono M, Ishii H, Yamamoto N, Koizumi K, et al. Identification of calreticulin as a marker for phagocytosis of apoptotic cells in Drosophila. Exp Cell Res. 2007;313:500-10 pubmed
    ..b>Calreticulin, a molecular chaperone that functions in the lumen of the endoplasmic reticulum, was recently reported to be ..
  3. Qin Q, Pei J, Ancona V, Shaw B, Ficht T, de Figueiredo P. RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1alpha in supporting Brucella replication. PLoS Pathog. 2008;4:e1000110 pubmed publisher
    ..Finally, we propose a model in which IRE1alpha, and other ER-associated genes uncovered in our screen, mediate Brucella replication by promoting autophagosome biogenesis. ..
  4. Casso D, Tanda S, Biehs B, Martoglio B, Kornberg T. Drosophila signal peptide peptidase is an essential protease for larval development. Genetics. 2005;170:139-48 pubmed
    ..Flies bearing mutations in conserved residues or carrying deficiencies for the Spp gene had defective tracheae and died as larvae. ..
  5. Yamamoto A, Anholt R, Mackay T. Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster. Genet Res (Camb). 2009;91:373-82 pubmed publisher
  6. Lighthouse D, Buszczak M, Spradling A. New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev Biol. 2008;317:59-71 pubmed publisher
    ..In contrast, rab11 is required to maintain the germline stem cells, and to maintain the vesicle content of the spectrosome, suggesting that the fusome mediates intercellular signals that depend on the recycling endosome. ..
  7. Schulze S, McAllister B, Sinclair D, FitzPatrick K, Marchetti M, Pimpinelli S, et al. Heterochromatic genes in Drosophila: a comparative analysis of two genes. Genetics. 2006;173:1433-45 pubmed publisher
    ..This study shows that Dbp80 and RpL15 can function in contrasting chromatin contexts on an evolutionary timescale. The complex history of these genes also provides unique insight into the dynamic nature of genome evolution...
  8. Tiklová K, Senti K, Wang S, Gräslund A, Samakovlis C. Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila. Nat Cell Biol. 2010;12:1071-7 pubmed publisher
    ..Mouse MTf complements the defects of Drosophila MTf mutants. Drosophila provides the first genetic model for the functional dissection of MTf in epithelial junction assembly and morphogenesis. ..
  9. Smith M. Nucleotide sequence of a Drosophila melanogaster gene encoding a calreticulin homologue. DNA Seq. 1992;3:247-50 pubmed
    A Drosophila melanogaster gene encoding a homologue of the mammalian ER calcium binding protein, calreticulin, was cloned and the nucleotide sequence determined...

More Information


  1. Yamamoto A, Zwarts L, Callaerts P, Norga K, Mackay T, Anholt R. Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2008;105:12393-8 pubmed publisher
    ..We find that behavioral and neuroanatomical phenotypes are determined by a common set of genes that are organized as partially overlapping genetic networks. ..
  2. Stoltzfus J, Horton W, Grotewiel M. Odor-guided behavior in Drosophila requires calreticulin. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2003;189:471-83 pubmed
    ..To further elucidate the molecular basis of olfaction, we explored the role of the calcium-binding chaperone calreticulin in the behavioral response of Drosophila to aversive odorants...
  3. Tolhuis B, Blom M, Kerkhoven R, Pagie L, Teunissen H, Nieuwland M, et al. Interactions among Polycomb domains are guided by chromosome architecture. PLoS Genet. 2011;7:e1001343 pubmed publisher
    ..Our results demonstrate that many interactions among PcG target genes exist and that these interactions are guided by overall chromosome architecture. ..
  4. Law A, Hirayoshi K, O BRIEN T, Lis J. Direct cloning of DNA that interacts in vivo with a specific protein: application to RNA polymerase II and sites of pausing in Drosophila. Nucleic Acids Res. 1998;26:919-24 pubmed
    ..At least some of these map to the 5'-ends of genes. These results suggest that transcriptional pausing of Pol II is a general phenomenon in vivo. ..
  5. Tao Y, Zeng Z, Li J, Hartl D, Laurie C. Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. II. Mapping hybrid male sterility loci on the third chromosome. Genetics. 2003;164:1399-418 pubmed
    ..These results are consistent with the gradual evolution of hybrid incompatibilities as a by-product of genetic divergence in allopatric populations...
  6. Gilchrist D, dos Santos G, Fargo D, Xie B, Gao Y, Li L, et al. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Cell. 2010;143:540-51 pubmed publisher
  7. Williams M, Klockars A, Eriksson A, Voisin S, Dnyansagar R, Wiemerslage L, et al. The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder. PLoS Genet. 2016;12:e1006104 pubmed publisher
    ..Finally, a connection between the obesity-linked gene ETV5 and bipolar disorder emphasizes a functional relationship between obesity and BD at the molecular level. ..
  8. Jayaram S, Senti K, Tiklová K, Tsarouhas V, Hemphälä J, Samakovlis C. COPI vesicle transport is a common requirement for tube expansion in Drosophila. PLoS ONE. 2008;3:e1964 pubmed publisher
    ..Thus, the programmed deposition and growth of distinct luminal molds may provide distending forces during tube expansion in diverse organs. ..
  9. Christodoulou S, Lockyer A, Foster J, Hoheisel J, Roberts D. Nucleotide sequence of a Drosophila melanogaster cDNA encoding a calnexin homologue. Gene. 1997;191:143-8 pubmed
    ..The gene was found to be transcribed in various tissues and at all developmental stages. We have mapped the gene at chromosomal position 99A and we have also mapped the related gene coding for Drosophila calreticulin at 85E.
  10. Williams M, Perland E, Eriksson M, Carlsson J, Erlandsson D, Laan L, et al. Recurrent Sleep Fragmentation Induces Insulin and Neuroprotective Mechanisms in Middle-Aged Flies. Front Aging Neurosci. 2016;8:180 pubmed publisher
    ..The fact that neuroprotective pathways remain upregulated in middle-aged flies beyond sleep fragmentation suggests it might represent a strong stressor for the brain during later life. ..
  11. Hausdorf B. Early evolution of the bilateria. Syst Biol. 2000;49:130-42 pubmed
    ..Estimations of the divergence times show that the major bilaterian phyla did not originate in an explosive radiation during the Cambrian but rather that the Bilateria have a several hundred million years long Precambrian history. ..
  12. Stein W. Kinetics of transport: analyzing, testing, and characterizing models using kinetic approaches. Methods Enzymol. 1989;171:23-62 pubmed
  13. Gamo S, Tomida J, Dodo K, Keyakidani D, Matakatsu H, Yamamoto D, et al. Calreticulin mediates anesthetic sensitivity in Drosophila melanogaster. Anesthesiology. 2003;99:867-75 pubmed
    ..authors isolated a Drosophila mutant, ethas311, that was hypersensitive to diethylether and characterized the calreticulin (crc) gene as a candidate of altered anesthetic sensitivity...
  14. Tao Y, Chen S, Hartl D, Laurie C. Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. I. Differential accumulation of hybrid male sterility effects on the X and autosomes. Genetics. 2003;164:1383-97 pubmed
    ..Possible mechanisms of a "large X" effect include selective fixation of new mutations that are recessive or partially recessive and the evolution of sex-ratio distortion systems...
  15. Swarup S, Harbison S, Hahn L, Morozova T, Yamamoto A, Mackay T, et al. Extensive epistasis for olfactory behaviour, sleep and waking activity in Drosophila melanogaster. Genet Res (Camb). 2012;94:9-20 pubmed publisher
    ..melanogaster population on the mutational effects of P-element insertions in Semaphorin-5C (Sema-5c) and Calreticulin (Crc), pleiotropic genes that affect olfactory behaviour and startle behaviour and, in the case of Crc, sleep ..
  16. Grotewiel M, Beck C, Wu K, Zhu X, Davis R. Integrin-mediated short-term memory in Drosophila. Nature. 1998;391:455-60 pubmed
    ..We propose a model in which integrins act as dynamic regulators of synapse structure or the signalling events underlying short-term memory formation. ..
  17. Walker M, Rylett C, Keen J, Audsley N, Sajid M, Shirras A, et al. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Proteome Sci. 2006;4:9 pubmed publisher
    ..Therefore, the present study has identified seven new secreted accessory gland proteins, including GGT-1, which was not recognised previously as a secreted accessory gland product...
  18. Kuraishi T, Nakagawa Y, Nagaosa K, Hashimoto Y, Ishimoto T, Moki T, et al. Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells. EMBO J. 2009;28:3868-78 pubmed publisher
    ..These results collectively suggest that Pretaporter relocates from the endoplasmic reticulum to the cell surface during apoptosis to serve as a ligand for Draper in the phagocytosis of apoptotic cells. ..
  19. Gamo S, Dodo K, Matakatsu H, Tanaka Y. Molecular genetical analysis of Drosophila ether sensitive mutants. Toxicol Lett. 1998;100-101:329-37 pubmed
    ..3. Another sensitive mutant, eth(as)311. has a P-element in the 5'-untranslated region of Drosophila calreticulin gene (86BC)...