cac

Summary

Gene Symbol: cac
Description: cacophony
Alias: CAC, CG1522, CG15928, CG43368, Ca-alpha1A, Ca[[V]]2.1, Cac, Cac1, Dmca1A, Dmcalpha1A, Dmel\CG43368, Dmel_CG1522, Dmel_CG15928, EE171, H18, H47, L13, P18, alpha1A, cac1, dCac1, l(1)11Aa, l(1)13, l(1)L13, ldg, nbA, nonB, opm18, opm47, cacophony, CG43368-PA, CG43368-PB, CG43368-PC, CG43368-PD, CG43368-PE, CG43368-PF, CG43368-PG, CG43368-PH, CG43368-PI, CG43368-PJ, CG43368-PL, CG43368-PM, CG43368-PN, CG43368-PO, CG43368-PP, cac-PA, cac-PB, cac-PC, cac-PD, cac-PE, cac-PF, cac-PG, cac-PH, cac-PI, cac-PJ, cac-PL, cac-PM, cac-PN, cac-PO, cac-PP, cacaphony, cacophany, calcium channel alpha1 subunit, type A, lamina-degeneration, lethal(1)11Aa, night blind A, nightblind, nightblind A, no-on-transient B
Species: fruit fly

Top Publications

  1. Ly C, Yao C, Verstreken P, Ohyama T, Bellen H. straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. J Cell Biol. 2008;181:157-70 pubmed publisher
    ..These defects likely stem from destabilization of Cacophony (Cac), the primary presynaptic alpha(1) subunit in D. melanogaster...
  2. Liu K, Siebert M, Mertel S, Knoche E, Wegener S, Wichmann C, et al. RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. Science. 2011;334:1565-9 pubmed publisher
    ..Our data identify RBP family proteins as prime effectors of the AZ scaffold that are essential for the coupling of SVs, Ca(2+) channels, and the SV fusion machinery. ..
  3. Frank C, Pielage J, Davis G. A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels. Neuron. 2009;61:556-69 pubmed publisher
    ..Based on these data, we propose that Ephexin/Cdc42 couples synaptic Eph signaling to the modulation of presynaptic CaV2.1 channels during the homeostatic enhancement of presynaptic release. ..
  4. Kawasaki F, Felling R, Ordway R. A temperature-sensitive paralytic mutant defines a primary synaptic calcium channel in Drosophila. J Neurosci. 2000;20:4885-9 pubmed
    ..We have isolated a temperature-sensitive paralytic allele of the Drosophila calcium channel alpha1 subunit gene, cacophony (cac)...
  5. Rieckhof G, Yoshihara M, Guan Z, Littleton J. Presynaptic N-type calcium channels regulate synaptic growth. J Biol Chem. 2003;278:41099-108 pubmed
    ..a screen for behavioral mutants that disrupt synaptic transmission, an allele of the N-type calcium channel locus (Dmca1A) was identified that caused synaptic undergrowth...
  6. Hou J, Tamura T, Kidokoro Y. Delayed synaptic transmission in Drosophila cacophonynull embryos. J Neurophysiol. 2008;100:2833-42 pubmed publisher
    Ca(2+) influx through the Drosophila N-type Ca(2+) channel, encoded by cacophony (cac), triggers fast synaptic transmission. We now ask whether the cac Ca(2+) channel is the Ca(2+) channel solely dedicated for fast synaptic transmission...
  7. Schmid A, Qin G, Wichmann C, Kittel R, Mertel S, Fouquet W, et al. Non-NMDA-type glutamate receptors are essential for maturation but not for initial assembly of synapses at Drosophila neuromuscular junctions. J Neurosci. 2006;26:11267-77 pubmed
    ..Thus, our data suggest that incorporation of non-NMDA-type glutamate receptors and likely their protein-protein interactions with additional PSD components triggers a conversion from an initial to a mature stage of PSD assembly. ..
  8. Rasse T, Fouquet W, Schmid A, Kittel R, Mertel S, Sigrist C, et al. Glutamate receptor dynamics organizing synapse formation in vivo. Nat Neurosci. 2005;8:898-905 pubmed
  9. Smith L, Wang X, Peixoto A, Neumann E, Hall L, Hall J. A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects. J Neurosci. 1996;16:7868-79 pubmed
    ..Dmca1A maps to a chromosomal region implicated in, and is the likely candidate for, the gene involved in the generation of behavioral, physiological, and lethal phenotypes of the cacophony, nightblind-A, and lethal(1)L13 mutants.
  10. Dickman D, Davis G. The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis. Science. 2009;326:1127-30 pubmed publisher
    ..Thus, dysbindin is essential for adaptive neural plasticity and may link altered homeostatic signaling with a complex neurological disease. ..

Detail Information

Publications86

  1. Ly C, Yao C, Verstreken P, Ohyama T, Bellen H. straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. J Cell Biol. 2008;181:157-70 pubmed publisher
    ..These defects likely stem from destabilization of Cacophony (Cac), the primary presynaptic alpha(1) subunit in D. melanogaster...
  2. Liu K, Siebert M, Mertel S, Knoche E, Wegener S, Wichmann C, et al. RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release. Science. 2011;334:1565-9 pubmed publisher
    ..Our data identify RBP family proteins as prime effectors of the AZ scaffold that are essential for the coupling of SVs, Ca(2+) channels, and the SV fusion machinery. ..
  3. Frank C, Pielage J, Davis G. A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels. Neuron. 2009;61:556-69 pubmed publisher
    ..Based on these data, we propose that Ephexin/Cdc42 couples synaptic Eph signaling to the modulation of presynaptic CaV2.1 channels during the homeostatic enhancement of presynaptic release. ..
  4. Kawasaki F, Felling R, Ordway R. A temperature-sensitive paralytic mutant defines a primary synaptic calcium channel in Drosophila. J Neurosci. 2000;20:4885-9 pubmed
    ..We have isolated a temperature-sensitive paralytic allele of the Drosophila calcium channel alpha1 subunit gene, cacophony (cac)...
  5. Rieckhof G, Yoshihara M, Guan Z, Littleton J. Presynaptic N-type calcium channels regulate synaptic growth. J Biol Chem. 2003;278:41099-108 pubmed
    ..a screen for behavioral mutants that disrupt synaptic transmission, an allele of the N-type calcium channel locus (Dmca1A) was identified that caused synaptic undergrowth...
  6. Hou J, Tamura T, Kidokoro Y. Delayed synaptic transmission in Drosophila cacophonynull embryos. J Neurophysiol. 2008;100:2833-42 pubmed publisher
    Ca(2+) influx through the Drosophila N-type Ca(2+) channel, encoded by cacophony (cac), triggers fast synaptic transmission. We now ask whether the cac Ca(2+) channel is the Ca(2+) channel solely dedicated for fast synaptic transmission...
  7. Schmid A, Qin G, Wichmann C, Kittel R, Mertel S, Fouquet W, et al. Non-NMDA-type glutamate receptors are essential for maturation but not for initial assembly of synapses at Drosophila neuromuscular junctions. J Neurosci. 2006;26:11267-77 pubmed
    ..Thus, our data suggest that incorporation of non-NMDA-type glutamate receptors and likely their protein-protein interactions with additional PSD components triggers a conversion from an initial to a mature stage of PSD assembly. ..
  8. Rasse T, Fouquet W, Schmid A, Kittel R, Mertel S, Sigrist C, et al. Glutamate receptor dynamics organizing synapse formation in vivo. Nat Neurosci. 2005;8:898-905 pubmed
  9. Smith L, Wang X, Peixoto A, Neumann E, Hall L, Hall J. A Drosophila calcium channel alpha1 subunit gene maps to a genetic locus associated with behavioral and visual defects. J Neurosci. 1996;16:7868-79 pubmed
    ..Dmca1A maps to a chromosomal region implicated in, and is the likely candidate for, the gene involved in the generation of behavioral, physiological, and lethal phenotypes of the cacophony, nightblind-A, and lethal(1)L13 mutants.
  10. Dickman D, Davis G. The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis. Science. 2009;326:1127-30 pubmed publisher
    ..Thus, dysbindin is essential for adaptive neural plasticity and may link altered homeostatic signaling with a complex neurological disease. ..
  11. Gu H, Jiang S, Campusano J, Iniguez J, Su H, Hoang A, et al. Cav2-type calcium channels encoded by cac regulate AP-independent neurotransmitter release at cholinergic synapses in adult Drosophila brain. J Neurophysiol. 2009;101:42-53 pubmed publisher
    ..In Drosophila, cac is the only Ca(v)2-type gene. Cacophony (CAC) channels are localized in motor neuron terminals where they have been shown to mediate evoked, but not AP-..
  12. Peixoto A, Hall J. Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila. Genetics. 1998;148:827-38 pubmed
    b>cacophony (cac), a mutation affecting the courtship song in Drosophila melanogaster, is revealed to cause temperature-sensitive (TS) abnormalities...
  13. Peng I, Wu C. Drosophila cacophony channels: a major mediator of neuronal Ca2+ currents and a trigger for K+ channel homeostatic regulation. J Neurosci. 2007;27:1072-81 pubmed
    The cacophony (cac) locus in Drosophila encodes a Ca2+ channel alpha subunit, but little is known about properties of cac-mediated currents and functional consequences of cac mutations in central neurons...
  14. Kurshan P, Oztan A, Schwarz T. Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions. Nat Neurosci. 2009;12:1415-23 pubmed publisher
    ..as stj) mutations cannot be explained by a channel defect; embryos lacking the pore-forming alpha(1) subunit cacophony formed boutons...
  15. Fouquet W, Owald D, Wichmann C, Mertel S, Depner H, Dyba M, et al. Maturation of active zone assembly by Drosophila Bruchpilot. J Cell Biol. 2009;186:129-45 pubmed publisher
    ..BRP seems responsible for effectively clustering Ca(2+) channels beneath the T-bar density late in a protracted AZ formation process, potentially through a direct molecular interaction with intracellular Ca(2+) channel domains. ..
  16. Tsurudome K, Tsang K, Liao E, Ball R, Penney J, Yang J, et al. The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction. Neuron. 2010;68:879-93 pubmed publisher
    ..Finally, we show that repression of Khc-73 by miR-310-313 cluster influences the establishment of normal synaptic homeostasis. Our findings establish a role for miRNAs in the regulation of neurotransmitter release. ..
  17. Hallermann S, Kittel R, Wichmann C, Weyhersmüller A, Fouquet W, Mertel S, et al. Naked dense bodies provoke depression. J Neurosci. 2010;30:14340-5 pubmed publisher
    ..Furthermore, rapid recovery following sustained release was slowed. Our results causally link, with intramolecular precision, the tethering of vesicles at the AZ cytomatrix to synaptic depression. ..
  18. Miskiewicz K, Jose L, Bento Abreu A, Fislage M, Taes I, Kasprowicz J, et al. ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot. Neuron. 2011;72:776-88 pubmed publisher
    ..We propose a model where ELP3-dependent acetylation of Bruchpilot at synapses regulates the structure of individual presynaptic densities and neurotransmitter release efficiency. ..
  19. Li J, Ashley J, Budnik V, Bhat M. Crucial role of Drosophila neurexin in proper active zone apposition to postsynaptic densities, synaptic growth, and synaptic transmission. Neuron. 2007;55:741-55 pubmed
    ..Together, our results provide compelling evidence for an in vivo role of neurexins in the modulation of synaptic architecture and adhesive interactions between pre- and postsynaptic compartments. ..
  20. Frank C, Kennedy M, Goold C, Marek K, Davis G. Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis. Neuron. 2006;52:663-77 pubmed
    ..1 calcium channel encoded by cacophony. These data confirm the presynaptic expression of synaptic homeostasis and implicate presynaptic Ca(V)2...
  21. Kittel R, Wichmann C, Rasse T, Fouquet W, Schmidt M, Schmid A, et al. Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release. Science. 2006;312:1051-4 pubmed
    ..BRP-like proteins seem to establish proximity between Ca2+ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity. ..
  22. Kawasaki F, Zou B, Xu X, Ordway R. Active zone localization of presynaptic calcium channels encoded by the cacophony locus of Drosophila. J Neurosci. 2004;24:282-5 pubmed
    ..Our previous genetic, molecular, and functional analysis has shown that the cacophony (cac) gene encodes a primary presynaptic calcium channel alpha1 subunit in Drosophila...
  23. Smith L, Peixoto A, Kramer E, Villella A, Hall J. Courtship and visual defects of cacophony mutants reveal functional complexity of a calcium-channel alpha1 subunit in Drosophila. Genetics. 1998;149:1407-26 pubmed
    ..that the Drosophila Dmca1A calcium-channel alpha1 subunit is encoded by the cacophony (cac) gene and that nightblind-A and lethal(1)L13 mutations are allelic to cac with respect to an expanded array of behavioral and ..
  24. Kawasaki F, Collins S, Ordway R. Synaptic calcium-channel function in Drosophila: analysis and transformation rescue of temperature-sensitive paralytic and lethal mutations of cacophony. J Neurosci. 2002;22:5856-64 pubmed
    ..The cacophony (cac) gene in Drosophila, also known as nightblind A, encodes a voltage-gated calcium-channel alpha1 subunit homologous to vertebrate alpha1 subunits implicated in ..
  25. Long A, Kim E, Leung H, Woodruff E, An L, Doerge R, et al. Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein. J Neurosci. 2008;28:3668-82 pubmed publisher
    ..These defects are causally linked with severe loss of the Cacophony voltage-gated Ca(2+) channels, which fail to localize normally at presynaptic active zone domains in the absence ..
  26. Dickman D, Kurshan P, Schwarz T. Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function. J Neurosci. 2008;28:31-8 pubmed publisher
    ..The photoreceptor phenotype of d alpha2delta-3 mutants resembles that of the calcium channel alpha1 mutant cacophony (cac), suggesting shared functions. We have examined in detail genotypes that survive to the third-instar stage...
  27. Palladino M, Keegan L, O Connell M, Reenan R. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell. 2000;102:437-49 pubmed
    ..Surprisingly, dADAR mutants are not short-lived. Thus, A-to-I editing of pre-mRNAs in Drosophila acts predominantly through nervous system targets to affect adult nervous system function, integrity, and behavior. ..
  28. Diao F, Ironfield H, Luan H, Diao F, Shropshire W, Ewer J, et al. Plug-and-play genetic access to drosophila cell types using exchangeable exon cassettes. Cell Rep. 2015;10:1410-21 pubmed publisher
    ..We also introduce an exchangeable, MiMIC-like Trojan exon construct that can be targeted to coding introns using the Crispr/Cas system. ..
  29. Copley R. Evolutionary convergence of alternative splicing in ion channels. Trends Genet. 2004;20:171-6 pubmed
    ..The result has important implications for the analysis of regulation of alternative splicing using comparative genomics and our understanding of molecular evolution. ..
  30. Lins R, Oliveira S, Souza N, de Queiroz R, Justiniano S, Ward R, et al. Molecular evolution of the cacophony IVS6 region in sandflies. Insect Mol Biol. 2002;11:117-22 pubmed
    ..The cacophony gene was identified by a mutation affecting the "lovesong" in Drosophila melanogaster...
  31. Dellinger B, Felling R, Ordway R. Genetic modifiers of the Drosophila NSF mutant, comatose, include a temperature-sensitive paralytic allele of the calcium channel alpha1-subunit gene, cacophony. Genetics. 2000;155:203-11 pubmed
    ..One of these mutations is a TS paralytic allele of the calcium channel alpha1-subunit gene, cacophony (cac)...
  32. Yu W, Kawasaki F, Ordway R. Activity-dependent interactions of NSF and SNAP at living synapses. Mol Cell Neurosci. 2011;47:19-27 pubmed publisher
    ..These observations extend current models describing the spatial organization of NSF, SNAP and SNARE proteins in synaptic vesicle trafficking. ..
  33. Repnikova E, Koles K, Nakamura M, Pitts J, Li H, Ambavane A, et al. Sialyltransferase regulates nervous system function in Drosophila. J Neurosci. 2010;30:6466-76 pubmed publisher
    ..Thus, our data shed light on one of the most ancient functions of sialic acids in metazoan organisms and suggest a possibility that this function is evolutionarily conserved between flies and mammals. ..
  34. Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, et al. A Drosophila full-length cDNA resource. Genome Biol. 2002;3:RESEARCH0080 pubmed
    ..Clones were eliminated either because they carry single nucleotide discrepancies, which most probably result from reverse transcriptase errors, or because they are truncated and contain only part of the protein-coding sequence. ..
  35. Keegan L, Brindle J, Gallo A, Leroy A, Reenan R, O Connell M. Tuning of RNA editing by ADAR is required in Drosophila. EMBO J. 2005;24:2183-93 pubmed
    ..Expression of this transcript in embryonic muscle is also lethal, with above-normal, adult-like levels of editing at sites in a transcript encoding a muscle voltage-gated calcium channel. ..
  36. Worrell J, Levine R. Characterization of voltage-dependent Ca2+ currents in identified Drosophila motoneurons in situ. J Neurophysiol. 2008;100:868-78 pubmed publisher
    ..The Drosophila genome contains three genes with homology to vertebrate voltage-dependent Ca2+ channels: Dmca1A, Dmca1D, and Dmalpha1G...
  37. MacPherson M, Pollock V, Broderick K, Kean L, O Connell F, Dow J, et al. Model organisms: new insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster. Am J Physiol Cell Physiol. 2001;280:C394-407 pubmed
    ..We have shown by RT-PCR that the Drosophila L-type calcium channel alpha1-subunit genes Dmca1D and Dmca1A (nbA) are both expressed in tubules...
  38. Tian X, Gala U, Zhang Y, Shang W, Nagarkar Jaiswal S, di Ronza A, et al. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol. 2015;13:e1002103 pubmed publisher
    ..in Drosophila designed to identify genes required for neuronal function and maintenance, we identified multiple cacophony (cac) mutant alleles...
  39. Hu W, Wang T, Wang X, Han J. Ih channels control feedback regulation from amacrine cells to photoreceptors. PLoS Biol. 2015;13:e1002115 pubmed publisher
    ..These results provide new mechanistic insight into how synaptic feedback regulation can participate in network processing by modulating neural information transfer and circuit excitability. ..
  40. Pflugfelder G. Genetic lesions in Drosophila behavioural mutants. Behav Brain Res. 1998;95:3-15 pubmed
    ..Various mutagens are reviewed as to their suitability in inducing selective regulatory mutations. ..
  41. Iyengar A, Wu C. Flight and seizure motor patterns in Drosophila mutants: simultaneous acoustic and electrophysiological recordings of wing beats and flight muscle activity. J Neurogenet. 2014;28:316-28 pubmed publisher
    ..We examined mutants of the genes enconding: 1) voltage-gated Ca(2+) channels (cacophony, cac), 2) Ca(2+)-activated K(+) channels (slowpoke, slo), and 3) voltage-gated K(+) channels (Shaker, Sh) and ..
  42. Hall J. The mating of a fly. Science. 1994;264:1702-14 pubmed
    ..Further behavioral mutations seemed originally to be courtship-specific, turned out not to have that property, and have led to a broadened perspective on the nature and action of Drosophila's sex-determination genes. ..
  43. Graf E, Valakh V, Wright C, Wu C, Liu Z, Zhang Y, et al. RIM promotes calcium channel accumulation at active zones of the Drosophila neuromuscular junction. J Neurosci. 2012;32:16586-96 pubmed publisher
  44. Peng I, Berke B, Zhu Y, Lee W, Chen W, Wu C. Temperature-dependent developmental plasticity of Drosophila neurons: cell-autonomous roles of membrane excitability, Ca2+ influx, and cAMP signaling. J Neurosci. 2007;27:12611-22 pubmed
    ..Presumably, activity-dependent Ca2+ accumulation triggers the cAMP cascade to confer the activity-dependent plasticity of neuronal excitability and growth. ..
  45. Ma E, Gu X, Wu X, Xu T, Haddad G. Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster. J Clin Invest. 2001;107:685-93 pubmed
    ..Disruption of the dADAR gene results in totally unedited sodium (Para), calcium (Dmca1A), and chloride (DrosGluCl-alpha) channels, a very prolonged recovery from anoxic stupor, a vulnerability to heat ..
  46. Eeken J, Sobels F, Hyland V, Schalet A. Distribution of MR-induced sex-linked recessive lethal mutations in Drosophila melanogaster. Mutat Res. 1985;150:261-75 pubmed
  47. Siebert M, Böhme M, Driller J, Babikir H, Mampell M, Rey U, et al. A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones. elife. 2015;4: pubmed publisher
  48. Küppers B, Sanchez Soriano N, Letzkus J, Technau G, Prokop A. In developing Drosophila neurones the production of gamma-amino butyric acid is tightly regulated downstream of glutamate decarboxylase translation and can be influenced by calcium. J Neurochem. 2003;84:939-51 pubmed
  49. Graf E, Daniels R, Burgess R, Schwarz T, DiAntonio A. Rab3 dynamically controls protein composition at active zones. Neuron. 2009;64:663-77 pubmed publisher
    ..While previous studies of Rab3 have focused on its role in the synaptic vesicle cycle, these findings demonstrate an additional and unexpected function for Rab3 in the localization of presynaptic proteins to active zones. ..
  50. Zou B, Yan H, Kawasaki F, Ordway R. MAP1 structural organization in Drosophila: in vivo analysis of FUTSCH reveals heavy- and light-chain subunits generated by proteolytic processing at a conserved cleavage site. Biochem J. 2008;414:63-71 pubmed publisher
  51. Ryglewski S, Kilo L, Duch C. Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growth during postembryonic maturation of an identified Drosophila motoneuron. Eur J Neurosci. 2014;39:1572-85 pubmed publisher
  52. Luo X, Rosenfeld J, Yamamoto S, Harel T, Zuo Z, Hall M, et al. Clinically severe CACNA1A alleles affect synaptic function and neurodegeneration differentially. PLoS Genet. 2017;13:e1006905 pubmed publisher
    ..We previously generated null and partial loss-of-function alleles of cac, the homolog of CACNA1A in Drosophila...
  53. Ranganathan R, Harris W, Zuker C. The molecular genetics of invertebrate phototransduction. Trends Neurosci. 1991;14:486-93 pubmed
    ..The results of a combination of molecular, genetic, physiological and biochemical studies are beginning to produce a clearer model for the complex mechanisms involved in invertebrate visual transduction. ..
  54. von Schilcher F. The behavior of cacophony, a courtship song mutant in Drosophila melanogaster. Behav Biol. 1976;17:187-96 pubmed
  55. Romero E, Cha G, Verstreken P, Ly C, Hughes R, Bellen H, et al. Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm. Neuron. 2008;57:27-40 pubmed publisher
    ..Thus, our data indicate that increased neurotransmission is at the root of neuronal degeneration caused by expanded full-length htt during early stages of pathogenesis. ..
  56. Wang P, Saraswati S, Guan Z, Watkins C, Wurtman R, Littleton J. A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function. J Neurosci. 2004;24:4518-29 pubmed
    ..Given the behavioral similarities between disruptions of PGK function in Drosophila and humans, the analysis of nubian animals may reveal conserved neuronal responses associated with altered ATP generation within the brain. ..
  57. Lepicard S, Franco B, de Bock F, Parmentier M. A presynaptic role of microtubule-associated protein 1/Futsch in Drosophila: regulation of active zone number and neurotransmitter release. J Neurosci. 2014;34:6759-71 pubmed publisher
    ..Altogether our data are in favor of a model by which Futsch locally stabilizes active zones, by reinforcing their link with the underlying microtubule cytoskeleton. ..
  58. Chan B, Villella A, Funes P, Hall J. Courtship and other behaviors affected by a heat-sensitive, molecularly novel mutation in the cacophony calcium-channel gene of Drosophila. Genetics. 2002;162:135-53 pubmed
    The cacophony (cac) locus of Drosophila melanogaster, which encodes a calcium-channel subunit, has been mutated to cause courtship-song defects or abnormal responses to visual stimuli...
  59. Macleod G, Chen L, Karunanithi S, Peloquin J, Atwood H, McRory J, et al. The Drosophila cacts2 mutation reduces presynaptic Ca2+ entry and defines an important element in Cav2.1 channel inactivation. Eur J Neurosci. 2006;23:3230-44 pubmed
    ..The cacophony gene encodes the primary presynaptic voltage-gated Ca2+ channel in Drosophila motor-nerve terminals...
  60. Kawasaki F, Ordway R. Molecular mechanisms determining conserved properties of short-term synaptic depression revealed in NSF and SNAP-25 conditional mutants. Proc Natl Acad Sci U S A. 2009;106:14658-63 pubmed publisher
    ..Together, the results reported here establish in vivo contributions of SNAP-25 and NSF to synaptic vesicle trafficking and define molecular mechanisms determining conserved functional properties of short-term depression. ..
  61. Ryglewski S, Lance K, Levine R, Duch C. Ca(v)2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons. J Physiol. 2012;590:809-25 pubmed publisher
    ..We further demonstrated that the Ca(v)2 homolog, Dmca1A, mediated the amiloride-insensitive component of LVA current...
  62. Huang F, Woodruff E, Mohrmann R, Broadie K. Rolling blackout is required for synaptic vesicle exocytosis. J Neurosci. 2006;26:2369-79 pubmed
    ..We conclude that RBO plays an essential role in neurotransmitter release, downstream of SV docking, likely mediating SV fusion. ..
  63. Bae H, Chen S, Roche J, Ai M, Wu C, DiAntonio A, et al. Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction. Eneuro. 2016;3: pubmed publisher
    ..Our results suggest that although Rab3-GEF acts upstream of Rab3 to control Rab3 localization and likely GTP-binding, it also acts downstream to regulate CAZ development, potentially as a Rab3 effector at the synapse. ..
  64. Urwyler O, Izadifar A, Dascenco D, Petrovic M, He H, Ayaz D, et al. Investigating CNS synaptogenesis at single-synapse resolution by combining reverse genetics with correlative light and electron microscopy. Development. 2015;142:394-405 pubmed publisher
    ..In principle, our CLEM approach is broadly applicable to the developmental and ultrastructural analysis of any cell type that can be targeted with genetically encoded markers. ..
  65. Ford K, Davis G. Archaerhodopsin voltage imaging: synaptic calcium and BK channels stabilize action potential repolarization at the Drosophila neuromuscular junction. J Neurosci. 2014;34:14517-25 pubmed publisher
    ..Thus, we have defined an essential role for Slo channels during synaptic AP repolarization and have revised our understanding of Shaker channels at this model synapse. ..
  66. Spring A, Brusich D, Frank C. C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction. PLoS Genet. 2016;12:e1005886 pubmed publisher
    ..Based on these data, we propose that Csk and its SFK substrates impinge upon homeostatic control of NMJ function by regulating downstream expression or localization of FasII. ..
  67. Brooks I, Felling R, Kawasaki F, Ordway R. Genetic analysis of a synaptic calcium channel in Drosophila: intragenic modifiers of a temperature-sensitive paralytic mutant of cacophony. Genetics. 2003;164:163-71 pubmed
    ..identified a temperature-sensitive paralytic mutant of the voltage-gated calcium channel alpha1 subunit gene, cacophony (cac)...
  68. Neumann E, Wheeler D, Bernstein A, Burnside J, Hall J. Artificial neural network classification of Drosophila courtship song mutants. Biol Cybern. 1992;66:485-96 pubmed
    Courtship songs produced by Drosophila males--wild-type, plus the cacophony and dissonance behavioral mutants--were examined with the aid of newly developed strategies for adaptive acoustic analysis and classification...
  69. Inagaki A, Frank C, Usachev Y, Benveniste M, Lee A. Pharmacological correction of gating defects in the voltage-gated Ca(v)2.1 Ca²? channel due to a familial hemiplegic migraine mutation. Neuron. 2014;81:91-102 pubmed publisher
    ..Our results reveal a mechanism by which a Ca(v)2.1 gating modifier can ameliorate defects associated with a disease-causing mutation in Ca(v)2.1. ..
  70. Lutas A, Wahlmark C, Acharjee S, Kawasaki F. Genetic analysis in Drosophila reveals a role for the mitochondrial protein p32 in synaptic transmission. G3 (Bethesda). 2012;2:59-69 pubmed publisher
    ..These studies are the first to address P32 function in Drosophila and expand our knowledge of mitochondrial proteins contributing to synaptic transmission. ..
  71. Johnson E, Fetter R, Davis G. Negative regulation of active zone assembly by a newly identified SR protein kinase. PLoS Biol. 2009;7:e1000193 pubmed publisher
    ..This mechanism could contribute to the speed and specificity with which AZs are assembled throughout the nervous system. ..
  72. Carrillo R, Olsen D, Yoon K, Keshishian H. Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement. Neuron. 2010;68:32-44 pubmed publisher
    ..Mutations affecting the Sema-2a ligand, the plexin B receptor (plexB), the voltage-gated Ca(v)2.1 calcium channel (cac), or the voltage-gated Na(v)1 sodium channel (mle(nap-ts);tipE) each result in ectopic neuromuscular contacts...
  73. Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, et al. The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles. J Cell Biol. 2013;202:667-83 pubmed publisher
    ..We propose that the macromolecular architecture created by the alternating pattern of the BRP isoforms determines the number of Ca(2+) channel-coupled SV release slots available per AZ and thereby sets the size of the RRP. ..
  74. Hall J. Courtship lite: a personal history of reproductive behavioral neurogenetics in Drosophila. J Neurogenet. 2002;16:135-63 pubmed
  75. Brusich D, Spring A, Frank C. A single-cross, RNA interference-based genetic tool for examining the long-term maintenance of homeostatic plasticity. Front Cell Neurosci. 2015;9:107 pubmed publisher
    ..Published experiments have demonstrated that hypomorphic missense mutations in the CaV2 α1a subunit gene cacophony (cac) can impair homeostatic plasticity at the NMJ...
  76. Yuan Q, Xiang Y, Yan Z, Han C, Jan L, Jan Y. Light-induced structural and functional plasticity in Drosophila larval visual system. Science. 2011;333:1458-62 pubmed publisher
  77. Kuromi H, Ueno K, Kidokoro Y. Two types of Ca2+ channel linked to two endocytic pathways coordinately maintain synaptic transmission at the Drosophila synapse. Eur J Neurosci. 2010;32:335-46 pubmed publisher
    ..Thus, intense synaptic transmission is coordinately maintained by synaptic vesicle recycling initiated by Ca(2+) influx through the two types of Ca(2+) channel. ..
  78. Gillespie J, Hodge J. CASK regulates CaMKII autophosphorylation in neuronal growth, calcium signaling, and learning. Front Mol Neurosci. 2013;6:27 pubmed publisher
    ..Expression of human CASK in Drosophila rescued the effect of CASK deletion on the activity state of CaMKII, suggesting that human CASK may also regulate CaMKII autophosphorylation. ..
  79. Gleason J. Mutations and natural genetic variation in the courtship song of Drosophila. Behav Genet. 2005;35:265-77 pubmed
    ..With many new tools in genetic analysis and the multiple Drosophila genome projects currently underway, the ability to relate mutational and quantitative analyses will improve. ..
  80. Huang J, Ma P, Ji S, Zhao X, Tan J, Sun X, et al. Age-dependent alterations in the presynaptic active zone in a Drosophila model of Alzheimer's disease. Neurobiol Dis. 2013;51:161-7 pubmed publisher
    ..Our study indicates that the chronic accumulation of intraneuronal A? can induce functional and structural changes in the presynaptic active zone prior to a loss of presynaptic buttons in the same neuron. ..
  81. Yamamoto D, Nakano Y. Genes for sexual behavior. Biochem Biophys Res Commun. 1998;246:1-6 pubmed
    ..This strategy of artificial control of fly behavior opens up an avenue for studies to identify the neural center for individual behavioral actions. ..
  82. Lefevre G. Salivary chromosome bands and the frequency of crossing over in Drosophila melanogaster. Genetics. 1971;67:497-513 pubmed