Gene Symbol: Ca-alpha1T
Description: Ca[2+]-channel protein alpha[] subunit T
Alias: CG12544, CG15899, CG4222, Ca-alphaT-RC, Ca1G, Caalpha1T, DmalphaG, Dmca1G, Dmel\CG15899, alpha1T, cat, Ca[2+]-channel protein alpha[] subunit T, CG15899-PB, CG15899-PC, CG15899-PD, CG15899-PE, CG15899-PF, Ca-alpha1T-PB, Ca-alpha1T-PC, Ca-alpha1T-PD, Ca-alpha1T-PE, Ca-alpha1T-PF, Ca1G
Species: fruit fly
Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
..These results point to a pivotal role for RNA editing in nervous system function. ..
Schneider C, Will C, BROSIUS J, Frilander M, Luhrmann R. Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila. Proc Natl Acad Sci U S A. 2004;101:9584-9 pubmed
..A comparison of U11 snRNAs that we have identified from vertebrates, plants, and insects, suggests that an evolutionarily divergent U11 snRNA may be unique to Drosophila and not characteristic of insects in general. ..
Alekseyenko A, Larschan E, Lai W, Park P, Kuroda M. High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome. Genes Dev. 2006;20:848-57 pubmed
..Distinguishing expressed genes from the bulk of the genome is likely to be an important function common to many chromatin organizing and modifying activities. ..
Kuromi H, Ueno K, Kidokoro Y. Two types of Ca2+ channel linked to two endocytic pathways coordinately maintain synaptic transmission at the Drosophila synapse. Eur J Neurosci. 2010;32:335-46 pubmed publisher
..Thus, intense synaptic transmission is coordinately maintained by synaptic vesicle recycling initiated by Ca(2+) influx through the two types of Ca(2+) channel. ..
Hu W, Wang T, Wang X, Han J. Ih channels control feedback regulation from amacrine cells to photoreceptors. PLoS Biol. 2015;13:e1002115 pubmed publisher
..These results provide new mechanistic insight into how synaptic feedback regulation can participate in network processing by modulating neural information transfer and circuit excitability. ..
Ryglewski S, Lance K, Levine R, Duch C. Ca(v)2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons. J Physiol. 2012;590:809-25 pubmed publisher
Jeong K, Lee S, Seo H, Oh Y, Jang D, Choe J, et al
. Ca-Î±1T, a fly T-type Ca2+ channel, negatively modulates sleep. Sci Rep. 2015;5:17893 pubmed publisher
..Thus, our study suggests invertebrate T-type Ca(2+) channels promote wakefulness rather than stabilizing sleep. ..
Agrawal R, Stormo G. Editing efficiency of a Drosophila gene correlates with a distant splice site selection. RNA. 2005;11:563-6 pubmed
..In contrast, when editing occurs downstream of alternative splicing, no correlation is seen. These results suggest some models for the coupling of editing and splicing processes. ..
Lin C, Mount S, Jarmołowski A, Makałowski W. Evolutionary dynamics of U12-type spliceosomal introns. BMC Evol Biol. 2010;10:47 pubmed publisher
..Loss of U12 introns or the genes containing them is more common than conversion to the U2-type. The degeneracy of U12-type terminal dinucleotides among natural U12-type introns is higher than previously thought. ..