Gene Symbol: Ca-alpha1D
Description: Ca[2+]-channel protein alpha[[1]] subunit D
Alias: BG:DS02795.1, CG4894, Ca-_1D, Ca-a1D, Ca-alpha1, Ca-alpha[[1]]D, Ca_alpha1D, Caalpha1D, DmCa1D, DmCa1alpha1, Dmca1D, Dmel\CG4894, DroCa1, alpha1, alpha1D, ca-alpha1D, ca-alpha1d, caID, cad, l(2)35Fa, l35Fa, Ca[2+]-channel protein alpha[[1]] subunit D, CG4894-PA, CG4894-PB, CG4894-PC, CG4894-PD, CG4894-PE, CG4894-PF, CG4894-PG, CG4894-PH, CG4894-PI, CG4894-PJ, Ca-alpha1D-PA, Ca-alpha1D-PB, Ca-alpha1D-PC, Ca-alpha1D-PD, Ca-alpha1D-PE, Ca-alpha1D-PF, Ca-alpha1D-PG, Ca-alpha1D-PH, Ca-alpha1D-PI, Ca-alpha1D-PJ, Ca2+-channel protein alpha1 subunit D, Ca[2+]-channel alpha1 subunit, alpha-1 subunit Ca2[+] channel type D, calcium channel alpha-1 subunit, drosophila melanogaster calcium channel alpha[[1]] subunit DHP-sensitive
Species: fruit fly

Top Publications

  1. Jepson J, Savva Y, Yokose C, Sugden A, Sahin A, Reenan R. Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem. 2011;286:8325-37 pubmed publisher
    ..Our data demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities. ..
  2. Keegan L, Brindle J, Gallo A, Leroy A, Reenan R, O Connell M. Tuning of RNA editing by ADAR is required in Drosophila. EMBO J. 2005;24:2183-93 pubmed
    ..Expression of this transcript in embryonic muscle is also lethal, with above-normal, adult-like levels of editing at sites in a transcript encoding a muscle voltage-gated calcium channel. ..
  3. Schneider C, Will C, BROSIUS J, Frilander M, Luhrmann R. Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila. Proc Natl Acad Sci U S A. 2004;101:9584-9 pubmed
    ..A comparison of U11 snRNAs that we have identified from vertebrates, plants, and insects, suggests that an evolutionarily divergent U11 snRNA may be unique to Drosophila and not characteristic of insects in general. ..
  4. Keegan L, McGurk L, Palavicini J, Brindle J, Paro S, Li X, et al. Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects. Nucleic Acids Res. 2011;39:7249-62 pubmed publisher
    ..The ADAR1 gene has been lost several times, including during the evolution of insects and crustacea. These data complement our rescue results, supporting the idea that ADAR1 and ADAR2 have evolved highly conserved, distinct functions. ..
  5. Peixoto A, Smith L, Hall J. Genomic organization and evolution of alternative exons in a Drosophila calcium channel gene. Genetics. 1997;145:1003-13 pubmed
    ..It is suggested that this divergence, rather than reflecting evolutionary age, is the likely result of accelerated rates of evolution following duplication. ..
  6. Jepson J, Reenan R. Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila. J Biol Chem. 2009;284:31391-400 pubmed publisher
  7. Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
    ..These results point to a pivotal role for RNA editing in nervous system function. ..
  8. Praveen K, Wen Y, Matera A. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep. 2012;1:624-31 pubmed publisher
    ..These findings have major implications for SMA etiology because they show that SMN's role in snRNP biogenesis can be uncoupled from the organismal viability and locomotor defects. ..
  9. Gellon G, Harding K, McGinnis N, Martin M, McGinnis W. A genetic screen for modifiers of Deformed homeotic function identifies novel genes required for head development. Development. 1997;124:3321-31 pubmed
    ..We propose that apt acts in parallel to, or as a cofactor with, HOX proteins to regulate homeotic targets in the ventral gnathal region. ..

More Information


  1. Frolov R, Singh S. Evidence of more ion channels inhibited by celecoxib: KV1.3 and L-type Ca(2+) channels. BMC Res Notes. 2015;8:62 pubmed publisher
    ..On the other hand, the Ca(2+) channel results are consistent with previous observations indicating that, in contrast to K(+) channels, strength of celecoxib effects on LTCCs strongly varies from species to species. ..
  2. MacPherson M, Pollock V, Broderick K, Kean L, O Connell F, Dow J, et al. Model organisms: new insights into ion channel and transporter function. L-type calcium channels regulate epithelial fluid transport in Drosophila melanogaster. Am J Physiol Cell Physiol. 2001;280:C394-407 pubmed
    ..We have shown by RT-PCR that the Drosophila L-type calcium channel alpha1-subunit genes Dmca1D and Dmca1A (nbA) are both expressed in tubules...
  3. Dickman D, Kurshan P, Schwarz T. Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function. J Neurosci. 2008;28:31-8 pubmed publisher
    ..In addition to their alpha1 subunit, which encodes the essential voltage gate and selective pore, calcium channels also contain auxiliary ..
  4. Ren D, Xu H, Eberl D, Chopra M, Hall L. A mutation affecting dihydropyridine-sensitive current levels and activation kinetics in Drosophila muscle and mammalian heart calcium channels. J Neurosci. 1998;18:2335-41 pubmed
    The Dmca1D gene encodes a Drosophila calcium channel alpha1 subunit. We describe the first functional characterization of a mutation in this gene...
  5. Kanamori T, Kanai M, Dairyo Y, Yasunaga K, Morikawa R, Emoto K. Compartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons. Science. 2013;340:1475-8 pubmed publisher
    ..Our findings reveal the importance of the compartmentalized subdendritic calcium signaling in spatiotemporally selective elimination of dendritic branches. ..
  6. Pervouchine D. IRBIS: a systematic search for conserved complementarity. RNA. 2014;20:1519-31 pubmed publisher
    ..g., transcription factor binding sites) contribute strongly to the false-discovery rate and, therefore, would confound every such analysis. IRBIS is an open-source software that is available at ..
  7. Rieder L, Savva Y, Reyna M, Chang Y, Dorsky J, Rezaei A, et al. Dynamic response of RNA editing to temperature in Drosophila. BMC Biol. 2015;13:1 pubmed publisher
    ..Environmental cues, in this case temperature, rapidly reprogram the Drosophila transcriptome through RNA editing, presumably resulting in altered proteomic ratios of edited and unedited proteins. ..
  8. Terada S, Matsubara D, Onodera K, Matsuzaki M, Uemura T, Usui T. Neuronal processing of noxious thermal stimuli mediated by dendritic Ca(2+) influx in Drosophila somatosensory neurons. elife. 2016;5: pubmed publisher
    ..The precipitous fluctuation of firing rate in Class IV neurons enhanced the robust heat avoidance. We hypothesize that the Ca(2+) influx can be a key signal encoding a specific modality. ..
  9. Rieckhof G, Yoshihara M, Guan Z, Littleton J. Presynaptic N-type calcium channels regulate synaptic growth. J Biol Chem. 2003;278:41099-108 pubmed
    ..Linking presynaptic voltage-gated calcium entry to downstream calcium-sensitive synaptic growth regulators provides an efficient activity-dependent mechanism for modifying synaptic strength. ..
  10. Romero E, Cha G, Verstreken P, Ly C, Hughes R, Bellen H, et al. Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm. Neuron. 2008;57:27-40 pubmed publisher
    ..Thus, our data indicate that increased neurotransmission is at the root of neuronal degeneration caused by expanded full-length htt during early stages of pathogenesis. ..
  11. Sénatore S, Rami Reddy V, Semeriva M, Perrin L, Lalevee N. Response to mechanical stress is mediated by the TRPA channel painless in the Drosophila heart. PLoS Genet. 2010;6:e1001088 pubmed publisher
  12. Hara Y, Koganezawa M, Yamamoto D. The Dmca1D channel mediates Ca(2+) inward currents in Drosophila embryonic muscles. J Neurogenet. 2015;29:117-23 pubmed publisher
    ..The Ca(2+) current in the embryonic muscle was completely eliminated in Dmca1D mutants, indicating that the Dmca1D-encoded Ca(2+) channel is the major mediator of inward currents in the body ..
  13. Bhogal B, Jepson J, Savva Y, Pepper A, Reenan R, Jongens T. Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein. Nat Neurosci. 2011;14:1517-24 pubmed publisher
    ..These results link dFMR1 with the RNA-editing pathway and suggest that proper NMJ synaptic architecture requires modulation of dADAR activity by dFMR1. ..
  14. Worrell J, Levine R. Characterization of voltage-dependent Ca2+ currents in identified Drosophila motoneurons in situ. J Neurophysiol. 2008;100:868-78 pubmed publisher
    ..The Drosophila genome contains three genes with homology to vertebrate voltage-dependent Ca2+ channels: Dmca1A, Dmca1D, and Dmalpha1G...
  15. Lee J, Wu C. Orchestration of stepwise synaptic growth by K+ and Ca2+ channels in Drosophila. J Neurosci. 2010;30:15821-33 pubmed publisher
    ..Post-synaptic L-type Ca(2+) channels, Dmca1D, and PSD-95-like scaffold protein, Discs large, are required for satellite budding induced by slowpoke and seizure ..
  16. Mahone M, Saffman E, Lasko P. Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1. EMBO J. 1995;14:2043-55 pubmed
    ..Alteration of a highly conserved KH domain codon by mutation abrogates in vivo Bic-C function. These results suggest roles for the Bic-C protein in localizing RNAs and in intercellular signaling. ..
  17. Kadas D, Klein A, Krick N, Worrell J, Ryglewski S, Duch C. Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. J Neurosci. 2017;37:10971-10982 pubmed publisher
    ..We demonstrate that Dmca1D (Cav1 homolog) L-type like calcium channels localize to both the somatodendritic and the axonal ..
  18. Hu W, Wang T, Wang X, Han J. Ih channels control feedback regulation from amacrine cells to photoreceptors. PLoS Biol. 2015;13:e1002115 pubmed publisher
    ..These results provide new mechanistic insight into how synaptic feedback regulation can participate in network processing by modulating neural information transfer and circuit excitability. ..
  19. Zheng W, Feng G, Ren D, Eberl D, Hannan F, Dubald M, et al. Cloning and characterization of a calcium channel alpha 1 subunit from Drosophila melanogaster with similarity to the rat brain type D isoform. J Neurosci. 1995;15:1132-43 pubmed
    We report the complete sequence of a calcium channel alpha 1 subunit cDNA cloned from a Drosophila head cDNA library. This cDNA encodes a deduced protein containing 2516 amino acids with a predicted molecular weight of 276,493...
  20. Küppers B, Sanchez Soriano N, Letzkus J, Technau G, Prokop A. In developing Drosophila neurones the production of gamma-amino butyric acid is tightly regulated downstream of glutamate decarboxylase translation and can be influenced by calcium. J Neurochem. 2003;84:939-51 pubmed
  21. Gaasterland T, Sczyrba A, Thomas E, Aytekin Kurban G, Gordon P, Sensen C. MAGPIE/EGRET annotation of the 2.9-Mb Drosophila melanogaster Adh region. Genome Res. 2000;10:502-10 pubmed
    ..The software modules that add eukaryotic genome annotation capability to MAGPIE are available as EGRET (Eukaryotic Genome Rapid Evaluation Tool). ..
  22. Eberl D, Ren D, Feng G, Lorenz L, Van Vactor D, Hall L. Genetic and developmental characterization of Dmca1D, a calcium channel alpha1 subunit gene in Drosophila melanogaster. Genetics. 1998;148:1159-69 pubmed
    ..significance of calcium channel diversity, we identified mutations in Dmca1D, a Drosophila calcium channel alpha1 subunit cDNA that we recently cloned. These mutations constitute the l(2)35Fa lethal locus, which we rename Dmca1D...
  23. Ryglewski S, Lance K, Levine R, Duch C. Ca(v)2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons. J Physiol. 2012;590:809-25 pubmed publisher
    ..vertebrate gene family for voltage-gated calcium channels is represented by a single gene in Drosophila, namely Dmca1D (Ca(v)1), Dmca1A (Ca(v)2) and Dm?G (Ca(v)3), but the commonly held view that LVA calcium currents are usually ..
  24. Li X, Overton I, Baines R, Keegan L, O Connell M. The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster. Nucleic Acids Res. 2014;42:1139-51 pubmed publisher
    ..GABA inhibitory signalling is impaired in human epileptic and autistic conditions, and vertebrate ADARs may have a relevant evolutionarily conserved control over neuronal excitability. ..
  25. Lin C, Mount S, Jarmołowski A, Makałowski W. Evolutionary dynamics of U12-type spliceosomal introns. BMC Evol Biol. 2010;10:47 pubmed publisher
    ..Loss of U12 introns or the genes containing them is more common than conversion to the U2-type. The degeneracy of U12-type terminal dinucleotides among natural U12-type introns is higher than previously thought. ..
  26. Reese M, Hartzell G, Harris N, Ohler U, Abril J, Lewis S. Genome annotation assessment in Drosophila melanogaster. Genome Res. 2000;10:483-501 pubmed
  27. Stocker J, Huang H, Wang H, Chang H, Chiu C, Cho C, et al. Reduction of RNA A-to-I editing in Drosophila acclimated to heat shock. Kaohsiung J Med Sci. 2013;29:478-83 pubmed publisher
    ..However, how RNA editing confers heat resistance is more complicated and requires further investigation. ..
  28. Kurshan P, Oztan A, Schwarz T. Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions. Nat Neurosci. 2009;12:1415-23 pubmed publisher
    ..Our results indicate that alpha(2)delta proteins have functions that are independent of their roles in the biophysics and localization of Ca(2+) channels and that synaptic architecture depends on these functions. ..
  29. Krüger J, Bohrmann J. Bioelectric patterning during oogenesis: stage-specific distribution of membrane potentials, intracellular pH and ion-transport mechanisms in Drosophila ovarian follicles. BMC Dev Biol. 2015;15:1 pubmed publisher
    ..Characteristic stage-specific changes of bioelectric activity in specialized cell types are correlated with various developmental processes. ..
  30. Lee J, Ueda A, Wu C. Distinct roles of Drosophila cacophony and Dmca1D Ca(2+) channels in synaptic homeostasis: genetic interactions with slowpoke Ca(2+) -activated BK channels in presynaptic excitability and postsynaptic response. Dev Neurobiol. 2014;74:1-15 pubmed publisher
    ..Here we report differential roles of cacophony (CaV 2) and Dmca1D (CaV 1) Ca(2+) channels in synaptic transmission and in synaptic homeostatic regulations induced by slowpoke (slo) ..
  31. Wang B, Sullivan K, Beckingham K. Drosophila calmodulin mutants with specific defects in the musculature or in the nervous system. Genetics. 2003;165:1255-68 pubmed
    ..Genetic interaction studies suggest that failed regulation of the muscle calcium release channel, the ryanodine receptor, is the major defect underlying the Cam7 phenotype. ..