Gene Symbol: by
Description: blistery
Alias: 3R-B, BcDNA:RE65113, CG9379, CT26639, Dmel\CG9379, blistery, 3R-B, CG9379-PA, CG9379-PC, CG9379-PD, by-PA, by-PC, by-PD, tensin
Species: fruit fly

Top Publications

  1. Lee S, Cho K, Kim E, Chung J. blistery encodes Drosophila tensin protein and interacts with integrin and the JNK signaling pathway during wing development. Development. 2003;130:4001-10 pubmed
    ..Interestingly, by(1)-the mutant allele of the gene blistery (by)-also showed a blistered wing phenotype, but failed to complement the wing blister phenotype of the ..
  2. Yuan L, Fairchild M, Perkins A, Tanentzapf G. Analysis of integrin turnover in fly myotendinous junctions. J Cell Sci. 2010;123:939-46 pubmed publisher
    ..We found that the IAC undergoes turnover in MTJs and that this process is mediated by clathrin-dependent endocytosis...
  3. Vakaloglou K, Chountala M, Zervas C. Functional analysis of parvin and different modes of IPP-complex assembly at integrin sites during Drosophila development. J Cell Sci. 2012;125:3221-32 pubmed publisher
    ..Parvin contains tandem unconventional calponin-homology (CH) domains separated by a linker sequence, and a less-well conserved N-terminal region...
  4. Torgler C, Narasimha M, Knox A, Zervas C, Vernon M, Brown N. Tensin stabilizes integrin adhesive contacts in Drosophila. Dev Cell. 2004;6:357-69 pubmed
    We report the functional characterization of the Drosophila ortholog of tensin, a protein implicated in linking integrins to the cytoskeleton and signaling pathways...
  5. Prout M, Damania Z, Soong J, Fristrom D, Fristrom J. Autosomal mutations affecting adhesion between wing surfaces in Drosophila melanogaster. Genetics. 1997;146:275-85 pubmed
    ..Chromosomal sites were determined by deficiency mapping, and genetic interactions with mutations in the beta PS integrin gene myospheroid were ..
  6. Walsh E, Brown N. A screen to identify Drosophila genes required for integrin-mediated adhesion. Genetics. 1998;150:791-805 pubmed
    ..Thus several of these loci are good candidates for genes encoding cytoplasmic proteins required for integrin function. ..
  7. Kemphues K, Raff E, Raff R, Kaufman T. Mutation in a testis-specific beta-tubulin in Drosophila: analysis of its effects on meiosis and map location of the gene. Cell. 1980;21:445-51 pubmed
    ..for a testis-specific beta--tubulin subunit in Drosophila melanogaster was mapped genetically and cytogenetically by means of a dominant male sterile mutation, B2tD, in which a variant form of the testis beta--tubulin is expressed...
  8. Löer B, Bauer R, Bornheim R, Grell J, Kremmer E, Kolanus W, et al. The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link. Nat Cell Biol. 2008;10:422-8 pubmed publisher
    ..The single murine Wech orthologue is also colocalized with Talin and ILK in muscle tissue. We propose that Wech proteins are crucial and evolutionarily conserved regulators of the integrin-cytoskeleton link. ..
  9. Bilousov O, Koval A, Keshelava A, Katanaev V. Identification of novel elements of the Drosophila blisterome sheds light on potential pathological mechanisms of several human diseases. PLoS ONE. 2014;9:e101133 pubmed publisher of the steps of which--apposition of the dorsal and ventral wing sheets during metamorphosis--is mediated by integrins...

More Information


  1. Zimmerman E, Palsson A, Gibson G. Quantitative trait loci affecting components of wing shape in Drosophila melanogaster. Genetics. 2000;155:671-83 pubmed
    ..candidate quantitative trait loci (QTL) affecting components of wing shape in Drosophila melanogaster defined by eight relative warp-based measures...
  2. Kemphues K, Raff E, Kaufman T. Genetic analysis of B2t, the structural gene for a testis-specific beta-tubulin subunit in Drosophila melanogaster. Genetics. 1983;105:345-56 pubmed
    ..All four mutant genes encode beta 2-tubulin subunits that are synthesized at normal rates but do not accumulate. All mutants are completely male sterile as homozygotes. ..
  3. Lo S. Focal adhesions: what's new inside. Dev Biol. 2006;294:280-91 pubmed
    ..Recent studies using genetic approaches in invertebrate and vertebrate systems have begun to reveal the structure and function of these complexes in vivo. ..
  4. Fuller M, Caulton J, Hutchens J, Kaufman T, Raff E. Mutations that encode partially functional beta 2 tubulin subunits have different effects on structurally different microtubule arrays. J Cell Biol. 1988;107:141-52 pubmed
  5. Wheeler G, Hynes R. The cloning, genomic organization and expression of the focal contact protein paxillin in Drosophila. Gene. 2001;262:291-9 pubmed
    ..The data support a role for paxillin as an adapter and/or signaling protein during developmental processes involving integrin-mediated adhesion. ..
  6. Wilczynski B, Liu Y, Yeo Z, Furlong E. Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. PLoS Comput Biol. 2012;8:e1002798 pubmed publisher
    ..Model predictions were validated using the expression patterns of more than 600 genes recently made available by the BDGP consortium, demonstrating an average 15-fold enrichment of genes expressed in the predicted tissue over a ..
  7. Bharadwaj R, Roy M, Ohyama T, Sivan Loukianova E, Delannoy M, Lloyd T, et al. Cbl-associated protein regulates assembly and function of two tension-sensing structures in Drosophila. Development. 2013;140:627-38 pubmed publisher
  8. Tanentzapf G, Martin Bermudo M, Hicks M, Brown N. Multiple factors contribute to integrin-talin interactions in vivo. J Cell Sci. 2006;119:1632-44 pubmed
    ..for recruitment, but the C-terminal domain also required endogenous talin, showing it was not recruited directly by integrins...
  9. Turner T, Stewart A, Fields A, Rice W, Tarone A. Population-based resequencing of experimentally evolved populations reveals the genetic basis of body size variation in Drosophila melanogaster. PLoS Genet. 2011;7:e1001336 pubmed publisher
    ..b>By using significantly associated polymorphisms as a priori candidates in follow-up studies, these data are expected to ..
  10. Pines M, Das R, Ellis S, Morin A, Czerniecki S, Yuan L, et al. Mechanical force regulates integrin turnover in Drosophila in vivo. Nat Cell Biol. 2012;14:935-43 pubmed publisher
    ..This effect was disrupted by point mutations in ?-integrin that interfere with ECM-induced conformational changes and activation of ?-integrin or ..
  11. Levi B, Ghabrial A, Krasnow M. Drosophila talin and integrin genes are required for maintenance of tracheal terminal branches and luminal organization. Development. 2006;133:2383-93 pubmed
    ..Drosophila tendrils mutations that compromise maintenance of tracheal terminal branches, fine gauge tubes formed by tracheal terminal cells that ramify on and adhere tightly to tissues in order to supply them with oxygen...
  12. Carmon A, Topbas F, Baron M, MacIntyre R. dumpy interacts with a large number of genes in the developing wing of Drosophila melanogaster. Fly (Austin). 2010;4:117-27 pubmed
    ..genes previously recovered in a screen for recessive lethals that generate blisters when somatic clones are produced by mitotic crossing over during wing development...
  13. Zervas C, Psarra E, Williams V, Solomon E, Vakaloglou K, Brown N. A central multifunctional role of integrin-linked kinase at muscle attachment sites. J Cell Sci. 2011;124:1316-27 pubmed publisher
    ..of ILK at MASs appears to follow an amplification mechanism, suggesting that numerous binding sites are generated by minimal levels of the upstream integrin and talin effectors...
  14. Delon I, Brown N. The integrin adhesion complex changes its composition and function during morphogenesis of an epithelium. J Cell Sci. 2009;122:4363-74 pubmed publisher
    ..reorientation requires new expression of alphaPS2betaPS, which also permits recruitment of the adaptor protein tensin. Unexpectedly, it is the extracellular portion of the alphaPS2 subunit that provides the specificity for ..
  15. Pronovost S, Beckerle M, Kadrmas J. Elevated expression of the integrin-associated protein PINCH suppresses the defects of Drosophila melanogaster muscle hypercontraction mutants. PLoS Genet. 2013;9:e1003406 pubmed publisher
    ..b>By testing a panel of IAC proteins, we show specificity for PINCH expression in the rescue of hypercontraction mutants...