bw

Summary

Gene Symbol: bw
Description: brown
Alias: CG17632, Dmel\CG17632, Su(w[co2]), Su(w[coJ]), ptm, CG17632-PA, brow, bw-PA, plum, pteridine-modifier, suppressor of white-coral J, suppressor of white-coral-2
Species: fruit fly

Top Publications

  1. pmc Transgene repeat arrays interact with distant heterochromatin and cause silencing in cis and trans
    D R Dorer
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Genetics 147:1181-90. 1997
  2. ncbi Heterochromatin protein 1 binds transgene arrays
    L Fanti
    Istituto di Genetica, Universita di Bari, I 70126 Bari, Italy
    Chromosoma 107:286-92. 1998
  3. pmc Heterochromatic self-association, a determinant of nuclear organization, does not require sequence homology in Drosophila
    Brian T Sage
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Genetics 165:1183-93. 2003
  4. pmc Large-scale chromosomal movements during interphase progression in Drosophila
    A K Csink
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Cell Biol 143:13-22. 1998
  5. pmc Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster
    Surendra S Ambegaokar
    Neuroscience Interdepartmental Ph D Program, Brain Research Institute, Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, and Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Genetics 186:435-42. 2010
  6. pmc A quantitative measure of the mitotic pairing of alleles in Drosophila melanogaster and the influence of structural heterozygosity
    M M Golic
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Genetics 143:385-400. 1996
  7. pmc The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes
    T D Dreesen
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Mol Cell Biol 8:5206-15. 1988
  8. ncbi Mutations in the white gene of Drosophila melanogaster affecting ABC transporters that determine eye colouration
    S M MacKenzie
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, The Australian National University, P O Box 4, Canberra City 0200, Australia
    Biochim Biophys Acta 1419:173-85. 1999
  9. ncbi Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery
    V Lloyd
    Dept of Biology and Biochemistry, Mt Allison University, Sackville, NB, Canada
    Trends Cell Biol 8:257-9. 1998
  10. ncbi Nuclear organization and gene expression: homologous pairing and long-range interactions
    S Henikoff
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Curr Opin Cell Biol 9:388-95. 1997

Research Grants

  1. MECHANISM OF MEIOTIC PAIRING IN DROSOPHILA MALES
    BRUCE MCKEE; Fiscal Year: 2002
  2. Mechanism of Meiotic Pairing in Drosophila
    BRUCE MCKEE; Fiscal Year: 2005
  3. Mechanism of Meiotic Pairing in Drosophila
    BRUCE MCKEE; Fiscal Year: 2007
  4. Mechanism of Meiotic Pairing in Drosophila
    BRUCE MCKEE; Fiscal Year: 2009
  5. MECHANISM OF MEIOTIC PAIRING IN DROSOPHILA MALES
    BRUCE MCKEE; Fiscal Year: 1993
  6. STIMULATION OF CHROMOSOME PAIRING AND EXCHANGE BY RDNA
    BRUCE MCKEE; Fiscal Year: 1992
  7. Mechanism of Meiotic Pairing in Drosophila
    Bruce D McKee; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications92

  1. pmc Transgene repeat arrays interact with distant heterochromatin and cause silencing in cis and trans
    D R Dorer
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Genetics 147:1181-90. 1997
    ..Such spreading of heterochromatic silencing correlates with array size. Finally, white transgene arrays cause pairing-dependent silencing of a non-variegating white insertion at the homologous position...
  2. ncbi Heterochromatin protein 1 binds transgene arrays
    L Fanti
    Istituto di Genetica, Universita di Bari, I 70126 Bari, Italy
    Chromosoma 107:286-92. 1998
    ..The results indicate that HP1 targets the chromatin of transposon insertions and binds more densely at a site with repeated sequences susceptible to heterochromatin formation...
  3. pmc Heterochromatic self-association, a determinant of nuclear organization, does not require sequence homology in Drosophila
    Brian T Sage
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Genetics 165:1183-93. 2003
    ..Our results show that intranuclear association of separate heterochromatic blocks does not require that they contain the same sequence...
  4. pmc Large-scale chromosomal movements during interphase progression in Drosophila
    A K Csink
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Cell Biol 143:13-22. 1998
    ....
  5. pmc Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogaster
    Surendra S Ambegaokar
    Neuroscience Interdepartmental Ph D Program, Brain Research Institute, Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, and Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Genetics 186:435-42. 2010
    ..Interaction with nucleotide-derived pigments or increased lysosomal dysregulation are potential mechanisms. Finally, tau toxicity correlates with increased GSK-3β activity, but not with tau phosphorylation at Ser202/Thr205...
  6. pmc A quantitative measure of the mitotic pairing of alleles in Drosophila melanogaster and the influence of structural heterozygosity
    M M Golic
    Department of Biology, University of Utah, Salt Lake City 84112, USA
    Genetics 143:385-400. 1996
    ..In support, we show that Minute mutations, which slow the rate of cell division, partially restore a transvection effect that is disrupted by inversion heterozygosity...
  7. pmc The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes
    T D Dreesen
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Mol Cell Biol 8:5206-15. 1988
    ..by hybridization to the cosmids, one class hybridized to a genomic region that is interrupted in two brown mutants, bw and In(2LR)CK, and to 2.8- and 3.0-kilobase poly(A)+ RNAs which are altered in the mutants...
  8. ncbi Mutations in the white gene of Drosophila melanogaster affecting ABC transporters that determine eye colouration
    S M MacKenzie
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, The Australian National University, P O Box 4, Canberra City 0200, Australia
    Biochim Biophys Acta 1419:173-85. 1999
    ..Red and brown pigments are reduced to very low levels by this mutation indicating this loop region is important for the function of both guanine and tryptophan transporters...
  9. ncbi Not just pretty eyes: Drosophila eye-colour mutations and lysosomal delivery
    V Lloyd
    Dept of Biology and Biochemistry, Mt Allison University, Sackville, NB, Canada
    Trends Cell Biol 8:257-9. 1998
    ..Thus, classical work describing more than 85 eye-colour mutations and their genetic interactions offers a remarkable, untapped resource for the genetic analysis of protein delivery to lysosomes...
  10. ncbi Nuclear organization and gene expression: homologous pairing and long-range interactions
    S Henikoff
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA
    Curr Opin Cell Biol 9:388-95. 1997
    ..Recent work has revealed that such influences are widespread in eukaryotes and that chromosome architecture is likely to be of fundamental importance for nuclear structure and function...
  11. pmc Modification of the Drosophila heterochromatic mutation brownDominant by linkage alterations
    P B Talbert
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Genetics 136:559-71. 1994
    ..melanogaster is associated with an insertion of heterochromatin into chromosome arm 2R at 59E, the site of the bw gene. Mutagenesis produced 150 dominant suppressors of bwD variegation...
  12. ncbi Genetic modification of heterochromatic association and nuclear organization in Drosophila
    A K Csink
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Nature 381:529-31. 1996
    ..This suggests that heterochromatin and proteins involved in its formation provide a structural framework for the interphase nucleus...
  13. pmc Comparative analysis of position-effect variegation mutations in Drosophila melanogaster delineates the targets of modifiers
    G L Sass
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Genetics 148:733-41. 1998
    ..These mutations include the inversions In(1)w(m4) and In(2R)bw(VDe2), which are classical chromosomal rearrangements that typify PEV mutations...
  14. pmc Differential gene silencing by trans-heterochromatin in Drosophila melanogaster
    Amy K Csink
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Genetics 160:257-69. 2002
    The brown(Dominant) (bw(D)) allele contains a large insertion of heterochromatin leading to the trans-inactivation of the wild-type allele in bw(D)/bw(+) heterozygous flies...
  15. ncbi Perturbation of nuclear architecture by long-distance chromosome interactions
    A F Dernburg
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 0554, USA
    Cell 85:745-59. 1996
    ..Moreover, they provide direct evidence for long-range chromosome interactions and their impact on three-dimensional nuclear architecture, while providing a cohesive explanation for the phenomenon of PEV...
  16. pmc A reexamination of spreading of position-effect variegation in the white-roughest region of Drosophila melanogaster
    P B Talbert
    Fred Hutchinson Cancer Research Center and Howard Hughes Medical Institute, Seattle, Washington 98109 1024, USA
    Genetics 154:259-72. 2000
    ..We frequently observed rough eye tissue that is pigmented, as though an active white gene is skipped...
  17. pmc Changes in chromosomal localization of heterochromatin-binding proteins during the cell cycle in Drosophila
    J S Platero
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    J Cell Biol 140:1297-306. 1998
    ..Upon decondensation, GAGA factor and Prod shift from low affinity sites within satellite DNA back to euchromatic sites as a self-assembly process...
  18. ncbi Chromatin: a sticky silence
    S Marcand
    Laboratoire de Biologie Moleculaire et Cellulaire, l Ecole Normale Supérieure de Lyon, UMR49 CNRS ENS, France
    Curr Biol 6:1222-5. 1996
    ....
  19. pmc Distance and pairing effects on the brownDominant heterochromatic element in Drosophila
    S Henikoff
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Genetics 140:1007-17. 1995
    ....
  20. ncbi Cytological study of the brown dominant position effect
    E S Belyaeva
    Institute of Cytology and Genetics of Russian Academy of Sciences, Novosibirsk 630090, Russia
    Chromosoma 106:124-32. 1997
    ..In contrast to this, dominant variegation of the bw gene is known to involve transcriptional silencing in both the cis and trans copy, if they are paired...
  21. pmc Pairing-dependent mislocalization of a Drosophila brown gene reporter to a heterochromatic environment
    G L Sass
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Genetics 152:595-604. 1999
    ..The frequency with which a brown (bw) reporter gene in 59E is silenced is influenced by chromosomal configurations...
  22. pmc Trans-inactivation of the Drosophila brown gene: evidence for transcriptional repression and somatic pairing dependence
    S Henikoff
    Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Proc Natl Acad Sci U S A 86:6704-8. 1989
    ..We propose that direct transmission of the altered chromatin structure characteristic of position-effect variegation (heterochromatinization) occurs between paired homologs in the region of the brown locus...
  23. pmc MicroRNA targets in Drosophila
    Anton J Enright
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Genome Biol 5:R1. 2003
    ..Application to the D. melanogaster, Drosophila pseudoobscura and Anopheles gambiae genomes identifies several hundred target genes potentially regulated by one or more known miRNAs...
  24. pmc Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes
    Patrick J Wightman
    Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e31779. 2012
    ....
  25. pmc Evidence of abundant stop codon readthrough in Drosophila and other metazoa
    Irwin Jungreis
    MIT Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Res 21:2096-113. 2011
    ....
  26. pmc Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing
    Dinari A Harris
    Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA
    J Cell Biol 194:77-87. 2011
    ..Negative regulation is also not linked to sorting into all LROs but only a specific class of pigment LRO. Thus, regulation of siRNA activity is tied to sorting of specific types of cargo to particular LROs...
  27. ncbi Eye color as an indicator of behavior: revisiting Worthy and Scott
    Vicky L Elias
    Department of Sociology, Oklahoma State University, USA
    Psychol Rep 102:759-78. 2008
    ..melanogaster pointed to significant behavioral differences among cell-defect groups, indicating that the cell defect which causes eye color, rather than eye color itself, may serve as a crude indicator of behavior...
  28. ncbi Transvection and chromosomal trans-interaction effects
    V Pirrotta
    Department of Zoology, University of Geneva, Switzerland
    Biochim Biophys Acta 1424:M1-8. 1999
  29. ncbi Structure and function of the nucleus: anatomy and physiology of chromatin
    M B Qumsiyeh
    Cytogenetics Laboratory, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell Mol Life Sci 55:1129-40. 1999
    ..5) Chromosomal autoconstruction and reconstruction into a functional nucleus are altered during cell cycle and during differentiation (much more work needed on this area)...
  30. ncbi The DPE, a conserved downstream core promoter element that is functionally analogous to the TATA box
    T W Burke
    Department of Biology, University of California, San Diego, La Jolla 92093 0347, USA
    Cold Spring Harb Symp Quant Biol 63:75-82. 1998
  31. pmc Cell-by-cell dissection of gene expression and chromosomal interactions reveals consequences of nuclear reorganization
    Brian Harmon
    University of California, San Francisco, California, USA
    PLoS Biol 3:e67. 2005
    ..Thus, long-range interactions between distal chromosome regions and their own heterochromatin have functional consequences for the organism...
  32. pmc The lawc gene is a new member of the trithorax-group that affects the function of the gypsy insulator of Drosophila
    I D Zorin
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 152:1045-55. 1999
    ..These results suggest that the lawc protein is involved in regulating the higher-order organization of chromatin...
  33. pmc Mutational analysis of a histone deacetylase in Drosophila melanogaster: missense mutations suppress gene silencing associated with position effect variegation
    R Mottus
    Department of Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Genetics 154:657-68. 2000
    ..We propose that the missense mutations reported here are acting as antimorphic mutations that "poison" the deacetylase complex and propose a model that accounts for the various phenotypes associated with lesions in the deacetylase locus...
  34. ncbi Changing chromatin dynamics and nuclear organization during differentiation in Drosophila larval tissue
    Rajika Thakar
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Cell Sci 118:951-60. 2005
    ..The brown(Dominant) (bw(D)) chromosome of Drosophila melanogaster contains a large block of heterochromatin near the end of 2R...
  35. pmc Sequence elements in cis influence heterochromatic silencing in trans
    Brian T Sage
    Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, PA 15213, USA
    Mol Cell Biol 25:377-88. 2005
    The brown(Dominant) (bw(D)) allele contains a large insertion of heterochromatin, which causes the locus to aberrantly associate with heterochromatin in interphase nuclei and silences the wild-type allele in heterozygotes...
  36. ncbi Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan
    Elena G Pasyukova
    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia
    Aging Cell 3:297-307. 2004
    ..Quantitative genetic analysis of naturally occurring variants with subtle effects on lifespan can identify novel candidate genes and pathways important in the regulation of longevity...
  37. ncbi The varieties of selectional experience in behavioral genetics
    Ralph J Greenspan
    The Neurosciences Institute, San Diego, CA 92121, USA
    J Neurogenet 17:241-70. 2003
  38. ncbi Homologous pairing and chromosome dynamics in meiosis and mitosis
    Bruce D McKee
    Department of Biochemistry and Cellular and Molecular Biology and Genome Sciences and Technology Program, University of Tennessee, Knoxville, M407 Walters Life Sciences Building, Knoxville, TN 37996 0840, USA
    Biochim Biophys Acta 1677:165-80. 2004
    ..I cite evidence that may point to a relationship between matrix attachment sites and homologous pairing sites...
  39. pmc Molecular nature of 11 spontaneous de novo mutations in Drosophila melanogaster
    H P Yang
    Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 157:1285-92. 2001
    ..melanogaster than in H. sapiens. If so, the per nucleotide mutation rate in D. melanogaster may be lower than in H. sapiens, even if their per locus mutation rates are similar...
  40. ncbi Closing the (Ran)GAP on segregation distortion in Drosophila
    Ayumi Kusano
    Laboratory of Genetics, University of Wisconsin, Madison 53706, USA
    Bioessays 25:108-15. 2003
    ..This previously mysterious genetic system may now offer unique insights into novel aspects of regulation by Ran...
  41. ncbi General transcription factors bind promoters repressed by Polycomb group proteins
    A Breiling
    DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Nature 412:651-5. 2001
    ..We further show that PcG proteins interact in vitro with GTFs. We suggest that PcG complexes maintain silencing by inhibiting GTF-mediated activation of transcription...
  42. ncbi Chromosomally-induced meiotic drive in Drosophila males: checkpoint or fallout?
    J E Tomkiel
    Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48202, USA
    Genetica 109:95-103. 2000
    ..We discuss how this hypothesis may account for previously described examples chromosomal causes of meiotic drive and sterility in Drosophila...
  43. ncbi Epigenetics. Satellite tools
    M Patterson
    Nat Rev Genet 2:4-5. 2001
  44. ncbi [Modeling dark puffs using P-transposons in Drosophila melanogaster polytene chromosomes]
    V F Semeshin
    Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia
    Genetika 37:29-35. 2001
    ..unusual "dark" puffs was conducted using Drosophila melanogaster strains transformed by construct P[ry; Prat:bw], in which gene brown is controlled by the promoter of the housekeeping gene Prat...
  45. ncbi Chromatin opening of DNA satellites by targeted sequence-specific drugs
    S Janssen
    Departments of Biochemistry and Molecular Biology University of Geneva 30, Quai Ernest Ansermet 1211 4, Geneva, Switzerland
    Mol Cell 6:999-1011. 2000
    ..These polyamides were shown to mediate satellite-specific chromatin opening of the chromatin fiber. Remarkably, certain polyamides induced defined gain or loss-of-function phenotypes when fed to Drosophila melanogaster...
  46. pmc The oxen gene of Drosophila encodes a homolog of subunit 9 of yeast ubiquinol-cytochrome c oxidoreductase complex: evidence for modulation of gene expression in response to mitochondrial activity
    M V Frolov
    University of Missouri, Columbia, Missouri 65211, USA
    Genetics 156:1727-36. 2000
    ..The oxen mutation provides a model for the genetic analysis in multicellular organisms of the effect of mitochondrial activity on nuclear gene expression...
  47. pmc Histone acetylation and gene expression analysis of sex lethal mutants in Drosophila
    U Bhadra
    Division of Biological Sciences, University of Missouri, Columbia 65211, USA
    Genetics 155:753-63. 2000
    ..In both cases we find relatively little effect upon X chromosomal gene expression...
  48. ncbi Krüppel homolog (Kr h) is a dosage-dependent modifier of gene expression in Drosophila
    E V Benevolenskaya
    Division of Biological Sciences, University of Missouri Columbia 65211, USA
    Genet Res 75:137-42. 2000
    ..Genetic analysis of different white alleles suggests that enhancer sequences are necessary for interaction with KR H. Thus, the Kr h gene is a member of the dosage-dependent hierarchy effective upon white...
  49. pmc rosy Function is required for juvenile hormone effects in Drosophila melanogaster
    Xiaofeng Zhou
    Department of Biology, University of Washington, Seattle, Washington 98195 1800, USA
    Genetics 178:273-81. 2008
    ....
  50. ncbi Characterization of a sex-influenced modifier of gene expression and suppressor of position-effect variegation in Drosophila
    U Bhadra
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Mol Gen Genet 250:601-13. 1996
    ..In addition, Mow acts as a weak suppressor of position effect variegation (PEV). These observations suggest a connection between dosage modulation of gene expression and suppression of position-effect variegation...
  51. ncbi Mutational analysis of the traffic ATPase (ABC) transporters involved in uptake of eye pigment precursors in Drosophila melanogaster. Implications for structure-function relationships
    G D Ewart
    Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Canberra City, Australia
    J Biol Chem 269:10370-7. 1994
    ..The implications of these mutations are discussed in terms of a model of the Drosophila pigment precursor transport system...
  52. pmc Evidence of a dual function in fl(2)d, a gene needed for Sex-lethal expression in Drosophila melanogaster
    B Granadino
    Centro de Investigaciones Biologicas, Madrid, Spain
    Genetics 130:597-612. 1992
    ..The fl(2)d mutations partially suppress the phenotype of the female germ cells homozygous for ovoDIrSI.(ABSTRACT TRUNCATED AT 400 WORDS)..
  53. pmc Weakener of white (Wow), a gene that modifies the expression of the white eye color locus and that suppresses position effect variegation in Drosophila melanogaster
    J A Birchler
    Division of Biological Sciences, University of Missouri, Columbia 65211
    Genetics 137:1057-70. 1994
    ..There are many dosage sensitive suppressors of position effect variegation and many dosage-sensitive modifiers of gene expression. The Wow mutations provide evidence for an overlap between the two types of modifiers...
  54. ncbi Characterization of sequences responsible for trans-inactivation of the Drosophila brown gene
    L E Martin-Morris
    Howard Hughes Medical Institute, Seattle, Washington
    Cold Spring Harb Symp Quant Biol 58:577-84. 1993
  55. ncbi The molecular analysis of brown eye color mutations isolated from geographically discrete populations of Drosophila melanogaster
    E Nitasaka
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Mol Gen Genet 247:164-8. 1995
    ..spontaneous laboratory mutations are predictive for mutational events occurring in the wild, recessive brown (bw) eye color mutants were isolated...
  56. ncbi Tissue specific effects of ommochrome pathway mutations in Drosophila melanogaster
    R Tearle
    Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia
    Genet Res 57:257-66. 1991
    ..Two mutations affecting the red eye pigments (drosopterins), bw and mal, do not substantially perturb brown pigment synthesis in any of the four organs.
  57. pmc Experimental population genetics of meiotic drive systems. III. Neutralization of sex-ratio distortion in Drosophila through sex-chromosome aneuploidy
    T W Lyttle
    Genetics 98:317-34. 1981
    ..Finally, these results suggest the possibility that genetic variants promoting sex-chromosome nondisjunction may have a selective advantage in natural populations faced with sex-ratio distortion...
  58. pmc The entire compound autosomes of Drosophila melanogaster
    E Novitski
    Genetics 98:257-73. 1981
    ..These large chromosomes are recovered in progeny with frequencies lower than expectation partly because of zygote mortality associated with these chromosomes, and partly because of a failure of spermiogenesis...
  59. pmc Identification of ORD, a Drosophila protein essential for sister chromatid cohesion
    S E Bickel
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, 02142, USA
    EMBO J 15:1451-9. 1996
    ..The position and nature of these unusual ord mutations demonstrate that the C-terminal half of ORD is essential for sister chromatid cohesion and suggest that it mediates protein binding...
  60. ncbi Functional assay of a putative Drosophila sodium channel gene in homozygous deficiency neurons
    S Germeraad
    Department of Biological Sciences, San Jose State University, CA 95192
    J Neurogenet 8:1-16. 1992
    ..The morphological development of both neurons and myotubes in these cultures was similar to wildtype, making it feasible to compare the properties of normal diploid cells and cells completely lacking a putative sodium channel gene...
  61. ncbi Boundary and insulator elements in chromosomes
    T I Gerasimova
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Curr Opin Genet Dev 6:185-92. 1996
    ..The latter seems to play a crucial role in conferring on the insulator its ability to unidirectionally affect enhancer function...
  62. pmc Female genotypes affect sperm displacement in Drosophila
    A G Clark
    Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 149:1487-93. 1998
    ..Genetic variation of this type is completely neutral in the absence of pleiotropy or interaction between variation in the two sexes...
  63. ncbi Heterochromatin and gene expression in Drosophila
    K S Weiler
    Department of Zoology, University of Washington, Seattle 98195 1800, USA
    Annu Rev Genet 29:577-605. 1995
    ....
  64. ncbi Chromatin complexes as aperiodic microcrystalline arrays that regulate genome organisation and expression
    P B Singh
    Department of Development and Genetics, Babraham Institute, Cambridge, England
    Dev Genet 22:85-99. 1998
    ..Aperiodicity is also a feature of the hypothesis that is directly testable...
  65. ncbi An allele-specific suppressor of white-coral in Drosophila melanogaster
    J L Farmer
    Heredity (Edinb) 39:297-303. 1977
    ..The degree of suppression is sensitive to the genetic background. There appears to be selection for Su(wco2) in a genotype where it does not affect eye pigmentation...
  66. ncbi Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression
    V Pirrotta
    Department of Zoology, University of Geneva, Switzerland
    Trends Genet 13:314-8. 1997
    ..In vivo, complexes formed at one genomic site can interact with those at other sites, suggesting that they, like heterochromatin complexes, affect the folding of chromatin and the organization of chromosomes in the nucleus...
  67. pmc Sixty years of mystery
    A C Spradling
    Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Genetics 126:779-84. 1990
  68. ncbi Transport defects as the physiological basis for eye color mutants of Drosophila melanogaster
    D T Sullivan
    Biochem Genet 13:603-13. 1975
    ..We have concluded that several of the eye color mutants in Drosophila are transport mutants...
  69. pmc Genetic analysis of the proximal region of chromosome 2 of Drosophila melanogaster. I. Detachment products of compound autosomes
    A J Hilliker
    Genetics 81:705-21. 1975
    ..The data further demonstrate that rolled, and probably light, are located within the proximal heterochromatin. Thus, functional genetic loci are found in heterochromatin, albeit at low density...
  70. ncbi Genetic location and biochemical characterization of eye-colour mutants from natural populations of Drosophila melanogaster
    M L Aparisi
    Departamento de Genetica, Facultad de Ciencias Biologicas, Universidad de Valencia, Burjassot, Spain
    Genome 33:203-8. 1990
    ..The eye-colour mutants show large effects on the red and brown pigments. The high variability of the eye-colour loci is discussed in relation to the mutation and selection hypotheses...
  71. ncbi Position-effect variegation after 60 years
    S Henikoff
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA
    Trends Genet 6:422-6. 1990
    ..However, new insights are being gained from recent studies of genetic modifiers, new model systems, and variegating genes showing exceptional behavior...
  72. pmc Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila
    Ana Bozas
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112 5650, USA
    Genetics 182:641-51. 2009
    ..They also demonstrate that the outcome can be biased toward gene replacement by disabling the major NHEJ pathway and toward simple mutagenesis by interfering with the major HR process...
  73. pmc A cytogenetic and genetic characterization of a group of closely linked second chromosome mutations that suppress position-effect variegation in Drosophila melanogaster
    D A Sinclair
    Department of Zoology, University of British Columbia, Canada
    Genetics 130:333-44. 1992
    ..We also report that two previously isolated mutants located in 31E and 31F-32A act as recessive suppressors of PEV...
  74. ncbi Trans-sensing effects from Drosophila to humans
    K D Tartof
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111
    Cell 65:201-3. 1991
  75. ncbi Remembrance of things past: maintaining gene expression patterns with altered chromatin
    K Hagstrom
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Curr Opin Genet Dev 7:814-21. 1997
    ..These studies suggest that, after gene activity states are selected during development, maintenance protein complexes provide a molecular memory of those states by altering a local domain of chromatin structure...
  76. pmc The rosy locus in Drosophila melanogaster: xanthine dehydrogenase and eye pigments
    A G Reaume
    Department of Molecular and Cell Biology, University of Connecticut, Storrs 06269 2131
    Genetics 129:1099-109. 1991
    ....
  77. ncbi GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7
    Jan A van der Knaap
    Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell 17:695-707. 2005
    ..Thus, GMPS can regulate the activity of a ubiquitin protease. Collectively, these results implicate a biosynthetic enzyme in chromatin control via ubiquitin regulation...
  78. pmc Efficient gene targeting in Drosophila with zinc-finger nucleases
    Kelly Beumer
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA
    Genetics 172:2391-403. 2006
    ..In the absence of a homologous donor DNA, ZFN cleavage led to the recovery of new mutants at three loci-y, ry and bw-through nonhomologous end joining (NHEJ) after cleavage...
  79. ncbi Trehalase polymorphism in Drosophila melanogaster
    R S Burton
    Biochem Genet 24:715-9. 1986
  80. pmc Competition between different variegating rearrangements for limited heterochromatic factors in Drosophila melanogaster
    V K Lloyd
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Genetics 145:945-59. 1997
    ..Consequently, even nonvariegation portions of the genome will be disrupted by re-allocation of heterochromatic proteins associated with PEV. These results have implications for models of PEV...
  81. pmc Selective loss of sperm bearing a compound chromosome in the Drosophila female
    A F Dernburg
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0554, USA
    Genetics 143:1629-42. 1996
    ..Our results are consistent with a model of meiotic drive in which aberrations occurring early in meiosis lead ultimately to sperm dysfunction...
  82. ncbi ABC transporters involved in transport of eye pigment precursors in Drosophila melanogaster
    G D Ewart
    John Curtin School of Medical Research, Australian National University, Canberra, Australia
    Methods Enzymol 292:213-24. 1998
  83. ncbi The HP1 protein family: getting a grip on chromatin
    J C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Curr Opin Genet Dev 10:204-10. 2000
    ..A number of intriguing interactions between HP1 and other proteins have been described, implicating HP1 in gene regulation, DNA replication, and nuclear architecture...
  84. ncbi Torso, a receptor tyrosine kinase required for embryonic pattern formation, shares substrates with the sevenless and EGF-R pathways in Drosophila
    H J Doyle
    G W Hooper Foundation, University of California, San Francisco 94143 0552
    Genes Dev 7:633-46. 1993
    ..The phenotypes of several other Su(tor) mutations suggest that they also function in other receptor tyrosine kinase-activated pathways at different times during Drosophila development...
  85. pmc The downstream promoter element DPE appears to be as widely used as the TATA box in Drosophila core promoters
    A K Kutach
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla 92093 0347, USA
    Mol Cell Biol 20:4754-64. 2000
    ..Thus, these data reveal that the DPE exhibits a strict spacing requirement yet some sequence flexibility and appears to be as widely used as the TATA box in Drosophila...
  86. ncbi Position-effect variegation and the new biology of heterochromatin
    G H Karpen
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099
    Curr Opin Genet Dev 4:281-91. 1994
    ..Investigations published within the past few years demonstrate that position-effect variegation is caused by multiple mechanisms, and that direct tests of hypotheses are possible with numerous model systems...
  87. ncbi Specific gain- and loss-of-function phenotypes induced by satellite-specific DNA-binding drugs fed to Drosophila melanogaster
    S Janssen
    Department of Biochemistry, University of Geneva 30, Quai Ernest Ansermet 1211 4, Geneva, Switzerland
    Mol Cell 6:1013-24. 2000
    ..Chromatin opening of satellite III by P9 is proposed to suppress PEV of white-mottled flies, whereas chromatin opening of satellite V by P31 is proposed to create an inopportune "sink" for the GAGA factor (GAF)...
  88. ncbi Harnessing the power of Drosophila genetics
    M F Wolfner
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853
    Methods Cell Biol 44:33-80. 1994
  89. ncbi Characterization of the genotoxic action of three structurally related 1,2-dihaloalkanes in Drosophila melanogaster
    L A Ballering
    Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratories, Leiden, Netherlands
    Mutat Res 285:209-17. 1993
    ..It is concluded that in accordance with other studies also in Drosophila the glutathione-mediated pathway is the major cause of genotoxicity caused by DBE, DCE and BCE...
  90. pmc Terminal synthesis of xanthommatin in Drosophila melanogaster. 3. Mutational pleiotropy and pigment granule association of phenoxazinone synthetase
    J P Phillips
    Genetics 73:45-56. 1973
    ..A model is proposed depicting several structural and enzymatic interrelationships involved in the developmental control of xanthommatin synthesis in Drosophila...
  91. ncbi Trans-sensing effects: the ups and downs of being together
    S Henikoff
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Cell 93:329-32. 1998
  92. ncbi Mutants affecting position-effect heterochromatinization in Drosophila melanogaster
    G Reuter
    Chromosoma 85:539-51. 1982
    ..It seems also reasonable to assume that in all the rearrangements tested identical heterochromatisation processes lead to inactivation of the genes whose phenotype is variegated...

Research Grants22

  1. MECHANISM OF MEIOTIC PAIRING IN DROSOPHILA MALES
    BRUCE MCKEE; Fiscal Year: 2002
    ..We will also search for sites outside the promoter region of the 240bp spacer repeats that are essential for pairing function of the repeats. ..
  2. Mechanism of Meiotic Pairing in Drosophila
    BRUCE MCKEE; Fiscal Year: 2005
    ..Taken together, these experiments are expected to advance our understanding of chromosome pairing in Drosophila and to provide models for pairing mechanisms that can be tested in mammals. ..
  3. Mechanism of Meiotic Pairing in Drosophila
    BRUCE MCKEE; Fiscal Year: 2007
    ..3) What is the molecular basis for homologous pairing in early prophase. 4) How are homologous pairing and conjunction related? We will use predominant genetic and cell biological methods to address these questions. ..
  4. Mechanism of Meiotic Pairing in Drosophila
    BRUCE MCKEE; Fiscal Year: 2009
    ..Better understanding of the mechanisms that underlie meiotic chromosome segregation could lead to improved treatments for infertility and chromosome segregation errors. ..
  5. MECHANISM OF MEIOTIC PAIRING IN DROSOPHILA MALES
    BRUCE MCKEE; Fiscal Year: 1993
    ....
  6. STIMULATION OF CHROMOSOME PAIRING AND EXCHANGE BY RDNA
    BRUCE MCKEE; Fiscal Year: 1992
    ..In addition, non-allelic homologous recombination between dispersed repeated genes is a likely cause of chromosome rearrangements responsible for birth defects and cancer...
  7. Mechanism of Meiotic Pairing in Drosophila
    Bruce D McKee; Fiscal Year: 2010
    ..mechanism by which SNM and MNM connect homologous chromatids? 4) What mechanisms are used by SUN and SOLO to connect sister chromatids? 5) How do SUN, SOLO, SNM and MNM interact to establish and maintain sister chromatid cohesion? ..