Bub1

Summary

Gene Symbol: Bub1
Description: Bub1 kinase
Alias: BUB1, BUB1-like, CG14030, CG14030/Bub1, Dmel\CG14030, bub1, Bub1 kinase, Bub1 homologue, Bub1-PA, Bub1-PB, Bub1-PC, CG14030-PA, CG14030-PB, CG14030-PC
Species: fruit fly

Top Publications

  1. Logarinho E, Bousbaa H, Dias J, Lopes C, Amorim I, Antunes Martins A, et al. Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells. J Cell Sci. 2004;117:1757-71 pubmed
    ..Here, we analyse how the kinetochore localization of the Drosophila spindle checkpoint proteins Bub1, Mad2, Bub3 and BubR1, behave in response to alterations in microtubule binding or tension...
  2. Schittenhelm R, Althoff F, Heidmann S, Lehner C. Detrimental incorporation of excess Cenp-A/Cid and Cenp-C into Drosophila centromeres is prevented by limiting amounts of the bridging factor Cal1. J Cell Sci. 2010;123:3768-79 pubmed publisher
    ..We demonstrate that the low amount of endogenous Cal1 prevents centromere expansion and mitotic kinetochore failure when Cenp-A/Cid and Cenp-C are present in excess. ..
  3. Szuplewski S, Kottler B, Terracol R. The Drosophila bZIP transcription factor Vrille is involved in hair and cell growth. Development. 2003;130:3651-62 pubmed
    ..The phenotypes observed are consistent with the hypothesis that vri is required for normal cell growth and proliferation via the regulation of the actin cytoskeleton. ..
  4. Cipressa F, Cenci G. DNA damage response, checkpoint activation and dysfunctional telomeres: face to face between mammalian cells and Drosophila. Tsitologiia. 2013;55:211-7 pubmed
    ..Here we review parallelisms and variations between mammalian and Drosophila cells in the crosstalks between telomeres and cell cycle regulation. ..
  5. Sopko R, Foos M, Vinayagam A, Zhai B, Binari R, Hu Y, et al. Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos. Dev Cell. 2014;31:114-27 pubmed publisher
    ..Further, we show how correlative phosphorylation at the site level can indicate function, as exemplified by Sterile20-like kinase-dependent regulation of Stat92E. ..
  6. Müller H, Fogeron M, Lehmann V, Lehrach H, Lange B. A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint. Science. 2006;314:654-7 pubmed
    ..However, their localization at the centrosome and centrosome integrity were not essential for this function. Thus, the spindle checkpoint can be activated at the level of microtubule nucleation. ..
  7. Graham A, Kiss D, Andrulis E. Core exosome-independent roles for Rrp6 in cell cycle progression. Mol Biol Cell. 2009;20:2242-53 pubmed publisher
    ..Collectively, these data support the idea that dRrp6 has a core exosome-independent role in cell cycle and mitotic progression. ..
  8. Schittenhelm R, Chaleckis R, Lehner C. Intrakinetochore localization and essential functional domains of Drosophila Spc105. EMBO J. 2009;28:2374-86 pubmed publisher
    ..protein, which can bind to the Mis12/MIND and Ndc80 complexes and to the spindle assembly checkpoint components Bub1 and BubR1...
  9. Oliveira R, Hamilton R, Pauli A, Davis I, Nasmyth K. Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. Nat Cell Biol. 2010;12:185-92 pubmed publisher
    ..We conclude that only two key events, opening of cohesin rings and downregulation of Cdk1, are sufficient to drive proper segregation of chromosomes in anaphase. ..

More Information

Publications15

  1. Podhraski V, Campo Fernandez B, Wörle H, Piatti P, Niederegger H, Böck G, et al. CenH3/CID incorporation is not dependent on the chromatin assembly factor CHD1 in Drosophila. PLoS ONE. 2010;5:e10120 pubmed publisher
    ..Therefore, centromeric chromatin assembly may involve different mechanisms in different organisms. ..
  2. Althoff F, Karess R, Lehner C. Spindle checkpoint-independent inhibition of mitotic chromosome segregation by Drosophila Mps1. Mol Biol Cell. 2012;23:2275-91 pubmed publisher
    ..These findings further expand Mps1's significance for faithful mitotic chromosome segregation and emphasize the importance of its careful regulation...
  3. Karess R. Rod-Zw10-Zwilch: a key player in the spindle checkpoint. Trends Cell Biol. 2005;15:386-92 pubmed
    ..This review (which is part of the Chromosome Segregation and Aneuploidy series) covers recent developments in our understanding of RZZ dynamics and its function in the checkpoint. ..
  4. Luo W, Peterson A, Garcia B, Coombs G, Kofahl B, Heinrich R, et al. Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J. 2007;26:1511-21 pubmed
    ..Specific inhibition of PP1 in this pathway may offer therapeutic approaches to disorders with increased beta-catenin signaling. ..
  5. Matos I, Pereira A, Lince Faria M, Cameron L, Salmon E, Maiato H. Synchronizing chromosome segregation by flux-dependent force equalization at kinetochores. J Cell Biol. 2009;186:11-26 pubmed publisher
    ..We propose that flux-dependent equalization of kinetochore tensions ensures a timely and uniform maturation of kinetochore-microtubule interfaces necessary for error-free and coordinated segregation of chromosomes in anaphase. ..
  6. Purdy A, Uyetake L, Cordeiro M, Su T. Regulation of mitosis in response to damaged or incompletely replicated DNA require different levels of Grapes (Drosophila Chk1). J Cell Sci. 2005;118:3305-15 pubmed
    ..Finally, our results demonstrate that Drosophila provides a unique opportunity to study the regulation of the entry into, and progress through, mitosis by DNA structure checkpoints in metazoa. ..