bs

Summary

Gene Symbol: bs
Description: blistered
Alias: CG3411, D-SRF, DSRF, DSrf, DSrf/bs, DmSRF, Dmel\CG3411, Group IIc, Mal, SRF, Serf, Srf, bs/DSRF, bs/Dsrf, dSRF, dsrf, l(2)03267, pruned/DSRF, CG3411-PA, CG3411-PB, SRF, balloon, blistered/DSRF, blistered/Drosophila serum response factor, bs-PA, bs-PB, drosophila serum response factor, pruned, serum response factor
Species: fruit fly

Top Publications

  1. ncbi Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system
    T Lee
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2185, USA
    Genes Dev 10:2912-21. 1996
  2. ncbi Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration
    Kalman Somogyi
    European Molecular Biology Laboratory, Developmental Biology Programme, Heidelberg 69117, Germany
    Dev Cell 7:85-93. 2004
  3. ncbi Polychaetoid/ZO-1 is required for cell specification and rearrangement during Drosophila tracheal morphogenesis
    Alain C Jung
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Curr Biol 16:1224-31. 2006
  4. ncbi Control of tracheal tubulogenesis by Wingless signaling
    T Chihara
    Genetic Strain Research Center and The Graduate University for Advanced Studies, National Institute of Genetics, Mishima 411 8540, Japan
    Development 127:4433-42. 2000
  5. pmc The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled
    Wangsun Choi
    Department of Biology, University of North Carolina at Chapel Hill, USA
    Mol Biol Cell 22:2010-30. 2011
  6. ncbi branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching
    D Sutherland
    Department of Biochemistry, Beckman Center, Stanford University School of Medicine, California 94305 5307, USA
    Cell 87:1091-101. 1996
  7. ncbi Genetic control of epithelial tube fusion during Drosophila tracheal development
    C Samakovlis
    Department of Biochemistry, Stanford University School of Medicine, CA 94305, USA
    Development 122:3531-6. 1996
  8. ncbi Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events
    C Samakovlis
    Department of Biochemistry, Stanford University, CA 94305, USA
    Development 122:1395-407. 1996
  9. ncbi Activation and repression activities of ash2 in Drosophila wing imaginal discs
    Mireia Angulo
    Departament de Genetica, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
    Development 131:4943-53. 2004
  10. pmc A myocardin-related transcription factor regulates activity of serum response factor in Drosophila
    Zhe Han
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:12567-72. 2004

Scientific Experts

  • Amin S Ghabrial
  • S J Bray
  • S S Blair
  • Florence Janody
  • Nicole Wagner
  • N Usha
  • Barry J Thompson
  • GEORG A HALDER
  • J D Schnorr
  • Esther M Verheyen
  • L Dubois
  • Arnar Palsson
  • Jose F de Celis
  • GREGORY C GIBSON
  • E Bier
  • S Carroll
  • Fernando Roch
  • Michel Vervoort
  • Louis Gervais
  • M A Krasnow
  • Markus Affolter
  • Amy Ralston
  • Jun Chen
  • Guang Chao Chen
  • C Samakovlis
  • Christian Bökel
  • M Affolter
  • Carolina Cela
  • Zhe Han
  • Sophie Layalle
  • Alexis Gambis
  • Ziguang Liu
  • Wangsun Choi
  • P Steneberg
  • Andrei Avanesov
  • Ana Terriente-Félix
  • Nicole C Grieder
  • David D O'Keefe
  • Mihaela Serpe
  • Ekaterina Lyulcheva
  • Lazaro Centanin
  • Rosa Barrio
  • N Hacohen
  • S D Weatherbee
  • Sofia J Araújo
  • Marta Llimargas
  • MICHAEL B O'CONNOR
  • Ana López-Varea
  • Lan Jiang
  • Alain C Jung
  • Daniel R Marenda
  • Hanh T Nguyen
  • Clemens Cabernard
  • Luis Alberto Baena-Lopez
  • Ana Ruiz Gómez
  • Sol Sotillos
  • Osamu Shimmi
  • Chulan Kwon
  • Eric N Olson
  • Jeffrey Settleman
  • Mireia Angulo
  • Kagayaki Kato
  • Kalman Somogyi
  • Valerie Petit
  • Kweon Yu
  • Nicholas H Brown
  • Johanna Hemphälä
  • J Groppe
  • David Tyler
  • C Englund
  • J Montagne
  • Christos Samakovlis
  • Michele Crozatier
  • Xavier Franch-Marro
  • Sonia Avila
  • K Guillemin
  • Camilla Englund
  • Marco Milan
  • B Biehs
  • Justin Schleede
  • Allen Laughon
  • K Shim
  • D R LaJeunesse
  • Shawn M Honeyager
  • Alain Joliot
  • Marie Laure Parmentier
  • Alan S Fanning
  • Mark Peifer
  • Ami Enoki
  • Bertrand Mollereau

Detail Information

Publications88

  1. ncbi Regulated Breathless receptor tyrosine kinase activity required to pattern cell migration and branching in the Drosophila tracheal system
    T Lee
    Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 2185, USA
    Genes Dev 10:2912-21. 1996
    ....
  2. ncbi Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration
    Kalman Somogyi
    European Molecular Biology Laboratory, Developmental Biology Programme, Heidelberg 69117, Germany
    Dev Cell 7:85-93. 2004
    ..We report that this migration requires the activity of the transcriptional factor serum response factor (SRF) and its cofactor MAL-D and present evidence that nuclear accumulation of MAL-D is induced by cell ..
  3. ncbi Polychaetoid/ZO-1 is required for cell specification and rearrangement during Drosophila tracheal morphogenesis
    Alain C Jung
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Curr Biol 16:1224-31. 2006
    ..Our study suggests that MAGUK proteins might play important roles during AJ remodeling in epithelial morphogenesis...
  4. ncbi Control of tracheal tubulogenesis by Wingless signaling
    T Chihara
    Genetic Strain Research Center and The Graduate University for Advanced Studies, National Institute of Genetics, Mishima 411 8540, Japan
    Development 127:4433-42. 2000
    ..These activities of Wingless signaling together specify the shape of the dorsal trunk and other fusion branches...
  5. pmc The single Drosophila ZO-1 protein Polychaetoid regulates embryonic morphogenesis in coordination with Canoe/afadin and Enabled
    Wangsun Choi
    Department of Biology, University of North Carolina at Chapel Hill, USA
    Mol Biol Cell 22:2010-30. 2011
    ..Canoe (Cno) and Pyd are required for proper Ena localization during dorsal closure, and strong genetic interactions suggest that Cno, Pyd, and Ena act together in regulating or anchoring the actin cytoskeleton during dorsal closure...
  6. ncbi branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching
    D Sutherland
    Department of Biochemistry, Beckman Center, Stanford University School of Medicine, California 94305 5307, USA
    Cell 87:1091-101. 1996
    ....
  7. ncbi Genetic control of epithelial tube fusion during Drosophila tracheal development
    C Samakovlis
    Department of Biochemistry, Stanford University School of Medicine, CA 94305, USA
    Development 122:3531-6. 1996
    ..This establishes a simple genetic system to study fusion of epithelial tubes...
  8. ncbi Development of the Drosophila tracheal system occurs by a series of morphologically distinct but genetically coupled branching events
    C Samakovlis
    Department of Biochemistry, Stanford University, CA 94305, USA
    Development 122:1395-407. 1996
    ..The combined morphological, marker expression and genetic data support a model in which successive branching events are mechanistically and genetically distinct but coupled through the action of a tracheal gene regulatory hierarchy...
  9. ncbi Activation and repression activities of ash2 in Drosophila wing imaginal discs
    Mireia Angulo
    Departament de Genetica, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
    Development 131:4943-53. 2004
    ..We show that ash2 is required to sustain the activation of the intervein-promoting genes net and blistered (bs) and to repress rhomboid (rho), a component of the EGF receptor (Egfr) pathway...
  10. pmc A myocardin-related transcription factor regulates activity of serum response factor in Drosophila
    Zhe Han
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:12567-72. 2004
    b>Serum response factor (SRF) regulates genes involved in cell proliferation, migration, cytoskeletal organization, and myogenesis...
  11. pmc Drosophila pico and its mammalian ortholog lamellipodin activate serum response factor and promote cell proliferation
    Ekaterina Lyulcheva
    Department of Zoology, Oxford University, South Parks Road, Oxford OX1 3PS, UK
    Dev Cell 15:680-90. 2008
    ..We show that pico and lamellipodin share the ability to activate serum response factor (SRF), a transcription factor that responds to reduced G:F-actin ratios via its co-factor Mal...
  12. ncbi The pruned gene encodes the Drosophila serum response factor and regulates cytoplasmic outgrowth during terminal branching of the tracheal system
    K Guillemin
    Department of Biochemistry, Stanford University School of Medicine, CA 94305, USA
    Development 122:1353-62. 1996
    ..pruned encodes the Drosophila homologue of serum response factor (SRF), which functions with an ETS domain ternary complex factor as a growth-factor-activated ..
  13. ncbi Grainy head controls apical membrane growth and tube elongation in response to Branchless/FGF signalling
    Johanna Hemphälä
    Department of Developmental Biology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
    Development 130:249-58. 2003
    ....
  14. ncbi The Drosophila Serum Response Factor gene is required for the formation of intervein tissue of the wing and is allelic to blistered
    J Montagne
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Development 122:2589-97. 1996
    ..Here we report that the Drosophila homolog of the mammalian Serum Response Factor gene (DSRF), which encodes a MADS-box containing transcriptional regulator, is expressed in the future ..
  15. pmc Crossveinless d is a vitellogenin-like lipoprotein that binds BMPs and HSPGs, and is required for normal BMP signaling in the Drosophila wing
    Jun Chen
    Department of Zoology, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 139:2170-6. 2012
    ....
  16. pmc Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila
    Alexis Gambis
    Howard Hughes Medical Institute, Laboratory of Apoptosis and Cancer, The Rockefeller University, New York, NY 10065, USA
    Dev Biol 351:128-34. 2011
    ..The "Tomato/GFP-FLP/FRT" method allows high-throughput, rapid and precise identification of survival and developmental pathways in living adult PRs at single-cell resolution...
  17. doi Engrailed homeoprotein acts as a signaling molecule in the developing fly
    Sophie Layalle
    Institut de Genetique Humaine, CNRS, UPR 1142, 141 rue de la Cardonille, 34396 Montpellier, France
    Development 138:2315-23. 2011
    ..This report thus suggests that direct signaling with homeoproteins is an evolutionarily conserved phenomenon that is not restricted to neural tissues and involves interactions with bona fide signal transduction pathways...
  18. doi Negative modulation of bone morphogenetic protein signaling by Dullard during wing vein formation in Drosophila
    Ziguang Liu
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Japan
    Dev Growth Differ 53:822-41. 2011
    ....
  19. ncbi The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing
    Osamu Shimmi
    Department of Genetics Cell Biology and Development, Howard Hughes Medical Institute, University of Minnesota, 6 160 Jackson Hall, Minneapolis, MN 55455, USA
    Dev Biol 282:70-83. 2005
    ..Taken together, these studies suggest that Sog and Cv promote BMP signaling by transporting a BMP heterodimer from the longitudinal veins into the crossvein regions...
  20. ncbi Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone
    Amy Ralston
    Department of Zoology, 250 N Mills Street, University of Wisconsin, Madison, WI 53706, USA
    Dev Biol 280:187-200. 2005
    ..However, this requirement can be overridden by co-misexpression of the BMP agonist Cv-2, indicating the presence of as yet unknown cues; we discuss possible candidates...
  21. ncbi Interactions between the Notch, EGFR, and decapentaplegic signaling pathways regulate vein differentiation during Drosophila pupal wing development
    Sol Sotillos
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Dev Dyn 232:738-52. 2005
    ..Once dpp expression is initiated, Dpp and EGFR activities in the provein maintain each other and, in cooperation, determine vein cell differentiation...
  22. pmc Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development
    Guang Chao Chen
    Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Mol Cell Biol 25:979-87. 2005
    ..Taken together, these data indicate the importance of paxillin modulation of Rho family GTPases during development and identify the LIMK pathway as a critical target of paxillin-mediated Rho regulation...
  23. ncbi Papillote and Piopio: Drosophila ZP-domain proteins required for cell adhesion to the apical extracellular matrix and microtubule organization
    Christian Bökel
    Wellcome Trust Cancer Research UK Gurdon Institute and Department of Anatomy, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    J Cell Sci 118:633-42. 2005
    ..Thus, ZP domain-containing proteins may have shared functions within the aECM, while also exhibiting specific interactions with the cytoskeleton...
  24. pmc Downstream-of-FGFR is a fibroblast growth factor-specific scaffolding protein and recruits Corkscrew upon receptor activation
    Valerie Petit
    Abteilung Zellbiologie, Biozentrum der Universitat Basel, CH 4056 Basel, Switzerland
    Mol Cell Biol 24:3769-81. 2004
    ..Additional proteins binding either to the FGFRs, to Dof, or to Csw appear to be crucial for a chemotactic response...
  25. pmc Cysteine repeat domains and adjacent sequences determine distinct bone morphogenetic protein modulatory activities of the Drosophila Sog protein
    Kweon Yu
    Section of Cell and Developmental Biology and Center for Molecular Genetics, University of California, San Diego, California 92093 0349, USA
    Genetics 166:1323-36. 2004
    ..Cumulatively, our analysis suggests that CR domains interact physically with adjacent protein sequences to create forms of Sog with distinct BMP modulatory activities...
  26. ncbi Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis
    Guang Chao Chen
    Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Curr Biol 14:309-13. 2004
    ..can modulate gene expression, in part, by activating LIM kinase (LIMK) and consequently affecting actin-induced SRF transcriptional activity...
  27. ncbi Size isn't everything
    David Tyler
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Bioessays 25:5-8. 2003
    ..A recent paper suggests that a hitherto overlooked cellular behaviour governs the size and shape of a growing tissue, and issues a challenge to developmental biologists to identify the molecular mechanisms involved...
  28. ncbi Attractive and repulsive functions of Slit are mediated by different receptors in the Drosophila trachea
    Camilla Englund
    Umea Centre for Molecular Pathogenesis, Umea University, Sweden
    Development 129:4941-51. 2002
    ..We propose that the attractive and repulsive tracheal responses to Slit are mediated by different combinations of Robo and Robo2 receptors on the cell surface...
  29. pmc Tests for the replication of an association between Egfr and natural variation in Drosophila melanogaster wing morphology
    Arnar Palsson
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    BMC Genet 6:44. 2005
    ..This re-evaluation utilized different genetic testcrosses to generate heterozygous individuals with a variety of genetic backgrounds as well as sampling of new alleles from Kenyan stocks...
  30. pmc MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing
    Daniel R Marenda
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 133:43-51. 2006
    ....
  31. pmc Mal/SRF is dispensable for cell proliferation in Drosophila
    Barry J Thompson
    Cancer Research UK, London Research Institute, London, United Kingdom
    PLoS ONE 5:e10077. 2010
    The Mal/SRF transcription factor is regulated by the level of G-actin in cells and has important roles in cell migration and other actin-dependent processes in Drosophila...
  32. doi Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila
    N Usha
    Centre for Cellular and Molecular Biology, Hyderabad 500007, India
    Dev Biol 341:389-99. 2010
    ..These results suggest a mechanism by which Ci may activate targets such as kn, which do not have classical Ci/Gli-binding sites...
  33. doi In vivo coupling of cell elongation and lumen formation in a single cell
    Louis Gervais
    Institut de Biologia Molecular de Barcelona CSIC, Baldiri Reixac 10 12, 08028 Barcelona, Spain
    Curr Biol 20:359-66. 2010
    ..Given the similarities in the formation of fine respiratory tubes and capillaries, we propose that an inward membrane growth model could account for lumen formation in both processes...
  34. pmc Rap1 maintains adhesion between cells to affect Egfr signaling and planar cell polarity in Drosophila
    David D O'Keefe
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Dev Biol 333:143-60. 2009
    ..Finally, we show that Rap1 acts through the effector Canoe to regulate these developmental processes...
  35. doi Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing
    Ana Terriente-Félix
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Dev Biol 329:350-61. 2009
    ....
  36. pmc The BMP-binding protein Crossveinless 2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling in Drosophila
    Mihaela Serpe
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Cell 14:940-53. 2008
    ..We also find that Cv-2 expression is controlled by BMP signaling, and these combined properties enable Cv-2 to exquisitely tune BMP signaling...
  37. doi Cell autonomy of HIF effects in Drosophila: tracheal cells sense hypoxia and induce terminal branch sprouting
    Lazaro Centanin
    Instituto Leloir and FBMC, FCEyN Universidad de Buenos Aires, CONICET, Patricias Argentinas 435, Buenos Aires 1405, Argentina
    Dev Cell 14:547-58. 2008
    ..We propose that the autonomous response to hypoxia that occurs in tracheal cells enhances tracheal sensitivity to increasing Branchless levels, and that this mechanism is a cardinal step in hypoxia-dependent tracheal sprouting...
  38. ncbi Tramtrack regulates different morphogenetic events during Drosophila tracheal development
    Sofia J Araújo
    Institut de Biologia Molecular de Barcelona IBMB CSIC, Parc Cientific de Barcelona, Josep Samitier 1 5, 08028 Barcelona, Spain
    Development 134:3665-76. 2007
    ..In summary, the involvement of Ttk in different steps of tube morphogenesis identifies it as a key player in tracheal development...
  39. ncbi Characterization of dSnoN and its relationship to Decapentaplegic signaling in Drosophila
    Rosa Barrio
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Dev Biol 306:66-81. 2007
    ....
  40. ncbi MicroRNAs in muscle differentiation: lessons from Drosophila and beyond
    Hanh T Nguyen
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Opin Genet Dev 16:533-9. 2006
    ..Other miRNAs might promote specific developmental switches during the development and regeneration of muscles...
  41. pmc Dysfusion transcriptional control of Drosophila tracheal migration, adhesion, and fusion
    Lan Jiang
    Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    Mol Cell Biol 26:6547-56. 2006
    ..These results indicate that fusion cells undergo dynamic changes in gene expression as they switch from migratory to fusion modes and that dysfusion regulates a discrete, but important, set of these genes...
  42. ncbi Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila
    Carolina Cela
    Institut de Biologia Molecular de Barcelona IBMB Samitier 1 5, 08028 Barcelona, Spain
    Development 133:3115-25. 2006
    ..This finding establishes a link between a developmental pathway governing tracheal formation and cell adhesiveness...
  43. pmc MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling
    Chulan Kwon
    Gladstone Institute of Cardiovascular Disease and Department of Pediatrics, University of California, 1650 Owens Street, San Francisco, CA 94158
    Proc Natl Acad Sci U S A 102:18986-91. 2005
    ..Drosophila miR-1 (dmiR-1) is regulated through a serum response factor-like binding site in cardiac progenitor cells...
  44. doi Spalt major controls the development of the notum and of wing hinge primordia of the Drosophila melanogaster wing imaginal disc
    Nicole C Grieder
    Biozentrum der Universtät Basel, Abteilung Zellbiologie, Klingelbergstrasse 50 70, 4056 Basel, Switzerland
    Dev Biol 329:315-26. 2009
    ..We also find that salm activity is down-regulated by its own product and by that of the Pax gene eyegone...
  45. ncbi Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila
    Clemens Cabernard
    Department of Biology, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Cell 9:831-42. 2005
    ..Ras and the Mapk pathway are also needed for Egf-regulated cell division/survival, but Pointed is dispensable...
  46. ncbi spalt-induced specification of distinct dorsal and ventral domains is required for Drosophila tracheal patterning
    Xavier Franch-Marro
    Institut de Biologia Molecular de Barcelona CSIC, C Jordi Girona 18 26, 08034 Barcelona, Spain
    Dev Biol 250:374-82. 2002
    ..These results indicate that tracheal patterning depends not only on signalling from surrounding cells but also in the different response of the tracheal cells depending on their allocation to the dorsal or ventral domains...
  47. ncbi Mitotic delay dependent survival identifies components of cell cycle control in the Drosophila blastoderm
    D M Ruden
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Gottingen, Germany
    Development 121:63-73. 1995
    ....
  48. ncbi Expression of the blistered/DSRF gene is controlled by different morphogens during Drosophila trachea and wing development
    U Nussbaumer
    Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056, Basel, Switzerland
    Mech Dev 96:27-36. 2000
    The Drosophila serum response factor (DSRF) is expressed in the precursors of the terminal tracheal cells and in the future intervein territories of the third instar wing imaginal disc...
  49. ncbi Drawing lines in the Drosophila wing: initiation of wing vein development
    E Bier
    Division of Biology, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla 92093 0349, USA
    Curr Opin Genet Dev 10:393-8. 2000
    ..As a consequence of this constraint, cells lying in a narrow line immediately outside the signal-producing domain are the only cells that can respond to the signal by activating expression of vein-promoting genes...
  50. pmc Ultrabithorax regulates genes at several levels of the wing-patterning hierarchy to shape the development of the Drosophila haltere
    S D Weatherbee
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genes Dev 12:1474-82. 1998
    ..protein and a subset of Wg- and Decapentaplegic-activated genes such as spalt-related, vestigial, Serum Response Factor, and achaete-scute, whose products regulate morphological features that differ between the wing and ..
  51. pmc Functional evolution of the Ultrabithorax protein
    J K Grenier
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 97:704-9. 2000
    ..The inability of OUbx to function like Drosophila Ubx (DUbx) in the embryonic ectoderm indicates that the Ubx protein may have acquired new cofactors or activity modifiers since the divergence of the onychophoran and insect lineages...
  52. ncbi Dpp and Notch specify the fusion cell fate in the dorsal branches of the Drosophila trachea
    P Steneberg
    Umeå Center for Molecular Pathogenesis, Umea University, S 90187, Umea, Sweden
    Mech Dev 87:153-63. 1999
    ....
  53. ncbi Selector genes and limb identity in arthropods and vertebrates
    S D Weatherbee
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison 53706, USA
    Cell 97:283-6. 1999
  54. ncbi Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila
    A Baonza
    Centro de Biologia Molecular Severo Ochoa, Cantoblanco 28049, Madrid, Spain
    Mech Dev 80:133-46. 1999
    ..The results show that genes of the Ras signalling pathway are co-operatively involved in the activity of emc during cell proliferation, and later antagonistically during cell differentiation, repressing EMC expression...
  55. ncbi The Drosophila SRF homolog is expressed in a subset of tracheal cells and maps within a genomic region required for tracheal development
    M Affolter
    Department of Cell Biology, Biozentrum, University of Basel, Switzerland
    Development 120:743-53. 1994
    The Drosophila homolog of the vertebrate serum response factor (SRF) was isolated by low stringency hybridization...
  56. pmc The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila
    G Halder
    Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, Madison, Wisconsin 53706 USA
    Genes Dev 12:3900-9. 1998
    ..Combinatorial regulation by selector proteins and signal transducers is likely to be a general feature of the tissue-specific control of gene expression during organogenesis...
  57. pmc A screen to identify Drosophila genes required for integrin-mediated adhesion
    E P Walsh
    Wellcome CRC Institute and Department of Biochemistry, Cambridge CB2 1QR, United Kingdom
    Genetics 150:791-805. 1998
    ..Thus several of these loci are good candidates for genes encoding cytoplasmic proteins required for integrin function...
  58. ncbi Boundaries in the Drosophila wing imaginal disc organize vein-specific genetic programs
    B Biehs
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0349, USA ucsd edu
    Development 125:4245-57. 1998
    ..We present a model in which different A/P boundaries organize vein-specific genetic programs to govern the development of individual veins...
  59. pmc Translational readthrough in the hdc mRNA generates a novel branching inhibitor in the drosophila trachea
    P Steneberg
    Umeå Center for Molecular Pathogenesis, Umea University, S 90187 Umea, Sweden
    Genes Dev 12:956-67. 1998
    ..We propose that hdc acts non-autonomously in an inhibitory signaling mechanism to determine the number of cells that will form unicellular sprouts in the trachea...
  60. ncbi sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways
    N Hacohen
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
    Cell 92:253-63. 1998
    ..sprouty encodes a novel cysteine-rich protein that defines a new family of putative signaling molecules that may similarly function as FGF antagonists in vertebrate development...
  61. ncbi Changing distributions of extracellular matrix components during early wing morphogenesis in Drosophila
    M A Murray
    Department of Zoology, University of Washington, Seattle 98195
    Dev Biol 168:150-65. 1995
    ..The features include cytoskeletal specializations and certain cell surface and ECM molecules...
  62. ncbi Cell fate choices in Drosophila tracheal morphogenesis
    E Zelzer
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Bioessays 22:219-26. 2000
    ..Tracheal cell fate choices are determined by signaling cascades triggered by signals emanating from the tracheal cells, as well as by ligands produced by adjacent tissues...
  63. ncbi The COE--Collier/Olf1/EBF--transcription factors: structural conservation and diversity of developmental functions
    L Dubois
    Centre de Biologie du Developpement, UMR 5547, CNRS Université Paul Sabatier, 118 route de Narbonne 31062 Toulouse cedex 04, France
    Mech Dev 108:3-12. 2001
    ..We also discuss the existence of an evolutionarily conserved pathway linking Notch signalling and COE regulatory functions in various developmental decisions...
  64. ncbi The tissue polarity gene nemo carries out multiple roles in patterning during Drosophila development
    E M Verheyen
    Department of Molecular Biology and Biochemistry, Simon Fraser University, B C, V5A 1S6, Burnaby, Canada
    Mech Dev 101:119-32. 2001
    ..The expression of nemo during embryogenesis is dynamic and dsRNA inhibition and ectopic expression studies indicate that nemo is essential during embryogenesis...
  65. ncbi EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins
    Fernando Roch
    University Museum of Zoology, Department of Zoology, University of Cambridge, Downing Street, Cambridge, UK, CB2 3EJ
    Development 129:993-1002. 2002
    ..Our results support the idea that localised inactivation of transcriptional repressors such as Cic is a rather general mechanism for regulation of target gene expression by the Ras/Raf pathway...
  66. pmc Ras1 interacts with multiple new signaling and cytoskeletal loci in Drosophila eggshell patterning and morphogenesis
    J D Schnorr
    Department of Biology, Whitman College, Walla Walla, Washington 99362, USA
    Genetics 159:609-22. 2001
    ..Mutations in Star and l(2)43Bb had no significant effect upon the lambdatop eggshell defect whereas smt3 and dock alleles significantly suppressed the lambdatop phenotype...
  67. pmc A systematic screen for dominant second-site modifiers of Merlin/NF2 phenotypes reveals an interaction with blistered/DSRF and scribbler
    D R LaJeunesse
    Developmental, Cell and Molecular Biology Group, Department of Biology, Duke University, Durham, North Carolina 27708 1000, USA
    Genetics 158:667-79. 2001
    ..Three of these groups, Group IIa/scribbler (also known as brakeless), Group IIc/blistered, and Group IId/net, are known genes, while two appear to be novel...
  68. ncbi Short-range cell interactions and cell survival in the Drosophila wing
    Marco Milan
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117 Heidelberg, Germany
    Dev Cell 2:797-805. 2002
    ..We also present evidence showing that activation of the Notch signal transduction pathway is involved in triggering apoptosis of cells misspecified for their dorsal-ventral position...
  69. ncbi Transactivation domains are not functionally conserved between vertebrate and invertebrate serum response factors
    Sonia Avila
    Insitituto de Investigaciones Biomédicas CSIC UAM, C Arturo Duperier, Madrid, Spain
    Eur J Biochem 269:3669-77. 2002
    The transcription factor serum response factor (SRF) regulates expression of growth factor-dependent genes and muscle-specific genes in vertebrates. Homologous factors regulate differentiation of some ectodermic tissues in invertebrates...
  70. ncbi Integrins in development: moving on, responding to, and sticking to the extracellular matrix
    Christian Bökel
    Department of Anatomy, Wellcome Trust Cancer Research UK Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Dev Cell 3:311-21. 2002
    ..Integrins also participate in signaling events that govern tissue differentiation and organogenesis. Finally, adhesion by integrin-mediated junctions allows tissues to withstand mechanical load and is essential for tissue integrity...
  71. ncbi Connecting Hh, Dpp and EGF signalling in patterning of the Drosophila wing; the pivotal role of collier/knot in the AP organiser
    Michele Crozatier
    Centre de Biologie du Developpement, UMR 5547 CNRS UPS, 118 route de Narbonne, 31062 Toulouse Cedex, France
    Development 129:4261-9. 2002
    ..A model recapitulating the molecular interplay between the Hh, Dpp and EGF signalling pathways in the wing AP organiser is presented...
  72. ncbi Genetic interactions and cell behaviour in blistered mutants during proliferation and differentiation of the Drosophila wing
    F Roch
    Centro de Biologia Molecular Severo Ochoa, Madrid, Spain
    Development 125:1823-32. 1998
    ..blistered encodes for a nuclear protein homologous to the mammalian Serum Response Factor and is expressed in presumptive intervein cells of third larval instar and pupal wing discs...
  73. ncbi The Drosophila ribbon gene encodes a nuclear BTB domain protein that promotes epithelial migration and morphogenesis
    K Shim
    Howard Hughes Medical Institute and Department of Biochemistry, Stanford University, Stanford, CA 94305 5307, USA
    Development 128:4923-33. 2001
    ..We propose that Rib is a key regulator of epithelial morphogenesis that promotes migration and morphogenesis of the tracheal cell bodies and apical surface and other morphogenetic movements...
  74. ncbi The knirps and knirps-related genes organize development of the second wing vein in Drosophila
    K Lunde
    Department of Biology and Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093, USA
    Development 125:4145-54. 1998
    ..We propose a model in which the combined activities of kni and knrl organize development of the L2 vein in the appropriate position...
  75. ncbi Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila
    C A Conley
    Department of Zoology, University of Wisconsin, Madison, WI 53706, USA
    Development 127:3947-59. 2000
    ..These features strongly suggest that Crossveinless 2 acts extracelluarly or in the secretory pathway to directly potentiate Dpp or Gbb signaling...
  76. ncbi Regulation of Drosophila wing vein patterning: net encodes a bHLH protein repressing rhomboid and is repressed by rhomboid-dependent Egfr signalling
    D Brentrup
    Institut fur Molekularbiologie, Universitat Zurich, CH 8057 Zurich, Switzerland
    Development 127:4729-41. 2000
    ..Our results further suggest that net is required to maintain intervein development by restricting Egfr signalling, which promotes vein development, to the Net-free vein regions of the wing disc...
  77. ncbi Genetic control of branching morphogenesis during Drosophila tracheal development
    M Affolter
    Biozentrum, Abteilung Zellbiologie, Klingelbergstrasse 70, 4056, Basel, Switzerland
    Curr Opin Cell Biol 12:731-5. 2000
    ..More than 30 genes have been identified and ordered into sequential steps controlling branching morphogenesis. These studies have revealed a number of important principles that might be conserved in other systems...
  78. ncbi adrift, a novel bnl-induced Drosophila gene, required for tracheal pathfinding into the CNS
    C Englund
    Umeå Center for Molecular Pathogenesis, Umea University, S 90187 Umea, Sweden
    Development 126:1505-14. 1999
    ....
  79. ncbi The orientation of cell divisions determines the shape of Drosophila organs
    Luis Alberto Baena-Lopez
    Centro de Biologia Molecular Severo Ochoa, Edificio Ciencias, Universidad Autonoma de Madrid, CX 504, 28049 Madrid, Spain
    Curr Biol 15:1640-4. 2005
    ..In addition, we find that a subset of planar cell polarity genes is required for the proper orientation of cell division during organ development...
  80. ncbi Snail/slug family of repressors: slowly going into the fast lane of development and cancer
    K Hemavathy
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Gene 257:1-12. 2000
    ..Moreover, the studies may enable us to trace the evolution of this gene family...
  81. ncbi The hindsight gene is required for epithelial maintenance and differentiation of the tracheal system in Drosophila
    R Wilk
    Program in Developmental Biology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada
    Dev Biol 219:183-96. 2000
    ..These data suggest that HNT is a tissue-specific factor that regulates maintenance of the tracheal epithelium as well as differentiation of taenidia...
  82. ncbi Conserved cross-interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual-specificity phosphatase MKP3
    Ana Ruiz Gómez
    Centro de Biologóa Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    Dev Dyn 232:695-708. 2005
    ..Furthermore, this restricted expression depends on ERK function both in Drosophila and Xenopus, suggesting that MKP3 constitutes a conserved negative feedback loop on the activity of the Ras/ERK signaling pathway...
  83. pmc Fibroblast growth factor receptor-dependent morphogenesis of the Drosophila mesoderm
    R Wilson
    Institute of Genetics, University of Cologne, Germany
    Philos Trans R Soc Lond B Biol Sci 355:891-5. 2000
    ..Analysis of the function of dof, which encodes a cytoplasmic protein required for FGF signal transduction may provide an insight into these issues...
  84. pmc Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium
    Florence Janody
    Developmental Biology Institute of Marseille Luminy, UMR6216 Case 907, Parc Scientific de Luminy, 13288 Marseille Cedex 09, France
    Development 133:3349-57. 2006
    ..Our results suggest that Vestigial specifies the cytoskeletal changes that lead to morphogenesis of the adult wing...
  85. ncbi Repression of the wing vein development in Drosophila by the nuclear matrix protein plexus
    H Matakatsu
    Genetic Strain Research Center, National Institute of Genetics, Mishima, Shizuoka ken 411 8540, Japan
    Development 126:5207-16. 1999
    ..Plexus may regulate transcription of vein-and intervein-specific genes by tethering transcriptional regulators to specific locations in the nucleus...
  86. ncbi Genetic control of branching morphogenesis
    R J Metzger
    Howard Hughes Medical Institute and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5307, USA
    Science 284:1635-9. 1999
    ..The reiterative use of a signaling pathway by both insects and mammals suggests a general scheme for patterning branching morphogenesis...
  87. ncbi Hedgehog and Decapentaplegic instruct polarized growth of cell extensions in the Drosophila trachea
    Kagayaki Kato
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo ku Kobe 650 0047, Japan
    Development 131:5253-61. 2004
    ..Orthogonal expression of Hedgehog and Decapentaplegic in the epidermis instructs monopolar extension of the terminal branch along the posterior compartment, thereby matching the pattern of airway growth with that of the epidermis...
  88. ncbi Insect evolution: Redesigning the fruitfly
    G Gibson
    Department of Genetics, North Carolina State University, Raleigh 27695 7614, USA
    Curr Biol 9:R86-9. 1999
    ....

Research Grants2

  1. Competition and morphogenesis in tip cell-mediated branching of tubular networks
    Amin S Ghabrial; Fiscal Year: 2010
    ..This proposal aims to use Drosophila tracheal branching as a model to uncover the genetic and molecular mechanisms by which tip cells are selected and by which they lead outgrowth of new tubes. ..
  2. A new site-specific recombination system in Drosophila
    Georg Halder; Fiscal Year: 2005
    ..These tools will have broad applications and will lead to the discovery of novel genetic interactions in Drosophila that could not have been detected using currently available methods. ..