Gene Symbol: brm
Description: brahma
Alias: BRD, BRM, Brahma, Brm, Brm @ Kto, CG18438, CG5942, Dmel\CG5942, E(E2F)3A, dBRM, dSMARCA4, dSNF2, l(3)72Aa, brahma, CG5942-PA, CG5942-PB, CG5942-PC, CG5942-PD, CG5942-PE, CG5942-PF, brm-PA, brm-PB, brm-PC, brm-PD, brm-PE, brm-PF, complementation group 3.5
Species: fruit fly

Top Publications

  1. Tamkun J. The role of brahma and related proteins in transcription and development. Curr Opin Genet Dev. 1995;5:473-7 pubmed
    ..During the past year, studies of a trithorax group member, brahma, and related yeast and human proteins have suggested that they are components of huge complexes that assist DNA-..
  2. Nakayama T, Shimojima T, Hirose S. The PBAP remodeling complex is required for histone H3.3 replacement at chromatin boundaries and for boundary functions. Development. 2012;139:4582-90 pubmed publisher
    ..3 replacement at chromatin boundaries. Here, we report that GAGA factor associates with the Polybromo-associated Brm (PBAP) remodeling complex, which consists of many Trithorax group proteins, and recruits this complex to chromatin ..
  3. Lopez A, Higuet D, Rosset R, Deutsch J, Peronnet F. corto genetically interacts with Pc-G and trx-G genes and maintains the anterior boundary of Ultrabithorax expression in Drosophila larvae. Mol Genet Genomics. 2001;266:572-83 pubmed
    ..Our results provide evidence that corto maintains the anterior border of Ubx expression in third-instar larvae. We suggest that this regulation is accomplished through an interaction with the products of the Pc-G and trx-G genes. ..
  4. Srinivasan S, Armstrong J, Deuring R, Dahlsveen I, McNeill H, Tamkun J. The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II. Development. 2005;132:1623-35 pubmed
    ..By contrast, the loss of KIS-L function does not affect the binding of PC to chromatin or the recruitment of Pol II to promoters. These data suggest that KIS-L facilitates an early step in transcriptional elongation by Pol II. ..
  5. Brizuela B, Elfring L, Ballard J, Tamkun J, Kennison J. Genetic analysis of the brahma gene of Drosophila melanogaster and polytene chromosome subdivisions 72AB. Genetics. 1994;137:803-13 pubmed
    The brahma gene is required for activation of the homeotic genes of the Antennapedia and bithorax complexes in Drosophila. We have isolated and characterized 21 mutations in brahma...
  6. Tsukiyama T, Daniel C, Tamkun J, Wu C. ISWI, a member of the SWI2/SNF2 ATPase family, encodes the 140 kDa subunit of the nucleosome remodeling factor. Cell. 1995;83:1021-6 pubmed
    ..The convergence of biochemical and genetic studies on ISWI and SWI2/SNF2 underscores these ATPases and their close relatives as key components of independent systems for chromatin remodeling. ..
  7. Shao Z, Raible F, Mollaaghababa R, Guyon J, Wu C, Bender W, et al. Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell. 1999;98:37-46 pubmed
    ..Several different types of repressive complexes, including deacetylases, interact with histone tails. In contrast, PRC1 was active on nucleosomal arrays formed with tailless histones. ..
  8. Waldholm J, Wang Z, Brodin D, Tyagi A, Yu S, Theopold U, et al. SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster. BMC Mol Biol. 2011;12:46 pubmed publisher
    ..SWI/SNF complexes contain one subunit with ATPase activity, which in Drosophila melanogaster is called Brahma (Brm)...
  9. Kal A, Mahmoudi T, Zak N, Verrijzer C. The Drosophila brahma complex is an essential coactivator for the trithorax group protein zeste. Genes Dev. 2000;14:1058-71 pubmed
    ..Reconstituted transcription reactions established that the Brahma (BRM) chromatin-remodeling complex is essential for Zeste-directed activation on nucleosomal templates...

More Information


  1. Vazquez M, Moore L, Kennison J. The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription. Development. 1999;126:733-42 pubmed
    The trithorax group gene brahma (brm) encodes the ATPase subunit of a chromatin-remodeling complex involved in homeotic gene regulation...
  2. Zraly C, Marenda D, Nanchal R, Cavalli G, Muchardt C, Dingwall A. SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during development. Dev Biol. 2003;253:291-308 pubmed
    The snr1 gene of Drosophila melanogaster encodes a conserved component of the multiprotein Brahma (Brm) complex, a counterpart to the SWI/SNF complexes that participate in ATP-dependent chromatin remodeling...
  3. Armstrong J, Papoulas O, Daubresse G, Sperling A, Lis J, Scott M, et al. The Drosophila BRM complex facilitates global transcription by RNA polymerase II. EMBO J. 2002;21:5245-54 pubmed
    Drosophila brahma (brm) encodes the ATPase subunit of a 2 MDa complex that is related to yeast SWI/SNF and other chromatin-remodeling complexes...
  4. Hirose F, Ohshima N, Shiraki M, Inoue Y, Taguchi O, Nishi Y, et al. Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteins. Mol Cell Biol. 2001;21:7231-42 pubmed
    ..of some of the trithorax group genes involved in determining chromatin structure or chromatin remodeling (brahma, moira, and osa) significantly suppressed and that reduction of Distal-less enhanced the DREF-induced rough eye ..
  5. Collins R, Treisman J. Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes. Genes Dev. 2000;14:3140-52 pubmed
    ..Osa functions as a component of the Brahma chromatin-remodeling complex; other components of this complex are likewise required to repress Wingless target ..
  6. Ivaldi M, Karam C, Corces V. Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in Drosophila. Genes Dev. 2007;21:2818-31 pubmed
    ..present evidence suggesting that JIl-1-mediated H3S10 phosphorylation is dependent on chromatin remodeling by the brahma complex and is required during early transcription elongation to release RNA polymerase II (Pol II) from promoter-..
  7. Elfring L, Deuring R, McCallum C, Peterson C, Tamkun J. Identification and characterization of Drosophila relatives of the yeast transcriptional activator SNF2/SWI2. Mol Cell Biol. 1994;14:2225-34 pubmed
    The Drosophila brahma (brm) gene encodes an activator of homeotic genes that is highly related to the yeast transcriptional activator SWI2 (SNF2), a potential helicase...
  8. Elfring L, Daniel C, Papoulas O, Deuring R, Sarte M, Moseley S, et al. Genetic analysis of brahma: the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2. Genetics. 1998;148:251-65 pubmed
    The Drosophila brahma (brm) gene encodes an activator of homeotic genes related to the yeast chromatin remodeling factor SWI2/SNF2. Here, we report the phenotype of null and dominant-negative brm mutations...
  9. Zeng X, Lin X, Hou S. The Osa-containing SWI/SNF chromatin-remodeling complex regulates stem cell commitment in the adult Drosophila intestine. Development. 2013;140:3532-40 pubmed publisher
    ..that regulate cell lineage determination in the posterior midgut, we identified that the Osa-containing SWI/SNF (Brahma) chromatin-remodeling complex regulates Drosophila midgut homeostasis...
  10. Kirilly D, Wong J, Lim E, Wang Y, Zhang H, Wang C, et al. Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in Drosophila. Neuron. 2011;72:86-100 pubmed publisher
    ..Here, we analyzed 81 epigenetic factors, from which a Brahma (Brm)-containing chromatin remodeler and a histone acetyltransferase CREB-binding protein (CBP) were identified ..
  11. Vorobyeva N, Soshnikova N, Kuzmina J, Kopantseva M, Nikolenko J, Nabirochkina E, et al. The novel regulator of metazoan development SAYP organizes a nuclear coactivator supercomplex. Cell Cycle. 2009;8:2152-6 pubmed
    ..SAYP function is related to the conserved domain SAY, which assembles a nuclear supercomplex BTFly consisting of Brahma and TFIID coactivators...
  12. Deuring R, Fanti L, Armstrong J, Sarte M, Papoulas O, Prestel M, et al. The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo. Mol Cell. 2000;5:355-65 pubmed
    ..These findings reveal novel functions for the ISWI ATPase and underscore its importance in chromatin remodeling in vivo...
  13. Oh H, Slattery M, Ma L, Crofts A, White K, Mann R, et al. Genome-wide association of Yorkie with chromatin and chromatin-remodeling complexes. Cell Rep. 2013;3:309-18 pubmed publisher
    ..Coimmunoprecipitation and mass spectrometry identify GAGA factor (GAF), the Brahma complex, and the Mediator complex as Yorkie-associated nuclear protein complexes...
  14. Herr A, Mckenzie L, Suryadinata R, Sadowski M, Parsons L, Sarcevic B, et al. Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila. Dev Biol. 2010;344:36-51 pubmed publisher
    ..In Xenopus, Geminin acts to antagonize the Brahma (Brm) chromatin-remodeling protein, Brg1, during neural differentiation...
  15. Vorobyeva N, Nikolenko J, Krasnov A, Kuzmina J, Panov V, Nabirochkina E, et al. SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation. Cell Cycle. 2011;10:1821-7 pubmed
    ..SAYP interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex...
  16. Gerasimova T, Corces V. Polycomb and trithorax group proteins mediate the function of a chromatin insulator. Cell. 1998;92:511-21 pubmed
    ..The results suggest a model in which PcG and TrxG proteins regulate insulator function by establishing higher order domains of chromatin organization required for the assembly of functional insulators at the nuclear matrix. ..
  17. Daubresse G, Deuring R, Moore L, Papoulas O, Zakrajsek I, Waldrip W, et al. The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity. Development. 1999;126:1175-87 pubmed
    ..The Kismet proteins contain a domain conserved in the trithorax group protein Brahma and related chromatin-remodeling factors, providing further evidence that alterations in chromatin structure are ..
  18. Srinivasan S, Dorighi K, Tamkun J. Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II. PLoS Genet. 2008;4:e1000217 pubmed publisher
    ..Our findings suggest that KIS-L promotes early elongation and counteracts Polycomb group repression by recruiting the ASH1 and TRX histone methyltransferases to chromatin. ..
  19. Moller A, Avila F, Erickson J, Jackle H. Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repression. J Mol Biol. 2005;352:329-37 pubmed
    The SWI/SNF-like chromatin remodeling complex of Drosophila, the Brahma complex, contains four subunits (Brahma, BAP155/Moira, SNR1 and BAP60) conserved from yeast to humans...
  20. Gellon G, McGinnis W. Shaping animal body plans in development and evolution by modulation of Hox expression patterns. Bioessays. 1998;20:116-25 pubmed
  21. Ruhf M, Braun A, Papoulas O, Tamkun J, Randsholt N, Meister M. The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes. Development. 2001;128:1429-41 pubmed
    ..Altogether, the data lead us to propose that domino acts as a repressor by interfering with chromatin structure. This activity is likely to be performed as a subunit of a chromatin-remodeling complex. ..
  22. Tripoulas N, Lajeunesse D, Gildea J, Shearn A. The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger. Genetics. 1996;143:913-28 pubmed
    ..The chromosomal localization of ASH1 implies that it functions at the transcriptional level to maintain the expression pattern of homeotic selector genes. ..
  23. Heitzler P, Vanolst L, Biryukova I, Ramain P. Enhancer-promoter communication mediated by Chip during Pannier-driven proneural patterning is regulated by Osa. Genes Dev. 2003;17:591-6 pubmed
    ..We show here that this communication is regulated by Osa, which is recruited by Pannier and Chip. Osa belongs to Brahma chromatin remodeling complexes and we show that Osa negatively regulates ac/sc...
  24. Kennison J, Tamkun J. Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila. Proc Natl Acad Sci U S A. 1988;85:8136-40 pubmed
    ..e., Sex combs reduced (Scr), Brista (Ba), trithorax (trx), Polycomb (Pc), Polycomblike (Pcl), and Sex comb on midleg (Scm)]. Mutations in several of the additional loci identified here have also been shown to have homoeotic phenotypes. ..
  25. Mohrmann L, Langenberg K, Krijgsveld J, Kal A, Heck A, Verrijzer C. Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes. Mol Cell Biol. 2004;24:3077-88 pubmed
    ..Therefore, it was puzzling that Drosophila appeared to contain only a single SWI/SNF-type remodeler, the Brahma (BRM) complex...
  26. Marenda D, Zraly C, Feng Y, Egan S, Dingwall A. The Drosophila SNR1 (SNF5/INI1) subunit directs essential developmental functions of the Brahma chromatin remodeling complex. Mol Cell Biol. 2003;23:289-305 pubmed
    The Drosophila melanogaster Brahma (Brm) complex, a counterpart of the Saccharomyces cerevisiae SWI/SNF ATP-dependent chromatin remodeling complex, is important for proper development by maintaining specific gene expression patterns...
  27. Gutierrez L, Zurita M, Kennison J, Vázquez M. The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein. Development. 2003;130:343-54 pubmed
    The trithorax group genes are required for positive regulation of homeotic gene function. The trithorax group gene brahma encodes a SWI2/SNF2 family ATPase that is a catalytic subunit of the Brm chromatin-remodeling complex...
  28. Fry C, Peterson C. Chromatin remodeling enzymes: who's on first?. Curr Biol. 2001;11:R185-97 pubmed
    ..Here we review recent developments concerning the role of chromatin remodeling enzymes in gene regulation, and propose several models to explain how different chromatin remodeling activities can be functionally coupled. ..
  29. Tamkun J, Deuring R, Scott M, Kissinger M, Pattatucci A, Kaufman T, et al. brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2. Cell. 1992;68:561-72 pubmed
    The brahma (brm) gene is required for the activation of multiple homeotic genes in Drosophila...
  30. Crosby M, Miller C, Alon T, Watson K, Verrijzer C, Goldman Levi R, et al. The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster. Mol Cell Biol. 1999;19:1159-70 pubmed
    ..In vitro, MOR can bind to itself and it interacts with Brahma (BRM), an SWI2-SNF2 homolog, with which it is associated in embryonic nuclear extracts...
  31. Cavalli G, Paro R. Epigenetic inheritance of active chromatin after removal of the main transactivator. Science. 1999;286:955-8 pubmed
    ..This feature may allow epigenetic maintenance of active states of developmental genes after decay of their early embryonic regulators. ..
  32. Moshkin Y, Chalkley G, Kan T, Reddy B, Ozgur Z, van Ijcken W, et al. Remodelers organize cellular chromatin by counteracting intrinsic histone-DNA sequence preferences in a class-specific manner. Mol Cell Biol. 2012;32:675-88 pubmed publisher
    ..We conclude that the cellular nucleosome landscape is the result of the balance between DNA sequence-driven nucleosome placement and active nucleosome repositioning by remodelers and the transcription machinery. ..
  33. Tie F, Banerjee R, Conrad P, Scacheri P, Harte P. Histone demethylase UTX and chromatin remodeler BRM bind directly to CBP and modulate acetylation of histone H3 lysine 27. Mol Cell Biol. 2012;32:2323-34 pubmed publisher
    ..on other TrxG proteins, including the histone H3K27-specific demethylase UTX and the chromatin-remodeling ATPase Brahma (BRM)...
  34. Hagstrom K, Muller M, Schedl P. A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex. Genetics. 1997;146:1365-80 pubmed
    ..The iab-7 PRE silencer is contained within a 0.8-kb fragment that spans a nuclease hypersensitive site, and silencing appears to depend on the chromatin remodeling protein, the GAGA factor. ..
  35. Karam C, Kellner W, Takenaka N, Clemmons A, Corces V. 14-3-3 mediates histone cross-talk during transcription elongation in Drosophila. PLoS Genet. 2010;6:e1000975 pubmed publisher
    ..These results suggest that 14-3-3 proteins mediate cross-talk between histone phosphorylation and acetylation at a critical step in transcription elongation. ..
  36. Vorobyeva N, Soshnikova N, Nikolenko J, Kuzmina J, Nabirochkina E, Georgieva S, et al. Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex. Proc Natl Acad Sci U S A. 2009;106:11049-54 pubmed publisher
    ..we have shown the existence of a stable coactivator supercomplex consisting of the chromatin-remodeling factor Brahma (SWI/SNF) and the transcription initiation factor TFIID, named BTFly (Brahma and TFIID in one assembly)...
  37. Tyagi A, Ryme J, Brodin D, Ostlund Farrants A, Visa N. SWI/SNF associates with nascent pre-mRNPs and regulates alternative pre-mRNA processing. PLoS Genet. 2009;5:e1000470 pubmed publisher
    ..Studies in human cells suggest that Brahma (Brm), the ATPase subunit of SWI/SNF, regulates alternative pre-mRNA splicing by modulating transcription ..
  38. Jin Y, Xu J, Yin M, Lu Y, Hu L, Li P, et al. Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling. elife. 2013;2:e00999 pubmed publisher
    ..In this study, we show that Brahma (Brm) chromatin-remodeling complex is required for ISC proliferation and damage-induced midgut regeneration in a ..
  39. Chalkley G, Moshkin Y, Langenberg K, Bezstarosti K, Blastyak A, Gyurkovics H, et al. The transcriptional coactivator SAYP is a trithorax group signature subunit of the PBAP chromatin remodeling complex. Mol Cell Biol. 2008;28:2920-9 pubmed publisher
    ..Both complexes share seven core subunits, including the Brahma ATPase, but differ in a few signature subunits; POLYBROMO and BAP170 specify PBAP, whereas OSA defines BAP...
  40. Corona D, Siriaco G, Armstrong J, Snarskaya N, McClymont S, Scott M, et al. ISWI regulates higher-order chromatin structure and histone H1 assembly in vivo. PLoS Biol. 2007;5:e232 pubmed
    ..These findings suggest that ISWI plays a global role in chromatin compaction in vivo by promoting the association of the linker histone H1 with chromatin. ..
  41. Moshkin Y, Mohrmann L, van Ijcken W, Verrijzer C. Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control. Mol Cell Biol. 2007;27:651-61 pubmed
    ..The two complexes share the same core subunits, including the BRM ATPase, but differ in a few signature subunits: OSA defines BAP, whereas Polybromo (PB) and BAP170 specify PBAP...
  42. Milan M, Pham T, Cohen S. Osa modulates the expression of Apterous target genes in the Drosophila wing. Mech Dev. 2004;121:491-7 pubmed
    ..We have found Osa, a member of the Brahma chromatin-remodeling complex, as a positive modulator of Apterous activity in the Drosophila wing...
  43. Terriente Félix A, de Celis J. Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing. Dev Biol. 2009;329:350-61 pubmed publisher
    ..In Drosophila there is only one SWI/SNF protein, named Brahma, which forms the catalytic subunit of two complexes composed of different proteins...
  44. Collins R, Furukawa T, Tanese N, Treisman J. Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genes. EMBO J. 1999;18:7029-40 pubmed
    ..We present genetic and biochemical evidence that Osa is a component of the Brahma complex, the Drosophila homolog of SWI/SNF...
  45. Zraly C, Marenda D, Dingwall A. SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex. Genetics. 2004;168:199-214 pubmed
    SNR1 is an essential subunit of the Drosophila Brahma (Brm) ATP-dependent chromatin remodeling complex, with counterparts in yeast (SNF5) and mammals (INI1)...
  46. Campbell R, Sinclair D, Couling M, Brock H. Genetic interactions and dosage effects of Polycomb group genes of Drosophila. Mol Gen Genet. 1995;246:291-300 pubmed
    ..Flies with increasing doses of esc+ exhibit anterior transformations, but these are not enhanced by mutations in trithorax group genes. The results are discussed with respect to current models of Pc group function. ..
  47. Kassis J. Unusual properties of regulatory DNA from the Drosophila engrailed gene: three "pairing-sensitive" sites within a 1.6-kb region. Genetics. 1994;136:1025-38 pubmed
    ..I propose that engrailed PS sites normally act to promote interactions between distantly located engrailed regulatory sites and the engrailed promoter. ..
  48. Maves L, Schubiger G. Transdetermination in Drosophila imaginal discs: a model for understanding pluripotency and selector gene maintenance. Curr Opin Genet Dev. 2003;13:472-9 pubmed
    ..An important future goal is to address how signaling pathways interact with chromatin structure to regulate and maintain the proper expression of selector genes. ..
  49. Zhu Y, Li D, Wang Y, Pei C, Liu S, Zhang L, et al. Brahma regulates the Hippo pathway activity through forming complex with Yki-Sd and regulating the transcription of Crumbs. Cell Signal. 2015;27:606-13 pubmed publisher
    ..This finding led us to investigate the in vivo functional interaction of Yki and Brahma (Brm), the Drosophila homolog of Brg1...
  50. Henikoff S. Transcriptional activator components and poxvirus DNA-dependent ATPases comprise a single family. Trends Biochem Sci. 1993;18:291-2 pubmed
  51. Vorob eva N, Soshnikova N, Nikolenko I, Kuz mina I, Nabirochkina E, Georgieva S, et al. [Novel conservative domain of SAYP coactivator mediates TFIID and Brahma transcriptional complexes interaction]. Mol Biol (Mosk). 2010;44:867-75 pubmed
    In the S2 cell system of Drosophila melanogaster a key protein domain mediating the interaction of TFIID and Brahma transcriptional complexes into the BTFly supercomplex has been shown to be an evolutionary conserved SAY domain of the ..
  52. Zhang W, Jin Y, Ji Y, Girton J, Johansen J, Johansen K. Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages. Genetics. 2003;165:1341-54 pubmed
    ..We propose that JIL-1 may exert such effects by a general regulation of chromatin structure affecting gene expression. ..
  53. Burgio G, La Rocca G, Sala A, Arancio W, Di Gesù D, Collesano M, et al. Genetic identification of a network of factors that functionally interact with the nucleosome remodeling ATPase ISWI. PLoS Genet. 2008;4:e1000089 pubmed publisher
    ..Consistent with these findings, the acetylation of histone H4 is altered when ISWI activity is perturbed in vivo. These findings suggest that ISWI associates with the Sin3A/Rpd3 complex to support its function in vivo. ..
  54. Varga Weisz P, Becker P. Chromatin-remodeling factors: machines that regulate?. Curr Opin Cell Biol. 1998;10:346-53 pubmed
  55. He J, Xuan T, Xin T, An H, Wang J, Zhao G, et al. Evidence for chromatin-remodeling complex PBAP-controlled maintenance of the Drosophila ovarian germline stem cells. PLoS ONE. 2014;9:e103473 pubmed publisher
    ..Here, we report that Brahma (Brm), the ATPase subunit of the Drosophila SWI/SNF chromatin-remodeling complexes, is required for maintaining ..
  56. Shi J, Zheng M, Ye Y, Li M, Chen X, Hu X, et al. Drosophila Brahma complex remodels nucleosome organizations in multiple aspects. Nucleic Acids Res. 2014;42:9730-9 pubmed publisher
    ..In Drosophila, gene Brm encodes the core Brahma complex, the ATPase subunit of SWI/SNF class of chromatin remodelers...
  57. Gregory P, Hörz W. Chromatin and transcription--how transcription factors battle with a repressive chromatin environment. Eur J Biochem. 1998;251:9-18 pubmed
    ..These data provide the latest and potentially most significant demonstration of the importance of the nucleosome in the regulation of transcription. ..
  58. Petruk S, Black K, Kovermann S, Brock H, Mazo A. Stepwise histone modifications are mediated by multiple enzymes that rapidly associate with nascent DNA during replication. Nat Commun. 2013;4:2841 pubmed publisher
    ..Epigenetic inheritance of gene expression patterns may require many aspects of chromatin structure to remain in close proximity to the replication complex followed by reassembly on nascent DNA shortly after replication. ..