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Genomes and Genes | brmSummaryGene Symbol: brm Description: brahma Alias: BRM, Brm, CG18438, CG5942, Dmel\CG5942, E(E2F)3A, dBRM, dSNF2, l(3)72Aa, CG5942-PA, CG5942-PB, CG5942-PC, CG5942-PD, CG5942-PE, CG5942-PF, brm-PA, brm-PB, brm-PC, brm-PD, brm-PE, brm-PF, complementation group 3.5 Species: fruit fly Top Publications
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Publications
Functional differentiation of SWI/SNF remodelers in transcription and cell cycle controlYuri M Moshkin
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
Mol Cell Biol 27:651-61. 2007..The two complexes share the same core subunits, including the BRM ATPase, but differ in a few signature subunits: OSA defines BAP, whereas Polybromo (PB) and BAP170 specify PBAP...- The transcriptional coactivator SAYP is a trithorax group signature subunit of the PBAP chromatin remodeling complexGillian E Chalkley
Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Mol Cell Biol 28:2920-9. 2008..We conclude that SAYP is a signature subunit that plays a major role in the functional specificity of the PBAP holoenzyme... - The Drosophila BRM complex facilitates global transcription by RNA polymerase IIJennifer A Armstrong
Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
EMBO J 21:5245-54. 2002Drosophila brahma (brm) encodes the ATPase subunit of a 2 MDa complex that is related to yeast SWI/SNF and other chromatin-remodeling complexes... 
The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identityG Daubresse
Department of Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Development 126:1175-87. 1999....- The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase IIShrividhya Srinivasan
Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Development 132:1623-35. 2005..By contrast, the loss of KIS-L function does not affect the binding of PC to chromatin or the recruitment of Pol II to promoters. These data suggest that KIS-L facilitates an early step in transcriptional elongation by Pol II... - SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during developmentClaudia B Zraly
Department of Biology, Syracuse University, Syracuse, NY 13244 1270, USA
Dev Biol 253:291-308. 2003The snr1 gene of Drosophila melanogaster encodes a conserved component of the multiprotein Brahma (Brm) complex, a counterpart to the SWI/SNF complexes that participate in ATP-dependent chromatin remodeling... - The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD fingerN Tripoulas
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
Genetics 143:913-28. 1996..The chromosomal localization of ASH1 implies that it functions at the transcriptional level to maintain the expression pattern of homeotic selector genes... - Shaping animal body plans in development and evolution by modulation of Hox expression patternsG Gellon
Department of Biology, Yale University, New Haven, CT, USA
Bioessays 20:116-25. 1998.... - Genetic analysis of brahma: the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2L K Elfring
Department of Biology, University of California, Santa Cruz 95064, USA
Genetics 148:251-65. 1998The Drosophila brahma (brm) gene encodes an activator of homeotic genes related to the yeast chromatin remodeling factor SWI2/SNF2. Here, we report the phenotype of null and dominant-negative brm mutations... - The Drosophila brahma complex is an essential coactivator for the trithorax group protein zesteA J Kal
Department of Molecular and Cell Biology, MGC, Centre for Biomedical Genetics, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
Genes Dev 14:1058-71. 2000..Reconstituted transcription reactions established that the Brahma (BRM) chromatin-remodeling complex is essential for Zeste-directed activation on nucleosomal templates... - Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1Christian Beisel
Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
Nature 419:857-62. 2002..Ash1 may serve as a binding surface for a chromatin remodelling complex containing the epigenetic activator Brahma (Brm), an ATPase, and inhibits the interaction of epigenetic repressors with chromatin... - The role of brahma and related proteins in transcription and developmentJ W Tamkun
Department of Biology, University of California, Santa Cruz 95064, USA
Curr Opin Genet Dev 5:473-7. 1995.... - The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivoR Deuring
Department of Biology, University of California, Santa Cruz 95064, USA
Mol Cell 5:355-65. 2000..These findings reveal novel functions for the ISWI ATPase and underscore its importance in chromatin remodeling in vivo... - Dosage-dependent modifiers of polycomb and antennapedia mutations in DrosophilaJ A Kennison
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892
Proc Natl Acad Sci U S A 85:8136-40. 1988..e., Sex combs reduced (Scr), Brista (Ba), trithorax (trx), Polycomb (Pc), Polycomblike (Pcl), and Sex comb on midleg (Scm)]. Mutations in several of the additional loci identified here have also been shown to have homoeotic phenotypes... - In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response elementJ Mihaly
Department of Zoology and Animal Biology, University of Geneva, Switzerland
Development 124:1809-20. 1997.... - Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machineryYuri M Moshkin
Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland
Genes Dev 16:2621-6. 2002..These findings suggest that ASF1 plays a crucial role in both chromatin assembly and SWI/SNF-mediated chromatin remodelling... - Genomic imprinting in Drosophila is maintained by the products of Suppressor of variegation and trithorax group, but not Polycomb group, genesV Joanis
Dept of Biology, Dalhousie University, 1355 Oxford St, Halifax, Nova Scotia B3H 1J4, Canada
Mol Genet Genomics 268:103-12. 2002.... - ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR In vitroF J Dilworth
Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP College de France 67404 Cedex CU de Strasbourg, Illkirch, France
Mol Cell 6:1049-58. 2000..Thus, both ATP-driven chromatin remodeling and HAT activities act in a temporally ordered and interdependent manner to alleviate the repressive effects of nucleosomal histones on transcription by RARalpha/RXRalpha heterodimers... - The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatusStéphane Calgaro
Centre de Biologie du Developpement, Universite Paul Sabatier, 31062 Toulouse Cedex, France
Genetics 160:547-60. 2002..polyhomeotic and (ii) they enhance the phenotypic effects of mutations in the trxG genes trithorax (trx), brahma (brm), and osa... - The LRR proteins capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wingM Milan
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany
Cell 106:785-94. 2001.... - The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activationN Barker
Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
EMBO J 20:4935-43. 2001..We conclude that beta-catenin recruits Brg-1 to Tcf target gene promoters, facilitating chromatin remodelling as a prerequisite for transcriptional activation... - Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genesR T Collins
Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
Genes Dev 14:3140-52. 2000..These results suggest that altering the conformation of chromatin is an important mechanism by which Wingless signaling activates gene expression... - The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genesM L Ruhf
UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, France
Development 128:1429-41. 2001..Altogether, the data lead us to propose that domino acts as a repressor by interfering with chromatin structure. This activity is likely to be performed as a subunit of a chromatin-remodeling complex... - Chromatin remodeling enzymes: who's on first?C J Fry
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech 2, Suite 301, Worcester, MA 01605, USA
Curr Biol 11:R185-97. 2001..Here we review recent developments concerning the role of chromatin remodeling enzymes in gene regulation, and propose several models to explain how different chromatin remodeling activities can be functionally coupled... 
Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in DrosophilaAnabel Herr
Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
Dev Biol 344:36-51. 2010..In Xenopus, Geminin acts to antagonize the Brahma (Brm) chromatin-remodeling protein, Brg1, during neural differentiation...- Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplexNadezhda E Vorobyeva
Department of Regulation of Gene Expression, Institute of Gene Biology, Russian Academy of Sciences, Vavilov Street 34 5, Moscow, 119334 Russia
Proc Natl Acad Sci U S A 106:11049-54. 2009..The integrity of BTFly is crucial for its ability to activate transcription. BTFly is distributed genome-wide and appears to be a means of effective transcription activation... - Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase IIShrividhya Srinivasan
Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA
PLoS Genet 4:e1000217. 2008..Our findings suggest that KIS-L promotes early elongation and counteracts Polycomb group repression by recruiting the ASH1 and TRX histone methyltransferases to chromatin... - Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activitySvetlana Petruk
Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
Development 135:2383-90. 2008..There is, however, no overall synergism or antagonism between and within the trxG and PcG proteins and, instead, only subsets of trxG proteins act synergistically... - Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene controlSoda Balla Diop
Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR6216 Université de la Méditerranée, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France
EMBO Rep 9:260-6. 2008..Furthermore, the enzymatic functions of Rept and Pont are indispensable for maintaining Hox gene expression states, highlighting the importance of these two antagonistic factors in transcriptional output... - Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in DrosophilaM Soledad Ivaldi
Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
Genes Dev 21:2818-31. 2007..Taken together, the results introduce H3S10 phosphorylation by JIL-1 as a hallmark of early transcription elongation in Drosophila... - Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphologyWesley B Grueber
Departments of Physiology and Biochemistry, University of California, San Francisco, Rock Hall, Room GD481, 1550 4th Street, San Francisco, CA 94143, USA
Development 134:55-64. 2007.... - A screen for genes regulating the wingless gradient in Drosophila embryosSabrina C Desbordes
Department of Genetics, University of Cambridge, UK
Genetics 170:749-66. 2005..Thus, our assay can be used effectively to screen for genes regulating Wingless distribution or transport... - Osa modulates the expression of Apterous target genes in the Drosophila wingMarco Milan
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Mech Dev 121:491-7. 2004..Osa has been shown to bind Chip. We propose that Chip recruits Osa to the Apterous target genes, thus mediating activation or repression of their expression... - Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexesLisette Mohrmann
Gene Regulation Laboratory, Centre for Biomedical Genetics, Department of Molecular and Cell Biology, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
Mol Cell Biol 24:3077-88. 2004..Therefore, it was puzzling that Drosophila appeared to contain only a single SWI/SNF-type remodeler, the Brahma (BRM) complex... - Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stagesWeiguo Zhang
Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
Genetics 165:1341-54. 2003..We propose that JIL-1 may exert such effects by a general regulation of chromatin structure affecting gene expression... - Chromatin remodeling by ATP-dependent molecular machinesAlexandra Lusser
Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093 0347, USA
Bioessays 25:1192-200. 2003..In this review, we provide an overview of chromatin-remodeling enzymes and discuss two possible mechanisms by which these factors might act to reorganize nucleosome structure... - Transdetermination in Drosophila imaginal discs: a model for understanding pluripotency and selector gene maintenanceLisa Maves
Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403 1254, USA
Curr Opin Genet Dev 13:472-9. 2003..An important future goal is to address how signaling pathways interact with chromatin structure to regulate and maintain the proper expression of selector genes... - The XNP remodeler targets dynamic chromatin in DrosophilaJonathan I Schneiderman
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 106:14472-7. 2009..Thus, the XNP focus appears to be a functional genetic element that can contribute to gene silencing throughout the nucleus... - Genetic factors controlling white gene expression of the transposon A(R) 4-24 at a telomere in Drosophila melanogasterM L Balasov
Institute of Cytology and Genetics, Siberian Division of Russia Academy of Sciences, Novosibirsk 630090, Russia
Genome 45:1025-34. 2002..To explain the results obtained with these modifiers, it is proposed that PEV and telomeric position effect can counteract each other at this particular cytological site... - Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in DrosophilaK Buchner
Institute of Genetics, Martin Luther University of Halle, D 06108 Halle, Germany
Genetics 155:141-57. 2000.... - Pc-G/trx-G and the SWI/SNF connection: developmental gene regulation through chromatin remodelingT C Gebuhr
Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
Genesis 26:189-97. 2000..genesis 26:189-197, 2000... - Are the same genes responsible for intra- and interspecific variability for sex comb tooth number in Drosophila?S V Nuzhdin
Section of Evolution and Ecology, University of California at Davis, Davis, CA 95616, USA
Heredity (Edinb) 84:97-102. 2000..One intraspecific QTL mapped to the same interval as the QTL for interspecific differences between D. simulans and D. mauritiana. Whether or not these effects result from the same genes requires further examination... - Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functionsJ A Eisen
Department of Biological Sciences, Stanford University, CA 94305 5020, USA
Nucleic Acids Res 23:2715-23. 1995..g. MOT1, SNF2 and BRM), maintenance of chromosome stability during mitosis (e.g... - Genetic interactions and dosage effects of Polycomb group genes of DrosophilaR B Campbell
Department of Zoology, University of British Columbia, Vancouver, Canada
Mol Gen Genet 246:291-300. 1995..Flies with increasing doses of esc+ exhibit anterior transformations, but these are not enhanced by mutations in trithorax group genes. The results are discussed with respect to current models of Pc group function... - The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complexA K Dingwall
Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5427, USA
Mol Biol Cell 6:777-91. 1995..brahma (brm), a member of the trithorax group, encodes a protein related to the yeast SWI2/SNF2 protein, a subunit of a protein .. - Mechanisms of heritable gene repression during development of DrosophilaR Paro
University of Heidelberg, Germany
Curr Opin Cell Biol 5:999-1005. 1993..Recent experiments demonstrate that, in particular, the heritable inactivation of regulatory genes relies on stable changes in the higher-order constitution of chromatin... - The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complexO Rozenblatt-Rosen
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
Proc Natl Acad Sci U S A 95:4152-7. 1998.... - Polycomb and trithorax group proteins mediate the function of a chromatin insulatorT I Gerasimova
Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Cell 92:511-21. 1998..The results suggest a model in which PcG and TrxG proteins regulate insulator function by establishing higher order domains of chromatin organization required for the assembly of functional insulators at the nuclear matrix... - Genetic analysis of the brahma gene of Drosophila melanogaster and polytene chromosome subdivisions 72ABB J Brizuela
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
Genetics 137:803-13. 1994..Two other transcripts are probably the products of a single gene whose protein products are similar to the catalytic subunits of cAMP-dependent protein kinases... - The SNF/SWI family of global transcriptional activatorsM Carlson
Department of Genetics and Development, Columbia University, New York, NY 10032
Curr Opin Cell Biol 6:396-402. 1994..SNF/SWI homologs have now been identified in Drosophila, mice and humans, suggesting a conserved role in transcriptional activation... - Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expressionV Pirrotta
Department of Zoology, University of Geneva, Switzerland
Trends Genet 13:314-8. 1997..In vivo, complexes formed at one genomic site can interact with those at other sites, suggesting that they, like heterochromatin complexes, affect the folding of chromatin and the organization of chromosomes in the nucleus... - The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene functionJ A Kennison
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2785, USA
Annu Rev Genet 29:289-303. 1995..The ZESTE protein may help to activate transcription by bringing distant cis-regulatory elements closer to promoter-bound proteins... - The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcriptionM Vazquez
Laboratory of Molecular Genetics, National Institute of Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Development 126:733-42. 1999The trithorax group gene brahma (brm) encodes the ATPase subunit of a chromatin-remodeling complex involved in homeotic gene regulation... - Molecular mechanisms of determination in DrosophilaM Bienz
MRC Laboratory of Molecular Biology, Cambridge, UK
Curr Opin Cell Biol 4:955-61. 1992..Interactions between these proteins and their target selector genes are beginning to be understood, shaping our molecular view as to how stable determination of cells is achieved... - brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2J W Tamkun
Department of Biology, University of California, Santa Cruz 95064
Cell 68:561-72. 1992The brahma (brm) gene is required for the activation of multiple homeotic genes in Drosophila... - The bromodomain: a conserved sequence found in human, Drosophila and yeast proteinsS R Haynes
Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892
Nucleic Acids Res 20:2603. 1992 - ATP-dependent remodeling and acetylation as regulators of chromatin fluidityR E Kingston
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, 02114 USA; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
Genes Dev 13:2339-52. 1999 - Rapid purification of intact minichromosomes over a glycerol cushionL Di Croce
IMT, Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Emil Mannkopff Strasse 2, D 35033 Marburg, Germany
Nucleic Acids Res 27:e11. 1999..As centrifugation through glycerol yields chromatin free of ATP and several characterized chromatin remodeling complexes, this method should be useful for structural and functional studies in vitro... - The lawc gene is a new member of the trithorax-group that affects the function of the gypsy insulator of DrosophilaI D Zorin
Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Genetics 152:1045-55. 1999..These results suggest that the lawc protein is involved in regulating the higher-order organization of chromatin... - Transcriptional regulation: SWItching circuitryP A Wade
Laboratory of Molecular Embryology, National Institute of Child Heath and Human Development, NIH, Building 18T, Room 106, Bethesda, Maryland 20892 5431, USA
Curr Biol 9:R221-4. 1999..How they do so is still mysterious, but recent studies indicate that they can be targeted to the nuclear infrastructure and to particular genes, where they cooperate with other enzymes to activate or repress transcription... - Regulatory regions of the homeotic gene proboscipedia are sensitive to chromosomal pairingA M Kapoun
Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington 47405, USA
Genetics 140:643-58. 1995..Interestingly, the intronic PS regions contain positive regulatory sequences for pb, whereas the upstream PS sites contain pb negative regulatory elements... - Sectorial gene repression in the control of developmentE Zuckerkandl
Institute of Molecular Medical Sciences, Stanford, CA 94309, USA
Gene 238:263-76. 1999.... - Repression and activation by multiprotein complexes that alter chromatin structureR E Kingston
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA
Genes Dev 10:905-20. 1996..This implies a regulation of the activity of these complexes in response to developmental cues and further implies that the work to fully understand these complexes will occupy a generation of scientists... - The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger proteinLuis Gutierrez
Departamento de Fisiologia Molecular y Genetica del Desarrollo, Instituto de Biotecnologia, UNAM, Cuernavaca, Morelos 62250, Mexico
Development 130:343-54. 2003..The trithorax group gene brahma encodes a SWI2/SNF2 family ATPase that is a catalytic subunit of the Brm chromatin-remodeling complex... - Histones, nucleosomes and transcriptionJ Svaren
Institut fur Physiologische Chemie, Universitat Munchen, Germany
Curr Opin Genet Dev 3:219-25. 1993..The mechanism of this process is just beginning to be elucidated, and genetic studies have implicated several proteins in the modulation of nucleosome structure... - High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in DrosophilaAnan Ragab
MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
Genetics 172:1069-78. 2006.... - Homeotic genes of DrosophilaG Morata
Centro de Biologia Molecular CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
Curr Opin Genet Dev 3:606-14. 1993..Comparison between Drosophila and other species suggests a common functional organization of homeotic complexes in the animal kingdom... - Chromatin multiprotein complexes involved in the maintenance of transcription patternsV Orlando
Zentrum fur Molekulare Biologie, Universitat Heidelberg, Germany
Curr Opin Genet Dev 5:174-9. 1995..The role of the trithorax-group factors is to counteract these repressed chromatin domains and thus to render the genes accessible to activating factors... - Expanding the Mot1 subfamily: 89B helicase encodes a new Drosophila melanogaster SNF2-related protein which binds to multiple sites on polytene chromosomesR Goldman-Levi
Hubert H Humphrey Center for Experimental Medicine and Cancer Research, Hebrew University Hadassah Medical School, Jerusalem, Israel
Nucleic Acids Res 24:3121-8. 1996.... - Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogasterN N Cheng
Department of Zoology, University of British Columbia, Vancouver, Canada
Genetics 138:1151-62. 1994..Based on this phenotypic analysis, we suggest that ph may perform different functions in conjunction with differing subsets of Pc group genes... - A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2J J Gildea
Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
Genetics 156:645-63. 2000..The gene has been called little imaginal discs based on the phenotype of mutant larvae. The protein encoded by the little imaginal discs gene is the Drosophila homologue of human retinoblastoma binding protein 2... - The Rb/E2F pathway: expanding roles and emerging paradigmsJ W Harbour
Division of Molecular Oncology, Washington University, St. Louis, Missouri 63110, USA
Genes Dev 14:2393-409. 2000 - Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiersF Bantignies
Vollum Institute and Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201, USA
Mol Cell Biol 20:9317-30. 2000..Our results thus implicate a second class of chromatin-associated proteins in mediating dCBP function and imply that dCBP might be involved in the regulation of higher-order chromatin structure... - Mutations in Drosophila heat shock cognate 4 are enhancers of PolycombR Mollaaghababa
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 98:3958-63. 2001..HSC4 might be needed for the proper folding of a component of the Polycomb repression complex, or it may be a functional member of that complex... - The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogasterM A Crosby
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Mol Cell Biol 19:1159-70. 1999..In vitro, MOR can bind to itself and it interacts with Brahma (BRM), an SWI2-SNF2 homolog, with which it is associated in embryonic nuclear extracts... - Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteinsF Hirose
Division of Biochemistry, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
Mol Cell Biol 21:7231-42. 2001..These deletions should be useful to identify novel targets of DREF and its positive or negative regulators... - Ectopic expression of BEAF32A in the Drosophila eye imaginal disc inhibits differentiation of photoreceptor cells and induces apoptosisM Yamaguchi
Division of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Japan
Chromosoma 110:313-21. 2001..The transgenic flies established in this study should be useful to identify targets of BEAF32A and its positive or negative regulators in Drosophila... - The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexesO Papoulas
Department of Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Development 125:3955-66. 1998The trithorax group gene brahma (brm) encodes an activator of Drosophila homeotic genes that functions as the ATPase subunit of a large protein complex... - Genetic characterization of Drosophila Mi-2 ATPaseShahryar Khattak
Department of Life Science, Kwangju Institute of Science and Technology, Kwangju, South Korea
Gene 293:107-14. 2002..The expression pattern of dMi-2 and the embryonic lethal phenotypes of mutants indicate that dMi-2 is essential for embryonic development in Drosophila melanagaster... - The complexity of chromatin remodeling and its links to cancerKristen E Neely
Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 306 Althouse Laboratory, University Park, PA 16802, USA
Biochim Biophys Acta 1603:19-29. 2002..Their subunit composition and brief overview of their functional properties will be discussed. Also, current links between human chromatin-remodeling complexes and cell growth and cancer will be presented... - Chromatin-remodeling factors: machines that regulate?P D Varga-Weisz
Marie Curie Research Institute, Oxted, Surrey, UK
Curr Opin Cell Biol 10:346-53. 1998.... - A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc developmentCédric Maurange
Zentrum für Molekulare Biologie Heidelberg ZMBH, University of Heidelberg, D 69120 Heidelberg, Germany
Genes Dev 16:2672-83. 2002.... - Remembrance of things past: maintaining gene expression patterns with altered chromatinK Hagstrom
Department of Molecular Biology, Princeton University, New Jersey 08544, USA
Curr Opin Genet Dev 7:814-21. 1997..These studies suggest that, after gene activity states are selected during development, maintenance protein complexes provide a molecular memory of those states by altering a local domain of chromatin structure... - Functions of mammalian Polycomb group and trithorax group related genesA Gould
MRC National Institute for Medical Research, London, UK
Curr Opin Genet Dev 7:488-94. 1997..Initial indications suggest the existence of a large mammalian PcG and trxG family, with a potential to encode multiple specialised functions in cell fate and cell-cycle control... - Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genesR T Collins
Skirball Institute for Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 550 First Avenue, New York, NY 10016, USA
EMBO J 18:7029-40. 1999..We show evidence that some Brahma-containing complexes do not contain Osa and that Osa is not required to localize Brahma to chromatin. These data suggest that Osa modulates the function of the Brahma complex...
Research Grants
- Regulation of Germ Cell Pluripotency Through The RNA-Binding Protein, DND1Blanche Capel; Fiscal Year: 2010..Although DND1 is specific to germ cells, we anticipate that the regulatory mechanisms involved may be common to many pluripotent stem cell populations. ..
- Quantitative genomics of sexual dimorphismSergey Nuzhdin; Fiscal Year: 2005..We expect our results to have a profound impact on our understanding of the evolution of sexual dimorphism, and the role that sexual differentiation plays in the generation of phenotypic diversity. ..
- Fourth Symposium Biology Vertebrate Sex DeterminationBlanche Capel; Fiscal Year: 2006..Understanding how critical genes in sex determining pathways evolved and how they function in lower vertebrates is expected to improve diagnosis and treatment of human disorders. ..
- Organ-specific Mechanisms of Vascular DevelopmentBlanche Capel; Fiscal Year: 2007..In addition, the molecular signals that control or repress the growth of vasculature into a tissue are of critical concern for the design of therapies in the fields of wound healing and tumor biology. ..
- Nucleotide polymorphisms responsible for expression variation in DrosophilaSergey Nuzhdin; Fiscal Year: 2007..These studies will contribute to building a pathway-minded description of complex character variation. They will shed light on the genetic architecture of transcript level variation in nature. ..
- OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATIONBlanche Capel; Fiscal Year: 2010....
- OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATIONBlanche Capel; Fiscal Year: 2009....
- ORGAN SPECIFIC MECHANISMS OF VASCULAR DEVELOPMENTBlanche Capel; Fiscal Year: 2002..Moreover, it serves as a general model of how the development of diverse vascular phenotypes is signaled and integrated with organogenesis throughout the embryo. ..
- Genetic and Molecular Studies of Drosophila Chromatin Remodeling FactorsJOHN WALTER TAMKUN; Fiscal Year: 2010..The information gained from this project will therefore be directly relevant to human health. ..
- Genetic and Molecular Studies of Drosophila Chromatin Remodeling FactorsJOHN TAMKUN; Fiscal Year: 2009..laboratory uses Drosophila melanogaster as a model system to study three different chromatin-remodeling factors: BRM, KIS-L and ISWI. We recently found that BRM and KIS-L play global roles in transcription by RNA Polymerase II...
- GENETIC/BIOCHEM STUDIES OF CHROMATIN REMODELING FACTORSJOHN TAMKUN; Fiscal Year: 2000..factors are the catalytic subunits of huge heterometric complexes (including the yeast SWI/SNF, Drosophila BRM and human BRG1/HBRM complexes) that play highly conserved roles in eukaryotic cells...
- Studies of Chromatin Remodeling FactorsJOHN TAMKUN; Fiscal Year: 2004..address these important issues, we are studying three different chromatin-remodeling factors in Drosophila: Brahma (BRM), Kismet (KIS) and Imitation-switch (ISWI)...
- Genetic and Molecular Studies of Drosophila Chromatin Remodeling FactorsJOHN TAMKUN; Fiscal Year: 2007..laboratory uses Drosophila melanogaster as a model system to study three different chromatin-remodeling factors: BRM, KIS-L and ISWI. We recently found that BRM and KIS-L play global roles in transcription by RNA Polymerase II...