brm

Summary

Gene Symbol: brm
Description: brahma
Alias: BRM, Brm, CG18438, CG5942, Dmel\CG5942, E(E2F)3A, dBRM, dSNF2, l(3)72Aa, CG5942-PA, CG5942-PB, CG5942-PC, CG5942-PD, CG5942-PE, CG5942-PF, brm-PA, brm-PB, brm-PC, brm-PD, brm-PE, brm-PF, complementation group 3.5
Species: fruit fly

Top Publications

  1. ncbi The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes
    M L Ruhf
    UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, France
    Development 128:1429-41. 2001
  2. pmc Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control
    Yuri M Moshkin
    Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 27:651-61. 2007
  3. doi Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing
    Ana Terriente-Félix
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Dev Biol 329:350-61. 2009
  4. ncbi Stabilization of chromatin structure by PRC1, a Polycomb complex
    Z Shao
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Cell 98:37-46. 1999
  5. ncbi The novel regulator of metazoan development SAYP organizes a nuclear coactivator supercomplex
    Nadezhda E Vorobyeva
    Department of Regulation of Gene Expression, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia
    Cell Cycle 8:2152-6. 2009
  6. ncbi SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation
    Nadezhda E Vorobyeva
    Russian Academy of Sciences, Moscow, Russia
    Cell Cycle 10:1821-7. 2011
  7. pmc Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes
    Lisette Mohrmann
    Gene Regulation Laboratory, Centre for Biomedical Genetics, Department of Molecular and Cell Biology, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
    Mol Cell Biol 24:3077-88. 2004
  8. pmc The Drosophila BRM complex facilitates global transcription by RNA polymerase II
    Jennifer A Armstrong
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    EMBO J 21:5245-54. 2002
  9. ncbi The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II
    Shrividhya Srinivasan
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Development 132:1623-35. 2005
  10. ncbi Shaping animal body plans in development and evolution by modulation of Hox expression patterns
    G Gellon
    Department of Biology, Yale University, New Haven, CT, USA
    Bioessays 20:116-25. 1998

Scientific Experts

  • K Hagstrom
  • Nadezhda E Vorobyeva
  • Bernardo Lemos
  • M Decoville
  • R E Kingston
  • M van Lohuizen
  • V Pirrotta
  • Sergey V Nuzhdin
  • Lindsey Mork
  • Martha Vázquez
  • Pascal Heitzler
  • Anan Ragab
  • JOHN WALTER TAMKUN
  • M L Balasov
  • Marco Milan
  • Lisa Maves
  • A Gould
  • Blanche Capel
  • Yuri M Moshkin
  • C Peter Verrijzer
  • Jennifer A Armstrong
  • Claudia B Zraly
  • Shrividhya Srinivasan
  • O Papoulas
  • Caline S Karam
  • Daniel R Marenda
  • Lisette Mohrmann
  • Scott J Nowak
  • Sara Rodriguez-Jato
  • R Deuring
  • B Ashok Reddy
  • Anabel Herr
  • O Lamiable
  • Andrew K Dingwall
  • Ana Terriente-Félix
  • Anu Tyagi
  • Jeroen A A Demmers
  • Jonathan I Schneiderman
  • R T Collins
  • Karel Bezstarosti
  • Victor G Corces
  • G Daubresse
  • Kumi Nakamura
  • Soda Balla Diop
  • Gillian E Chalkley
  • Svetlana Petruk
  • M Soledad Ivaldi
  • Wesley B Grueber
  • Davide F V Corona
  • F Hirose
  • M Yamaguchi
  • J A Kennison
  • Karin Langenberg
  • F Peronnet
  • R Mollaaghababa
  • Sabrina C Desbordes
  • Andre Moller
  • Matthew P Scott
  • M Sarte
  • Weiguo Zhang
  • Alexandra Lusser
  • Luis Gutierrez
  • T I Gerasimova
  • N B Zak
  • James A Kennison
  • L K Elfring
  • Christian Beisel
  • A Shearn
  • Stéphane Calgaro
  • Kristen E Neely
  • V Joanis
  • Cédric Maurange
  • Shahryar Khattak
  • Hitoshi Aihara
  • Mary K Baylies
  • A Matsukage
  • C J Fry
  • A Lopez
  • M L Ruhf
  • Katie Gonzalez
  • Yutaka Nibu
  • Y H Inoue
  • N Barker
  • Y Nishi
  • Winship Herr
  • S J Beek
  • R Goldman-Levi
  • J A Armstrong
  • Ana Busturia
  • Wendy A Kellner

Detail Information

Publications104 found, 100 shown here

  1. ncbi The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes
    M L Ruhf
    UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, France
    Development 128:1429-41. 2001
    ..Altogether, the data lead us to propose that domino acts as a repressor by interfering with chromatin structure. This activity is likely to be performed as a subunit of a chromatin-remodeling complex...
  2. pmc Functional differentiation of SWI/SNF remodelers in transcription and cell cycle control
    Yuri M Moshkin
    Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 27:651-61. 2007
    ..The two complexes share the same core subunits, including the BRM ATPase, but differ in a few signature subunits: OSA defines BAP, whereas Polybromo (PB) and BAP170 specify PBAP...
  3. doi Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing
    Ana Terriente-Félix
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Cantoblanco, Madrid 28049, Spain
    Dev Biol 329:350-61. 2009
    ..Other members of the BAP complex, such as Snr1, Bap55, Mor and Brm, also share these functions of Osa. We focused on the requirement of Osa during the formation of the wing veins...
  4. ncbi Stabilization of chromatin structure by PRC1, a Polycomb complex
    Z Shao
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Cell 98:37-46. 1999
    ..Several different types of repressive complexes, including deacetylases, interact with histone tails. In contrast, PRC1 was active on nucleosomal arrays formed with tailless histones...
  5. ncbi The novel regulator of metazoan development SAYP organizes a nuclear coactivator supercomplex
    Nadezhda E Vorobyeva
    Department of Regulation of Gene Expression, Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia
    Cell Cycle 8:2152-6. 2009
    ..We suggest that nuclear supercomplexes may be important means of gene-specific regulation of transcription during development...
  6. ncbi SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation
    Nadezhda E Vorobyeva
    Russian Academy of Sciences, Moscow, Russia
    Cell Cycle 10:1821-7. 2011
    ..The knockdown of SAYP leads to a decrease in the level of DHR3-activated transcription. DHR3 and SAYP interact during development and have multiple common targets across the genome...
  7. pmc Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes
    Lisette Mohrmann
    Gene Regulation Laboratory, Centre for Biomedical Genetics, Department of Molecular and Cell Biology, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
    Mol Cell Biol 24:3077-88. 2004
    ..Therefore, it was puzzling that Drosophila appeared to contain only a single SWI/SNF-type remodeler, the Brahma (BRM) complex...
  8. pmc The Drosophila BRM complex facilitates global transcription by RNA polymerase II
    Jennifer A Armstrong
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA
    EMBO J 21:5245-54. 2002
    Drosophila brahma (brm) encodes the ATPase subunit of a 2 MDa complex that is related to yeast SWI/SNF and other chromatin-remodeling complexes...
  9. ncbi The Drosophila trithorax group protein Kismet facilitates an early step in transcriptional elongation by RNA Polymerase II
    Shrividhya Srinivasan
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Development 132:1623-35. 2005
    ..By contrast, the loss of KIS-L function does not affect the binding of PC to chromatin or the recruitment of Pol II to promoters. These data suggest that KIS-L facilitates an early step in transcriptional elongation by Pol II...
  10. ncbi Shaping animal body plans in development and evolution by modulation of Hox expression patterns
    G Gellon
    Department of Biology, Yale University, New Haven, CT, USA
    Bioessays 20:116-25. 1998
    ....
  11. ncbi brahma: a regulator of Drosophila homeotic genes structurally related to the yeast transcriptional activator SNF2/SWI2
    J W Tamkun
    Department of Biology, University of California, Santa Cruz 95064
    Cell 68:561-72. 1992
    The brahma (brm) gene is required for the activation of multiple homeotic genes in Drosophila...
  12. pmc The Drosophila SNR1 (SNF5/INI1) subunit directs essential developmental functions of the Brahma chromatin remodeling complex
    Daniel R Marenda
    Department of Biology, Syracuse University, New York 13244 1270, USA
    Mol Cell Biol 23:289-305. 2003
    The Drosophila melanogaster Brahma (Brm) complex, a counterpart of the Saccharomyces cerevisiae SWI/SNF ATP-dependent chromatin remodeling complex, is important for proper development by maintaining specific gene expression patterns...
  13. pmc Identification and characterization of Drosophila relatives of the yeast transcriptional activator SNF2/SWI2
    L K Elfring
    Department of Biology, University of California, Santa Cruz 95064
    Mol Cell Biol 14:2225-34. 1994
    The Drosophila brahma (brm) gene encodes an activator of homeotic genes that is highly related to the yeast transcriptional activator SWI2 (SNF2), a potential helicase...
  14. pmc Enhancer-promoter communication mediated by Chip during Pannier-driven proneural patterning is regulated by Osa
    Pascal Heitzler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch Cedex, Strasbourg, France
    Genes Dev 17:591-6. 2003
    ..Consequently, Pannier and Chip also play an essential role during repression of proneural gene expression. Our study suggests that altering chromatin structure is essential for regulation of enhancer-promoter communication...
  15. ncbi corto genetically interacts with Pc-G and trx-G genes and maintains the anterior boundary of Ultrabithorax expression in Drosophila larvae
    A Lopez
    Equipe Developpement et Evolution, Biologie du Développement, UMR 7622 CNRS, Universite Pierre et Marie Curie, 9, quai Saint Bernard, 75252 Paris Cedex 05, France
    Mol Genet Genomics 266:572-83. 2001
    ..Our results provide evidence that corto maintains the anterior border of Ubx expression in third-instar larvae. We suggest that this regulation is accomplished through an interaction with the products of the Pc-G and trx-G genes...
  16. pmc The trithorax group gene moira encodes a brahma-associated putative chromatin-remodeling factor in Drosophila melanogaster
    M A Crosby
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell Biol 19:1159-70. 1999
    ..In vitro, MOR can bind to itself and it interacts with Brahma (BRM), an SWI2-SNF2 homolog, with which it is associated in embryonic nuclear extracts...
  17. pmc A Polycomb and GAGA dependent silencer adjoins the Fab-7 boundary in the Drosophila bithorax complex
    K Hagstrom
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Genetics 146:1365-80. 1997
    ..The iab-7 PRE silencer is contained within a 0.8-kb fragment that spans a nuclease hypersensitive site, and silencing appears to depend on the chromatin remodeling protein, the GAGA factor...
  18. pmc SNR1 (INI1/SNF5) mediates important cell growth functions of the Drosophila Brahma (SWI/SNF) chromatin remodeling complex
    Claudia B Zraly
    Oncology Institute, Cardinal Bernardin Cancer Center, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 60153, USA
    Genetics 168:199-214. 2004
    SNR1 is an essential subunit of the Drosophila Brahma (Brm) ATP-dependent chromatin remodeling complex, with counterparts in yeast (SNF5) and mammals (INI1)...
  19. ncbi Polycomb and trithorax group proteins mediate the function of a chromatin insulator
    T I Gerasimova
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Cell 92:511-21. 1998
    ..The results suggest a model in which PcG and TrxG proteins regulate insulator function by establishing higher order domains of chromatin organization required for the assembly of functional insulators at the nuclear matrix...
  20. pmc Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteins
    F Hirose
    Division of Biochemistry, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
    Mol Cell Biol 21:7231-42. 2001
    ..These deletions should be useful to identify novel targets of DREF and its positive or negative regulators...
  21. pmc The transcriptional coactivator SAYP is a trithorax group signature subunit of the PBAP chromatin remodeling complex
    Gillian E Chalkley
    Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Cell Biol 28:2920-9. 2008
    ..We conclude that SAYP is a signature subunit that plays a major role in the functional specificity of the PBAP holoenzyme...
  22. pmc Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genes
    R T Collins
    Skirball Institute for Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 550 First Avenue, New York, NY 10016, USA
    EMBO J 18:7029-40. 1999
    ..We show evidence that some Brahma-containing complexes do not contain Osa and that Osa is not required to localize Brahma to chromatin. These data suggest that Osa modulates the function of the Brahma complex...
  23. ncbi The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity
    G Daubresse
    Department of Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Development 126:1175-87. 1999
    ....
  24. ncbi The ISWI chromatin-remodeling protein is required for gene expression and the maintenance of higher order chromatin structure in vivo
    R Deuring
    Department of Biology, University of California, Santa Cruz 95064, USA
    Mol Cell 5:355-65. 2000
    ..These findings reveal novel functions for the ISWI ATPase and underscore its importance in chromatin remodeling in vivo...
  25. pmc Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila
    J A Kennison
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 85:8136-40. 1988
    ..e., Sex combs reduced (Scr), Brista (Ba), trithorax (trx), Polycomb (Pc), Polycomblike (Pcl), and Sex comb on midleg (Scm)]. Mutations in several of the additional loci identified here have also been shown to have homoeotic phenotypes...
  26. ncbi The role of brahma and related proteins in transcription and development
    J W Tamkun
    Department of Biology, University of California, Santa Cruz 95064, USA
    Curr Opin Genet Dev 5:473-7. 1995
    ....
  27. pmc The Drosophila ash1 gene product, which is localized at specific sites on polytene chromosomes, contains a SET domain and a PHD finger
    N Tripoulas
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 143:913-28. 1996
    ..The chromosomal localization of ASH1 implies that it functions at the transcriptional level to maintain the expression pattern of homeotic selector genes...
  28. ncbi Genetic characterization of Drosophila Mi-2 ATPase
    Shahryar Khattak
    Department of Life Science, Kwangju Institute of Science and Technology, Kwangju, South Korea
    Gene 293:107-14. 2002
    ..The expression pattern of dMi-2 and the embryonic lethal phenotypes of mutants indicate that dMi-2 is essential for embryonic development in Drosophila melanagaster...
  29. ncbi Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1
    Christian Beisel
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Nature 419:857-62. 2002
    ..Ash1 may serve as a binding surface for a chromatin remodelling complex containing the epigenetic activator Brahma (Brm), an ATPase, and inhibits the interaction of epigenetic repressors with chromatin...
  30. ncbi SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during development
    Claudia B Zraly
    Department of Biology, Syracuse University, Syracuse, NY 13244 1270, USA
    Dev Biol 253:291-308. 2003
    The snr1 gene of Drosophila melanogaster encodes a conserved component of the multiprotein Brahma (Brm) complex, a counterpart to the SWI/SNF complexes that participate in ATP-dependent chromatin remodeling...
  31. pmc The Drosophila brahma complex is an essential coactivator for the trithorax group protein zeste
    A J Kal
    Department of Molecular and Cell Biology, MGC, Centre for Biomedical Genetics, Leiden University Medical Centre, 2300 RA Leiden, The Netherlands
    Genes Dev 14:1058-71. 2000
    ..Reconstituted transcription reactions established that the Brahma (BRM) chromatin-remodeling complex is essential for Zeste-directed activation on nucleosomal templates...
  32. pmc Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes
    R T Collins
    Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    Genes Dev 14:3140-52. 2000
    ..These results suggest that altering the conformation of chromatin is an important mechanism by which Wingless signaling activates gene expression...
  33. ncbi Drosophila BAP60 is an essential component of the Brahma complex, required for gene activation and repression
    Andre Moller
    Abteilung Molekulare Entwicklungsbiologie, Max Planck Institut fur biophysikalische Chemie, Am Fassberg, D 37077 Gottingen, Germany
    J Mol Biol 352:329-37. 2005
    ..The results support the conclusion that BAP60 participates in site-specific recruitment of the Brahma complex in Drosophila...
  34. pmc SWI/SNF associates with nascent pre-mRNPs and regulates alternative pre-mRNA processing
    Anu Tyagi
    Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
    PLoS Genet 5:e1000470. 2009
    ..Studies in human cells suggest that Brahma (Brm), the ATPase subunit of SWI/SNF, regulates alternative pre-mRNA splicing by modulating transcription elongation ..
  35. pmc Genetic analysis of the brahma gene of Drosophila melanogaster and polytene chromosome subdivisions 72AB
    B J Brizuela
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    Genetics 137:803-13. 1994
    ..Two other transcripts are probably the products of a single gene whose protein products are similar to the catalytic subunits of cAMP-dependent protein kinases...
  36. pmc Genetic analysis of brahma: the Drosophila homolog of the yeast chromatin remodeling factor SWI2/SNF2
    L K Elfring
    Department of Biology, University of California, Santa Cruz 95064, USA
    Genetics 148:251-65. 1998
    The Drosophila brahma (brm) gene encodes an activator of homeotic genes related to the yeast chromatin remodeling factor SWI2/SNF2. Here, we report the phenotype of null and dominant-negative brm mutations...
  37. pmc ISWI regulates higher-order chromatin structure and histone H1 assembly in vivo
    Davide F V Corona
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, United States of America
    PLoS Biol 5:e232. 2007
    ..These findings suggest that ISWI plays a global role in chromatin compaction in vivo by promoting the association of the linker histone H1 with chromatin...
  38. doi Rm62, a DEAD-box RNA helicase, complexes with DSP1 in Drosophila embryos
    O Lamiable
    Centre de Biophysique Moleculaire, CNRS UPR 4301, conventionnée avec l Université d Orléans, Orleans, France
    Genesis 48:244-53. 2010
    ..We show here for the first time that an RNA helicase is involved in the maintenance of homeotic genes...
  39. pmc Transcriptional regulation of the Drosophila moira and osa genes by the DREF pathway
    Kumi Nakamura
    Department of Applied Biology and Insect Biomedical Research Center, Kyoto Institute of Technology, Matsugasaki, Sakyo ku, Kyoto 606 8585, Japan
    Nucleic Acids Res 36:3905-15. 2008
    ..in adults, which can be suppressed by half dose reduction of the osa or moira (mor) genes encoding subunits of the BRM complex. This ATP-dependent chromatin remodeling complex is known to control gene expression and the cell cycle...
  40. pmc 14-3-3 mediates histone cross-talk during transcription elongation in Drosophila
    Caline S Karam
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Genet 6:e1000975. 2010
    ..These results suggest that 14-3-3 proteins mediate cross-talk between histone phosphorylation and acetylation at a critical step in transcription elongation...
  41. pmc Akirin links twist-regulated transcription with the Brahma chromatin remodeling complex during embryogenesis
    Scott J Nowak
    Program in Developmental Biology, Sloan Kettering Institute, New York, New York, United States of America
    PLoS Genet 8:e1002547. 2012
    ....
  42. pmc Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD
    B Ashok Reddy
    Department of Biochemistry, Center for Biomedical Genetics, Erasmus University Medical Center, Rotterdam, Netherlands
    Mol Cell Biol 30:5234-44. 2010
    ..Thus, there appears to be a hierarchical relationship in which transcription factor binding precedes remodeler recruitment...
  43. pmc Drosophila melanogaster dHCF interacts with both PcG and TrxG epigenetic regulators
    Sara Rodriguez-Jato
    Center for Integrative Genomics, University of Lausanne, Genopode, Lausanne, Switzerland
    PLoS ONE 6:e27479. 2011
    ..Thus, dHCF inactivation enhances the mutant phenotypes of the Pc PcG as well as brm and mor TrxG genes, suggesting that dHCF possesses Enhancer of TrxG and PcG (ETP) properties...
  44. doi Geminin and Brahma act antagonistically to regulate EGFR-Ras-MAPK signaling in Drosophila
    Anabel Herr
    Peter MacCallum Cancer Center, Melbourne, Victoria, Australia
    Dev Biol 344:36-51. 2010
    ..In Xenopus, Geminin acts to antagonize the Brahma (Brm) chromatin-remodeling protein, Brg1, during neural differentiation...
  45. pmc Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery
    Yuri M Moshkin
    Department of Zoology and Animal Biology, University of Geneva, 1211 Geneva 4, Switzerland
    Genes Dev 16:2621-6. 2002
    ..These findings suggest that ASF1 plays a crucial role in both chromatin assembly and SWI/SNF-mediated chromatin remodelling...
  46. pmc The XNP remodeler targets dynamic chromatin in Drosophila
    Jonathan I Schneiderman
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:14472-7. 2009
    ..Thus, the XNP focus appears to be a functional genetic element that can contribute to gene silencing throughout the nucleus...
  47. pmc Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex
    Nadezhda E Vorobyeva
    Department of Regulation of Gene Expression, Institute of Gene Biology, Russian Academy of Sciences, Vavilov Street 34 5, Moscow, 119334 Russia
    Proc Natl Acad Sci U S A 106:11049-54. 2009
    ..The integrity of BTFly is crucial for its ability to activate transcription. BTFly is distributed genome-wide and appears to be a means of effective transcription activation...
  48. pmc The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus
    Stéphane Calgaro
    Centre de Biologie du Developpement, Universite Paul Sabatier, 31062 Toulouse Cedex, France
    Genetics 160:547-60. 2002
    ..polyhomeotic and (ii) they enhance the phenotypic effects of mutations in the trxG genes trithorax (trx), brahma (brm), and osa...
  49. ncbi Genomic imprinting in Drosophila is maintained by the products of Suppressor of variegation and trithorax group, but not Polycomb group, genes
    V Joanis
    Dept of Biology, Dalhousie University, 1355 Oxford St, Halifax, Nova Scotia B3H 1J4, Canada
    Mol Genet Genomics 268:103-12. 2002
    ....
  50. ncbi Genetic factors controlling white gene expression of the transposon A(R) 4-24 at a telomere in Drosophila melanogaster
    M L Balasov
    Institute of Cytology and Genetics, Siberian Division of Russia Academy of Sciences, Novosibirsk 630090, Russia
    Genome 45:1025-34. 2002
    ..To explain the results obtained with these modifiers, it is proposed that PEV and telomeric position effect can counteract each other at this particular cytological site...
  51. pmc Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II
    Shrividhya Srinivasan
    Department of Molecular, Cell, and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA, USA
    PLoS Genet 4:e1000217. 2008
    ..Our findings suggest that KIS-L promotes early elongation and counteracts Polycomb group repression by recruiting the ASH1 and TRX histone methyltransferases to chromatin...
  52. pmc A screen for genes regulating the wingless gradient in Drosophila embryos
    Sabrina C Desbordes
    Department of Genetics, University of Cambridge, UK
    Genetics 170:749-66. 2005
    ..Thus, our assay can be used effectively to screen for genes regulating Wingless distribution or transport...
  53. ncbi Projections of Drosophila multidendritic neurons in the central nervous system: links with peripheral dendrite morphology
    Wesley B Grueber
    Departments of Physiology and Biochemistry, University of California, San Francisco, Rock Hall, Room GD481, 1550 4th Street, San Francisco, CA 94143, USA
    Development 134:55-64. 2007
    ....
  54. pmc Reptin and Pontin function antagonistically with PcG and TrxG complexes to mediate Hox gene control
    Soda Balla Diop
    Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR6216 Université de la Méditerranée, Parc Scientifique de Luminy, Case 907, 13288 Marseille Cedex 9, France
    EMBO Rep 9:260-6. 2008
    ..Furthermore, the enzymatic functions of Rept and Pont are indispensable for maintaining Hox gene expression states, highlighting the importance of these two antagonistic factors in transcriptional output...
  55. pmc Phosphorylation of histone H3 at Ser10 facilitates RNA polymerase II release from promoter-proximal pausing in Drosophila
    M Soledad Ivaldi
    Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genes Dev 21:2818-31. 2007
    ..Taken together, the results introduce H3S10 phosphorylation by JIL-1 as a hallmark of early transcription elongation in Drosophila...
  56. pmc Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages
    Weiguo Zhang
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    Genetics 165:1341-54. 2003
    ..We propose that JIL-1 may exert such effects by a general regulation of chromatin structure affecting gene expression...
  57. ncbi Chromatin remodeling by ATP-dependent molecular machines
    Alexandra Lusser
    Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093 0347, USA
    Bioessays 25:1192-200. 2003
    ..In this review, we provide an overview of chromatin-remodeling enzymes and discuss two possible mechanisms by which these factors might act to reorganize nucleosome structure...
  58. ncbi Transdetermination in Drosophila imaginal discs: a model for understanding pluripotency and selector gene maintenance
    Lisa Maves
    Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403 1254, USA
    Curr Opin Genet Dev 13:472-9. 2003
    ..An important future goal is to address how signaling pathways interact with chromatin structure to regulate and maintain the proper expression of selector genes...
  59. doi Association of trxG and PcG proteins with the bxd maintenance element depends on transcriptional activity
    Svetlana Petruk
    Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 135:2383-90. 2008
    ..There is, however, no overall synergism or antagonism between and within the trxG and PcG proteins and, instead, only subsets of trxG proteins act synergistically...
  60. ncbi Osa modulates the expression of Apterous target genes in the Drosophila wing
    Marco Milan
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Mech Dev 121:491-7. 2004
    ..Osa has been shown to bind Chip. We propose that Chip recruits Osa to the Apterous target genes, thus mediating activation or repression of their expression...
  61. pmc The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins
    S R Haynes
    Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892
    Nucleic Acids Res 20:2603. 1992
  62. pmc Rapid purification of intact minichromosomes over a glycerol cushion
    L Di Croce
    IMT, Institut fur Molekularbiologie und Tumorforschung, Philipps Universitat Marburg, Emil Mannkopff Strasse 2, D 35033 Marburg, Germany
    Nucleic Acids Res 27:e11. 1999
    ..As centrifugation through glycerol yields chromatin free of ATP and several characterized chromatin remodeling complexes, this method should be useful for structural and functional studies in vitro...
  63. pmc The lawc gene is a new member of the trithorax-group that affects the function of the gypsy insulator of Drosophila
    I D Zorin
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 152:1045-55. 1999
    ..These results suggest that the lawc protein is involved in regulating the higher-order organization of chromatin...
  64. ncbi Transcriptional regulation: SWItching circuitry
    P A Wade
    Laboratory of Molecular Embryology, National Institute of Child Heath and Human Development, NIH, Building 18T, Room 106, Bethesda, Maryland 20892 5431, USA
    Curr Biol 9:R221-4. 1999
    ..How they do so is still mysterious, but recent studies indicate that they can be targeted to the nuclear infrastructure and to particular genes, where they cooperate with other enzymes to activate or repress transcription...
  65. ncbi The trithorax group gene osa encodes an ARID-domain protein that genetically interacts with the brahma chromatin-remodeling factor to regulate transcription
    M Vazquez
    Laboratory of Molecular Genetics, National Institute of Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 126:733-42. 1999
    The trithorax group gene brahma (brm) encodes the ATPase subunit of a chromatin-remodeling complex involved in homeotic gene regulation...
  66. ncbi Chromatin-silencing mechanisms in Drosophila maintain patterns of gene expression
    V Pirrotta
    Department of Zoology, University of Geneva, Switzerland
    Trends Genet 13:314-8. 1997
    ..In vivo, complexes formed at one genomic site can interact with those at other sites, suggesting that they, like heterochromatin complexes, affect the folding of chromatin and the organization of chromosomes in the nucleus...
  67. pmc The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex
    O Rozenblatt-Rosen
    Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 95:4152-7. 1998
    ....
  68. ncbi In situ dissection of the Fab-7 region of the bithorax complex into a chromatin domain boundary and a Polycomb-response element
    J Mihaly
    Department of Zoology and Animal Biology, University of Geneva, Switzerland
    Development 124:1809-20. 1997
    ....
  69. ncbi The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function
    J A Kennison
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 2785, USA
    Annu Rev Genet 29:289-303. 1995
    ..The ZESTE protein may help to activate transcription by bringing distant cis-regulatory elements closer to promoter-bound proteins...
  70. ncbi The SNF/SWI family of global transcriptional activators
    M Carlson
    Department of Genetics and Development, Columbia University, New York, NY 10032
    Curr Opin Cell Biol 6:396-402. 1994
    ..SNF/SWI homologs have now been identified in Drosophila, mice and humans, suggesting a conserved role in transcriptional activation...
  71. ncbi Mechanisms of heritable gene repression during development of Drosophila
    R Paro
    University of Heidelberg, Germany
    Curr Opin Cell Biol 5:999-1005. 1993
    ..Recent experiments demonstrate that, in particular, the heritable inactivation of regulatory genes relies on stable changes in the higher-order constitution of chromatin...
  72. ncbi Genetic interactions and dosage effects of Polycomb group genes of Drosophila
    R B Campbell
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Mol Gen Genet 246:291-300. 1995
    ..Flies with increasing doses of esc+ exhibit anterior transformations, but these are not enhanced by mutations in trithorax group genes. The results are discussed with respect to current models of Pc group function...
  73. pmc The Drosophila snr1 and brm proteins are related to yeast SWI/SNF proteins and are components of a large protein complex
    A K Dingwall
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5427, USA
    Mol Biol Cell 6:777-91. 1995
    ..brahma (brm), a member of the trithorax group, encodes a protein related to the yeast SWI2/SNF2 protein, a subunit of a protein ..
  74. pmc Regulatory regions of the homeotic gene proboscipedia are sensitive to chromosomal pairing
    A M Kapoun
    Howard Hughes Medical Institute, Department of Biology, Indiana University, Bloomington 47405, USA
    Genetics 140:643-58. 1995
    ..Interestingly, the intronic PS regions contain positive regulatory sequences for pb, whereas the upstream PS sites contain pb negative regulatory elements...
  75. ncbi Molecular mechanisms of determination in Drosophila
    M Bienz
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Opin Cell Biol 4:955-61. 1992
    ..Interactions between these proteins and their target selector genes are beginning to be understood, shaping our molecular view as to how stable determination of cells is achieved...
  76. ncbi Sectorial gene repression in the control of development
    E Zuckerkandl
    Institute of Molecular Medical Sciences, Stanford, CA 94309, USA
    Gene 238:263-76. 1999
    ....
  77. ncbi Are the same genes responsible for intra- and interspecific variability for sex comb tooth number in Drosophila?
    S V Nuzhdin
    Section of Evolution and Ecology, University of California at Davis, Davis, CA 95616, USA
    Heredity (Edinb) 84:97-102. 2000
    ..One intraspecific QTL mapped to the same interval as the QTL for interspecific differences between D. simulans and D. mauritiana. Whether or not these effects result from the same genes requires further examination...
  78. ncbi The LRR proteins capricious and Tartan mediate cell interactions during DV boundary formation in the Drosophila wing
    M Milan
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany
    Cell 106:785-94. 2001
    ....
  79. pmc The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation
    N Barker
    Department of Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    EMBO J 20:4935-43. 2001
    ..We conclude that beta-catenin recruits Brg-1 to Tcf target gene promoters, facilitating chromatin remodelling as a prerequisite for transcriptional activation...
  80. pmc Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions
    J A Eisen
    Department of Biological Sciences, Stanford University, CA 94305 5020, USA
    Nucleic Acids Res 23:2715-23. 1995
    ..g. MOT1, SNF2 and BRM), maintenance of chromosome stability during mitosis (e.g...
  81. ncbi Chromatin remodeling enzymes: who's on first?
    C J Fry
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech 2, Suite 301, Worcester, MA 01605, USA
    Curr Biol 11:R185-97. 2001
    ..Here we review recent developments concerning the role of chromatin remodeling enzymes in gene regulation, and propose several models to explain how different chromatin remodeling activities can be functionally coupled...
  82. ncbi ATP-dependent remodeling and acetylation as regulators of chromatin fluidity
    R E Kingston
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, 02114 USA Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115 USA
    Genes Dev 13:2339-52. 1999
  83. ncbi ATP-driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR/RXR In vitro
    F J Dilworth
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP College de France 67404 Cedex CU de Strasbourg, Illkirch, France
    Mol Cell 6:1049-58. 2000
    ..Thus, both ATP-driven chromatin remodeling and HAT activities act in a temporally ordered and interdependent manner to alleviate the repressive effects of nucleosomal histones on transcription by RARalpha/RXRalpha heterodimers...
  84. ncbi Pc-G/trx-G and the SWI/SNF connection: developmental gene regulation through chromatin remodeling
    T C Gebuhr
    Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Genesis 26:189-97. 2000
    ..genesis 26:189-197, 2000...
  85. pmc Genetic and molecular complexity of the position effect variegation modifier mod(mdg4) in Drosophila
    K Buchner
    Institute of Genetics, Martin Luther University of Halle, D 06108 Halle, Germany
    Genetics 155:141-57. 2000
    ....
  86. ncbi Chromatin-remodeling factors: machines that regulate?
    P D Varga-Weisz
    Marie Curie Research Institute, Oxted, Surrey, UK
    Curr Opin Cell Biol 10:346-53. 1998
    ....
  87. ncbi Homeotic genes of Drosophila
    G Morata
    Centro de Biologia Molecular CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Curr Opin Genet Dev 3:606-14. 1993
    ..Comparison between Drosophila and other species suggests a common functional organization of homeotic complexes in the animal kingdom...
  88. pmc Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogaster
    N N Cheng
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Genetics 138:1151-62. 1994
    ..Based on this phenotypic analysis, we suggest that ph may perform different functions in conjunction with differing subsets of Pc group genes...
  89. pmc Mutations in Drosophila heat shock cognate 4 are enhancers of Polycomb
    R Mollaaghababa
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 98:3958-63. 2001
    ..HSC4 might be needed for the proper folding of a component of the Polycomb repression complex, or it may be a functional member of that complex...
  90. ncbi Ectopic expression of BEAF32A in the Drosophila eye imaginal disc inhibits differentiation of photoreceptor cells and induces apoptosis
    M Yamaguchi
    Division of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Japan
    Chromosoma 110:313-21. 2001
    ..The transgenic flies established in this study should be useful to identify targets of BEAF32A and its positive or negative regulators in Drosophila...
  91. ncbi Chromatin multiprotein complexes involved in the maintenance of transcription patterns
    V Orlando
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Germany
    Curr Opin Genet Dev 5:174-9. 1995
    ..The role of the trithorax-group factors is to counteract these repressed chromatin domains and thus to render the genes accessible to activating factors...
  92. ncbi The complexity of chromatin remodeling and its links to cancer
    Kristen E Neely
    Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 306 Althouse Laboratory, University Park, PA 16802, USA
    Biochim Biophys Acta 1603:19-29. 2002
    ..Their subunit composition and brief overview of their functional properties will be discussed. Also, current links between human chromatin-remodeling complexes and cell growth and cancer will be presented...
  93. pmc A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2
    J J Gildea
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Genetics 156:645-63. 2000
    ..The gene has been called little imaginal discs based on the phenotype of mutant larvae. The protein encoded by the little imaginal discs gene is the Drosophila homologue of human retinoblastoma binding protein 2...
  94. pmc A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc development
    Cédric Maurange
    Zentrum für Molekulare Biologie Heidelberg ZMBH, University of Heidelberg, D 69120 Heidelberg, Germany
    Genes Dev 16:2672-83. 2002
    ....
  95. ncbi Histones, nucleosomes and transcription
    J Svaren
    Institut fur Physiologische Chemie, Universitat Munchen, Germany
    Curr Opin Genet Dev 3:219-25. 1993
    ..The mechanism of this process is just beginning to be elucidated, and genetic studies have implicated several proteins in the modulation of nucleosome structure...
  96. pmc Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers
    F Bantignies
    Vollum Institute and Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon 97201, USA
    Mol Cell Biol 20:9317-30. 2000
    ..Our results thus implicate a second class of chromatin-associated proteins in mediating dCBP function and imply that dCBP might be involved in the regulation of higher-order chromatin structure...
  97. ncbi Remembrance of things past: maintaining gene expression patterns with altered chromatin
    K Hagstrom
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Curr Opin Genet Dev 7:814-21. 1997
    ..These studies suggest that, after gene activity states are selected during development, maintenance protein complexes provide a molecular memory of those states by altering a local domain of chromatin structure...
  98. ncbi Functions of mammalian Polycomb group and trithorax group related genes
    A Gould
    MRC National Institute for Medical Research, London, UK
    Curr Opin Genet Dev 7:488-94. 1997
    ..Initial indications suggest the existence of a large mammalian PcG and trxG family, with a potential to encode multiple specialised functions in cell fate and cell-cycle control...
  99. pmc High mobility group proteins HMGD and HMGZ interact genetically with the Brahma chromatin remodeling complex in Drosophila
    Anan Ragab
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Genetics 172:1069-78. 2006
    ....
  100. ncbi The Drosophila trithorax group gene tonalli (tna) interacts genetically with the Brahma remodeling complex and encodes an SP-RING finger protein
    Luis Gutierrez
    Departamento de Fisiologia Molecular y Genetica del Desarrollo, Instituto de Biotecnologia, UNAM, Cuernavaca, Morelos 62250, Mexico
    Development 130:343-54. 2003
    ..The trithorax group gene brahma encodes a SWI2/SNF2 family ATPase that is a catalytic subunit of the Brm chromatin-remodeling complex...
  101. ncbi The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes
    O Papoulas
    Department of Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Development 125:3955-66. 1998
    The trithorax group gene brahma (brm) encodes an activator of Drosophila homeotic genes that functions as the ATPase subunit of a large protein complex...

Research Grants40

  1. Regulation of Germ Cell Pluripotency Through The RNA-Binding Protein, DND1
    Blanche Capel; Fiscal Year: 2010
    ..Although DND1 is specific to germ cells, we anticipate that the regulatory mechanisms involved may be common to many pluripotent stem cell populations. ..
  2. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
    ..We expect our results to have a profound impact on our understanding of the evolution of sexual dimorphism, and the role that sexual differentiation plays in the generation of phenotypic diversity. ..
  3. Fourth Symposium Biology Vertebrate Sex Determination
    Blanche Capel; Fiscal Year: 2006
    ..Understanding how critical genes in sex determining pathways evolved and how they function in lower vertebrates is expected to improve diagnosis and treatment of human disorders. ..
  4. Organ-specific Mechanisms of Vascular Development
    Blanche Capel; Fiscal Year: 2007
    ..In addition, the molecular signals that control or repress the growth of vasculature into a tissue are of critical concern for the design of therapies in the fields of wound healing and tumor biology. ..
  5. Nucleotide polymorphisms responsible for expression variation in Drosophila
    Sergey Nuzhdin; Fiscal Year: 2007
    ..These studies will contribute to building a pathway-minded description of complex character variation. They will shed light on the genetic architecture of transcript level variation in nature. ..
  6. OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATION
    Blanche Capel; Fiscal Year: 2010
    ....
  7. OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATION
    Blanche Capel; Fiscal Year: 2009
    ....
  8. ORGAN SPECIFIC MECHANISMS OF VASCULAR DEVELOPMENT
    Blanche Capel; Fiscal Year: 2002
    ..Moreover, it serves as a general model of how the development of diverse vascular phenotypes is signaled and integrated with organogenesis throughout the embryo. ..
  9. Genetic and Molecular Studies of Drosophila Chromatin Remodeling Factors
    JOHN WALTER TAMKUN; Fiscal Year: 2010
    ..The information gained from this project will therefore be directly relevant to human health. ..
  10. Genetic and Molecular Studies of Drosophila Chromatin Remodeling Factors
    JOHN TAMKUN; Fiscal Year: 2009
    ..laboratory uses Drosophila melanogaster as a model system to study three different chromatin-remodeling factors: BRM, KIS-L and ISWI. We recently found that BRM and KIS-L play global roles in transcription by RNA Polymerase II...
  11. GENETIC/BIOCHEM STUDIES OF CHROMATIN REMODELING FACTORS
    JOHN TAMKUN; Fiscal Year: 2000
    ..factors are the catalytic subunits of huge heterometric complexes (including the yeast SWI/SNF, Drosophila BRM and human BRG1/HBRM complexes) that play highly conserved roles in eukaryotic cells...
  12. Studies of Chromatin Remodeling Factors
    JOHN TAMKUN; Fiscal Year: 2004
    ..address these important issues, we are studying three different chromatin-remodeling factors in Drosophila: Brahma (BRM), Kismet (KIS) and Imitation-switch (ISWI)...
  13. Genetic and Molecular Studies of Drosophila Chromatin Remodeling Factors
    JOHN TAMKUN; Fiscal Year: 2007
    ..laboratory uses Drosophila melanogaster as a model system to study three different chromatin-remodeling factors: BRM, KIS-L and ISWI. We recently found that BRM and KIS-L play global roles in transcription by RNA Polymerase II...