Gene Symbol: Bre1
Description: Bre1
Alias: BRE1, Bre-1, CG10542, Dmel\CG10542, EC3-8, bre-1, bre1, dBRE1, dBre1, l(3)01640, Bre1, Bre1-PA, Bre1-PB, CG10542-PA, CG10542-PB, lethal (3) 01640
Species: fruit fly

Top Publications

  1. Bray S, Musisi H, Bienz M. Bre1 is required for Notch signaling and histone modification. Dev Cell. 2005;8:279-86 pubmed
    ..Here, we identify dBre1 as a nuclear component required cell autonomously for the expression of Notch target genes in Drosophila ..
  2. van der Knaap J, Kozhevnikova E, Langenberg K, Moshkin Y, Verrijzer C. Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes. Mol Cell Biol. 2010;30:736-44 pubmed publisher
    ..established a strong cooperation between GMPS and USP7, which is counteracted by the histone H2B ubiquitin ligase BRE1. Loss of either GMPS or USP7 led to increased levels of histone H2Bub in mutant animals...
  3. Mohan M, Herz H, Takahashi Y, Lin C, Lai K, Zhang Y, et al. Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom). Genes Dev. 2010;24:574-89 pubmed publisher
    ..yeast to human, specific trimethylation of H3K79 by Dot1 requires the monoubiquitination of histone H2B by the Rad6/Bre1 complex...
  4. Xuan T, Xin T, He J, Tan J, Gao Y, Feng S, et al. dBre1/dSet1-dependent pathway for histone H3K4 trimethylation has essential roles in controlling germline stem cell maintenance and germ cell differentiation in the Drosophila ovary. Dev Biol. 2013;379:167-81 pubmed publisher
    ..Here, we find that dBre1, an E3 ubiquitin ligase, functions in controlling GSC self-renewal and germ cell differentiation via distinct ..
  5. König A, Shcherbata H. Soma influences GSC progeny differentiation via the cell adhesion-mediated steroid-let-7-Wingless signaling cascade that regulates chromatin dynamics. Biol Open. 2015;4:285-300 pubmed publisher
    ..Thus, our data first show the intrinsic role for Wg signaling in the germline and support a model where the soma influences the tempo of germline differentiation in response to external conditions. ..
  6. Akan I, Love D, Harwood K, Bond M, Hanover J. Drosophila O-GlcNAcase Deletion Globally Perturbs Chromatin O-GlcNAcylation. J Biol Chem. 2016;291:9906-19 pubmed publisher
    ..Our results show that the loss of OGA in Drosophila globally impacts the epigenetic machinery allowing O-GlcNAc accumulation on RNA polymerase II and numerous chromatin factors including TRX, ASH1, and SET1. ..
  7. Kim S, Bugga L, Hong E, Zabinsky R, Edwards R, Deodhar P, et al. An RNAi-Based Candidate Screen for Modifiers of the CHD1 Chromatin Remodeler and Assembly Factor in Drosophila melanogaster. G3 (Bethesda). 2015;6:245-54 pubmed publisher
    ..Our results indicate that CHD1 may act in opposition to other remodeling factors, including INO80, and that the recruitment of CHD1 to active genes by RTF1 is conserved in flies. ..
  8. Li G, Zhou L. Genome-wide identification of chromatin transitional regions reveals diverse mechanisms defining the boundary of facultative heterochromatin. PLoS ONE. 2013;8:e67156 pubmed publisher
    ..However, boundary-associated insulator binding sites are distinctively flanked by nucleosome destabilizing sequences, which correlates with significantly decreased nucleosome density and increased binding of co-factors. ..
  9. Nannapaneni K, Ben Shahar Y, Keen H, Welsh M, Casavant T, Scheetz T. Computational identification of operon-like transcriptional loci in eukaryotes. Comput Biol Med. 2013;43:738-43 pubmed publisher
    ..elegans and some instances in Drosophila. We identify several candidate operons in Drosophila melanogaster of which two have been subsequently molecularly validated. ..

More Information


  1. Mohan M, Herz H, Smith E, Zhang Y, Jackson J, Washburn M, et al. The COMPASS family of H3K4 methylases in Drosophila. Mol Cell Biol. 2011;31:4310-8 pubmed publisher
    ..Taken together, this study provides a springboard for the functional dissection of the COMPASS family members and their role in the regulation of histone H3K4 methylation throughout development in Drosophila. ..
  2. Rao S, Janiszewski M, Duca E, Nelson B, Abhinav K, Panagakou I, et al. Invadolysin acts genetically via the SAGA complex to modulate chromosome structure. Nucleic Acids Res. 2015;43:3546-62 pubmed publisher
    ..Over-expression of the Bre1 ubiquitin ligase phenocopies the effects of mutating either the invadolysin or nonstop genes...
  3. Ben Shahar Y, Nannapaneni K, Casavant T, Scheetz T, Welsh M. Eukaryotic operon-like transcription of functionally related genes in Drosophila. Proc Natl Acad Sci U S A. 2007;104:222-7 pubmed
    ..These data reveal eukaryotic operon-like transcription of functionally related genes in Drosophila. The results also suggest that operon-based transcription may be more common in eukaryotes than previously appreciated. ..
  4. Haddad D, Vilain S, Vos M, Esposito G, Matta S, Kalscheuer V, et al. Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy. Mol Cell. 2013;50:831-43 pubmed publisher
    ..Hence, we identify RAD6A as a regulator of Parkin-dependent mitophagy and establish a critical role for RAD6A in maintaining neuronal function. ..
  5. Fereres S, Simón R, Mohd Sarip A, Verrijzer C, Busturia A. dRYBP counteracts chromatin-dependent activation and repression of transcription. PLoS ONE. 2014;9:e113255 pubmed publisher
    ..Further we show that dRYBP interacts with the repressive SCE and dKDM2 proteins as well as the activating dBRE1 protein...
  6. Bajpe P, van der Knaap J, Demmers J, Bezstarosti K, Bassett A, van Beusekom H, et al. Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack. Mol Cell Biol. 2008;28:1606-15 pubmed
    ..We conclude that the balance of TTK ubiquitylation by SINA and deubiquitylation by UBP64 constitutes a specific posttranslational switch controlling cell fate. ..
  7. Jin Z, Homola E, Goldbach P, Choi Y, Brill J, Campbell S. Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis. Development. 2005;132:4075-85 pubmed
    ..Based on these observations, we propose that Myt1 serves unique Cdk1 regulatory functions required for efficient coupling of cell differentiation with cell cycle progression. ..
  8. Demakov S, Vatolina T, Babenko V, Semeshin V, Belyaeva E, Zhimulev I. Protein composition of interband regions in polytene and cell line chromosomes of Drosophila melanogaster. BMC Genomics. 2011;12:566 pubmed publisher
    ..of proteins generally characteristic of the "open" chromatin (RNA polymerase II, CHRIZ (CHRO), BEAF-32, BRE1, dMI-2, GAF, NURF301, WDS and TRX)...