brat

Summary

Gene Symbol: brat
Description: brain tumor
Alias: BRAT, Brat, CG10719, Dmel\CG10719, E60, anon-37CDa, fs(2)ltoPM43, l(2)37Cf, l(2)E60, l(2)brat, CG10719-PA, CG10719-PB, CG10719-PC, CG10719-PE, brain tumour, brat-PA, brat-PB, brat-PC, brat-PE
Species: fruit fly

Top Publications

  1. pmc Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos
    Park F Cho
    Department of Biochemistry and McGill Cancer Center, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Curr Biol 16:2035-41. 2006
  2. ncbi The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis
    Deborah J Frank
    Division of Basic Sciences and Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Development 129:399-407. 2002
  3. ncbi The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila
    Bruno Bello
    Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 133:2639-48. 2006
  4. ncbi Mutations in the beta-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brain
    E Arama
    Department of Biology, Technion Israel Institute of Technology, Haifa
    Oncogene 19:3706-16. 2000
  5. pmc Drosophila Brain Tumor is a translational repressor
    J Sonoda
    Howard Hughes Medical Institute, Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 15:762-73. 2001
  6. pmc Pumilio binds para mRNA and requires Nanos and Brat to regulate sodium current in Drosophila motoneurons
    Nara I Muraro
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 28:2099-109. 2008
  7. pmc The mei-P26 gene encodes a RING finger B-box coiled-coil-NHL protein that regulates seizure susceptibility in Drosophilia
    Edward Glasscock
    Department of Molecular and Cell Biology, Division of Neurobiology, University of California, Berkeley, CA 94720, USA
    Genetics 170:1677-89. 2005
  8. ncbi Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    Joerg Betschinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 124:1241-53. 2006
  9. pmc klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division
    Qi Xiao
    Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Development 139:2670-80. 2012
  10. pmc Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage
    Ralph A Neumüller
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Nature 454:241-5. 2008

Research Grants

  1. Function of 3'UTRs
    MARVIN P WICKENS; Fiscal Year: 2011
  2. RNA Localization 2006
    Joel Richter; Fiscal Year: 2007
  3. TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENT
    Joel Richter; Fiscal Year: 2007
  4. CPEB and Cell Senescence
    Joel Richter; Fiscal Year: 2007
  5. CELL BIOLOGY OF DEVELOPMENT
    Joel Richter; Fiscal Year: 2007
  6. POLYADENYLATION AND TRANSLATIONAL CONTROL
    Joel Richter; Fiscal Year: 2007
  7. CLEAVAGE, POLYADENYLATION, AND TRANSPORT OF MRNA
    Marvin Wickens; Fiscal Year: 2007
  8. Function of 3' UTRs
    Marvin Wickens; Fiscal Year: 2007
  9. CPEB and Cell Senescence
    Joel D Richter; Fiscal Year: 2010
  10. POLYADENYLATION AND TRANSLATIONAL CONTROL
    Joel D Richter; Fiscal Year: 2010

Scientific Experts

  • Joel Richter
  • Cathy Slack
  • Eric A Stone
  • Hongyan Wang
  • Andreas Wodarz
  • Amy E Pasquinelli
  • MARVIN P WICKENS
  • Paul Jorgensen
  • Fergal O'Farrell
  • Edward Glasscock
  • Nara I Muraro
  • Cheng Yu Lee
  • Joerg Betschinger
  • Juergen A Knoblich
  • Michelle Beaucher
  • Sarah K Bowman
  • Rita Sousa-Nunes
  • Ralph A Neumüller
  • Yun Li
  • Steven E Justiniano
  • Qi Xiao
  • Wayne O Miles
  • Marija Mihailovic
  • Chase A Weidmann
  • Sijun Zhu
  • Robin E Harris
  • Robin P Wharton
  • Tomoko Mastushita-Sakai
  • Kai Chen Chang
  • Claudia Temme
  • William Chia
  • Viktoria Hessle
  • Nicolas Robine
  • Mitsuhiko Kurusu
  • Anja Fischer
  • Stephan Speicher
  • Cayetano Gonzalez
  • Evelyn Hersperger
  • Allen Shearn
  • Karl Mechtler
  • Park F Cho
  • S Brun
  • Chris Q Doe
  • Bruno Bello
  • Emmanuel Caussinus
  • Brian D Wilkinson
  • Thomas A Edwards
  • Aneel K Aggarwal
  • Kellie A Dean
  • Deborah J Frank
  • T R Wright
  • Jean Z Maines
  • T A Edwards
  • Guglielmo Roma
  • Laurence Wurth
  • T Lukacsovich
  • Nicholas J Dyson
  • J A Lorenzen
  • Omür Y Tastan
  • Sayan Mitra
  • Federico Zambelli
  • Jun Yuan Ji
  • Sathiya N Manivannan
  • Michael Buszczak
  • C A Callahan
  • Katrin Tschop
  • Anabel Herr
  • Irina Abaza
  • Anne Mathew
  • Dennis M McKearin
  • Francesco M Mancuso
  • Cristina Militti
  • Giulio Pavesi
  • Amanda Simcox
  • R P Wharton
  • Fátima Gebauer
  • Hideyuki Komori
  • J Sonoda
  • Aaron C Goldstrohm
  • Marija Mihailovich
  • Lily Yeh Jan
  • Yuh Nung Jan
  • Michael Pargett
  • Catherine Sutcliffe
  • Suzanne Barshow
  • Jill Wildonger
  • Hilary L Ashe
  • David Umulis
  • Lianbing Zhang
  • Chris Seidel

Detail Information

Publications60

  1. pmc Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos
    Park F Cho
    Department of Biochemistry and McGill Cancer Center, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    Curr Biol 16:2035-41. 2006
    ..requires an mRNP complex (the NRE complex), which consists of Nanos (Nos), Pumilio (Pum), and Brain tumor (Brat) proteins, and the Nos responsive element (NRE) present in the 3' UTR of hb mRNA ...
  2. ncbi The Drosophila melanogaster gene brain tumor negatively regulates cell growth and ribosomal RNA synthesis
    Deborah J Frank
    Division of Basic Sciences and Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Development 129:399-407. 2002
    ..We now indicate that the Drosophila melanogaster tumor suppressor brain tumor (brat) is an inhibitor of cell growth and is a functional homolog of the C. elegans gene ncl-1...
  3. ncbi The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila
    Bruno Bello
    Biozentrum, University of Basel, Klingelbergstrasse 50, CH 4056 Basel, Switzerland
    Development 133:2639-48. 2006
    ..in brat mutant clones promotes cell cycle exit and differentiation of brat mutant cells, thereby abrogating brain tumour formation...
  4. ncbi Mutations in the beta-propeller domain of the Drosophila brain tumor (brat) protein induce neoplasm in the larval brain
    E Arama
    Department of Biology, Technion Israel Institute of Technology, Haifa
    Oncogene 19:3706-16. 2000
    Inactivation of both alleles of the fruit fly D. melanogaster brain tumor (brat) gene results in the production of a tumor-like neoplasm in the larval brain, and lethality in the larval third instar and pupal stages...
  5. pmc Drosophila Brain Tumor is a translational repressor
    J Sonoda
    Howard Hughes Medical Institute, Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 15:762-73. 2001
    The Drosophila brain tumor (brat) gene encodes a member of the conserved NHL family of proteins, which appear to regulate differentiation and growth in a variety of organisms...
  6. pmc Pumilio binds para mRNA and requires Nanos and Brat to regulate sodium current in Drosophila motoneurons
    Nara I Muraro
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 28:2099-109. 2008
    ..the cofactor Nanos is essential for Pum-dependent para repression, whereas the requirement for Brain Tumor (Brat) is cell type specific...
  7. pmc The mei-P26 gene encodes a RING finger B-box coiled-coil-NHL protein that regulates seizure susceptibility in Drosophilia
    Edward Glasscock
    Department of Molecular and Cell Biology, Division of Neurobiology, University of California, Berkeley, CA 94720, USA
    Genetics 170:1677-89. 2005
    ..These results reveal a surprising role for mei-P26 outside of the germline as a regulator of seizure susceptibility, possibly by affecting synaptic development as a ubiquitin ligase...
  8. ncbi Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    Joerg Betschinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 124:1241-53. 2006
    ..neuroblasts-stem cell-like precursors of the adult brain-regulate proliferation by segregating the growth inhibitor Brat and the transcription factor Prospero into only one daughter cell...
  9. pmc klumpfuss distinguishes stem cells from progenitor cells during asymmetric neuroblast division
    Qi Xiao
    Department of Cell and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Development 139:2670-80. 2012
    ..These results led us to propose that multiple mechanisms converge to exert precise control of klu and distinguish a progenitor cell from its sibling stem cell during asymmetric neuroblast division...
  10. pmc Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage
    Ralph A Neumüller
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Nature 454:241-5. 2008
    ..neuroblasts segregate the Trim-NHL (tripartite motif and Ncl-1, HT2A and Lin-41 domain)-containing protein Brain tumour (Brat) into one of the two daughter cells, ovarian stem cells are regulated by an extracellular signal from the ..
  11. pmc Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation
    Claudia Temme
    Institute of Biochemistry and Biotechnology, Martin Luther University Halle Wittenberg, 06099 Halle, Germany
    RNA 16:1356-70. 2010
    ..Nocturnin may also be involved in mRNA deadenylation, whereas there is no evidence for a similar role of Angel and 3635...
  12. pmc Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains
    Sijun Zhu
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:20615-20. 2011
    ..Our findings suggest that PntP1 is both necessary and sufficient for the suppression of Ase in type II NBs and the generation of INPs in Drosophila larval brains...
  13. pmc Widespread generation of alternative UTRs contributes to sex-specific RNA binding by UNR
    Marija Mihailovic
    Gene Regulation Programme, Centre for Genomic Regulation CRG and UPF, 08003 Barcelona, Spain
    RNA 18:53-64. 2012
    ..These results suggest that UNR exploits the transcript diversity generated by alternative processing and alternative promoter usage to bind and regulate target genes in a sex-specific manner...
  14. pmc Drosophila Pumilio protein contains multiple autonomous repression domains that regulate mRNAs independently of Nanos and brain tumor
    Chase A Weidmann
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Mol Cell Biol 32:527-40. 2012
    ..Other PUF proteins lack these repression domains. Our findings suggest that PUF proteins have evolved new regulatory functions through protein sequences appended to their conserved PUF repeat RNA-binding domains...
  15. pmc Pumilio facilitates miRNA regulation of the E2F3 oncogene
    Wayne O Miles
    Massachusetts General Hospital Cancer Center, Laboratory of Molecular Oncology, Harvard Medical School, Charlestown, 02129, USA
    Genes Dev 26:356-68. 2012
    ..These studies suggest that Pumilio-miRNA repression of E2F3 translation provides an important level of E2F regulation that is frequently abrogated in cancer cells...
  16. pmc Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines
    Steven E Justiniano
    Department of Molecular Genetics, Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 7:e31417. 2012
    ..We conclude that the use of Pten mutants is a powerful means to derive new Drosophila cell lines...
  17. doi Interplay between the transcription factor Zif and aPKC regulates neuroblast polarity and self-renewal
    Kai Chen Chang
    Temasek Life Sciences Laboratory, 1 Research Link, Singapore 117604
    Dev Cell 19:778-85. 2010
    ..Thus, reciprocal repression between Zif and aPKC act as a critical regulatory mechanism for establishing cell polarity and controlling neuroblast self-renewal...
  18. pmc Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling
    Yun Li
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9148, USA
    Development 139:1547-56. 2012
    ..Loss of mei-P26 results in premature translation of the BMP antagonist Brat in germline stem cells...
  19. pmc Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover
    Tomoko Mastushita-Sakai
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Proc Natl Acad Sci U S A 107:11987-92. 2010
    ..These targets suggest that the persistent form of the memory trace might be comprised of molecules that maintain a sustained, permissive environment for synaptic growth in an activated synapse...
  20. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
    ..We have identified a novel mechanism for controlling the balance between self-renewal and neuronal differentiation during the asymmetric division of Drosophila larval NBs...
  21. ncbi Metastatic ability of Drosophila tumors depends on MMP activity
    Michelle Beaucher
    Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Dev Biol 303:625-34. 2007
    We analyzed how cells from tumors caused by mutations in either lgl or brat use matrix metalloproteinases (MMPs) to facilitate metastasis in Drosophila...
  22. pmc Polo inhibits progenitor self-renewal and regulates Numb asymmetry by phosphorylating Pon
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Nature 449:96-100. 2007
    ..Our results reveal a biochemical link between the cell cycle and the asymmetric protein localization machinery, and indicate that Polo can inhibit progenitor self-renewal by regulating the localization and function of Numb...
  23. ncbi Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase-promoting complex/cyclosome
    Cathy Slack
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 1UL, UK
    Development 134:3781-7. 2007
    ..the asymmetric localisation of the adapter protein Miranda and its associated cargo proteins Staufen, Prospero and Brat, but not other components of the asymmetric division machinery...
  24. pmc Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Genes Dev 20:3464-74. 2006
    ..We conclude that Aurora-A and Numb are novel inhibitors of neuroblast self-renewal and that spindle orientation regulates neuroblast self-renewal...
  25. ncbi Regulation of the Drosophila lin-41 homologue dappled by let-7 reveals conservation of a regulatory mechanism within the LIN-41 subclade
    Fergal O'Farrell
    Department of Natural Sciences, Södertörns högskola, Huddinge, Sweden
    Dev Dyn 237:196-208. 2008
    ..A cell-based assay verified let-7 miRNA down-regulation of dpld expression by means of its 3'-untranslated region. Thus, dpld seems also to be miRNA regulated, suggesting that miRNAs represent an ancient mechanism of LIN-41 regulation...
  26. pmc A broadly conserved pathway generates 3'UTR-directed primary piRNAs
    Nicolas Robine
    Department of Developmental Biology, Sloan Kettering Institute, New York, NY 10065, USA
    Curr Biol 19:2066-76. 2009
    ..Certain stages of mammalian testis also accumulate abundant piRNAs of unknown function, which derive from noncoding RNAs that are depleted in transposable element content and do not engage in ping-pong...
  27. pmc The tumor suppressors Brat and Numb regulate transit-amplifying neuroblast lineages in Drosophila
    Sarah K Bowman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Dev Cell 14:535-46. 2008
    ..PAN neuroblasts rely on the segregating determinants Numb and Brat to generate smaller, secondary neuroblasts that in turn give rise to ganglion mother cells (GMCs) and neurons ..
  28. doi The PDZ protein Canoe regulates the asymmetric division of Drosophila neuroblasts and muscle progenitors
    Stephan Speicher
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas University Miguel Hernandez, Sant Joan d Alacant, 03550 Alicante, Spain
    Curr Biol 18:831-7. 2008
    ....
  29. doi A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain
    Mitsuhiko Kurusu
    Structural Biology Center, National Institute of Genetics, and Department of Genetics, The Graduate University for Advanced Studies, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Dev Biol 326:224-36. 2009
    ..These results as a whole uncover a distinct regulatory mechanism of self-renewal and differentiation of the MB progenitors that is different from the mechanisms found in other progenitors...
  30. pmc Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signaling
    Robin E Harris
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Dev Cell 20:72-83. 2011
    ..Here, we identify Brain Tumor (Brat) as a potent differentiation factor and target of Pum-Nos regulation...
  31. pmc Modulated modularity clustering as an exploratory tool for functional genomic inference
    Eric A Stone
    Department of Statistics, North Carolina State University, Raleigh, NC, USA
    PLoS Genet 5:e1000479. 2009
    ..We show MMC to be effective and suitable to applications of large scale. In light of these features, we advocate MMC as a standard tool for exploration and hypothesis generation...
  32. pmc The exosome associates cotranscriptionally with the nascent pre-mRNP through interactions with heterogeneous nuclear ribonucleoproteins
    Viktoria Hessle
    Department of Molecular Biology and Functional Genomics, Stockholm University, SE 10691 Stockholm, Sweden
    Mol Biol Cell 20:3459-70. 2009
    ..Our results lead to a revised mechanistic model for cotranscriptional quality control in which the exosome is constantly recruited to newly synthesized RNAs through direct interactions with specific hnRNP proteins...
  33. pmc Protein phosphatase 4 mediates localization of the Miranda complex during Drosophila neuroblast asymmetric divisions
    Rita Sousa-Nunes
    Department of Biological Sciences, Temasek Life Sciences Laboratory, National University of Singapore, Singapore
    Genes Dev 23:359-72. 2009
    ..Our findings suggest that Flfl may target PP4 to the MIra protein complex to facilitate dephosphorylation step(s) crucial for its cortical association/asymmetric localization...
  34. pmc Drosophila brain tumor metastases express both neuronal and glial cell type markers
    Michelle Beaucher
    Department of Biology, The Johns Hopkins University, Baltimore, MD 21218, USA
    Dev Biol 301:287-97. 2007
    Loss of either lgl or brat gene activity in Drosophila larvae causes neoplastic brain tumors. Fragments of tumorous brains from either mutant transplanted into adult hosts over-proliferate, and kill their hosts within 2 weeks...
  35. ncbi Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes
    E Woodhouse
    Department of Biology, The Johns Hopkins University, Baltimore, Maryland 21218, USA
    Dev Genes Evol 207:542-50. 1998
    ....
  36. ncbi derailed is required for muscle attachment site selection in Drosophila
    C A Callahan
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, San Diego, CA 92186, USA
    Development 122:2761-7. 1996
    ..The data suggest that both neurons and muscles use common mechanisms to recognize their paths or targets, and that Drl plays an analogous role in both developing systems...
  37. ncbi The Wilhelmine E. Key 1992 Invitational lecture. Phenotypic analysis of the Dopa decarboxylase gene cluster mutants in Drosophila melanogaster
    T R Wright
    University of Virginia, Department of Biology, Charlottesville 22903 2477, USA
    J Hered 87:175-90. 1996
    ..Thus, the Ddc gene cluster represents in higher eukaryotes an unusual example of a large cluster of functionally related genes involved in a common physiological process...
  38. pmc The genetic and molecular organization of the Dopa decarboxylase gene cluster of Drosophila melanogaster
    D G Stathakis
    Department of Biology, University of Virginia, Charlottesville 22903 2477, USA
    Genetics 141:629-55. 1995
    ....
  39. ncbi Effects of Ddc cluster lethal alleles on ovary growth, attachment, and egg production in Drosophila
    E McCrady
    Department of Biology, University of North Carolina at Greensboro 27412
    J Exp Zool 268:469-76. 1994
    ..Heteroallelic heterozygotes of Bd7 x Bd4 also produced fully fertile ovaries, but no other heteroallelic combinations did so.(ABSTRACT TRUNCATED AT 250 WORDS)..
  40. ncbi Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member
    C A Callahan
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, California 92186, USA
    Nature 376:171-4. 1995
    ..In drl mutant embryos these neurons fail to make the correct pathway choices. Our results provide evidence for receptor protein-tyrosine kinase involvement in key aspects of neuronal pathway recognition...
  41. ncbi The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 region
    T R Wright
    Chromosoma 83:45-58. 1981
    ..It eliminates Ddc+ and 1(2)37Ca+ function and at 30 degrees C reduces 1(2)37Ce+ function. It is not a deficiency but could be a polar mutant...
  42. pmc Molecular mapping of a gene cluster flanking the Drosophila Dopa decarboxylase gene
    D Gilbert
    Genetics 106:679-94. 1984
    ..Six of these complementation groups are within 23 kb of DNA, and all ten complementation groups, including Ddc, lie within 78-82 kb of DNA. The potential significance of this unusually high gene density is discussed...
  43. pmc A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in Drosophila. II. Molecular localization of the Dox-A2 coding region
    E S Pentz
    Genetics 112:843-59. 1986
    ..The Dox-A2 locus is within 3.4 to 4.4 kb of the Df(2L)OD15 breakpoint, placing four of the vital loci within a maximum of 15.5 kb. The location of Dox-A2 in a cluster of genes affecting cuticle formation is discussed...
  44. ncbi Tumor-suppressor genes of Drosophila melanogaster
    E Gateff
    Institute of Genetics, Johannes Gutenberg University, Mainz, West Germany
    Crit Rev Oncog 1:221-45. 1989
  45. ncbi The fruit fly Drosophila and the fish Xiphophorus as model systems for cancer studies
    B Mechler
    Department of Development Genetics, Deutsches Krebsforschungszentrum, German Cancer Research Center, Heidelberg
    Cancer Surv 9:505-27. 1990
    ..This gene encodes a receptor tyrosine kinase related to the EGF-receptor, and its activation and overexpression are thought to play a critical part in melanoma formation...
  46. pmc Dual-tagging gene trap of novel genes in Drosophila melanogaster
    T Lukacsovich
    School of Human Sciences and Advanced Research Institute for Science and Engineering, Waseda University, Saitama 359 1192, Japan
    Genetics 157:727-42. 2001
    ....
  47. ncbi Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin
    J A Lorenzen
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Development 128:1403-14. 2001
    ..Mutations in the Drosophila Importin beta homolog Ketel, also reduce the nuclear localization of activated D-ERK. Together, these data indicate that DIM-7 and Ketel are components of the nuclear import machinery for activated D-ERK...
  48. ncbi Structure of Pumilio reveals similarity between RNA and peptide binding motifs
    T A Edwards
    Structural Biology Program, Department of Physiology and Biophysics, Mount Sinai School of Medicine, Box 1677, 1425 Madison Avenue, New York, NY 10029, USA
    Cell 105:281-9. 2001
    ..This analysis suggests that similar features in helical repeat proteins are used to bind extended peptides and RNA...
  49. ncbi The Drosophila NuMA Homolog Mud regulates spindle orientation in asymmetric cell division
    Sarah K Bowman
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Dev Cell 10:731-42. 2006
    ..This can lead to symmetric segregation of the cell fate determinants Brat and Prospero, resulting in the mis-specification of daughter cell fates and tumor-like over proliferation in the ..
  50. ncbi Connecting cancer to the asymmetric division of stem cells
    Andreas Wodarz
    Department of Stem Cell Biology, DFG Research Center for Molecular Physiology of the Brain CMPB, University of Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Cell 124:1121-3. 2006
    ..one in this issue of Cell and the other in Developmental Cell show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell...
  51. ncbi Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Dev Cell 10:441-9. 2006
    ..Here, we report that the Brain tumor (Brat) translation repressor is partitioned into GMCs via direct interaction with the Miranda scaffolding protein...
  52. ncbi The myb-related gene stonewall induces both hyperplasia and cell death in Drosophila: rescue of fly lethality by coexpression of apoptosis inducers
    S Brun
    Laboratoire de Genetique et Biologie Cellulaire, CNRS MR 8159, Universite de Versailles St Quentin en Yvelines, 45 Avenue des Etats Unis, F 78035 Versailles cedex, France
    Cell Death Differ 13:1752-62. 2006
    ..Our results suggest that stwl(UY823) kills flies by causing inappropriate cell cycle entry, and that triggering the death of these overproliferating cells or slowing their proliferation restores viability...
  53. ncbi Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
    Emmanuel Caussinus
    Cell Biology and Biophysics Program, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nat Genet 37:1125-9. 2005
    ....
  54. ncbi How cells coordinate growth and division
    Paul Jorgensen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto ON, Canada M5S 1A8
    Curr Biol 14:R1014-27. 2004
    ..Recently, genetic screens in Drosophila and functional genomics approaches in yeast have macheted into the thicket of cell size control...
  55. pmc Model of the brain tumor-Pumilio translation repressor complex
    Thomas A Edwards
    Department of Physiology and Biophysics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genes Dev 17:2508-13. 2003
    The Brain Tumor (Brat) protein is recruited to the 3' untranslated region (UTR) of hunchback mRNA to regulate its translation...
  56. ncbi Translational repressors in Drosophila
    Kellie A Dean
    Howard Hughes Medical Institute, Dept of Molecular Genetics and Microbiology, Box 3657, Duke University Medical Center, Durham, NC 27710, USA
    Trends Genet 18:572-7. 2002
    ..These repressors do not work in isolation - each binds multiple sites in the appropriate mRNA, and the resulting RNA-protein complexes appear to recruit co-repressors by a variety of mechanisms...
  57. ncbi Control of developmental timing by micrornas and their targets
    Amy E Pasquinelli
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Cell Dev Biol 18:495-513. 2002
    ..Instead of inventing new gene functions, even subtle changes in temporal expression of pre-existing control genes can result in speciation by altering the time at which they function...
  58. ncbi A PUF family portrait: 3'UTR regulation as a way of life
    Marvin Wickens
    Dept of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Trends Genet 18:150-7. 2002
    ..Here, we discuss the evolution, biological function and mechanisms of action of the PUF protein family, and suggest that a primordial function of PUF proteins is to sustain mitotic proliferation of stem cells...
  59. ncbi Development. The message is in the translation
    J D Richter
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 293:60-2. 2001
  60. pmc The genetics of dopa decarboxylase in Drosophila melanogaster. II. Isolation and characterization of dopa-decarboxylase-deficient mutants and their relationship to the alpha-methyl-dopa-hypersensitive mutants
    T R Wright
    Genetics 84:287-310. 1976
    ..Although no biochemical phene has yet been established for the alphaMD hypersensitive amd alleles, it seems likely that the two groups of mutants are functionally related...

Research Grants47

  1. Function of 3'UTRs
    MARVIN P WICKENS; Fiscal Year: 2011
    ..These proteins control stem cells and participate in the formation of memory. Understanding how they work should provide practical opportunities for intervention. ..
  2. RNA Localization 2006
    Joel Richter; Fiscal Year: 2007
    ..The cross-disciplinary nature of this meeting will be attractive to molecular, cellular, developmental, and neurobiological scientists. ..
  3. TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENT
    Joel Richter; Fiscal Year: 2007
    ..The importance of CPEB3 for oocytedevelopment will be assessed. The proposed experiments will examine the molecular basis of oocyte development, and thus are relevant to human health especially human reproduction. ..
  4. CPEB and Cell Senescence
    Joel Richter; Fiscal Year: 2007
    ..This proposal focuses on new molecules that regulate cell senescence. Because this process is strongly linked to cancer and ageing, it clearly has important implications for human health. ..
  5. CELL BIOLOGY OF DEVELOPMENT
    Joel Richter; Fiscal Year: 2007
    ....
  6. POLYADENYLATION AND TRANSLATIONAL CONTROL
    Joel Richter; Fiscal Year: 2007
    ..Therefore, mechanistic studies of polyadenylation-induced translation are likely to have important implications for human health. ..
  7. CLEAVAGE, POLYADENYLATION, AND TRANSPORT OF MRNA
    Marvin Wickens; Fiscal Year: 2007
    ..In focusing sharply on a few specific examples, we hope to illuminate the broad molecular questions of how 3'UTR controls function, evolve, and coordinate exoression of multiole mRNAs. ..
  8. Function of 3' UTRs
    Marvin Wickens; Fiscal Year: 2007
    ..We focus sharply on PUF proteins to illuminate broadly how 3'UTR controls function, evolve, and coordinate expression of multiple mRNAs. ..
  9. CPEB and Cell Senescence
    Joel D Richter; Fiscal Year: 2010
    ..This proposal focuses on new molecules that regulate cell senescence. Because this process is strongly linked to cancer and ageing, it clearly has important implications for human health. ..
  10. POLYADENYLATION AND TRANSLATIONAL CONTROL
    Joel D Richter; Fiscal Year: 2010
    ..In particular, we will examine RNA processing and translational control. Because of the fundamental nature of this work, it has important implications for fertility, neurodegeneration, and cancer. ..
  11. Function of 3'UTRs
    MARVIN P WICKENS; Fiscal Year: 2010
    ..These proteins control stem cells and participate in the formation of memory. Understanding how they work should provide practical opportunities for intervention. ..
  12. POLYADENYLATION AND TRANSLATIONAL CONTROL
    Joel Richter; Fiscal Year: 2009
    ..Finally, an upstream event that is necessary for CPEB-mediated polyadenylation is the translational activation of RINGO/Spy mRNA, which encodes an atypical cyclin B1-like protein. Pumilio is the ..
  13. CPEB and Cell Senescence
    Joel Richter; Fiscal Year: 2009
    ..This proposal focuses on new molecules that regulate cell senescence. Because this process is strongly linked to cancer and ageing, it clearly has important implications for human health. ..
  14. POLYADENYLATION AND TRANSLATIONAL CONTROL
    Joel Richter; Fiscal Year: 2009
    ..In particular, we will examine RNA processing and translational control. Because of the fundamental nature of this work, it has important implications for fertility, neurodegeneration, and cancer. ..
  15. POLYADENYLATION AND TRANSLATIONAL CONTROL
    Joel Richter; Fiscal Year: 1999
    ....
  16. POLYADENYLATION AND TRANSLATIONAL CONTROL
    Joel Richter; Fiscal Year: 2003
    ..The mechanism responsible for, and the biological significance of, this localization will be investigated. ..
  17. FUNCTION OF 3 UTRS
    Marvin Wickens; Fiscal Year: 2002
    ..Our detailed investigations of the regulation of c-mos, a proto-oncogene normally expressed only in the germ line, bear on how cell division is controlled both in normal and abnormal growth. ..
  18. TRANSLATIONAL CONTROL IN EARLY MAMMALIAN DEVELOPMENT
    Joel Richter; Fiscal Year: 2001
    ..Finally, an mRNA that is deadenylated and stored in a dormant form in mouse oocytes undergoes prior CPE-mediated deadenylation. The possible role of mCPEB in the process will be assessed. ..