Gene Symbol: br
Description: broad
Alias: 2B5, 2Bc, A18, BR-C, BR-C Z1, BR-Z1, BR-Z2, BR-Z3, BR-Z4, BR-c, BRC, BRC-Z1, BRC-Z2, BRC-Z3, BRC-Z4, BR_C, Br-C, Br-C Z2, Br-C-Z3, Br-Z4, BrC, BrC-Z1, BrZ3, CG11491, CG11509, CG11511, CG11514, Dmel\CG11491, Dmel_CG11509, EG:123F11.1, EG:17A9.1, EG:25D2.1, PP1, PP2, br-C, br-Z1, br-Z2, br-Z3, br-Z4, de12, ecs, l(1)2Ba, l(1)2Bab, l(1)2Bad, l(1)2Bb, l(1)2Bc, l(1)2Bd, l(1)ESHS5, l(1)G0018, l(1)G0042, l(1)G0284, l(1)G0284a, l(1)G0318, l(1)G0401, l(1)PP1, l(1)d norm-12, l(1)d.norm.1, l(1)dn1, l(1)n34, l(1)npr-1, l(1)npr1, l(1)pp-1, l(1)pp-2, l(1)pp1, l(1)pp2, l(1)ts132, l(1)ts144, l(1)ts358, l(1)ts376, npr, npr-1, npr1, nprl, nrp, nrp1, rbp, rdp, rds, broad, Br-C, CG11491-PA, CG11491-PB, CG11491-PC, CG11491-PE, CG11491-PG, CG11491-PH, CG11491-PI, CG11491-PJ, CG11491-PL, CG11491-PM, CG11491-PN, CG11491-PO, CG11491-PP, CG11491-PQ, br-PA, br-PB, br-PC, br-PE, br-PG, br-PH, br-PI, br-PJ, br-PL, br-PM, br-PN, br-PO, br-PP, br-PQ, broad complex, broad-complex, ecdysone-sensitivity, lethal(1)2Bab, lethal(1)2Bc, lethal(1)2Bd, lethal(1)discs normal, lethal(1)non-pupariating-1, non-pupariating, non-pupariating-1, overlapping-complementation-complex, reduced bristles on palps, reduced palps, unequal wings
Species: fruit fly
Products:     br

Top Publications

  1. Schubiger M, Truman J. The RXR ortholog USP suppresses early metamorphic processes in Drosophila in the absence of ecdysteroids. Development. 2000;127:1151-9 pubmed 20E, but other genes that are normally expressed later, such as (&bgr;)-Ftz-F1 and the Z1 isoform of the Broad-Complex (BRC-Z1), are expressed precociously...
  2. Schubiger M, Carré C, Antoniewski C, Truman J. Ligand-dependent de-repression via EcR/USP acts as a gate to coordinate the differentiation of sensory neurons in the Drosophila wing. Development. 2005;132:5239-48 pubmed
    ..the wing margin, the block is at the level of senseless expression and is indirect, via the repressive control of broad expression...
  3. Boyle M, Berg C. Control in time and space: Tramtrack69 cooperates with Notch and Ecdysone to repress ectopic fate and shape changes during Drosophila egg chamber maturation. Development. 2009;136:4187-97 pubmed publisher
    ..We hypothesize that TTK69 then cooperates with spatially restricted co-factors to define appropriate responses to a globally available (but as yet unidentified) temporal signal that initiates the S10B transformations. ..
  4. Bashirullah A, Lam G, Yin V, Thummel C. dTrf2 is required for transcriptional and developmental responses to ecdysone during Drosophila metamorphosis. Dev Dyn. 2007;236:3173-9 pubmed
    ..The transcription of key ecdysone-regulated target genes is delayed and reduced in dTrf2 mutants. dTrf2 appears to be required for the proper timing and levels of ecdysone-regulated gene expression required for entry into metamorphosis. ..
  5. DiBello P, Withers D, Bayer C, Fristrom J, Guild G. The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers. Genetics. 1991;129:385-97 pubmed
    The Broad-Complex (BR-C) is essential for metamorphosis in Drosophila melanogaster...
  6. Francis V, Zorzano A, Teleman A. dDOR is an EcR coactivator that forms a feed-forward loop connecting insulin and ecdysone signaling. Curr Biol. 2010;20:1799-808 pubmed publisher
    ..Furthermore, because ecdysone signaling inhibits insulin signaling in the fat body, this also uncovers a feed-forward mechanism whereby ecdysone potentiates its own signaling via dDOR. ..
  7. Dalton J, Lebo M, Sanders L, Sun F, Arbeitman M. Ecdysone receptor acts in fruitless- expressing neurons to mediate drosophila courtship behaviors. Curr Biol. 2009;19:1447-52 pubmed publisher
    ..Thus, EcR-A is required in fru P1-expressing neurons for wild-type male courtship behaviors and the establishment of male-specific neuronal architecture. ..
  8. Chen G, Gajowniczek P, Settleman J. Rho-LIM kinase signaling regulates ecdysone-induced gene expression and morphogenesis during Drosophila metamorphosis. Curr Biol. 2004;14:309-13 pubmed
    ..ecdysone-responsive genes, including those encoding the ecdysone receptor itself, a downstream transcription factor (Br-C), and Stubble, a transmembrane protease required for proper leg formation...
  9. Deng W, Bownes M. Two signalling pathways specify localised expression of the Broad-Complex in Drosophila eggshell patterning and morphogenesis. Development. 1997;124:4639-47 pubmed
    ..We show that the Broad-Complex, a gene encoding zinc-finger transcription factors, is essential for the morphogenesis of dorsal ..

More Information


  1. Beckstead R, Ortiz J, Sanchez C, Prokopenko S, Chambon P, Losson R, et al. Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription. Mol Cell. 2001;7:753-65 pubmed
    ..Bon binds via an LxxLL motif to the AF-2 activation domain present in the ligand binding domain of betaFTZ-F1 and behaves as a transcriptional inhibitor in vivo. ..
  2. French R, Cosand K, Berg C. The Drosophila female sterile mutation twin peaks is a novel allele of tramtrack and reveals a requirement for Ttk69 in epithelial morphogenesis. Dev Biol. 2003;253:18-35 pubmed
    ..We hypothesize that loss of Ttk69 in all follicle cells disrupts chorion gene expression and lack of function in dorsal anterior follicle cells inhibits morphogenetic changes required for elongating the dorsal appendages. ..
  3. Li T, Bender M. A conditional rescue system reveals essential functions for the ecdysone receptor (EcR) gene during molting and metamorphosis in Drosophila. Development. 2000;127:2897-905 pubmed
    ..These results show that EcR mediates ecdysone signaling at multiple developmental stages and implicate EcR in the reorganization of imaginal and larval tissues at the onset of metamorphosis. ..
  4. McBrayer Z, Ono H, Shimell M, Parvy J, Beckstead R, Warren J, et al. Prothoracicotropic hormone regulates developmental timing and body size in Drosophila. Dev Cell. 2007;13:857-71 pubmed
    ..These results indicate that final body size in insects is determined by a balance between growth-rate regulators such as insulin and developmental timing cues such as PTTH that set the duration of the feeding interval. ..
  5. Minakuchi C, Zhou X, Riddiford L. Krüppel homolog 1 (Kr-h1) mediates juvenile hormone action during metamorphosis of Drosophila melanogaster. Mech Dev. 2008;125:91-105 pubmed the abdomen of Drosophila melanogaster due to its prolongation of expression of the transcription factor Broad (BR)...
  6. Bayer C, von Kalm L, Fristrom J. Relationships between protein isoforms and genetic functions demonstrate functional redundancy at the Broad-Complex during Drosophila metamorphosis. Dev Biol. 1997;187:267-82 pubmed
    ..The Broad-Complex (BR-C) early gene, which acts as a global regulator of tissue-specific responses to ecdysone, encodes a ..
  7. Sedkov Y, Cho E, Petruk S, Cherbas L, Smith S, Jones R, et al. Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila. Nature. 2003;426:78-83 pubmed
    ..TRR, EcR and trimethylated H3-K4 are detected at the ecdysone-inducible promoters of hh and BR-C in cultured cells, and H3-K4 trimethylation at these promoters is decreased in embryos lacking a functional copy ..
  8. Lembong J, Yakoby N, Shvartsman S. Pattern formation by dynamically interacting network motifs. Proc Natl Acad Sci U S A. 2009;106:3213-8 pubmed publisher
    ..accounts for the dynamic interaction of the feedforward and feedback network motifs that control the expression of Broad, a zinc finger transcription factor expressed in the cells that form the upper part of the respiratory eggshell ..
  9. Bialecki M, Shilton A, Fichtenberg C, Segraves W, Thummel C. Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila. Dev Cell. 2002;3:209-20 pubmed
    ..We propose that ecdysteroid-induced E75A expression defines a feed-forward pathway that amplifies or maintains the ecdysteroid titer during larval development, ensuring proper temporal progression through the life cycle. ..
  10. Brennan C, Li T, Bender M, Hsiung F, Moses K. Broad-complex, but not ecdysone receptor, is required for progression of the morphogenetic furrow in the Drosophila eye. Development. 2001;128:1-11 pubmed
    ..There is a switch from Broad complex Z2 to Z1 zinc-finger isoform expression at the furrow which requires Z2 expression and responds to Hedgehog ..
  11. Lehmann M. Drosophila Sgs genes: stage and tissue specificity of hormone responsiveness. Bioessays. 1996;18:47-54 pubmed
    ..g. secretion enhancer binding proteins, which act together in a synergistic manner with the 20E receptor and early gene products to establish a stage- and tissue-specific expression pattern. ..
  12. Fuchs A, Cheung L, Charbonnier E, Shvartsman S, Pyrowolakis G. Transcriptional interpretation of the EGF receptor signaling gradient. Proc Natl Acad Sci U S A. 2012;109:1572-7 pubmed publisher
    ..We report the regulatory elements of broad (br) and pipe (pip), two important targets of EGFR signaling in Drosophila oogenesis...
  13. Johnston D, Sedkov Y, Petruk S, Riley K, Fujioka M, Jaynes J, et al. Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development. Mol Cell. 2011;44:51-61 pubmed publisher
    ..These results suggest a mechanism for sequential modulation of gene expression during development by competing nuclear receptors and their effector molecules, ecdysone and NO. ..
  14. Hall B, Thummel C. The RXR homolog ultraspiracle is an essential component of the Drosophila ecdysone receptor. Development. 1998;125:4709-17 pubmed
  15. Lee C, Baehrecke E. Steroid regulation of autophagic programmed cell death during development. Development. 2001;128:1443-55 pubmed
    ..The steroid-regulated BR-C, E74A and E93 genes are required for salivary gland cell death...
  16. Zhou X, Zhou B, Truman J, Riddiford L. Overexpression of broad: a new insight into its role in the Drosophila prothoracic gland cells. J Exp Biol. 2004;207:1151-61 pubmed
    Insect molting is triggered by ecdysteroids, which are produced in the prothoracic glands (PG). The broad (br) gene is one of the 'early genes' directly regulated by ecdysteroids...
  17. Chao A, Guild G. Molecular analysis of the ecdysterone-inducible 2B5 "early' puff in Drosophila melanogaster. EMBO J. 1986;5:143-50 pubmed
    The 2B5 region of the X-chromosome in Drosophila melanogaster plays a developmentally important role in the ecdysterone-triggered response of the late third instar salivary gland...
  18. Ward E, Zhou X, Riddiford L, Berg C, Ruohola Baker H. Border of Notch activity establishes a boundary between the two dorsal appendage tube cell types. Dev Biol. 2006;297:461-70 pubmed
    ..Notch signaling establishes the boundary between two types of post-mitotic epithelial cells, the Rhomboid- and the Broad-positive cells...
  19. Huang J, Tian L, Peng C, Abdou M, Wen D, Wang Y, et al. DPP-mediated TGFbeta signaling regulates juvenile hormone biosynthesis by activating the expression of juvenile hormone acid methyltransferase. Development. 2011;138:2283-91 pubmed publisher
    ..A Drosophila genetic screen identified that Tkv and Mad are required for JH-mediated suppression of broad (br) expression in young larvae...
  20. Baehrecke E. Steroid regulation of programmed cell death during Drosophila development. Cell Death Differ. 2000;7:1057-62 pubmed
    ..This article reviews the current knowledge of steroid signaling and the regulation of programmed cell death during development of Drosophila. ..
  21. Dubrovsky E, Dubrovskaya V, Berger E. Hormonal regulation and functional role of Drosophila E75A orphan nuclear receptor in the juvenile hormone signaling pathway. Dev Biol. 2004;268:258-70 pubmed
    ..Finally, in the presence of JH, E75A can repress ecdysone activation of early genes including Broad-Complex. Based on these data, we propose a model for the role of E75A in the ecdysone-JH regulatory interplay.
  22. Zhou X, Riddiford L. Broad specifies pupal development and mediates the 'status quo' action of juvenile hormone on the pupal-adult transformation in Drosophila and Manduca. Development. 2002;129:2259-69 pubmed
    ..In both Manduca and Drosophila, the broad (br) gene is expressed in the epidermis during the formation of the pupa, but not during adult differentiation...
  23. Boisclair Lachance J, Fregoso Lomas M, Eleiche A, Bouchard Kerr P, Nilson L. Graded Egfr activity patterns the Drosophila eggshell independently of autocrine feedback. Development. 2009;136:2893-902 pubmed publisher
  24. Zhou B, Williams D, Altman J, Riddiford L, Truman J. Temporal patterns of broad isoform expression during the development of neuronal lineages in Drosophila. Neural Dev. 2009;4:39 pubmed publisher
    ..These latter, 'secondary' neurons show a complex pattern of expression of broad, which encodes a transcription factor usually associated with metamorphosis, where it acts as a key regulator in ..
  25. Peri F, Roth S. Combined activities of Gurken and decapentaplegic specify dorsal chorion structures of the Drosophila egg. Development. 2000;127:841-50 pubmed
    ..a posterior ring of dorsal appendage material that is produced by main-body follicle cells expressing the gene Broad-Complex...
  26. Ables E, Drummond Barbosa D. The steroid hormone ecdysone functions with intrinsic chromatin remodeling factors to control female germline stem cells in Drosophila. Cell Stem Cell. 2010;7:581-92 pubmed publisher
    ..Our findings support a link between systemic steroid hormones and the intrinsic chromatin remodeling machinery as a potential mechanism to promote broad transcriptional programs required for adult stem cell self-renewal.
  27. Fletcher J, D Avino P, Thummel C. A steroid-triggered switch in E74 transcription factor isoforms regulates the timing of secondary-response gene expression. Proc Natl Acad Sci U S A. 1997;94:4582-6 pubmed
    ..However, ectopic expression of both Broad-Complex and E74A activators in an E74B mutant background is not sufficient to prematurely induce all late genes, ..
  28. Bayer C, Halsell S, Fristrom J, Kiehart D, von Kalm L. Genetic interactions between the RhoA and Stubble-stubbloid loci suggest a role for a type II transmembrane serine protease in intracellular signaling during Drosophila imaginal disc morphogenesis. Genetics. 2003;165:1417-32 pubmed
    ..Our results provide evidence that the type II transmembrane serine proteases, a class of proteins linked to human developmental abnormalities and pathology, may be associated with intracellular signaling required for normal development. ..
  29. Fletcher J, Thummel C. The ecdysone-inducible Broad-complex and E74 early genes interact to regulate target gene transcription and Drosophila metamorphosis. Genetics. 1995;141:1025-35 pubmed
    ..The Broad-Complex (BR-C) and E74 are induced directly by ecdysone and encode families of transcription factors that regulate ..
  30. Huet F, Ruiz C, Richards G. Puffs and PCR: the in vivo dynamics of early gene expression during ecdysone responses in Drosophila. Development. 1993;118:613-27 pubmed
    ..A number of these early puffs (2B5, 74EF and 75B) contain complex transcription units (Broad-Complex, E74 and E75 respectively) encoding families of regulatory proteins which are expressed in most if not all ..
  31. Roth S, Jordan P, Karess R. Binuclear Drosophila oocytes: consequences and implications for dorsal-ventral patterning in oogenesis and embryogenesis. Development. 1999;126:927-34 pubmed
    ..Thus, processes exist in the ventral follicular epithelium or in the perivitelline space that compensate for the expansion of dorsal follicle cell fates and consequently allow the formation of a normal embryonic axis. ..
  32. von Kalm L, Crossgrove K, Von Seggern D, Guild G, Beckendorf S. The Broad-Complex directly controls a tissue-specific response to the steroid hormone ecdysone at the onset of Drosophila metamorphosis. EMBO J. 1994;13:3505-16 pubmed
    ..Here we examine how a key regulator of metamorphosis and primary ecdysone response gene, the Broad-Complex, transmits the hormonal signal to one of its targets, the Sgs-4 glue gene...
  33. Pecasse F, Beck Y, Ruiz C, Richards G. Krüppel-homolog, a stage-specific modulator of the prepupal ecdysone response, is essential for Drosophila metamorphosis. Dev Biol. 2000;221:53-67 pubmed
    ..Our studies on the corresponding gene, named Krüppel-homolog (Kr-h), add to a growing body of evidence that specific isoforms of a number of key genes are implicated in both embryogenesis and metamorphosis. ..
  34. Galceran J, Llanos J, Sampedro J, Pongs O, Izquierdo M. Transcription at the ecdysone-inducible locus 2B5 in Drosophila. Nucleic Acids Res. 1990;18:539-45 pubmed
    The Broad-Complex (BR-C) of D. melanogaster, mapping at the 2B5 early ecdysone puff, mediates ecdysone-induced processes. We present here the transcriptional analysis of the locus in both wild type and representative mutants...
  35. Restifo L, Hauglum W. Parallel molecular genetic pathways operate during CNS metamorphosis in Drosophila. Mol Cell Neurosci. 1998;11:134-48 pubmed
    ..The Drosophila Broad Complex (BRC) holds a pivotal position in the gene expression cascade triggered by the molting hormone 20-..
  36. Belyaeva E, Aizenzon M, Semeshin V, Kiss I, Koczka K, Baritcheva E, et al. Cytogenetic analysis of the 2B3-4--2B11 region of the X-chromosome of Drosophila melanogaster. I. Cytology of the region and mutant complementation groups. Chromosoma. 1980;81:281-306 pubmed
    ..Complementation groups br, rbp, l(1)pp-1, l(1)pp-2 (overlapping complex) have been located by rearrangements in very narrow cytological limit 2B3-..
  37. Ward E, Berg C. Juxtaposition between two cell types is necessary for dorsal appendage tube formation. Mech Dev. 2005;122:241-55 pubmed
    ..rho-lacZ) marker form the ventral floor of the tube and cells expressing high levels of the transcription factor Broad form a roof over the rho-lacZ cells...
  38. Ward R, Reid P, Bashirullah A, D Avino P, Thummel C. GFP in living animals reveals dynamic developmental responses to ecdysone during Drosophila metamorphosis. Dev Biol. 2003;256:389-402 pubmed
    ..These death responses fail to occur in rbp(5) mutants of the Broad-Complex (BR-C), and imaginal disc elongation and eversion is abolished in br(5) mutants of the BR-C...
  39. Baehrecke E, Thummel C. The Drosophila E93 gene from the 93F early puff displays stage- and tissue-specific regulation by 20-hydroxyecdysone. Dev Biol. 1995;171:85-97 pubmed
    ..We propose that E93 acts in a stage-specific regulatory hierarchy in the salivary gland to direct its histolysis in response to the prepupal ecdysteroid pulse. ..
  40. Bayer C, Holley B, Fristrom J. A switch in broad-complex zinc-finger isoform expression is regulated posttranscriptionally during the metamorphosis of Drosophila imaginal discs. Dev Biol. 1996;177:1-14 pubmed
    The Broad-Complex (BR-C) is a key member of the 20-hydroxyecdysone regulatory hierarchy that coordinates changes in gene expression during Drosophila metamorphosis...
  41. Sawatsubashi S, Murata T, Lim J, Fujiki R, Ito S, Suzuki E, et al. A histone chaperone, DEK, transcriptionally coactivates a nuclear receptor. Genes Dev. 2010;24:159-70 pubmed publisher
    ..Thus, the present study suggests that at least one histone chaperone can be categorized as a type of transcriptional coactivator for nuclear receptors. ..
  42. Ghbeish N, McKeown M. Analyzing the repressive function of ultraspiracle, the Drosophila RXR, in Drosophila eye development. Mech Dev. 2002;111:89-98 pubmed
    ..that USP both represses and activates a gene affecting furrow movement, the ecdysone-responsive Z1 isoform of Broad-Complex, and we report additional usp mutant phenotypes...
  43. Kiss I, Beaton A, Tardiff J, Fristrom D, Fristrom J. Interactions and developmental effects of mutations in the Broad-Complex of Drosophila melanogaster. Genetics. 1988;118:247-59 pubmed
    ..The region contains a complex genetic locus, the Broad-Complex (BR-C) composed of four groups of fully complementing (br, rbp, l(1)2Bc, and l(1)2Bd) alleles, and classes ..
  44. Stewart M, Murphy C, Fristrom J. The recovery and preliminary characterization of X chromosome mutants affecting imaginal discs of Drosophila melanogaster. Dev Biol. 1972;27:71-83 pubmed
  45. Lee C, Simon C, Woodard C, Baehrecke E. Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila. Dev Biol. 2002;252:138-48 pubmed
    ..Here, we analyze the function of the steroid-regulated genes betaFTZ-F1, BR-C, E74A, and E93 during salivary gland programmed cell death...
  46. Andres A, Thummel C. Hormones, puffs and flies: the molecular control of metamorphosis by ecdysone. Trends Genet. 1992;8:132-8 pubmed
    ..Molecular characterization of some of these genes has provided valuable clues to regulatory mechanisms by which the ecdysone signal is transduced and amplified. ..
  47. Jiang C, Lamblin A, Steller H, Thummel C. A steroid-triggered transcriptional hierarchy controls salivary gland cell death during Drosophila metamorphosis. Mol Cell. 2000;5:445-55 pubmed
    ..The Broad-Complex (BR-C) is required for both rpr and hid transcription, while E74A is required for maximal levels of hid ..
  48. Atkey M, Lachance J, Walczak M, Rebello T, Nilson L. Capicua regulates follicle cell fate in the Drosophila ovary through repression of mirror. Development. 2006;133:2115-23 pubmed
    ..We propose that Capicua regulates the pattern of follicle cell fates along the dorsoventral axis by blocking the induction of appendage determinants, such as mirror, by anterior positional cues. ..
  49. Cao C, Liu Y, Lehmann M. Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. J Cell Biol. 2007;176:843-52 pubmed
    ..Loss of fkh itself is a steroid-controlled event that is mediated by the 20E-induced BR-C gene, and that renders the key death regulators hid and reaper hormone responsive. These results implicate the D...
  50. Shravage B, Altmann G, Technau M, Roth S. The role of Dpp and its inhibitors during eggshell patterning in Drosophila. Development. 2007;134:2261-71 pubmed
  51. Karim F, Thummel C. Temporal coordination of regulatory gene expression by the steroid hormone ecdysone. EMBO J. 1992;11:4083-93 pubmed
    ..from staged animals and cultured organs to study the transcription of three primary response regulatory genes, E75, BR-C and EcR...
  52. Dorman J, James K, Fraser S, Kiehart D, Berg C. bullwinkle is required for epithelial morphogenesis during Drosophila oogenesis. Dev Biol. 2004;267:320-41 pubmed
    ..Roof-forming cells constrict apically and express high levels of Broad protein. Floor cells lack Broad, express the rhomboid-lacZ marker, and form the floor by directed cell elongation...
  53. Brennan C, Ashburner M, Moses K. Ecdysone pathway is required for furrow progression in the developing Drosophila eye. Development. 1998;125:2653-64 pubmed
    ..both of a reporter of transcriptional activity of the Ecdysone Receptor and of the Z1 isoform of the Broad Complex, are localized in and close to the furrow...
  54. Buszczak M, Freeman M, Carlson J, Bender M, Cooley L, Segraves W. Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila. Development. 1999;126:4581-9 pubmed
    ..E75, E74 and BR-C are expressed in a stage-specific manner while EcR expression is ubiquitous throughout oogenesis...
  55. Nakamura Y, Matsuno K. Species-specific activation of EGF receptor signaling underlies evolutionary diversity in the dorsal appendage number of the genus Drosophila eggshells. Mech Dev. 2003;120:897-907 pubmed
    ..Thus, our results link the species-specific activation of EGFR signaling and the evolution of eggshell morphology in Drosophila. ..
  56. Sempere L, Dubrovsky E, Dubrovskaya V, Berger E, Ambros V. The expression of the let-7 small regulatory RNA is controlled by ecdysone during metamorphosis in Drosophila melanogaster. Dev Biol. 2002;244:170-9 pubmed
    ..Experiments were conducted to test the role of Broad-Complex (BR-C), an essential component in the ecdysone pathway, in let-7 expression...
  57. Gonzy G, Pokholkova G, Peronnet F, Mugat B, Demakova O, Kotlikova I, et al. Isolation and characterization of novel mutations of the Broad-Complex, a key regulatory gene of ecdysone induction in Drosophila melanogaster. Insect Biochem Mol Biol. 2002;32:121-32 pubmed
    Seven new alleles of the Broad-Complex gene of Drosophila melanogaster, which encodes a family of four zinc finger protein isoforms BR-C Z1, Z2, Z3 and Z4, were generated by transposase-induced mobilization of a P[Zw] element inserted in ..
  58. Yamada M, Murata T, Hirose S, Lavorgna G, Suzuki E, Ueda H. Temporally restricted expression of transcription factor betaFTZ-F1: significance for embryogenesis, molting and metamorphosis in Drosophila melanogaster. Development. 2000;127:5083-92 pubmed of the phenotypes of the ftz-f1 mutant, is rescued by forced expression of the ftz-f1 downstream gene BR-C during the late prepupal period...
  59. Bender M, Imam F, Talbot W, Ganetzky B, Hogness D. Drosophila ecdysone receptor mutations reveal functional differences among receptor isoforms. Cell. 1997;91:777-88 pubmed
    ..Comparable transgenic expression of EcR-B1, EcR-B2, and EcR-A in these mutant glands results, respectively, in full, partial, and no repair of that loss. ..
  60. Lehmann M, Korge G. The fork head product directly specifies the tissue-specific hormone responsiveness of the Drosophila Sgs-4 gene. EMBO J. 1996;15:4825-34 pubmed
    ..gland secretion protein gene 4 (Sgs-4) and show that despite these sites' correspondence with previously described Broad-Complex protein binding sites, SEBP2 is a Broad-Complex-independent factor encoded by the region-specific homeotic ..
  61. Bernardi F, Romani P, Tzertzinis G, Gargiulo G, Cavaliere V. EcR-B1 and Usp nuclear hormone receptors regulate expression of the VM32E eggshell gene during Drosophila oogenesis. Dev Biol. 2009;328:541-51 pubmed publisher
  62. Crowley T, Mathers P, Meyerowitz E. A trans-acting regulatory product necessary for expression of the Drosophila melanogaster 68C glue gene cluster. Cell. 1984;39:149-56 pubmed
    The mutation l(1)npr-1 is located at cytological location 2B5 on the X chromosome in Drosophila melanogaster...
  63. Lee C, Wendel D, Reid P, Lam G, Thummel C, Baehrecke E. E93 directs steroid-triggered programmed cell death in Drosophila. Mol Cell. 2000;6:433-43 pubmed
    ..Furthermore, expression of E93 is sufficient to induce programmed cell death. We propose that the steroid induction of E93 determines a programmed cell death response during development. ..
  64. Zartman J, Kanodia J, Cheung L, Shvartsman S. Feedback control of the EGFR signaling gradient: superposition of domain-splitting events in Drosophila oogenesis. Development. 2009;136:2903-11 pubmed publisher
    ..We demonstrate that during Drosophila oogenesis, the two-domain expression pattern of Broad, a transcription factor essential for the formation of the two respiratory eggshell appendages, is established by ..
  65. Emery I, Bedian V, Guild G. Differential expression of Broad-Complex transcription factors may forecast tissue-specific developmental fates during Drosophila metamorphosis. Development. 1994;120:3275-87 pubmed
    ..The Broad-Complex (BR-C) primary response gene is composed of several distinct genetic functions and encodes a family of ..
  66. Chen Y, Schupbach T. The role of brinker in eggshell patterning. Mech Dev. 2006;123:395-406 pubmed
    ..In brk mutant follicle cell clones at the dorsal anterior region, Broad Complex (BR-C) expression is down-regulated in a larger domain than in wild type...
  67. Belyaeva E, Vlassova I, Biyasheva Z, Kakpakov V, Richards G, Zhimulev I. Cytogenetic analysis of the 2B3-4-2B11 region of the X chromosome of Drosophila melanogaster. II. Changes in 20-OH ecdysone puffing caused by genetic defects of puff 2B5. Chromosoma. 1981;84:207-19 pubmed
    Larvae homozygous or hemizygous for the l(1)t435 mutation located within the early ecdysteroid puff 2B5, or carrying a deletion of the 2B5 band, die at the end of the third larval instar...
  68. Chiang P, Kurnit D. Study of dosage compensation in Drosophila. Genetics. 2003;165:1167-81 pubmed
    ..As exemplified by the BR-C locus and its dependent Sgs genes, multiple genes in a given pathway could exhibit coordinate regulatory ..
  69. Biyasheva A, Do T, Lu Y, Vaskova M, Andres A. Glue secretion in the Drosophila salivary gland: a model for steroid-regulated exocytosis. Dev Biol. 2001;231:234-51 pubmed
    ..We show that 20E mediates secretion through the EcR/USP receptor, and two early-gene products, the rbp(+) function of BR-C and the Ca2+ binding protein E63-1, are involved...
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    ..Mutations in each of four Broad-Complex locus (BR-C) complementation groups were analyzed for their effects on the expression of other genes that ..
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    The Broad-Complex (BR-C) is a complex regulatory locus at 2B-5 on the X chromosome of Drosophila melanogaster. The wild-type BR-C products are apparent transcription factors necessary for imaginal disc morphogenesis...
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    ..The early ecdysone-response Broad-Complex (BR-C) gene, a key regulator of this cascade, is defined by three complementing functions (rbp, br, and ..