Gene Symbol: borr
Alias: BORR, Bor, Borr, CG4454, Dmel\CG4454, dBor, borealin-related, Borealin-related, CG4454-PA, CG4454-PB, borealin, borr-PA, borr-PB
Species: fruit fly
Eggert U, Kiger A, Richter C, Perlman Z, Perrimon N, Mitchison T, et al
. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004;2:e379 pubmed
..inhibitors of cytokinesis and 214 genes important for cytokinesis, including a new protein in the Aurora B pathway (Borr)...
Hanson K, Kelley A, Bienz M. Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development. Development. 2005;132:4777-87 pubmed
..we report the first detailed characterisation of a CPC mutation in Drosophila, using a loss-of-function allele of borealin (borr)...
D Avino P, Archambault V, Przewloka M, Zhang W, Laue E, Glover D. Isolation of protein complexes involved in mitosis and cytokinesis from Drosophila cultured cells. Methods Mol Biol. 2009;545:99-112 pubmed publisher
..Although this method has proven very successful in isolating mitotic and cytokinetic complexes, it can also be used to characterise protein complexes involved in many other cellular processes. ..
Ahmad S, Tansey T, Busser B, Nolte M, Jeffries N, Gisselbrecht S, et al
. Two forkhead transcription factors regulate the division of cardiac progenitor cells by a Polo-dependent pathway. Dev Cell. 2012;23:97-111 pubmed publisher
..This pathway demonstrates how transcription factors integrate diverse developmental processes during organogenesis. ..
Chang C, Goulding S, Adams R, Earnshaw W, Carmena M. Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system. J Cell Sci. 2006;119:1144-53 pubmed
..In addition, the segregation of the cell-fate determinant Prospero in asymmetric neuroblast division is abnormal, suggesting a role for the chromosomal passenger complex in the regulation of this process. ..
Gao S, Giansanti M, Buttrick G, Ramasubramanyan S, Auton A, Gatti M, et al
. Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis. J Cell Biol. 2008;180:521-35 pubmed publisher
..complex (CPC), which is composed of conserved proteins aurora B, inner centromere protein (INCENP), survivin, and Borealin/DASRA, localizes to chromatin, kinetochores, microtubules, and the cell cortex in a cell cycle-dependent manner...
Carmena M, Pinson X, Platani M, Salloum Z, Xu Z, Clark A, et al
. The chromosomal passenger complex activates Polo kinase at centromeres. PLoS Biol. 2012;10:e1001250 pubmed publisher
..subunit of the chromosomal passenger complex (CPC), which consists of Aurora B kinase, INCENP, Survivin, and Borealin/Dasra B, also interacts with Polo kinase in Drosophila cells...
Capalbo L, Montembault E, Takeda T, Bassi Z, Glover D, D Avino P. The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. Open Biol. 2012;2:120070 pubmed publisher
..Here, we show that the CPC subunit Borealin interacts directly with the Snf7 components of ESCRT-III in both Drosophila and human cells...
Das A, Shah S, Fan B, Paik D, DiSanto D, Hinman A, et al
. Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes. Genetics. 2016;202:61-75 pubmed publisher
..In combination our results support a model where the meiotic central spindle and associated proteins are essential for acentrosomal chromosome segregation. ..