Gene Symbol: bic
Description: bicaudal
Alias: 107/12, BcDNA.GM05329, BcDNA:GM05329, Bic, Btf, CG3644, Dmel\CG3644, E(2)Bic, E(Bic), l(2)49Da, l(2)k10712, l(2)vr22, vr22, bicaudal, CG3644-PA, CG3644-PB, bic-PA, bic-PB, enhancer of bicaudal
Species: fruit fly

Top Publications

  1. Markesich D, Gajewski K, Nazimiec M, Beckingham K. bicaudal encodes the Drosophila beta NAC homolog, a component of the ribosomal translational machinery*. Development. 2000;127:559-72 pubmed
    ..Genomic DNA encoding beta NAC completely rescues the bicaudal phenotype. The lethal phenotype of Enhancer of Bicaudal, E(Bic), a mutation hypothesized to affect the bicaudal locus, is also completely rescued by the beta NAC ..
  2. Mohler J, Wieschaus E. Dominant maternal-effect mutations of Drosophila melanogaster causing the production of double-abdomen embryos. Genetics. 1986;112:803-22 pubmed
    ..embryos is caused by mutations at either locus and is similar to that produced by the original mutation at bicaudal (bic)...
  3. Nüsslein Volhard C. The bicoid morphogen papers (I): account from CNV. Cell. 2004;116:S1-5, 2 p following S9 pubmed
  4. Mihailovic M, Mihailovich M, Wurth L, Zambelli F, Abaza I, Militti C, et al. Widespread generation of alternative UTRs contributes to sex-specific RNA binding by UNR. RNA. 2012;18:53-64 pubmed publisher
    ..These results suggest that UNR exploits the transcript diversity generated by alternative processing and alternative promoter usage to bind and regulate target genes in a sex-specific manner. ..
  5. Berleth T, Burri M, Thoma G, Bopp D, Richstein S, Frigerio G, et al. The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo. EMBO J. 1988;7:1749-56 pubmed
    ..The localization of the transcript requires the function of the maternal effect genes exuperantia and swallow while transcript stability is reduced by functions depending on posterior group genes. ..
  6. Bearer E. Actin in the Drosophila embryo: is there a relationship to developmental cue localization?. Bioessays. 1991;13:199-204 pubmed
    ..My purpose is to juxtapose these two bodies of information such that the relationship between them may be revealed. ..
  7. Creagh E, Brumatti G, Sheridan C, Duriez P, Taylor R, Cullen S, et al. Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival. PLoS ONE. 2009;4:e5055 pubmed publisher
    ..This approach identified multiple novel substrates for the fly caspases and revealed that bicaudal/betaNAC is a conserved substrate for Drosophila and mammalian caspases...
  8. Ho M. An exercise in rational taxonomy. J Theor Biol. 1990;147:43-57 pubmed
    ..Attempts to recover the "true" phylogeny by various numerical methods are summarized and their implications for the validity of the basic assumptions of contemporary systematics discussed. ..
  9. Braat A, Yan N, Arn E, Harrison D, Macdonald P. Localization-dependent oskar protein accumulation; control after the initiation of translation. Dev Cell. 2004;7:125-31 pubmed
    ..Thus, the mechanisms that prevent accumulation of Oskar protein until it can be secured at the posterior pole of the oocyte include regulated degradation or inhibition of translational elongation. ..

More Information


  1. MacDonald P. Diversity in translational regulation. Curr Opin Cell Biol. 2001;13:326-31 pubmed
    ..Diversity seems to be a central feature of translational control, both in the mechanisms themselves and in the situations where this form of regulation is used. ..
  2. Wu C, Howe M. A genetic analysis of the Suppressor 2 of zeste complex of Drosophila melanogaster. Genetics. 1995;140:139-81 pubmed
    ..Psc is a member of the homeotic Polycomb group of genes. A general discussion of the Polycomb and trithorax group of genes, position-effect variegation, transvection, chromosome pairing and chromatin structure is presented...
  3. Kauffman S, Goodwin B. Spatial harmonics and pattern specification in early Drosophila development. Part II. The four colour wheels model. J Theor Biol. 1990;144:321-45 pubmed
    ..The alternative familiar hypothesis that longitudinal position is specified in an "on" "off" combinatorial code does not readily account for the duplication deletion phenomena. ..
  4. Frohnhofer H, Lehmann R, Nusslein Volhard C. Manipulating the anteroposterior pattern of the Drosophila embryo. J Embryol Exp Morphol. 1986;97 Suppl:169-79 pubmed
  5. Pauli D, Oliver B, Mahowald A. Identification of regions interacting with ovoD mutations: potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster. Genetics. 1995;139:713-32 pubmed
    ..These regions probably contain genes whose products act in developmental hierarchies that include ovo+ protein. ..
  6. Lasko P, Pardue M. Studies of the genetic organization of the vestigial microregion of Drosophila melanogaster. Genetics. 1988;120:495-502 pubmed
    ..The distal breakpoints of twelve of 20 deficiencies overlapping Df(2R)vgB are genetically identical to that of Df(2R)vgD, coinciding with the position of a complex, pleiotropic locus, l(2)49Ea-Psc-Su(z)2. ..
  7. Roth S. Mathematics and biology: a Kantian view on the history of pattern formation theory. Dev Genes Evol. 2011;221:255-79 pubmed publisher
  8. Temme C, Zhang L, Kremmer E, Ihling C, Chartier A, Sinz A, et al. Subunits of the Drosophila CCR4-NOT complex and their roles in mRNA deadenylation. RNA. 2010;16:1356-70 pubmed publisher
    ..Nocturnin may also be involved in mRNA deadenylation, whereas there is no evidence for a similar role of Angel and 3635. ..