Gene Symbol: bgm
Description: bubblegum
Alias: 2a9hom, BG:DS01514.2, BG:DS0514.2, Bgm, CG4501, Dmel\CG4501, bubblegum, CG4501-PA, CG4501-PC, bgm-PA, bgm-PC
Species: fruit fly

Top Publications

  1. Min K, Benzer S. Preventing neurodegeneration in the Drosophila mutant bubblegum. Science. 1999;284:1985-8 pubmed
    The Drosophila melanogaster recessive mutant bubblegum (bgm) exhibits adult neurodegeneration, with marked dilation of photoreceptor axons...
  2. Berkaeva M, Demakov S, Schwartz Y, Zhimulev I. Functional analysis of Drosophila polytene chromosomes decompacted unit: the interband. Chromosome Res. 2009;17:745-54 pubmed publisher
    ..Our results suggest that, in the absence of transcription, the decondensed state of interband regions does not depend on the presence of insulator elements but instead correlates with the presence of transcriptional enhancers. ..
  3. Oba Y, Ojika M, Inouye S. Characterization of CG6178 gene product with high sequence similarity to firefly luciferase in Drosophila melanogaster. Gene. 2004;329:137-45 pubmed
    ..Further, phylogenic analyses strongly suggest that the firefly luciferase gene may have evolved from a fatty acyl-CoA synthetase gene as a common ancestral gene. ..
  4. Marsh J, Thompson L. Can flies help humans treat neurodegenerative diseases?. Bioessays. 2004;26:485-96 pubmed
  5. Barinaga M. Mutant fruit flies respond to Lorenzo's oil. Science. 1999;284:1899, 1901 pubmed
  6. Fortini M, Bonini N. Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer. Trends Genet. 2000;16:161-7 pubmed
    ..With the advent of complete genomic sequencing on the horizon, Drosophila will continue to be an outstanding model system in which to unravel the complexities, causes and treatments for human neural degeneration. ..
  7. Chow C, Wolfner M, Clark A. Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes. Proc Natl Acad Sci U S A. 2013;110:9013-8 pubmed publisher
    ..This study establishes Drosophila as a useful model for studying variation in ER stress and identifying ER stress genes that may contribute to human disease. ..
  8. Kedmi A, Zehavi Y, Glick Y, Orenstein Y, Ideses D, Wachtel C, et al. Drosophila TRF2 is a preferential core promoter regulator. Genes Dev. 2014;28:2163-74 pubmed publisher
    ..Using microfluidic affinity analysis, we discovered that short TRF2-bound DNA oligos are enriched for Inr and DPE motifs. Taken together, our findings highlight the role of short TRF2 as a preferential core promoter regulator. ..
  9. Sivachenko A, Gordon H, Kimball S, Gavin E, Bonkowsky J, Letsou A. Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases. Dis Model Mech. 2016;9:377-87 pubmed publisher
    ..We show that the Drosophila bubblegum(bgm) and double bubble(dbb) genes have overlapping functions, and that the consequences of double knockout of ..

More Information


  1. Zhao X, Feng D, Wang Q, Abdulla A, Xie X, Zhou J, et al. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest. 2012;122:2417-27 pubmed publisher
    ..Taken together, these results demonstrate that CDK8 and CycC function as evolutionarily conserved components of the insulin signaling pathway in regulating lipid homeostasis. ..