Gene Symbol: bgcn
Description: benign gonial cell neoplasm
Alias: BGCN, Bgcn, CG10330, CG10331, CG30170, Dmel\CG30170, PNBP, b(2)cgn, b(2)gcn, bcgn, ben(2)gcn, cg10331, fs(2)eo-C, fs(2)eo6, fs(2)eoQS2, gcn, pep, benign gonial cell neoplasm, CG30170-PA, CG30170-PB, benign gonial, benign gonial cell neoplasia, benign-(2)-gonial-cell-neoplasm, bgcn-PA, bgcn-PB, cell neoplasm, gonial-cell-neoplasm, peppercorn
Species: fruit fly

Top Publications

  1. Lin H, Yue L, Spradling A. The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation. Development. 1994;120:947-56 pubmed
    ..Our results imply that Drosophila fusomes are required for ovarian cyst formation and suggest that membrane skeletal proteins regulate cystocyte divisions. ..
  2. Jin Z, Kirilly D, Weng C, Kawase E, Song X, Smith S, et al. Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell. 2008;2:39-49 pubmed publisher
    ..The differentiation-defective bam or bgcn mutant GSCs invade the niche space of neighboring wild-type GSCs and gradually push them out of the niche by ..
  3. Fuller M, Spradling A. Male and female Drosophila germline stem cells: two versions of immortality. Science. 2007;316:402-4 pubmed
    ..Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production. ..
  4. Xie T, Spradling A. decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell. 1998;94:251-60 pubmed
    ..We constructed mutant germline stem cell clones to show that the dpp signal is directly received by germline stem cells. Thus, dpp signaling helps define a niche that controls germline stem cell proliferation. ..
  5. Kim J, Lee Y, Kim C. Direct inhibition of Pumilo activity by Bam and Bgcn in Drosophila germ line stem cell differentiation. J Biol Chem. 2010;285:4741-6 pubmed publisher conjunction with Nanos (Nos) is required for self-renewal, whereas Bam (bag-of-marbles) and Bgcn (benign gonial cell neoplasm) promote differentiation of germ line stem cells in the Drosophila ovary...
  6. Li Y, Maines J, Tastan O, McKearin D, Buszczak M. Mei-P26 regulates the maintenance of ovarian germline stem cells by promoting BMP signaling. Development. 2012;139:1547-56 pubmed publisher
    ..These data suggest that Mei-P26 has distinct functions in the ovary and participates in regulating the fates of both GSCs and their differentiating daughters. ..
  7. Ohlstein B, Lavoie C, Vef O, Gateff E, McKearin D. The Drosophila cystoblast differentiation factor, benign gonial cell neoplasm, is related to DExH-box proteins and interacts genetically with bag-of-marbles. Genetics. 2000;155:1809-19 pubmed
    ..for cystoblast fate in Drosophila germline cells and shown that it requires active product from the benign gonial cell neoplasm (bgcn) gene. Here we present the cloning and characterization of bgcn...
  8. Lavoie C, Ohlstein B, McKearin D. Localization and function of Bam protein require the benign gonial cell neoplasm gene product. Dev Biol. 1999;212:405-13 pubmed
    ..In this paper, we compare the oogenic phenotype of benign gonial cell neoplasm mutations to that of mutations in bam...
  9. Insco M, Bailey A, Kim J, Olivares G, Wapinski O, Tam C, et al. A self-limiting switch based on translational control regulates the transition from proliferation to differentiation in an adult stem cell lineage. Cell Stem Cell. 2012;11:689-700 pubmed publisher
    ..In turn, Bam and its partner Bgcn bind the mei-P26 3' untranslated region and repress translation of mei-P26 in late TA cells...

More Information


  1. Insco M, Leon A, Tam C, McKearin D, Fuller M. Accumulation of a differentiation regulator specifies transit amplifying division number in an adult stem cell lineage. Proc Natl Acad Sci U S A. 2009;106:22311-6 pubmed publisher
  2. Li Y, Minor N, Park J, McKearin D, Maines J. Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenance. Proc Natl Acad Sci U S A. 2009;106:9304-9 pubmed publisher
    ..Previous evidence showed that Bgcn is an obligate factor for the ability of Bam to drive differentiation, and we now report that Bam forms a complex ..
  3. GONCZY P, Matunis E, DiNardo S. bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis. Development. 1997;124:4361-71 pubmed
    ..Mutations at two previously identified loci, bag-of-marbles (bam) and benign gonial cell neoplasm (bgcn), prevent progression through spermatogenesis and oogenesis, resulting in the overproliferation ..
  4. Sturgill D, Zhang Y, Parisi M, Oliver B. Demasculinization of X chromosomes in the Drosophila genus. Nature. 2007;450:238-41 pubmed publisher
  5. Shen R, Weng C, Yu J, Xie T. eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary. Proc Natl Acad Sci U S A. 2009;106:11623-8 pubmed publisher
    ..Furthermore, BAM and BGCN together repress translation of E-cadherin through its 3' UTR in S2 cells...
  6. Lukacsovich T, Asztalos Z, Juni N, Awano W, Yamamoto D. The Drosophila melanogaster 60A chromosomal division is extremely dense with functional genes: their sequences, genomic organization, and expression. Genomics. 1999;57:43-56 pubmed
    ..4 superfamily (TM4SF) gene, a new homeodomain gene, and a gene coding for a putative nuclear binding protein (PNBP) that is homologous to maleless, and a Copia-like element...
  7. Hong X, Doddapaneni H, Comeron J, Rodesch M, Halvensleben H, Nien C, et al. Microarray-based capture of novel expressed cell type-specific transfrags (CoNECT) to annotate tissue-specific transcription in Drosophila melanogaster. G3 (Bethesda). 2012;2:873-82 pubmed publisher
    ..Ovary and testis isotigs over 200 bp have been deposited with the GenBank Transcriptome Shotgun Assembly Sequence Database as bioproject no.PRJNA89451 (accession nos. JV208106–JV230865). ..
  8. Gateff E, Wismar J, Habtemichael N, Löffler T, Dreschers S, Kaiser S, et al. Functional analysis of Drosophila developmental genes instrumental in tumor suppression. In Vivo. 1996;10:211-5 pubmed
    ..blood neoplasm-1 [1(3)mbn-1], for whose function only vague predictions can be made; 4) benign (2) gonial cell neoplasm [b(2)gcn], which may function as a splice factor...
  9. Tokusumi T, Tokusumi Y, Hopkins D, Shoue D, Corona L, Schulz R. Germ line differentiation factor Bag of Marbles is a regulator of hematopoietic progenitor maintenance during Drosophila hematopoiesis. Development. 2011;138:3879-84 pubmed publisher
    ..Together, these results demonstrate that Bam and mir-7 antagonize the differentiation-promoting function of Yan to maintain the stem-like hematopoietic progenitor state during hematopoiesis. ..
  10. Vibranovski M. Meiotic sex chromosome inactivation in Drosophila. J Genomics. 2014;2:104-17 pubmed publisher
    ..Therefore, conclusion about level, degree or precise timing is inadequate until new approaches are implemented to know the details of MSCI or other processes involved for D. melanogaster model. ..
  11. Gateff E, Kurzik Dumke U, Wismar J, Löffler T, Habtemichael N, Konrad L, et al. Drosophila differentiation genes instrumental in tumor suppression. Int J Dev Biol. 1996;40:149-56 pubmed
    ..structure, expression and possible function of the following four tumor suppressor genes are discussed: tumorous imaginal disc, lethal (3) malignant brain tumor, lethal (3) malignant blood neoplasm-1 and benign (2) gonial cell neoplasm.
  12. Tian J, Jin Z, Xie T. Mathematical model for two germline stem cells competing for niche occupancy. Bull Math Biol. 2012;74:1207-25 pubmed publisher
    ..The model predicts several qualitative features in the competition process, which may help to design rational experiments for a better understanding of the stem cell competition process. ..
  13. Monk A, Abud H, Hime G. Dmp53 is sequestered to nuclear bodies in spermatogonia of Drosophila melanogaster. Cell Tissue Res. 2012;350:385-94 pubmed publisher
    ..Dmp53 thus has differential effects depending upon the stage of male germline maturation...
  14. Gan Q, Schones D, Ho Eun S, Wei G, Cui K, Zhao K, et al. Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis. Genome Biol. 2010;11:R42 pubmed publisher
  15. Munn K, Steward R. The shut-down gene of Drosophila melanogaster encodes a novel FK506-binding protein essential for the formation of germline cysts during oogenesis. Genetics. 2000;156:245-56 pubmed
    ..In plants, high-molecular-weight immunophilins have been shown to regulate cell divisions in the root meristem in response to extracellular signals. Our results suggest that shut-down may regulate germ cell divisions in the germarium. ..
  16. Jung A, Hollmann M, Schäfer M. The fatty acid elongase NOA is necessary for viability and has a somatic role in Drosophila sperm development. J Cell Sci. 2007;120:2924-34 pubmed
    ..An RNAi construct selectively driven in cyst cells leads to male sterility, demonstrating the necessity of noa function for male germline development and the interaction of the somatic cyst cells with the developing sperm. ..
  17. Chen D, Wu C, Zhao S, Geng Q, Gao Y, Li X, et al. Three RNA binding proteins form a complex to promote differentiation of germline stem cell lineage in Drosophila. PLoS Genet. 2014;10:e1004797 pubmed publisher
    ..Bam and Bgcn are both RBPs that have also been shown to repress mei-P26 expression...
  18. Ghosh S, Obrdlik A, Marchand V, Ephrussi A. The EJC binding and dissociating activity of PYM is regulated in Drosophila. PLoS Genet. 2014;10:e1004455 pubmed publisher
    ..This, together with the fact that the EJC-disassembly activity of DmPYM is regulated, implicates PYM as an effector of EJC homeostasis in vivo. ..
  19. Gilboa L, Forbes A, Tazuke S, Fuller M, Lehmann R. Germ line stem cell differentiation in Drosophila requires gap junctions and proceeds via an intermediate state. Development. 2003;130:6625-34 pubmed
  20. Wang X, Pan L, Wang S, Zhou J, McDowell W, Park J, et al. Histone H3K9 trimethylase Eggless controls germline stem cell maintenance and differentiation. PLoS Genet. 2011;7:e1002426 pubmed publisher
    ..Normally, Bam and Bgcn interact with each other to promote GSC differentiation...
  21. Fu Z, Geng C, Wang H, Yang Z, Weng C, Li H, et al. Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways. Cell Rep. 2015;13:1366-1379 pubmed publisher
    ..It promotes GSC progeny differentiation by forming protein complexes with differentiation factors Bam and Bgcn independently of other CCR4-NOT components...
  22. Quénerch du E, Anand A, Kai T. The piRNA pathway is developmentally regulated during spermatogenesis in Drosophila. RNA. 2016;22:1044-54 pubmed publisher
  23. Matsui M, Sharma K, Cooke C, Wakimoto B, Rasool M, Hayworth M, et al. Nuclear structure and chromosome segregation in Drosophila male meiosis depend on the ubiquitin ligase dTopors. Genetics. 2011;189:779-93 pubmed publisher
    ..We suggest that dtopors plays a structural role in spermatocyte lamina that is critical for multiple aspects of meiotic chromosome transmission. ..
  24. Vibranovski M, Lopes H, Karr T, Long M. Stage-specific expression profiling of Drosophila spermatogenesis suggests that meiotic sex chromosome inactivation drives genomic relocation of testis-expressed genes. PLoS Genet. 2009;5:e1000731 pubmed publisher
    ..These results suggest MSCI as a general mechanism affecting the evolution of some testis-expressed genes. ..
  25. Mahowald A, Wei G. Sex determination of germ cells in Drosophila. Ciba Found Symp. 1994;182:193-202; discussion 202-9 pubmed
    ..g. ovo, otu) or differentiation (snf, Sxl, fl(2)d, bgcn) of female germ cells. ovo is required during embryogenesis for survival of pole cells...
  26. Sinenko S, Kim E, Wynn R, Manfruelli P, Ando I, Wharton K, et al. Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development. Dev Biol. 2004;273:48-62 pubmed
    ..Ytr function has been preserved in evolution as hematopoietic specific expression of the Drosophila or mouse Ytr proteins rescue the differentiation defects in mutant hemocytes. ..
  27. Baker J, Adhikarakunnathu S, Kernan M. Mechanosensory-defective, male-sterile unc mutants identify a novel basal body protein required for ciliogenesis in Drosophila. Development. 2004;131:3411-22 pubmed
    ..UNC is thus specifically required for normal ciliogenesis. Its localization is an early marker for the centriole-basal body transition, a central but enigmatic event in eukaryotic cell differentiation. ..
  28. Li Y, Zhang Q, Carreira Rosario A, Maines J, McKearin D, Buszczak M. Mei-p26 cooperates with Bam, Bgcn and Sxl to promote early germline development in the Drosophila ovary. PLoS ONE. 2013;8:e58301 pubmed publisher
    ..Here we present data showing that Mei-P26 associates with Bam, Bgcn and Sxl and nanos mRNA during early cyst development, suggesting that this protein helps to repress the translation ..
  29. Gateff E, Mechler B. Tumor-suppressor genes of Drosophila melanogaster. Crit Rev Oncog. 1989;1:221-45 pubmed
  30. Parma D, Bennett P, Boswell R. Mago Nashi and Tsunagi/Y14, respectively, regulate Drosophila germline stem cell differentiation and oocyte specification. Dev Biol. 2007;308:507-19 pubmed
    ..On the other hand, Tsunagi/Y14 is essential for restricting oocyte fate to a single cell and may function with mago nashi in this process. ..
  31. Bauer DuMont V, Flores H, Wright M, Aquadro C. Recurrent positive selection at bgcn, a key determinant of germ line differentiation, does not appear to be driven by simple coevolution with its partner protein bam. Mol Biol Evol. 2007;24:182-91 pubmed publisher
    ..simulans were performed at 2 interacting loci crucial for gametogenesis: bag-of-marbles (bam) and benign gonial cell neoplasm (bgcn)...
  32. Flores H, Bubnell J, Aquadro C, Barbash D. The Drosophila bag of marbles Gene Interacts Genetically with Wolbachia and Shows Female-Specific Effects of Divergence. PLoS Genet. 2015;11:e1005453 pubmed publisher
    ..More generally, we suggest that microbial infections of the germline may explain the unexpected pattern of evolution of several GSC regulatory genes. ..
  33. Löffler T, Wismar J, Sass H, Miyamoto T, Becker G, Konrad L, et al. Genetic and molecular analysis of six tumor suppressor genes in Drosophila melanogaster. Environ Health Perspect. 1990;88:157-61 pubmed
    ..The tumors show all major characteristics of malignant and benign neoplastic growth. Genomic sequences of four of the genes have been identified and are currently being characterized. ..
  34. Mechler B. The fruit fly Drosophila and the fish Xiphophorus as model systems for cancer studies. Cancer Surv. 1990;9:505-27 pubmed
    ..This gene encodes a receptor tyrosine kinase related to the EGF-receptor, and its activation and overexpression are thought to play a critical part in melanoma formation. ..
  35. Perinthottathil S, Kim C. Bam and Bgcn in Drosophila germline stem cell differentiation. Vitam Horm. 2011;87:399-416 pubmed publisher
    ..Bam/Bgcn complex plays a pivotal role in promoting stem cell differentiation...
  36. Spradling A, Drummond Barbosa D, Kai T. Stem cells find their niche. Nature. 2001;414:98-104 pubmed
    ..These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically. ..
  37. Lin H. The tao of stem cells in the germline. Annu Rev Genet. 1997;31:455-91 pubmed
    ..In addition, the GSC mechanism is related to that for germline and sex determination. Current knowledge has provided a solid framework for further study of GSCs and stem cells in general. ..
  38. Pan L, Wang S, Lu T, Weng C, Song X, Park J, et al. Protein competition switches the function of COP9 from self-renewal to differentiation. Nature. 2014;514:233-6 pubmed publisher