betaTub97EF

Summary

Gene Symbol: betaTub97EF
Description: beta-Tubulin at 97EF
Alias: B4t, BETA 98B, CG4869, DTB1, Dmbeta4, Dmel\CG4869, Tub, beta-Tub, beta-Tub97EF, beta-tub, beta4, beta4t, beta97F, betaTub4, betaTub98BC, betaTub98C, Beta4-tubulin, CG4869-PB, CG4869-PC, beta tubulin, beta-Tubulin, beta4 tubulin, betaTub97EF-PB, betaTub97EF-PC, betatubulin, tubulin
Species: fruit fly

Top Publications

  1. ncbi Microtubule architecture specified by a beta-tubulin isoform
    E C Raff
    Department of Biology and Indiana Molecular Biology Institute, Indiana University, Bloomington, IN 47405, USA
    Science 275:70-3. 1997
  2. ncbi Functional constraint underlies 60 million year stasis of Dipteran testis-specific beta-tubulin
    Mark G Nielsen
    Department of Biology, University of Dayton, 300 College Park, Dayton, OH 45469 2320, USA
    Evol Dev 8:23-9. 2006
  3. pmc pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis
    R R Adams
    Cancer Research Campaign CRC Laboratories, Cell Cycle Genetics Research Group, Department of Anatomy and Physiology, Medical Sciences Institute, University of Dundee, Dundee DD1 4HN, UK
    Genes Dev 12:1483-94. 1998
  4. pmc Functional coordination of three mitotic motors in Drosophila embryos
    D J Sharp
    Section of Molecular and Cellular Biology, University of California Davis, Davis, California 95616, USA
    Mol Biol Cell 11:241-53. 2000
  5. pmc The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles
    D J Sharp
    Section of Molecular and Cellular Biology, University of California Davis, Davis, California 95616, USA
    J Cell Biol 144:125-38. 1999
  6. ncbi The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes
    E Logarinho
    Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, Portugal
    J Cell Sci 111:2897-909. 1998
  7. ncbi The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function
    Nick Trotta
    Department of Biological Sciences, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37235, USA
    Curr Biol 14:1135-47. 2004
  8. pmc Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila
    J T Robinson
    University of Minnesota, Department of Genetics, Cell Biology and Development, St Paul, Minnesota 55108 1095, USA
    J Cell Biol 146:597-608. 1999
  9. ncbi Regulation of Drosophila alpha- and beta-tubulin genes during development
    J E Natzle
    Dev Biol 104:187-98. 1984
  10. pmc Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
    Alexander Stark
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Genome Res 17:1865-79. 2007

Scientific Experts

  • Mark G Nielsen
  • Kimberly Mace
  • Elena Drosopoulou
  • Satish Sasikumar
  • Alexander Stark
  • D F Eberl
  • Faith L W Liebl
  • E C Raff
  • D M Glover
  • Manika Pal Bhadra
  • Maria Giovanna Riparbelli
  • Mark Peifer
  • Stacie A Dilks
  • D J Sharp
  • G V Reddy
  • Jenna L Yuen
  • James A Birchler
  • Utpal Bhadra
  • James Ashley
  • Zhigang Jin
  • Kirsten K Hanson
  • Katherine D Cygnar
  • Tony J C Harris
  • Xiaoyi Jin
  • Gohta Goshima
  • Anne Royou
  • Valeria Naim
  • Qiaofang Chen
  • Nick Trotta
  • Silvia Bonaccorsi
  • Maurizio Gatti
  • Giuliano Callaini
  • Elizabeth E Grevengoed
  • Fengwei Yu
  • Elisabetta Bucciarelli
  • Melanie Anderson
  • Kathryn Akong
  • V Kondylis
  • S Bulgheresi
  • C Vied
  • Stephen Dinardo
  • N C Grieder
  • F Yu
  • J M Scholey
  • H M Brown
  • John L Brubacher
  • J T Robinson
  • V Rodrigues
  • A Debec
  • Steven Whyard
  • S J Vidwans
  • B M McCartney
  • Aditi D Singh
  • Scott A Read
  • F Hirth
  • K R Fitch
  • M Carmena
  • R R Adams
  • J M Crawford
  • E Logarinho
  • Vivian Budnik
  • Ellen M Homola
  • Mariann Bienz
  • Yunhee Choi
  • Joydeep Kundu
  • Julie A Brill
  • Duojia Pan
  • Francois Nedelec
  • Shelagh D Campbell
  • Ronald D Vale
  • Xinsheng Gao
  • Thomas P Neufeld
  • Ann C Kelley
  • Mary Packard
  • Philip Goldbach
  • Xiaoping Sun
  • Qisheng Song
  • Bulent Ataman
  • Gabriel G Haddad
  • Christine Field
  • B H Reed
  • Chiara Massarelli
  • William Sullivan
  • Ferdinando Di Cunto
  • Roger Karess
  • Andrea Daga
  • A Stoltzfus
  • Sara Imarisio
  • John C Sisson
  • Genny Orso

Detail Information

Publications61

  1. ncbi Microtubule architecture specified by a beta-tubulin isoform
    E C Raff
    Department of Biology and Indiana Molecular Biology Institute, Indiana University, Bloomington, IN 47405, USA
    Science 275:70-3. 1997
    In Drosophila melanogaster, a testis-specific beta-tubulin (beta2) is required for spermatogenesis. A sequence motif was identified in carboxyl termini of axonemal beta-tubulins in diverse taxa...
  2. ncbi Functional constraint underlies 60 million year stasis of Dipteran testis-specific beta-tubulin
    Mark G Nielsen
    Department of Biology, University of Dayton, 300 College Park, Dayton, OH 45469 2320, USA
    Evol Dev 8:23-9. 2006
    ..find a highly stringent structure/function relationship between the Drosophila melanogaster testis-specific tubulin beta2 and the spermtail axoneme, such that small changes in the beta2 protein render it unable to generate a ..
  3. pmc pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis
    R R Adams
    Cancer Research Campaign CRC Laboratories, Cell Cycle Genetics Research Group, Department of Anatomy and Physiology, Medical Sciences Institute, University of Dundee, Dundee DD1 4HN, UK
    Genes Dev 12:1483-94. 1998
    ..We suggest that PAV-KLP is required both to establish the structure of the telophase spindle to provide a framework for the assembly of the contractile ring, and to mobilize mitotic regulator proteins...
  4. pmc Functional coordination of three mitotic motors in Drosophila embryos
    D J Sharp
    Section of Molecular and Cellular Biology, University of California Davis, Davis, California 95616, USA
    Mol Biol Cell 11:241-53. 2000
    ..During anaphase, however, Ncd appears to have no effect on spindle pole movements, suggesting that its activity is down-regulated at this time, allowing dynein and KLP61F to drive spindle elongation during anaphase B...
  5. pmc The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles
    D J Sharp
    Section of Molecular and Cellular Biology, University of California Davis, Davis, California 95616, USA
    J Cell Biol 144:125-38. 1999
    ..Thus we propose that bipolar kinesin motors and MTs interact by a "sliding filament mechanism" during the formation and function of the mitotic spindle...
  6. ncbi The Drosophila POLO kinase localises to multiple compartments of the mitotic apparatus and is required for the phosphorylation of MPM2 reactive epitopes
    E Logarinho
    Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua do Campo Alegre 823, Portugal
    J Cell Sci 111:2897-909. 1998
    ....
  7. ncbi The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function
    Nick Trotta
    Department of Biological Sciences, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37235, USA
    Curr Biol 14:1135-47. 2004
    ..Previous work in cell culture has proposed a role for Spastin in regulating microtubules...
  8. pmc Cytoplasmic dynein is required for the nuclear attachment and migration of centrosomes during mitosis in Drosophila
    J T Robinson
    University of Minnesota, Department of Genetics, Cell Biology and Development, St Paul, Minnesota 55108 1095, USA
    J Cell Biol 146:597-608. 1999
    ..The disruption of these centrosome attachments in mutant embryos reveals a critical role for dynein function and centrosome positioning in the spatial organization of the syncytial cytoplasm of the developing embryo...
  9. ncbi Regulation of Drosophila alpha- and beta-tubulin genes during development
    J E Natzle
    Dev Biol 104:187-98. 1984
    Both the alpha and the beta subunit of tubulin in Drosophila melanogaster are encoded by small multigene families...
  10. pmc Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes
    Alexander Stark
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA
    Genome Res 17:1865-79. 2007
    ..For mir-10 in particular, both arms show abundant processing, and both show highly conserved target sites in Hox genes, suggesting a possible cooperation of the two arms, and their role as a master Hox regulator...
  11. pmc Non-cell-autonomous control of denticle diversity in the Drosophila embryo
    Stacie A Dilks
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 137:1395-404. 2010
    ..We propose that stripe mediates its effect on hook orientation, in part, via upregulation of shot...
  12. pmc Tubulin evolution in insects: gene duplication and subfunctionalization provide specialized isoforms in a functionally constrained gene family
    Mark G Nielsen
    Department of Biology, University of Dayton, OH 45467, USA
    BMC Evol Biol 10:113. 2010
    ..Previous in vivo studies in Drosophila find a stringent relationship between tubulin structure and function; small, biochemically similar changes in the major alpha 1 or testis-specific beta 2 ..
  13. ncbi Woc gene mutation causes 20E-dependent alpha-tubulin detyrosination in Drosophila melanogaster
    Xiaoyi Jin
    Department of Entomology, University of Missouri, Columbia, MO 65211, USA
    Arch Insect Biochem Physiol 60:116-29. 2005
    ..present study, we investigated the effect of the woc gene mutation on the expression and tyrosination of alpha-tubulin in the woc(rgl) mutant...
  14. ncbi Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development
    Kirsten K Hanson
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Development 132:4777-87. 2005
    ..Unexpectedly, during late larval development, cells survive loss of borr and develop giant bristles that may reflect their high degree of ploidy...
  15. ncbi Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammals
    Qiaofang Chen
    Department of Pediatrics and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA
    J Exp Biol 207:3125-9. 2004
    ..The mechanism of this protection is probably related to a decrease in protein denaturation through protein-trehalose interactions...
  16. ncbi The abnormal spindle protein is required for germ cell mitosis and oocyte differentiation during Drosophila oogenesis
    Maria Giovanna Riparbelli
    Department of Evolutionary Biology, University of Siena, I 53100, Italy
    Exp Cell Res 298:96-106. 2004
    ..spindles of the mutant cystocytes are composed by wavy microtubules and have abnormal poles that often lack gamma-tubulin. The fusome structure is also compromised...
  17. pmc The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila
    Katherine D Cygnar
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, 55455, USA
    Genetics 170:733-40. 2005
    ..Our results demonstrate that the role of Tap42 in TOR signaling has not been conserved in higher eukaryotes, indicating fundamental differences in the mechanisms of TOR signaling between yeast and higher eukaryotes...
  18. pmc Misregulation of sex-lethal and disruption of male-specific lethal complex localization in Drosophila species hybrids
    Manika Pal Bhadra
    Division of Biological Sciences, University of Missouri, Columbia 65211 7400, USA
    Genetics 174:1151-9. 2006
    ..Lethal hybrid rescue (Lhr), which allows hybrid males from this cross to survive, corrects the SXL and MSL defects. The reciprocal cross of D. simulans mothers by D. melanogaster males exhibits underexpression of Sxl in embryos...
  19. pmc Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled
    Elizabeth E Grevengoed
    University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 3280, USA
    J Cell Biol 163:1267-79. 2003
    ..We also examined other actin regulators. Loss of Abl leads to changes in the localization of the Arp2/3 complex and the formin Diaphanous, and mutations in diaphanous or capping protein beta enhance abl phenotypes...
  20. pmc Reassessing the role and dynamics of nonmuscle myosin II during furrow formation in early Drosophila embryos
    Anne Royou
    CNRS Centre de Génétique Moléculaire, 91198 Gif sur Yvette, France
    Mol Biol Cell 15:838-50. 2004
    ..We suggest that cellularization can be divided into two distinct processes: furrow ingression, driven by microtubule mediated vesicle delivery, and basal closure, which is mediated by actin/myosin based constriction...
  21. ncbi Assembly of yolk spindles in the early Drosophila embryo
    Maria Giovanna Riparbelli
    Department of Evolutionary Biology, University of Siena, Via Aldo Moro 4, I 53100 Siena, Italy
    Mech Dev 120:441-54. 2003
    ..The presence of normal and abnormal centrosomes in the same cytoplasm provides an useful model for investigating the common regulators of the nucleus and centrosome cycle which ensure precise spindle pole duplication...
  22. pmc Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis
    Elisabetta Bucciarelli
    Istituto Pasteur Fondazione Cenci Bolognetti, 00185 Rome, Italy
    J Cell Biol 160:993-9. 2003
    ..This suggests that the association of Aurora B with chromosomes is not a prerequisite for its accumulation at the central spindle, or for its function during cytokinesis...
  23. pmc Drosophila citron kinase is required for the final steps of cytokinesis
    Valeria Naim
    Istituto di Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, 00185 Rome, Italy
    Mol Biol Cell 15:5053-63. 2004
    ....
  24. pmc The product of the split ends gene is required for the maintenance of positional information during Drosophila development
    Kimberly Mace
    Surgical Research Lab, University of California, San Francisco, Box 1302, San Francisco, CA 94143 1302, USA
    BMC Dev Biol 4:15. 2004
    ..Although spen mutants affect only a small subset of morphological structures in embryos, it has been difficult to find a common theme in spen mutant structural alterations, or in the interactions of spen with known signaling pathways...
  25. pmc The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 170:813-23. 2005
    ..These results reveal key steps in the assembly of the apical domain in Drosophila...
  26. ncbi Drosophila Myt1 is a Cdk1 inhibitory kinase that regulates multiple aspects of cell cycle behavior during gametogenesis
    Zhigang Jin
    Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada
    Development 132:4075-85. 2005
    ..Based on these observations, we propose that Myt1 serves unique Cdk1 regulatory functions required for efficient coupling of cell differentiation with cell cycle progression...
  27. doi Developmental expression of Rab11, a small GTP-binding protein in Drosophila epithelia
    Satish Sasikumar
    Cytogenetics Laboratory, Department of Zoology, Banaras Hindu University, Varanasi 221 005, India
    Genesis 47:32-9. 2009
    ..genesis 47:32-39, 2009. (c) 2008 Wiley-Liss, Inc...
  28. ncbi Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint
    James Ashley
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    J Neurosci 25:5943-55. 2005
    ..These results provide a novel mechanism by which cell adhesion molecules are regulated and provide fresh insights into the normal operation of APP during synapse development...
  29. pmc Mechanisms for focusing mitotic spindle poles by minus end-directed motor proteins
    Gohta Goshima
    The Howard Hughes Medical Institute and the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94107, USA
    J Cell Biol 171:229-40. 2005
    ..From these results and simulations, we propose a model on how two minus end-directed motors cooperate to ensure spindle pole coalescence during mitosis...
  30. pmc Increased synaptic microtubules and altered synapse development in Drosophila sec8 mutants
    Faith L W Liebl
    Department of Cell and Structural Biology, University of Illinois at Urbana Champaign, 601 South Goodwin Avenue, C626, Urbana, IL 61801, USA
    BMC Biol 3:27. 2005
    ..However, these models have never been tested in vivo. Nervous system development and function have not been described after mutation of sec8 in any organism...
  31. pmc Gene expression analysis of the function of the male-specific lethal complex in Drosophila
    Manika Pal Bhadra
    Division of Biological Sciences, University of Missouri, Columbia, 65211, USA
    Genetics 169:2061-74. 2005
    ....
  32. ncbi Biolistics for high-throughput transformation and RNA interference in Drosophila melanogaster
    Jenna L Yuen
    Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    Fly (Austin) 2:247-54. 2008
    ..These results suggest that biolistic delivery of dsRNA into embryos could be adapted for high throughput RNAi screens of early Drosophila developmental genes...
  33. ncbi Drosophila APC2 and APC1 have overlapping roles in the larval brain despite their distinct intracellular localizations
    Kathryn Akong
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
    Dev Biol 250:71-90. 2002
    ..Our experiments suggest that this does not result from misregulation of Wg signaling, and thus may involve the cytoskeletal or adhesive roles of APC proteins...
  34. ncbi Isolation, characterization, and localization of beta-tubulin genomic clones of three Drosophila montium subgroup species
    Elena Drosopoulou
    Department of Genetics, Development, and Molecular Biology, School of Biology, Faculty of Science, Aristole University of Thessaloniki, Greece
    Genome 45:604-7. 2002
    ..Clones containing beta-tubulin specific sequences were isolated, characterized by restriction endonuclease digestions and Southern ..
  35. ncbi A new family of cyclophilins with an RNA recognition motif that interact with members of the trx/MLL protein family in Drosophila and human cells
    Melanie Anderson
    Cancer Center, Department of Medicine, Stritch School of Medicine, Loyola University Medical Center, 2160 South First Avenue, Maywood, IL 60153, USA
    Dev Genes Evol 212:107-13. 2002
    ..Over expression of Dcyp33 in DrosophilaSL1 cells results in down-regulation of AbdominalB Hoxgene expression, mirroring the effect of human Cyp33 on the expression of human HOXgenes...
  36. ncbi Promoter melting and TFIID complexes on Drosophila genes in vivo
    C Giardina
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    Genes Dev 6:2190-200. 1992
    ..with the pause site of the uninduced hsp70 and hsp26 heat shock genes and the constitutively expressed beta-1 tubulin gene. The histone H1 and H2B genes, which lack a paused polymerase, have no comparable region of melted DNA...
  37. ncbi Homeotic gene action in embryonic brain development of Drosophila
    F Hirth
    Institute of Zoology, University of Basel, Basel, Switzerland
    Development 125:1579-89. 1998
    ..Our findings demonstrate that the action of the homeotic genes labial and Deformed are required for neuronal differentiation in the developing brain of Drosophila...
  38. pmc Intron "sliding" and the diversity of intron positions
    A Stoltzfus
    Canadian Institute for Advanced Research Program in Evolutionary Biology, and Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    Proc Natl Acad Sci U S A 94:10739-44. 1997
    ..The results suggest that sliding, if it occurs at all, has contributed little to the diversity of intron positions...
  39. ncbi The Drosophila gene morula inhibits mitotic functions in the endo cell cycle and the mitotic cell cycle
    B H Reed
    Whitehead Institute for Biomedical Research and Dept of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Development 124:3543-53. 1997
    ..Thus morula serves a dual function as a cell cycle regulator that promotes exit from mitosis and maintains the absence of mitosis during the endo cycle, possibly by activating the cyclin destruction machinery...
  40. pmc A new enhancer of position-effect variegation in Drosophila melanogaster encodes a putative RNA helicase that binds chromosomes and is regulated by the cell cycle
    D F Eberl
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genetics 146:951-63. 1997
    ....
  41. pmc Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila
    S Eaton
    Programme in Cell Biology, European Molecular Biology Laboratory, Heidelberg, Germany
    J Cell Biol 135:1277-89. 1996
    ..During hair formation, the apical microtubules that point distally elongate and fill the emerging wing hair. As the hair elongates, junctional proteins are reorganized on the proximal and distal edges of each cell...
  42. ncbi Effect of hydrogen peroxide on cytoskeletal proteins of Drosophila cells: comparison with heat shock and other stresses
    A M Courgeon
    Groupe de Génétique Cellulaire et Moléculaire, UA CNRS 1135, Universite Pierre et Marie Curie, Paris, France
    Exp Cell Res 204:30-7. 1993
    ..The synthesis of two cytoskeletal proteins, tubulin and a 46-kDa insoluble protein of the intermediate filament fraction, was also slightly increased by H2O2 in ..
  43. ncbi Organization and expression of alpha-tubulin genes in Drosophila melanogaster. One member of the alpha-tubulin multigene family is transcribed in both oogenesis and later embryonic development
    D Mischke
    J Mol Biol 156:449-66. 1982
  44. pmc Genetics of microtubule systems
    E C Raff
    J Cell Biol 99:1-10. 1984
    In most eucaryotes the tubulin genes comprise small multigene families with approximately equal numbers of genes for alpha- and beta-tubulin, the structural proteins of microtubules...
  45. ncbi The expression of beta 1 and beta 3 tubulin genes of Drosophila melanogaster is spatially regulated during embryogenesis
    A Gasch
    Gentechnologische Arbeitsgruppe am MPI für Biochemie, Martinsried, Federal Republic of Germany
    Mol Gen Genet 211:8-16. 1988
    ..mRNAs transcribed from two of these genes, namely the beta 1 and beta 3 tubulin genes, are abundant during embryogenesis...
  46. pmc In situ hybridization analysis of chromosomal homologies in Drosophila melanogaster and Drosophila virilis
    J H Whiting
    Department of Zoology, Brigham Young University, Provo, Utah 84602
    Genetics 122:99-109. 1989
    ..Probes representing two multigene families (beta-tubulin and yolk-protein) hybridized as would be expected if all sites had been conserved in the two species on the same ..
  47. ncbi The paternal effect gene ms(3)sneaky is required for sperm activation and the initiation of embryogenesis in Drosophila melanogaster
    K R Fitch
    Department of Genetics, University of Washington, Seattle 98195, USA
    Dev Biol 197:270-82. 1998
    ..Immunolocalization of tubulin and Drosophila Centrosomin, a known centrosomal component, showed that snky-inseminated eggs failed to ..
  48. pmc Drosophila polo kinase is required for cytokinesis
    M Carmena
    CRC Cell Cycle Group, Cancer Research Campaign Laboratories, Department of Anatomy and Physiology, Medical Sciences Institute, University of Dundee, Dundee DD1 4HN, Scotland
    J Cell Biol 143:659-71. 1998
    ..We discuss these findings in respect to conserved functions for the Polo-like kinases in regulating progression through M phase, including the earliest events of cytokinesis...
  49. ncbi Cellularization in Drosophila melanogaster is disrupted by the inhibition of rho activity and the activation of Cdc42 function
    J M Crawford
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, 27710 7599, USA
    Dev Biol 204:151-64. 1998
    ..These embryos halt in cellularization and do not proceed to gastrulation. We conclude that Rho activity and Cdc42 regulation are required for cytoskeletal function in actomyosin-driven furrow canal formation and nuclear positioning...
  50. ncbi Inscuteable-dependent apical localization of the microtubule-binding protein Cornetto suggests a role in asymmetric cell division
    S Bulgheresi
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    J Cell Sci 114:3655-62. 2001
    ....
  51. ncbi The sex determination master switch, Sex-lethal, responds to Hedgehog signaling in the Drosophila germline
    C Vied
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, Alabama 35294, USA
    Development 128:2649-60. 2001
    ..This is the first demonstration that downstream components of the Hedgehog signaling pathway regulate a target other than Cubitus interruptus...
  52. pmc Biogenesis of Golgi stacks in imaginal discs of Drosophila melanogaster
    V Kondylis
    The Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh, EH9 3JR, Scotland, United Kingdom
    Mol Biol Cell 12:2308-27. 2001
    ..Taken together, these results suggest that we have developed an in vivo system to study the ecdysone-triggered Golgi stack biogenesis...
  53. ncbi The fusome organizes the microtubule network during oocyte differentiation in Drosophila
    N C Grieder
    Howard Hughes Medical Institute, Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 127:4253-64. 2000
    ..We have investigated how the microtubule network polarizes using a GFP-tubulin construct that allows germ-cell microtubules to be visualized with greater sensitivity than in previous studies...
  54. ncbi Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization
    F Yu
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Cell 100:399-409. 2000
    ....
  55. pmc Mitotic regulators govern progress through steps in the centrosome duplication cycle
    S J Vidwans
    Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143 0448, USA
    J Cell Biol 147:1371-8. 1999
    ..Common regulation of the nuclear and centrosome cycles by mitotic regulators may ensure precise duplication of the centrosome...
  56. ncbi The centrosome cycle in syncytial Drosophila embryos analyzed by energy filtering transmission electron microscopy
    A Debec
    Laboratoire de Physiologie Cellulaire des Invertébrés, Universite Pierre et Marie Curie, Paris, France
    Biol Cell 91:379-91. 1999
    ..We conclude that in the early Drosophila embryo there is an unusual delay between the separation of the parent centrioles and their duplication. This leaves a surprisingly short time to assemble a daughter centriole...
  57. ncbi A glial cell arises from an additional division within the mechanosensory lineage during development of the microchaete on the Drosophila notum
    G V Reddy
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400 005 and the National Centre for Biological Sciences, TIFR, Bangalore 560 065, India
    Development 126:4617-22. 1999
    ..The proposed modification in lineage has important implications for previous studies on sibling cell fate choice and cell fate specification in sensory systems...
  58. pmc Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    J Cell Biol 146:1303-18. 1999
    ..We discuss the implications of our results for Wg signaling, and suggest a role for dAPC2 as a mediator of Wg effects on the cytoskeleton. We also speculate on more general roles that APCs may play in cytoskeletal dynamics...
  59. ncbi Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch
    G V Reddy
    Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Rd, Mumbai 400005, India
    Development 126:2083-92. 1999
    ..Pros misexpression is sufficient for the transformation of PIIa to PIIb fate. The expression of Pros in the normal PIIb cell appears to be regulated by Notch signaling...
  60. pmc Postinitiation transcriptional control in Drosophila melanogaster
    A E Rougvie
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    Mol Cell Biol 10:6041-5. 1990
    ..We propose that a rate-limiting step in early elongation occurs in many Drosophila genes and may be a target for transcriptional regulation...
  61. pmc Distinct roles of Galphai and Gbeta13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions
    Fengwei Yu
    MRC Centre for Developmental Neurobiology, 4th Fl, New Hunts House, Guy s Campus, King s College London, London SE1 1UL, UK
    J Cell Biol 162:623-33. 2003
    ..Importantly, our results have also revealed a novel aspect of apical complex function, that is, the two apical pathways act redundantly to suppress the formation of basal astral microtubules in neuroblasts...