beta4GalNAcTA

Summary

Gene Symbol: beta4GalNAcTA
Description: beta4GalNAcTA
Alias: BcDNA:GH13356, CG8536, DmGalT, Dmel\CG8536, anon-WO0118547.128, b4GalNAcTA, beta4Gal-NAcTA, beta4GalNAcT1, beta4GalNacTA, beta4GalTA, dbeta4GalTA, beta4GalNAcTA, CG8536-PA, beta1,4-N-acetylgalactosaminyltransferase, beta4GalNAcTA-PA
Species: fruit fly

Top Publications

  1. Sasaki N, Yoshida H, Fuwa T, Kinoshita Toyoda A, Toyoda H, Hirabayashi Y, et al. Drosophila beta 1,4-N-acetylgalactosaminyltransferase-A synthesizes the LacdiNAc structures on several glycoproteins and glycosphingolipids. Biochem Biophys Res Commun. 2007;354:522-7 pubmed
    ..In this study, we examined acceptor substrate specificity of Drosophila beta4GalNAcTA by using some N- and O-glycans on glycoproteins and neutral glycosphingolipids (GSLs)...
  2. Chen Y, Pedersen J, Wandall H, Levery S, Pizette S, Clausen H, et al. Glycosphingolipids with extended sugar chain have specialized functions in development and behavior of Drosophila. Dev Biol. 2007;306:736-49 pubmed
    ..Two beta4-N-Acetylgalactosyltransferase enzymes can carry out step 4 (beta4GalNAcTA and beta4GalNAcTB), and while they may have overlapping activity, the mutants produce distinct phenotypes...
  3. Haines N, Stewart B. Functional roles for beta1,4-N-acetlygalactosaminyltransferase-A in Drosophila larval neurons and muscles. Genetics. 2007;175:671-9 pubmed
    Adult Drosophila mutant for the glycosyltransferase beta1,4-N-acetlygalactosaminyltransferase-A (beta4GalNAcTA) display an abnormal locomotion phenotype, indicating a role for this enzyme, and the glycan structures that it generates, in ..
  4. Stolz A, Haines N, Pich A, Irvine K, Hokke C, Deelder A, et al. Distinct contributions of beta 4GalNAcTA and beta 4GalNAcTB to Drosophila glycosphingolipid biosynthesis. Glycoconj J. 2008;25:167-75 pubmed
    Drosophila melanogaster has two beta4-N-acetylgalactosaminyltransferases, beta4GalNAcTA and beta4GalNAcTB, that are able to catalyse the formation of lacdiNAc (GalNAcbeta,4GlcNAc)...
  5. Johswich A, Kraft B, Wuhrer M, Berger M, Deelder A, Hokke C, et al. Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot. J Cell Biol. 2009;184:173-83 pubmed publisher
    ..In summary, our data provide evidence that GABPI is required for ER export and activity of beta4GalNAcTB. ..
  6. Haines N, Irvine K. Functional analysis of Drosophila beta1,4-N-acetlygalactosaminyltransferases. Glycobiology. 2005;15:335-46 pubmed
    ..Here, we describe analysis of two Drosophila genes, beta4GalNAcTA (CG8536) and beta4GalNAcTB (CG14517), that are homologous to mammalian beta1,4-galactosyltransferases...
  7. Ramakrishnan B, Qasba P. Role of a single amino acid in the evolution of glycans of invertebrates and vertebrates. J Mol Biol. 2007;365:570-6 pubmed
    ..Subsequently, the pre-existing alpha-LA-binding site was utilized during mammalian evolution to synthesize lactose in the mammary gland during lactation. ..
  8. Takemae H, Ueda R, Okubo R, Nakato H, Izumi S, Saigo K, et al. Proteoglycan UDP-galactose:beta-xylose beta 1,4-galactosyltransferase I is essential for viability in Drosophila melanogaster. J Biol Chem. 2003;278:15571-8 pubmed
    ..The lethality among the progeny proved that beta4GalTI is essential for viability. This study is the first to use reverse genetics, RNA interference, to study the Drosophila glycosyltransferase systematically. ..
  9. Kraft B, Johswich A, Kauczor G, Scharenberg M, Gerardy Schahn R, Bakker H. "Add-on" domains of Drosophila ?1,4-N-acetylgalactosaminyltransferase B in the stem region and its pilot protein. Cell Mol Life Sci. 2011;68:4091-100 pubmed publisher
    ..Moreover, some inactive GABPI mutants could be rescued by fusion with ?4GalNAcTB, indicating their importance in direct GABPI-?4GalNAcTB interaction. ..

More Information

Publications16

  1. Kim K, Lawrence S, Park J, Pitts L, Vann W, Betenbaugh M, et al. Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene: evidence for endogenous sialic acid biosynthetic ability in insects. Glycobiology. 2002;12:73-83 pubmed
    ..Homology searches of the Drosophila genome identified putative orthologues of other genes required for sialylation of glycoconjugates. ..
  2. Xu A, Haines N, Dlugosz M, Rana N, Takeuchi H, Haltiwanger R, et al. In vitro reconstitution of the modulation of Drosophila Notch-ligand binding by Fringe. J Biol Chem. 2007;282:35153-62 pubmed
  3. Swanson L, Yu M, Nelson K, Laprise P, Tepass U, Beitel G. Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization. Genetics. 2009;181:1281-90 pubmed publisher
    ..Moreover, we present evidence indicating that Conv/dALS has a novel, IGF-signaling independent function in tracheal morphogenesis. ..
  4. Nakamura M, Pandey D, Panin V. Genetic Interactions Between Drosophila sialyltransferase and ?1,4-N-acetylgalactosaminyltransferase-A Genes Indicate Their Involvement in the Same Pathway. G3 (Bethesda). 2012;2:653-6 pubmed publisher
    ..We found that ?4GalNAcTA is epistatic to DSiaT. Our data suggest an intriguing possibility that ?4GalNAcTA may participate in the biosynthesis of sialylated glycans. ..
  5. Viswanathan K, Tomiya N, Park J, Singh S, Lee Y, Palter K, et al. Expression of a functional Drosophila melanogaster CMP-sialic acid synthetase. Differential localization of the Drosophila and human enzymes. J Biol Chem. 2006;281:15929-40 pubmed
  6. Harbison S, Sehgal A. Quantitative genetic analysis of sleep in Drosophila melanogaster. Genetics. 2008;178:2341-60 pubmed publisher
    ..The large mutational target that we observed implicates genes functioning in a variety of biological processes, suggesting that sleep may serve a number of different functions rather than a single purpose. ..
  7. Fernandes C, Rao Y. Genome-wide screen for modifiers of Parkinson's disease genes in Drosophila. Mol Brain. 2011;4:17 pubmed publisher
    ..Further study of novel PD-interacting genes will shed new light on the function of PD genes and help in the development of new therapeutic strategies for treating Parkinson's disease. ..