Gene Symbol: bel
Description: belle
Alias: BEL, Bel, CG9748, DmRH6, Dmel\CG9748, anon-85Ab, cap, cg9748, l(3)85Ac, l(3)L3, l(3)L4740, l(3)S047110, l(3)S097074, ms(3)Pneo85A, ms(3)neo30, psg9, belle, CG9748-PA, CG9748-PB, bel-PA, bel-PB, capon, lethal (3) L4740, lethal (3) S047110
Species: fruit fly

Top Publications

  1. Bender M, Turner F, Kaufman T. A development genetic analysis of the gene regulator of postbithorax in Drosophila melanogaster. Dev Biol. 1987;119:418-32 pubmed
    ..A possible formal relationship between Rg-pbx, ftz, and the postbithorax (pbx) locus is proposed. ..
  2. Jones W, Rawls J. Genetic and molecular mapping of chromosome region 85A in Drosophila melanogaster. Genetics. 1988;120:733-42 pubmed
    ..The breakpoint sites of a number of 85A chromosome rearrangements were localized on the molecular map, thereby delimiting regions of the DNA that contain the various genetic complementation groups. ..
  3. Clyne P, Brotman J, Sweeney S, Davis G. Green fluorescent protein tagging Drosophila proteins at their native genomic loci with small P elements. Genetics. 2003;165:1433-41 pubmed
    ..This technology allows the generation of GFP-tagged reagents on a genome-wide scale with diverse potential applications. ..
  4. Ihry R, Sapiro A, Bashirullah A. Translational control by the DEAD Box RNA helicase belle regulates ecdysone-triggered transcriptional cascades. PLoS Genet. 2012;8:e1003085 pubmed publisher
    ..We identified a mutation in the evolutionarily conserved DEAD box RNA helicase belle/DDX3 that disrupts a subset of responses to the steroid hormone ecdysone during Drosophila melanogaster ..
  5. Ambrus A, Nicolay B, Rasheva V, Suckling R, Frolov M. dE2F2-independent rescue of proliferation in cells lacking an activator dE2F1. Mol Cell Biol. 2007;27:8561-70 pubmed
    ..Here, we report that in mosaic animals, in addition to de2f2, the loss of a DEAD box protein Belle (Bel) also rescues proliferation of de2f1 mutant cells...
  6. Kibanov M, Egorova K, Ryazansky S, Sokolova O, Kotov A, Olenkina O, et al. A novel organelle, the piNG-body, in the nuage of Drosophila male germ cells is associated with piRNA-mediated gene silencing. Mol Biol Cell. 2011;22:3410-9 pubmed publisher
    ..This body contains known ovarian nuage proteins, including Vasa, Aub, AGO3, Tud, Spn-E, Bel, Squ, and Cuff, as well as AGO1, the key component of the microRNA pathway...
  7. Johnstone O, Deuring R, Bock R, Linder P, Fuller M, Lasko P. Belle is a Drosophila DEAD-box protein required for viability and in the germ line. Dev Biol. 2005;277:92-101 pubmed
    ..Here, we report identification and characterization of the Drosophila protein Belle (Bel), which belongs to a highly conserved subfamily of DEAD-box proteins including yeast Ded1p, Xenopus An3, ..
  8. Jenny F, Basler K. Drosophila DDX3/Belle Exerts Its Function Outside of the Wnt/Wingless Signaling Pathway. PLoS ONE. 2016;11:e0166862 pubmed publisher
    The helicases human DDX3 and Drosophila Belle (Bel) are part of a well-defined subfamily of the DEAD-box helicases. Individual subfamily-members perform a myriad of functions in nuclear and cytosolic RNA metabolism...
  9. Ambrus A, Frolov M. Mutation of the DEAD-box helicase belle downregulates the cyclin-dependent kinase inhibitor Dacapo. Cell Cycle. 2010;9:1016-20 pubmed
    ..In Drosophila, mutation of the DEAD-box helicase belle (bel) relieves an E2F/pRB induced G(1) cell cycle arrest; however, the mechanism of this rescue is unknown...

More Information


  1. Cooley L, Berg C, Spradling A. Controlling P element insertional mutagenesis. Trends Genet. 1988;4:254-8 pubmed
  2. Doiguchi M, Nakagawa T, Imamura Y, Yoneda M, Higashi M, Kubota K, et al. SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation. Sci Rep. 2016;6:20179 pubmed publisher
    ..The interplay between the remodeling activity of SMARCAD1 and histone acetylation by CBP sheds light on the function of chromatin and the genome-integrity network. ..
  3. Ihry R, Bashirullah A. Genetic control of specificity to steroid-triggered responses in Drosophila. Genetics. 2014;196:767-80 pubmed publisher
  4. Götze M, Dufourt J, Ihling C, Rammelt C, Pierson S, Sambrani N, et al. Translational repression of the Drosophila nanos mRNA involves the RNA helicase Belle and RNA coating by Me31B and Trailer hitch. RNA. 2017;23:1552-1568 pubmed publisher
    ..As a novel component, the RNA-dependent ATPase Belle (DDX3) was found, and its involvement in deadenylation and repression of nanos was confirmed in vivo...
  5. Kotov A, Olenkina O, Kibanov M, Olenina L. RNA helicase Belle (DDX3) is essential for male germline stem cell maintenance and division in Drosophila. Biochim Biophys Acta. 2016;1863:1093-105 pubmed publisher
    The present study showed that RNA helicase Belle (DDX3) was required intrinsically for mitotic progression and survival of germline stem cells (GSCs) and spermatogonial cells in the Drosophila melanogaster testes...
  6. Yarunin A, Harris R, Ashe M, Ashe H. Patterning of the Drosophila oocyte by a sequential translation repression program involving the d4EHP and Belle translational repressors. RNA Biol. 2011;8:904-12 pubmed publisher
    ..Here we show that the belle (bel) mRNA is translationally repressed by the d4EHP protein in the Drosophila ovary...
  7. Poulton J, Huang Y, Smith L, Sun J, Leake N, Schleede J, et al. The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells. Development. 2011;138:1737-45 pubmed publisher
    ..From a screen for modifiers of Notch signaling in Drosophila we have identified the RNA helicase Belle, a recently described component of the RNA interference pathway, as an important regulator of the timing of Notch ..
  8. Bradley S, Narayanan S, Rosbash M. NAT1/DAP5/p97 and atypical translational control in the Drosophila Circadian Oscillator. Genetics. 2012;192:943-57 pubmed publisher
    ..It also dramatically reduced PER protein levels in pigment dispersing factor (PDF) neurons. BELLE (BEL) protein was also reduced by the NAT1 knockdown, presumably reflecting a role of NAT1 in belle mRNA ..
  9. Shimada Y, Burn K, Niwa R, Cooley L. Reversible response of protein localization and microtubule organization to nutrient stress during Drosophila early oogenesis. Dev Biol. 2011;355:250-62 pubmed publisher
    ..This response implies a mechanism for preserving young egg chambers so that egg production can rapidly resume when nutrient availability improves. ..
  10. Pek J, Kai T. DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. Proc Natl Acad Sci U S A. 2011;108:12007-12 pubmed publisher
    ..Here, we present evidence that belle (vasa paralog) and the RNA interference pathway regulate chromosome segregation in Drosophila somatic cells...
  11. Rolls M, Satoh D, Clyne P, Henner A, Uemura T, Doe C. Polarity and intracellular compartmentalization of Drosophila neurons. Neural Dev. 2007;2:7 pubmed
    ..In addition, we track EB1-GFP dynamics and determine microtubules in axons and dendrites have opposite polarity. We conclude that Drosophila will be a powerful system to study the establishment and maintenance of neuronal compartments. ..
  12. Sapiro A, Ihry R, Buhr D, Konieczko K, Ives S, Engstrom A, et al. Rapid recombination mapping for high-throughput genetic screens in Drosophila. G3 (Bethesda). 2013;3:2313-9 pubmed publisher
    ..By facilitating the rapid identification of mutated genes, our mapping strategy removes a primary obstacle to the widespread use of powerful chemical mutagenesis screens to understand fundamental biological phenomena. ..
  13. Link N, Chen P, Lu W, Pogue K, Chuong A, Mata M, et al. A collective form of cell death requires homeodomain interacting protein kinase. J Cell Biol. 2007;178:567-74 pubmed
    ..Extra cells also persisted in other tissues, establishing a more generalized requirement for HIPK in the regulation of cell death and cell numbers. ..
  14. Lim S, Boyle P, Chinen M, Dale R, Lei E. Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. Nucleic Acids Res. 2013;41:2963-80 pubmed publisher
    ..Taken together, our results reveal a novel positive relationship between exosome and chromatin insulators throughout the genome. ..
  15. Nashchekin D, Zhao J, Visa N, Daneholt B. A novel Ded1-like RNA helicase interacts with the Y-box protein ctYB-1 in nuclear mRNP particles and in polysomes. J Biol Chem. 2006;281:14263-72 pubmed
  16. Miles W, Tschop K, Herr A, Ji J, Dyson N. Pumilio facilitates miRNA regulation of the E2F3 oncogene. Genes Dev. 2012;26:356-68 pubmed publisher
    ..These studies suggest that Pumilio-miRNA repression of E2F3 translation provides an important level of E2F regulation that is frequently abrogated in cancer cells. ..
  17. Xiong X, Kurthkoti K, Chang K, Lichinchi G, De N, Schneemann A, et al. Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila. Proc Natl Acad Sci U S A. 2013;110:16520-5 pubmed publisher
  18. Kibanov M, Gvozdev V, Olenina L. Germ granules in spermatogenesis of Drosophila: Evidences of contribution to the piRNA silencing. Commun Integr Biol. 2012;5:130-3 pubmed publisher
    ..In this mini-review, we analyze the recent published data about structure and functions of Drosophila male germ granules, and especially their involvement in the piRNA silencing pathway. ..
  19. Syrzycka M, McEachern L, Kinneard J, Prabhu K, Fitzpatrick K, Schulze S, et al. The pink gene encodes the Drosophila orthologue of the human Hermansky-Pudlak syndrome 5 (HPS5) gene. Genome. 2007;50:548-56 pubmed
    ..Here we confirm this gene assignment, making pink the first eye colour gene in flies to be identified as a BLOC complex gene. ..
  20. Lo P, Huang Y, Poulton J, Leake N, Palmer W, Vera D, et al. RNA helicase Belle/DDX3 regulates transgene expression in Drosophila. Dev Biol. 2016;412:57-70 pubmed publisher
    b>Belle (Bel), the Drosophila homolog of the yeast DEAD-box RNA helicase DED1 and human DDX3, has been shown to be required for oogenesis and female fertility...
  21. Ulvila J, Parikka M, Kleino A, Sormunen R, Ezekowitz R, Kocks C, et al. Double-stranded RNA is internalized by scavenger receptor-mediated endocytosis in Drosophila S2 cells. J Biol Chem. 2006;281:14370-5 pubmed
    ..machinery, and three gene products previously unknown to be involved in RNAi in Drosophila: DEAD-box RNA helicase Belle, 26 S proteasome regulatory subunit 8 (Pros45), and clathrin heavy chain, a component of the endocytic machinery...
  22. Gao M, Arkov A. Next generation organelles: structure and role of germ granules in the germline. Mol Reprod Dev. 2013;80:610-23 pubmed publisher
  23. Arkov A, Ramos A. Building RNA-protein granules: insight from the germline. Trends Cell Biol. 2010;20:482-90 pubmed publisher
    ..These data suggest a widespread use of several protein motifs in germline development and further our understanding of other ribonucleoprotein structures, for example, processing bodies and neuronal granules. ..
  24. Irion U, Leptin M. Developmental and cell biological functions of the Drosophila DEAD-box protein abstrakt. Curr Biol. 1999;9:1373-81 pubmed
    ..Abstrakt must affect processing of specific subsets of RNAs, suggesting that differential post-translational control during development is more common than previously suspected. ..