BEAF-32

Summary

Gene Symbol: BEAF-32
Description: Boundary element-associated factor of 32kD
Alias: BEAF, BEAF-32A, BEAF-32B, BEAF32, BEAF32A, BEAF32B, BEAF32b, Beaf-32, Beaf32, CG10159, Dmel\CG10159, beaf, bs04c01.y1, boundary element-associated factor of 32kD, BEAF-32-PA, BEAF-32-PB, BEAF-32-PC, CG10159-PA, CG10159-PB, CG10159-PC, boundary element associated factor, boundary element associated factor 32, boundary element associated factor of 32, boundary element-associated factor
Species: fruit fly
Products:     BEAF-32

Top Publications

  1. Gilbert M, Tan Y, Hart C. The Drosophila boundary element-associated factors BEAF-32A and BEAF-32B affect chromatin structure. Genetics. 2006;173:1365-75 pubmed
    Binding sites for the Drosophila boundary element-associated factors BEAF-32A and -32B are required for the insulator activity of the scs' insulator...
  2. Moon H, Filippova G, Loukinov D, Pugacheva E, Chen Q, Smith S, et al. CTCF is conserved from Drosophila to humans and confers enhancer blocking of the Fab-8 insulator. EMBO Rep. 2005;6:165-70 pubmed
    ..Four proteins have been identified in Drosophila mediating enhancer blocking-Su(Hw), Zw5, BEAF32 and GAGA factor...
  3. Wallace H, Plata M, Kang H, Ross M, Labrador M. Chromatin insulators specifically associate with different levels of higher-order chromatin organization in Drosophila. Chromosoma. 2010;119:177-94 pubmed publisher
    ..In addition, clusters of coexpressed genes in this region form bands characterized by the lack of CP190 and BEAF-32 insulator proteins...
  4. Bell A, West A, Felsenfeld G. Insulators and boundaries: versatile regulatory elements in the eukaryotic genome. Science. 2001;291:447-50 pubmed
  5. Rach E, Winter D, Benjamin A, Corcoran D, Ni T, Zhu J, et al. Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level. PLoS Genet. 2011;7:e1001274 pubmed publisher
  6. van Bemmel J, Pagie L, Braunschweig U, Brugman W, Meuleman W, Kerkhoven R, et al. The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome. PLoS ONE. 2010;5:e15013 pubmed publisher
    ..shows that only SU(HW) binds preferentially at LAD borders and at specific positions inside LADs, while GAF, CTCF, BEAF-32 and DWG are mostly absent from these regions...
  7. Oliver D, Sheehan B, South H, Akbari O, Pai C. The chromosomal association/dissociation of the chromatin insulator protein Cp190 of Drosophila melanogaster is mediated by the BTB/POZ domain and two acidic regions. BMC Cell Biol. 2010;11:101 pubmed publisher
    ..essential to the function of at least three-types of chromatin insulator complexes organized by Su(Hw), CTCF and BEAF32. We mapped functional regions of Cp190 in vivo and identified three domains that are essential for the insulator ..
  8. Yoshida H, Inoue Y, Hirose F, Sakaguchi K, Matsukage A, Yamaguchi M. Over-expression of DREF in the Drosophila wing imaginal disc induces apoptosis and a notching wing phenotype. Genes Cells. 2001;6:877-86 pubmed
    ..In addition, over-expression of the 32 kDa boundary element-associated factor (BEAF-32), thought to compete against DREF for common binding sites in genomic regions, rescued the DREF-induced notching ..
  9. Matzat L, Dale R, Moshkovich N, Lei E. Tissue-specific regulation of chromatin insulator function. PLoS Genet. 2012;8:e1003069 pubmed publisher
    ..Taken together, these data reveal a novel, tissue-specific mode of regulation of a chromatin insulator. ..

More Information

Publications74

  1. Bushey A, Ramos E, Corces V. Three subclasses of a Drosophila insulator show distinct and cell type-specific genomic distributions. Genes Dev. 2009;23:1338-50 pubmed publisher
    ..experiments with whole-genome tiling arrays to compare Su(Hw), dCTCF, boundary element-associated factor (BEAF), and CP190 localization on DNA in two different cell lines and found evidence that BEAF is a third subclass of ..
  2. Liang J, Lacroix L, Gamot A, Cuddapah S, Queille S, Lhoumaud P, et al. Chromatin immunoprecipitation indirect peaks highlight long-range interactions of insulator proteins and Pol II pausing. Mol Cell. 2014;53:672-81 pubmed publisher
    ..Our data illustrate how indirect peaks may decipher gene regulatory networks through specific long-range interactions. ..
  3. Gerasimova T, Corces V. Chromatin insulators and boundaries: effects on transcription and nuclear organization. Annu Rev Genet. 2001;35:193-208 pubmed
    ..Insulators might modulate transcription by organizing the chromatin fiber within the nucleus through the establishment of higher-order domains of chromatin structure. ..
  4. Gurudatta B, Yang J, Van Bortle K, Donlin Asp P, Corces V. Dynamic changes in the genomic localization of DNA replication-related element binding factor during the cell cycle. Cell Cycle. 2013;12:1605-15 pubmed publisher
    ..involved in DNA replication and found to interact with sequences similar to the DNA recognition motif of the BEAF-32 insulator protein. Insulators are DNA-protein complexes that mediate intra- and inter-chromosome interactions...
  5. Blanton J, Gaszner M, Schedl P. Protein:protein interactions and the pairing of boundary elements in vivo. Genes Dev. 2003;17:664-75 pubmed
    ..We show that the Drosophila scs and scs' boundary proteins, Zw5 and BEAF, respectively, interact with each other in vitro and in vivo...
  6. Pathak R, Rangaraj N, Kallappagoudar S, Mishra K, Mishra R. Boundary element-associated factor 32B connects chromatin domains to the nuclear matrix. Mol Cell Biol. 2007;27:4796-806 pubmed
    ..One such protein is the boundary element-associated factor (BEAF), which binds to the scs' boundary element of Drosophila melanogaster...
  7. Roy S, Tan Y, Hart C. A genetic screen supports a broad role for the Drosophila insulator proteins BEAF-32A and BEAF-32B in maintaining patterns of gene expression. Mol Genet Genomics. 2007;277:273-86 pubmed
    ..that is under GAL4 UAS control and encodes a dominant-negative form of the Boundary Element-Associated Factors BEAF-32A and BEAF-32B. The BID transgene encodes the BEAF self-interaction domain but lacks a DNA binding domain...
  8. Yang J, Ramos E, Corces V. The BEAF-32 insulator coordinates genome organization and function during the evolution of Drosophila species. Genome Res. 2012;22:2199-207 pubmed publisher
    ..Here we identify the Drosophila BEAF-32 insulator as a cis regulatory element separating close head-to-head genes with different transcription ..
  9. Jiang N, Emberly E, Cuvier O, Hart C. Genome-wide mapping of boundary element-associated factor (BEAF) binding sites in Drosophila melanogaster links BEAF to transcription. Mol Cell Biol. 2009;29:3556-68 pubmed publisher
    ..DNA isolated by chromatin immunoprecipitation to genome tiling microarrays to construct a genome-wide map of BEAF binding locations. A distinct difference in the association of 32A and 32B with chromatin was noted...
  10. Schwartz Y, Linder Basso D, Kharchenko P, Tolstorukov M, Kim M, Li H, et al. Nature and function of insulator protein binding sites in the Drosophila genome. Genome Res. 2012;22:2188-98 pubmed publisher
    ..Taken together, these observations argue against the concept of a genome partitioned by specialized boundary elements and suggest that insulators are reserved for specific regulation of selected genes. ..
  11. Zhao K, Hart C, Laemmli U. Visualization of chromosomal domains with boundary element-associated factor BEAF-32. Cell. 1995;81:879-89 pubmed
    ..We have cloned a cDNA for one of these proteins, BEAF-32 (boundary element-associated factor of 32 kDa)...
  12. Ishii K, Laemmli U. Structural and dynamic functions establish chromatin domains. Mol Cell. 2003;11:237-48 pubmed
    ..The Drosophila boundary protein BEAF and, unexpectedly, the mammalian factor Sp1 exhibited a robust BA in yeast...
  13. Hart C, Zhao K, Laemmli U. The scs' boundary element: characterization of boundary element-associated factors. Mol Cell Biol. 1997;17:999-1009 pubmed
    ..We previously characterized a cDNA encoding the BEAF-32A protein (32A), which binds with high affinity to the scs' boundary element from the Drosophila melanogaster ..
  14. Negre N, Brown C, Shah P, Kheradpour P, Morrison C, Henikoff J, et al. A comprehensive map of insulator elements for the Drosophila genome. PLoS Genet. 2010;6:e1000814 pubmed publisher
    ..We studied by ChIP-chip the genome-wide binding sites of 6 insulator-associated proteins-dCTCF, CP190, BEAF-32, Su(Hw), Mod(mdg4), and GAF-to obtain the first comprehensive map of insulator elements in Drosophila embryos...
  15. Roy S, Gilbert M, Hart C. Characterization of BEAF mutations isolated by homologous recombination in Drosophila. Genetics. 2007;176:801-13 pubmed
    The Drosophila BEAF-32A and BEAF-32B proteins bind to the scs' insulator and to hundreds of other sites on Drosophila chromosomes. These two proteins are encoded by the same gene...
  16. Emberly E, Blattes R, Schuettengruber B, Hennion M, Jiang N, Hart C, et al. BEAF regulates cell-cycle genes through the controlled deposition of H3K9 methylation marks into its conserved dual-core binding sites. PLoS Biol. 2008;6:2896-910 pubmed publisher
    ..computational approaches to break down the binding signature of the Drosophila boundary element-associated factor (BEAF) subfamily...
  17. Cuvier O, Hart C, Käs E, Laemmli U. Identification of a multicopy chromatin boundary element at the borders of silenced chromosomal domains. Chromosoma. 2002;110:519-31 pubmed
    ..of a class of chromatin BEs in Drosophila melanogaster whose insulating activity requires the DNA-binding protein BEAF (boundary element-associated factor). Here we focus on the characterization of a moderately repeated 1...
  18. Wood A, Van Bortle K, Ramos E, Takenaka N, Rohrbaugh M, Jones B, et al. Regulation of chromatin organization and inducible gene expression by a Drosophila insulator. Mol Cell. 2011;44:29-38 pubmed publisher
  19. Schoborg T, Labrador M. The phylogenetic distribution of non-CTCF insulator proteins is limited to insects and reveals that BEAF-32 is Drosophila lineage specific. J Mol Evol. 2010;70:74-84 pubmed publisher
    ..insulators and their associated proteins have been characterized, including Su(Hw), Zw5, CTCF, GAF, Mod(mdg4), and BEAF-32...
  20. Van Bortle K, Ramos E, Takenaka N, Yang J, Wahi J, Corces V. Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains. Genome Res. 2012;22:2176-87 pubmed publisher
    ..the genome with other Drosophila insulator proteins such as Suppressor of Hairy wing [SU(HW)] and Boundary Element Associated Factor of 32 kDa (BEAF-32) at the borders of H3K27me3 domains, which are also enriched for associated ..
  21. Cuvier O, Hart C, Laemmli U. Identification of a class of chromatin boundary elements. Mol Cell Biol. 1998;18:7478-86 pubmed
    ..The Drosophila protein BEAF binds the scs' boundary element of the 87A7 hsp70 locus and roughly half of polytene chromosome interband loci...
  22. Hou C, Li L, Qin Z, Corces V. Gene density, transcription, and insulators contribute to the partition of the Drosophila genome into physical domains. Mol Cell. 2012;48:471-84 pubmed publisher
    ..These results suggest that the higher-order physical organization of chromatin may impose an additional level of regulation over classical epigenetic marks. ..
  23. Roy S, Jiang N, Hart C. Lack of the Drosophila BEAF insulator proteins alters regulation of genes in the Antennapedia complex. Mol Genet Genomics. 2011;285:113-23 pubmed publisher
    In a screen based on a rough eye phenotype caused by a dominant negative form of the BEAF-32A and BEAF-32B insulator proteins, we previously identified 17 proteins that genetically interact with BEAF...
  24. Hart C, Cuvier O, Laemmli U. Evidence for an antagonistic relationship between the boundary element-associated factor BEAF and the transcription factor DREF. Chromosoma. 1999;108:375-83 pubmed
    ..Understanding this activity will require identifying the proteins involved. The boundary element-associated factor BEAF is one protein that is implicated in boundary element function...
  25. Petesch S, Lis J. Rapid, transcription-independent loss of nucleosomes over a large chromatin domain at Hsp70 loci. Cell. 2008;134:74-84 pubmed publisher
    ..An RNAi screen of 28 transcription and chromatin-related factors reveals that depletion of heat shock factor, GAGA Factor, or Poly(ADP)-Ribose Polymerase or its activity abolishes the loss of nucleosomes upon Hsp70 activation. ..
  26. Lim S, Boyle P, Chinen M, Dale R, Lei E. Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila. Nucleic Acids Res. 2013;41:2963-80 pubmed publisher
    ..of exosome by ChIP-seq in two different embryonic cell lines reveals extensive and specific overlap with the CP190, BEAF-32 and CTCF insulator proteins...
  27. Demakov S, Vatolina T, Babenko V, Semeshin V, Belyaeva E, Zhimulev I. Protein composition of interband regions in polytene and cell line chromosomes of Drosophila melanogaster. BMC Genomics. 2011;12:566 pubmed publisher
    ..set of proteins generally characteristic of the "open" chromatin (RNA polymerase II, CHRIZ (CHRO), BEAF-32, BRE1, dMI-2, GAF, NURF301, WDS and TRX)...
  28. Schoborg T, Rickels R, Barrios J, Labrador M. Chromatin insulator bodies are nuclear structures that form in response to osmotic stress and cell death. J Cell Biol. 2013;202:261-76 pubmed publisher
  29. Rubin A, Green P. Expression-based segmentation of the Drosophila genome. BMC Genomics. 2013;14:812 pubmed publisher
    ..Coexpression segments appear to reflect a level of regulatory organization related to, but below that of physical interaction domains, and depending in part on insulator binding. ..
  30. Silva Sousa R, Varela M, Casacuberta E. The Putzig partners DREF, TRF2 and KEN are involved in the regulation of the Drosophila telomere retrotransposons, HeT-A and TART. Mob DNA. 2013;4:18 pubmed publisher
    ..Our results offer some clues on which other chromatin-related proteins might be involved in telomere regulation and retrotransposon control. ..
  31. Andreyeva E, Kolesnikova T, Demakova O, Mendez Lago M, Pokholkova G, Belyaeva E, et al. High-resolution analysis of Drosophila heterochromatin organization using SuUR Su(var)3-9 double mutants. Proc Natl Acad Sci U S A. 2007;104:12819-24 pubmed
    ..for the proteins characteristic of active chromatin RNA Pol II, H3triMetK4, Z4, and JIL1, the boundary protein BEAF, and the heterochromatin-enriched proteins HP1, HP2, and SU(VAR)3-7...
  32. Kyrchanova O, Leman D, Parshikov A, Fedotova A, Studitsky V, Maksimenko O, et al. New properties of Drosophila scs and scs' insulators. PLoS ONE. 2013;8:e62690 pubmed publisher
    ..Zw5 and BEAF bind to scs and scs', respectively, and are responsible for the interaction between these insulators...
  33. Sultana H, Verma S, Mishra R. A BEAF dependent chromatin domain boundary separates myoglianin and eyeless genes of Drosophila melanogaster. Nucleic Acids Res. 2011;39:3543-57 pubmed publisher
    ..We also report that BEAF and GAF are the two major proteins responsible for the ME boundary function...
  34. Lhoumaud P, Hennion M, Gamot A, Cuddapah S, Queille S, Liang J, et al. Insulators recruit histone methyltransferase dMes4 to regulate chromatin of flanking genes. EMBO J. 2014;33:1599-613 pubmed publisher
    Chromosomal domains in Drosophila are marked by the insulator-binding proteins (IBPs) dCTCF/Beaf32 and cofactors that participate in regulating long-range interactions...
  35. Kellner W, Van Bortle K, Li L, Ramos E, Takenaka N, Corces V. Distinct isoforms of the Drosophila Brd4 homologue are present at enhancers, promoters and insulator sites. Nucleic Acids Res. 2013;41:9274-83 pubmed publisher
  36. Sage B, Jones J, Holmes A, Wu M, Csink A. Sequence elements in cis influence heterochromatic silencing in trans. Mol Cell Biol. 2005;25:377-88 pubmed
    ..Intriguingly, this region encompasses the upstream regions of two divergently transcribed genes and contains a sequence motif that may bind BEAF, a protein involved in delimiting chromatin boundaries.
  37. Follmer N, Wani A, Francis N. A polycomb group protein is retained at specific sites on chromatin in mitosis. PLoS Genet. 2012;8:e1003135 pubmed publisher
  38. Dai Q, Ren A, Westholm J, Duan H, Patel D, Lai E. Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Genes Dev. 2015;29:48-62 pubmed publisher
    ..Altogether, our data define an array of common and distinct biochemical and functional properties of this new family of transcription factors. ..
  39. Van Bortle K, Nichols M, Li L, Ong C, Takenaka N, Qin Z, et al. Insulator function and topological domain border strength scale with architectural protein occupancy. Genome Biol. 2014;15:R82 pubmed publisher
  40. Darbo E, Herrmann C, Lecuit T, Thieffry D, van Helden J. Transcriptional and epigenetic signatures of zygotic genome activation during early Drosophila embryogenesis. BMC Genomics. 2013;14:226 pubmed publisher
  41. Gurudatta B, Ramos E, Corces V. The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. Dev Biol. 2012;369:124-32 pubmed publisher
    b>Boundary Element Associated Factor-32 (BEAF-32) is an insulator protein predominantly found near gene promoters and thought to play a role in gene expression...
  42. Pathak R, Srinivasan A, Mishra R. Genome-wide mapping of matrix attachment regions in Drosophila melanogaster. BMC Genomics. 2014;15:1022 pubmed publisher
    ..We also identified sequence motifs and repeats that constitute MARs. Our data reveal the contact points of genome to the nuclear architecture and provide a link between nuclear functions and genomic packaging. ..
  43. Avva S, Hart C. Characterization of the Drosophila BEAF-32A and BEAF-32B Insulator Proteins. PLoS ONE. 2016;11:e0162906 pubmed publisher
    Data implicate the Drosophila 32 kDa Boundary Element-Associated Factors BEAF-32A and BEAF-32B in both chromatin domain insulator element function and promoter function...
  44. Vogelmann J, Le Gall A, Dejardin S, Allemand F, Gamot A, Labesse G, et al. Chromatin insulator factors involved in long-range DNA interactions and their role in the folding of the Drosophila genome. PLoS Genet. 2014;10:e1004544 pubmed publisher
    ..Here, we investigate the molecular associations between different components of insulator complexes (BEAF32, CP190 and Chromator) by biochemical and biophysical means, and develop a novel single-molecule assay to determine ..
  45. Magbanua J, Runneburger E, Russell S, White R. A variably occupied CTCF binding site in the ultrabithorax gene in the Drosophila bithorax complex. Mol Cell Biol. 2015;35:318-30 pubmed publisher
  46. Fuda N, Guertin M, Sharma S, Danko C, Martins A, Siepel A, et al. GAGA factor maintains nucleosome-free regions and has a role in RNA polymerase II recruitment to promoters. PLoS Genet. 2015;11:e1005108 pubmed publisher
    ..In addition, the insulator factor BEAF, the BEAF-interacting protein Chriz, and the transcription factor M1BP are strikingly enriched on those GAF-..
  47. Chambeyron S, Bickmore W. Does looping and clustering in the nucleus regulate gene expression?. Curr Opin Cell Biol. 2004;16:256-62 pubmed
    ..Nuclear compartments may also be involved in the post-translational modification of proteins by sumoylation and ubiquitylation. ..
  48. Li G, Zhou L. Genome-wide identification of chromatin transitional regions reveals diverse mechanisms defining the boundary of facultative heterochromatin. PLoS ONE. 2013;8:e67156 pubmed publisher
    ..However, boundary-associated insulator binding sites are distinctively flanked by nucleosome destabilizing sequences, which correlates with significantly decreased nucleosome density and increased binding of co-factors. ..
  49. Guertin M, Lis J. Chromatin landscape dictates HSF binding to target DNA elements. PLoS Genet. 2010;6:e1001114 pubmed publisher
  50. Heger P, George R, Wiehe T. Successive gain of insulator proteins in arthropod evolution. Evolution. 2013;67:2945-56 pubmed publisher
    ..Expansion of insulator systems may therefore be a general strategy to increase an organism's gene regulatory repertoire and its potential for morphological plasticity. ..
  51. Maksimenko O, Bartkuhn M, Stakhov V, Herold M, Zolotarev N, Jox T, et al. Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin. Genome Res. 2015;25:89-99 pubmed publisher
    ..The Drosophila CP190 protein is a cofactor for the DNA-binding insulator proteins Su(Hw), CTCF, and BEAF-32...
  52. Li L, Lyu X, Hou C, Takenaka N, Nguyen H, Ong C, et al. Widespread rearrangement of 3D chromatin organization underlies polycomb-mediated stress-induced silencing. Mol Cell. 2015;58:216-31 pubmed publisher
    ..These results suggest that the TAD organization of metazoan genomes is plastic and can be reconfigured quickly. ..
  53. Hayashi Y, Hirose F, Nishimoto Y, Shiraki M, Yamagishi M, Matsukage A, et al. Identification of CFDD (common regulatory factor for DNA replication and DREF genes) and role of its binding site in regulation of the proliferating cell nuclear antigen gene promoter. J Biol Chem. 1997;272:22848-58 pubmed
    ..and 3 overlapped with DRE and URE, respectively, and the 5'-CGATA matched with the reported recognition sequence of BEAF-32 (boundary element-associated factor of 32 kDa)...
  54. Udvardy A. Dividing the empire: boundary chromatin elements delimit the territory of enhancers. EMBO J. 1999;18:1-8 pubmed
  55. Dubois L, Enriquez J, Daburon V, Crozet F, Lebreton G, Crozatier M, et al. Collier transcription in a single Drosophila muscle lineage: the combinatorial control of muscle identity. Development. 2007;134:4347-55 pubmed
  56. Saberi S, Farré P, Cuvier O, Emberly E. Probing long-range interactions by extracting free energies from genome-wide chromosome conformation capture data. BMC Bioinformatics. 2015;16:171 pubmed publisher
    ..PCA filtering can improve the fit, and the predicted coupling energies lead to biologically meaningful insights for how various chromatin bound factors influence the stability of DNA loops in chromatin. ..
  57. Vatolina T, Demakov S, Semeshin V, Makunin I, Babenko V, Beliaeva E, et al. [Identification and molecular genetic characterization of the polytene chromosome interbands in Drosophila melanogaster]. Genetika. 2011;47:597-609 pubmed
    ..Our results suggest that band-interband structure is a fundamental principle of the interphase chromosome organization. ..
  58. Korenjak M, Kwon E, Morris R, Anderssen E, Amzallag A, Ramaswamy S, et al. dREAM co-operates with insulator-binding proteins and regulates expression at divergently paired genes. Nucleic Acids Res. 2014;42:8939-53 pubmed publisher
    ..and unexpected overlap between dE2F2/dREAM sites and binding sites for the insulator-binding proteins CP190 and Beaf-32...
  59. Bell A, Boyes J, Chung J, Pikaart M, Prioleau M, Recillas F, et al. The establishment of active chromatin domains. Cold Spring Harb Symp Quant Biol. 1998;63:509-14 pubmed
  60. Vorobyeva N, Mazina M, Golovnin A, Kopytova D, Gurskiy D, Nabirochkina E, et al. Insulator protein Su(Hw) recruits SAGA and Brahma complexes and constitutes part of Origin Recognition Complex-binding sites in the Drosophila genome. Nucleic Acids Res. 2013;41:5717-30 pubmed publisher
    ..Su(Hw) is the first example of such a protein. ..
  61. Schuettengruber B, Cavalli G. Polycomb domain formation depends on short and long distance regulatory cues. PLoS ONE. 2013;8:e56531 pubmed publisher
    ..Future work aimed to pinpoint the factors providing this barrier function will be required to understand the precise molecular mechanism by which active promoter regions can act as boundaries to stop spreading of H3K27me3. ..
  62. Wei Y, Mondal S, Mouawad R, Wilczyński B, Henry R, Arnosti D. Genome-Wide Analysis of Drosophila RBf2 Protein Highlights the Diversity of RB Family Targets and Possible Role in Regulation of Ribosome Biosynthesis. G3 (Bethesda). 2015;5:1503-15 pubmed publisher
    ..The presence of unique RBf2 targets suggest that evolutionary appearance of this corepressor represents the acquisition of potentially novel roles in gene regulation for the RB family. ..
  63. Merzetti E, Hackett J, Clark D. Transcriptional regulation of the purine de novo synthesis gene Prat in Drosophila melanogaster. Gene. 2013;518:280-6 pubmed publisher
    ..Finally, the genes Distal-less, Mi-2 and dMyc, which influence Dref activity, do not appear to affect Prat transcription. ..
  64. Cuartero S, Fresán U, Reina O, Planet E, Espinàs M. Ibf1 and Ibf2 are novel CP190-interacting proteins required for insulator function. EMBO J. 2014;33:637-47 pubmed publisher
    ..In Drosophila different proteins, dCTCF, Su(Hw), and BEAF bind to specific subsets of insulators most of them having in common CP190...
  65. Hart C. Do the BEAF insulator proteins regulate genes involved in cell polarity and neoplastic growth?. Dev Biol. 2014;389:121-3 pubmed publisher
    It was reported that a chromosome with the BEAF(NP6377) (NP6377) allele leads to a loss of cell polarity and neoplastic growth in Drosophila melanogaster when homozygous (Gurudatta et al., 2012)...