baz

Summary

Gene Symbol: baz
Description: bazooka
Alias: Baz, Baz/Par-3, Baz/Par3, Bazooka, CG5055, D-Par3, D-par3, Dmel\CG5055, PAR-3, PAR3, Par-3, Par3, dPar-3, l(1)G0484, par-3, Bazooka-Par3, Bazooka/Par-3, Bazooka/Par3, CG5055-PA, CG5055-PB, baz-PA, baz-PB
Species: fruit fly

Top Publications

  1. pmc PAR-1 kinase regulates epithelial detachment and directional protrusion of migrating border cells
    Jocelyn A McDonald
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Curr Biol 18:1659-67. 2008
  2. pmc Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia
    Michael P Krahn
    Abteilung Stammzellbiologie, Forschungszentrum der Deutschen Forschungsgemeinschaft für Molekularphysiologie des Gehirns CMPB, Georg August Universitat Gottingen, 37077 Gottingen, Germany
    J Cell Biol 190:751-60. 2010
  3. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
  4. ncbi The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole
    J M Shulman
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, United Kingdom
    Cell 101:377-88. 2000
  5. pmc aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells
    Eurico Morais-de-Sá
    The Gurdon Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 141:509-23. 2010
  6. ncbi Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts
    M Schober
    Research Institute of Molecular Pathology, Vienna, Austria
    Nature 402:548-51. 1999
  7. ncbi Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila
    Isabelle E Bécam
    Institut Jacques Monod, CNRS, Universités Paris 6 et 7, 2, place Jussieu, F 75251 Paris Cedex 05, France
    Nat Cell Biol 7:510-6. 2005
  8. ncbi Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila
    J R Huynh
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, CB21QR, Cambridge, United Kingdom
    Curr Biol 11:901-6. 2001
  9. pmc Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
    J Cell Biol 150:1361-74. 2000
  10. ncbi New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants
    Catalina Ruiz-Canada
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 USA
    Neuron 42:567-80. 2004

Research Grants

  1. Physiological regulation and function of asymmetric stem cell division
    Yukiko Yamashita; Fiscal Year: 2011
  2. PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTION
    Richard Carthew; Fiscal Year: 2005
  3. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2005
  4. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2005
  5. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2009
  6. Molecular Mechanisms of Gene Silencing by RNAi
    Richard W Carthew; Fiscal Year: 2010
  7. Tight Junction Proteins and Epithelial Polarity
    Benjamin Margolis; Fiscal Year: 2009
  8. GENETIC AND MOLECULAR STUDIES OF NEUROGENESIS
    Chris Doe; Fiscal Year: 2009
  9. Molecular Mechanisms of Gene Silencing by RNAi
    Richard Carthew; Fiscal Year: 2007
  10. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications115 found, 100 shown here

  1. pmc PAR-1 kinase regulates epithelial detachment and directional protrusion of migrating border cells
    Jocelyn A McDonald
    Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Curr Biol 18:1659-67. 2008
    ....
  2. pmc Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia
    Michael P Krahn
    Abteilung Stammzellbiologie, Forschungszentrum der Deutschen Forschungsgemeinschaft für Molekularphysiologie des Gehirns CMPB, Georg August Universitat Gottingen, 37077 Gottingen, Germany
    J Cell Biol 190:751-60. 2010
    ..on several evolutionarily conserved proteins that have been assigned to two distinct protein complexes: the Bazooka (Baz)-PAR-6 (partitioning defective 6)-atypical protein kinase C (aPKC) complex and the Crumbs (Crb)-Stardust (..
  3. pmc Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts
    Hongyan Wang
    Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore 117604
    Genes Dev 20:3453-63. 2006
    ..We have identified a novel mechanism for controlling the balance between self-renewal and neuronal differentiation during the asymmetric division of Drosophila larval NBs...
  4. ncbi The Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole
    J M Shulman
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, United Kingdom
    Cell 101:377-88. 2000
    ..These results identify a molecular parallel between anterior-posterior polarization in Drosophila and C. elegans...
  5. pmc aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells
    Eurico Morais-de-Sá
    The Gurdon Institute and the Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Cell 141:509-23. 2010
    b>Bazooka (PAR-3), PAR-6, and aPKC form a complex that plays a key role in the polarization of many cell types. In epithelial cells, however, Bazooka localizes below PAR-6 and aPKC at the apical/lateral junction...
  6. ncbi Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts
    M Schober
    Research Institute of Molecular Pathology, Vienna, Austria
    Nature 402:548-51. 1999
    ..Here we show that the apical localizaton of Inscuteable requires Bazooka, a protein containing a PDZ domain that is essential for apical-basal polarity in epithelial cells...
  7. ncbi Integrin-independent repression of cadherin transcription by talin during axis formation in Drosophila
    Isabelle E Bécam
    Institut Jacques Monod, CNRS, Universités Paris 6 et 7, 2, place Jussieu, F 75251 Paris Cedex 05, France
    Nat Cell Biol 7:510-6. 2005
    ..Surprisingly, this function of talin is independent of integrins. These results uncover a new role for talin in regulating cadherin-mediated cell adhesion...
  8. ncbi Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila
    J R Huynh
    Wellcome CRC Institute and Department of Genetics, University of Cambridge, Tennis Court Road, CB21QR, Cambridge, United Kingdom
    Curr Biol 11:901-6. 2001
    ..Here, we show that the homologs of PAR-3 (Bazooka) and PAR-6 are also required to maintain oocyte fate...
  9. pmc Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, 40225 Dusseldorf, Germany
    J Cell Biol 150:1361-74. 2000
    ..In Drosophila, the multi-PDZ domain protein Bazooka (Baz) is required for establishment of apico-basal polarity in epithelia and in neuroblasts, the stem cells of ..
  10. ncbi New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants
    Catalina Ruiz-Canada
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 USA
    Neuron 42:567-80. 2004
    The Baz/Par-3-Par-6-aPKC complex is an evolutionarily conserved cassette critical for the development of polarity in epithelial cells, neuroblasts, and oocytes...
  11. ncbi DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila
    M Petronczki
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Nat Cell Biol 3:43-9. 2001
    The Drosophila protein Bazooka is required for both apical-basal polarity in epithelial cells and directing asymmetric cell division in neuroblasts...
  12. ncbi Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Dev Cell 10:441-9. 2006
    ..Single neuroblast clones lacking Prospero have a similar phenotype. We conclude that Brat suppresses neuroblast stem cell self-renewal and promotes neuronal differentiation...
  13. ncbi Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells
    Richard Benton
    The Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, CB2 1QR Cambridge, United Kingdom
    Cell 115:691-704. 2003
    ..We show that PAR-1 phosphorylates Bazooka/PAR-3 on two conserved serines to generate 14-3-3 binding sites...
  14. ncbi E-cadherin-mediated adhesion is not the founding event of epithelial cell polarity in Drosophila
    Andre Le Bivic
    Developmental Biology Institute of Marseille, Faculte des Sciences de Luminy, UMR 6156, Case 907, Marseille 13288, France
    Trends Cell Biol 15:237-40. 2005
    ..b>Bazooka, a Par-3 homolog, is properly localized in the absence of adherens junctions, indicating that the formation of ..
  15. ncbi Intercellular junctions and cellular polarity: the PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity
    S Ohno
    Department of Molecular Biology, Yokohama City University School of Medicine, 3 9, Fuku ura, Kanazawa Ku, Yokohama 236 0004, Japan
    Curr Opin Cell Biol 13:641-8. 2001
    ..Recent studies on the role of this PAR-aPKC complex in epithelial cell polarization provide new insights into the molecular basis of epithelial junctional formation and cell polarity...
  16. ncbi Drosophila Ric-8 regulates Galphai cortical localization to promote Galphai-dependent planar orientation of the mitotic spindle during asymmetric cell division
    Nicolas B David
    Institute Curie, CNRS UMR 144, 26 Rue d Ulm, Paris 75248, France
    Nat Cell Biol 7:1083-90. 2005
    ..Thus, Frizzled and heterotrimeric G-protein signalling act in opposition to ensure that the spindle aligns both in the plane of the epithelium and along the tissue polarity axis...
  17. ncbi Patterned gene expression directs bipolar planar polarity in Drosophila
    Jennifer A Zallen
    Department of Molecular Biology, Princeton University, Lewis Thomas Lab, Washington Road, Princeton, NJ 08544, USA
    Dev Cell 6:343-55. 2004
    ..This polarity consists of an enrichment of nonmuscle myosin II at A-P cell borders and Bazooka/PAR-3 protein at the reciprocal D-V cell borders. Moreover, bazooka mutants are defective for germband extension...
  18. ncbi A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila
    M Schaefer
    Research Institute of Molecular Pathology IMP, Vienna, A 1030, Austria
    Curr Biol 10:353-62. 2000
    ..Asymmetric localisation of Inscuteable is initiated during neuroblast delamination by direct binding to Bazooka, an apically localised protein that contains protein-interaction motifs known as PDZ domains...
  19. pmc Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization
    Frederik Wirtz-Peitz
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Cell 135:161-73. 2008
    ..Phosphorylated Lgl is released from aPKC and thereby allows the PDZ domain protein Bazooka to enter the complex...
  20. pmc Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation
    Cheng Yu Lee
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Genes Dev 20:3464-74. 2006
    ..We conclude that Aurora-A and Numb are novel inhibitors of neuroblast self-renewal and that spindle orientation regulates neuroblast self-renewal...
  21. pmc Regulation of cadherin adhesive activity
    B M Gumbiner
    Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Cell Biol 148:399-404. 2000
  22. ncbi Requirement for Par-6 and Bazooka in Drosophila border cell migration
    Elaine M Pinheiro
    Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Development 131:5243-51. 2004
    ..Here, we report the localization of several apical epithelial proteins, Par-6, Par-3/Bazooka and aPKC, during border cell migration in the Drosophila ovary...
  23. pmc The positioning and segregation of apical cues during epithelial polarity establishment in Drosophila
    Tony J C Harris
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Cell Biol 170:813-23. 2005
    ..Adherens junctions (AJs) often direct this polarity, but we previously found that Bazooka (Baz) acts upstream of AJs as epithelial polarity is first established in Drosophila...
  24. ncbi Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization
    F Yu
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Cell 100:399-409. 2000
    ..pins function in neuroblasts reveal two distinct steps for Insc apical cortical localization: A pins-independent, bazooka-dependent initiation step during delamination (interphase) and a later maintenance step during which Baz, Pins, ..
  25. ncbi Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz
    Fanny Pilot
    Institut de Biologie du Développement de Marseille Luminy IBDML UMR 6216, CNRS Université de la Méditerrannée Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Nature 442:580-4. 2006
    ..These results provide a mechanism for the spatial order of actin organization underlying junction stabilization in primary embryonic epithelia...
  26. ncbi Multicellular rosette formation links planar cell polarity to tissue morphogenesis
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Dev Cell 11:459-70. 2006
    ..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis...
  27. doi Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids
    Michael P Krahn
    Abteilung Stammzellbiologie, DFG Research Center for Molecular Physiology of the Brain CMPB, Georg August Universitat Gottingen, Justus von Liebig Weg 11, Gottingen, Germany
    Curr Biol 20:636-42. 2010
    ..The first component of the PAR-3/PAR-6/aPKC complex that is localized to the cortex is Bazooka/PAR-3 (Baz), a large scaffolding protein...
  28. ncbi Domain-specific early and late function of Dpatj in Drosophila photoreceptor cells
    Sang Chul Nam
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas
    Dev Dyn 235:1501-7. 2006
    ..Our study provides evidence that Dpatj has domain-specific early and late functions in regulating the localization and stability of the Crb-Sdt complex in photoreceptor cells...
  29. ncbi Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila
    Sang Chul Nam
    Department of Molecular and Cellular Biology, Baylor College of Medicine, TX 77030, USA
    Development 130:4363-72. 2003
    ..These results suggest that the interaction of Crb and Par-6 complexes is required for the organization and maintenance of apical membranes and AJs of photoreceptors...
  30. ncbi A genetic hierarchy controlling cell polarity
    Kevin Johnson
    Nat Cell Biol 5:12-4. 2003
  31. ncbi crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis
    Barry Denholm
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Development 132:2389-400. 2005
    ....
  32. ncbi Asymmetric division of Drosophila neural stem cells: a basis for neural diversity
    F Matsuzaki
    CREST, Japan Science and Technology Corporation, Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Aoba ku, 980 8575, Japan tohoku ac jp
    Curr Opin Neurobiol 10:38-44. 2000
    ..Our understanding now extends to the molecular nature of the cell polarity that underlies asymmetric divisions. This polarity is conserved among neural stem cells, epithelial cells and fertilized eggs...
  33. doi Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions
    Marios Georgiou
    MRC Laboratory of Molecular Cell Biology, UCL, London, WC1E 6BT, UK
    J Cell Sci 123:1089-98. 2010
    ..b>Bazooka/Par3 acts upstream of the RacGEF Sif/TIAM1 to limit filopodia to the basal domain, whereas Cdc42, aPKC and Par6 ..
  34. doi Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability
    Marios Georgiou
    MRC Laboratory for Molecular Cell Biology, Division of Life Sciences, University College London, Gower Street, London WC1E 6BT, UK
    Curr Biol 18:1631-8. 2008
    ....
  35. ncbi Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Germany
    Nature 402:544-7. 1999
    ..Here we show that localization of Inscuteable depends on Bazooka, a protein containing three PDZ domains with overall sequence similarity to Par-3 of Caenorhabditis elegans...
  36. ncbi Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka
    U Kuchinke
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Curr Biol 8:1357-65. 1998
    ..None of the genes identified so far that are involved in these processes seems to have been conserved between flies and nematodes...
  37. pmc armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila
    H A Muller
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA
    J Cell Biol 134:149-63. 1996
    ..We show that embryos mutant for both stardust (sdt) and bazooka (baz) fail to form a ZA...
  38. ncbi The Drosophila homolog of the Exo84 exocyst subunit promotes apical epithelial identity
    J Todd Blankenship
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    J Cell Sci 120:3099-110. 2007
    ..Loss of Crumbs from the cell surface precedes the disruption of Bazooka and Armadillo localization in Exo84 mutants...
  39. pmc Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC
    Scott X Atwood
    Institute of Molecular Biology and Department of Chemistry, University of Oregon, Eugene, OR 97403, USA
    J Cell Sci 120:3200-6. 2007
    ..polarity and asymmetric cell division, we show that Cdc42 colocalizes with Par-6-aPKC at the apical cortex in a Bazooka-dependent manner, and is required for Par-6-aPKC localization...
  40. pmc Antagonistic functions of Par-1 kinase and protein phosphatase 2A are required for localization of Bazooka and photoreceptor morphogenesis in Drosophila
    Sang Chul Nam
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Biol 306:624-35. 2007
    ..b>Bazooka (Baz), a component of the Par-6 complex, plays important roles in cell polarity in diverse cell types including ..
  41. ncbi Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis
    Andrea Hutterer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Dev Cell 6:845-54. 2004
    ..On the basolateral side, Lgl is active and excludes Par-6 from the cell cortex, suggesting that complementary cortical domains are maintained by mutual inhibition of aPKC and Lgl on opposite sides of an epithelial cell...
  42. ncbi Junctions and vesicular trafficking during Drosophila cellularization
    Thomas Lecuit
    Laboratoire de Genetique et de Physiologie du Developpement, UMR 6545 CNRS Université de la Méditerranée, Institut de Biologie du Developpement de Marseille, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    J Cell Sci 117:3427-33. 2004
    ..The novel proteins Nullo and Slam, which are specifically induced during cellularization, represent developmental regulators of membrane growth during cellularization...
  43. pmc Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia
    Melissa M Rolls
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, OR 97403, USA
    J Cell Biol 163:1089-98. 2003
    ..In many organisms, cell polarity is regulated by the atypical protein kinase C (aPKC), Bazooka (Baz/Par3), and Par6 proteins...
  44. pmc DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila
    Sol Sotillos
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Univerisidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Cell Biol 166:549-57. 2004
    ..These results provide a mechanistic framework for the functional interaction between the Par-3-Par-6-aPKC and Crumbs-Sdt-Patj complexes based in the posttranslational modification of Crb by DaPKC...
  45. pmc Crumbs stabilises epithelial polarity during tissue remodelling
    Kyra Campbell
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    J Cell Sci 122:2604-12. 2009
    ..Here we show that, whereas the Bazooka and Scribble protein groups are required for the establishment of tubule cell polarity, the key apical ..
  46. ncbi Baz, Par-6 and aPKC are not required for axon or dendrite specification in Drosophila
    Melissa M Rolls
    Institute of Neuroscience and Institute of Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, Oregon 97403, USA
    Nat Neurosci 7:1293-5. 2004
    Par-3/Baz, Par-6, and aPKC are evolutionarily conserved regulators of cell polarity, and overexpression experiments implicate them as axon determinants in vertebrate hippocampal neurons...
  47. ncbi Direct association of Bazooka/PAR-3 with the lipid phosphatase PTEN reveals a link between the PAR/aPKC complex and phosphoinositide signaling
    Walter von Stein
    Abteilung Stammzellbiologie, CMPB, Georg August Universitat Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Development 132:1675-86. 2005
    ..PAR/aPKC complex, which consists of the serine-threonine protein kinase aPKC and the PDZ-domain proteins Bazooka (Baz) and PAR-6...
  48. ncbi Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion
    Shu Yi Wei
    Institute of Molecular Medicine, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30034, Republic of China
    Dev Cell 8:493-504. 2005
    ..beta-catenin (a DE-Cadherin interacting protein) each possess a C-terminal PDZ domain binding motif that binds to Bazooka/PAR-3; these motifs redundantly position Bazooka to adherens junctions...
  49. pmc Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP
    Bulent Ataman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
    Proc Natl Acad Sci U S A 103:7841-6. 2006
    ..These results provide a mechanism by which DFz2 is transported from the postsynaptic membrane to the postsynaptic nucleus during synapse formation and implicate dGRIP as an essential molecule in the transport of this signal...
  50. doi Control of cell flattening and junctional remodeling during squamous epithelial morphogenesis in Drosophila
    Karen L Pope
    Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, M5S 3G5, Canada
    Development 135:2227-38. 2008
    ..Myosin II localizes to anterior-posterior contacts, while the polarity protein Bazooka (PAR-3) localizes to dorsoventral contacts...
  51. ncbi Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo
    Jennifer Bayraktar
    Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
    J Cell Sci 119:711-21. 2006
    ..Epistasis analysis indicates that Par-1 functions upstream of Notch and is critical for proper localization of the Notch ligand Delta...
  52. ncbi Regulated and polarized PtdIns(3,4,5)P3 accumulation is essential for apical membrane morphogenesis in photoreceptor epithelial cells
    Noelia Pinal
    Medical Research Council Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Anatomy and Developmental Biology, University College London, Gower Street, WC1E 6BT London, United Kingdom
    Curr Biol 16:140-9. 2006
    ..the establishment of polarity, its maintenance, or both--in Drosophila, these proteins include the apical factors Bazooka, D-atypical protein kinase C, and D-Par6 together with D-Ecadherin...
  53. ncbi Par-1 and PP2A: Yin-Yang of Bazooka localization
    Kwang Wook Choi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Fly (Austin) 1:235-7. 2007
    ..b>Bazooka (Baz, Drosophila homolog of Par-3) plays a crucial role in organizing cell polarity in several different tissues...
  54. ncbi Endocytic control of epithelial polarity and proliferation in Drosophila
    Han Lu
    Department of Molecular and Cell Biology, University of California Berkeley, 142 LSA 3200 Berkeley, CA 94720 3200 USA
    Nat Cell Biol 7:1232-9. 2005
    ..Our findings reveal a critical and specific role for endocytic traffic in the control of both apico-basal polarity and cell proliferation...
  55. doi Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis
    Andrea Leibfried
    Institut Curie, Centre National de la Recherche, UMR 144, Equipe Polarité Cellulaire chez la Drosophile, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Curr Biol 18:1639-48. 2008
    ..A mechanism regulating E-Cadherin (E-Cad) exocytosis to the AJs has implicated proteins of the exocyst complex, but mechanisms regulating E-Cad endocytosis from the AJs remain less well understood...
  56. pmc Independent cadherin-catenin and Bazooka clusters interact to assemble adherens junctions
    Melanie A McGill
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S3G5, Canada
    J Cell Biol 185:787-96. 2009
    ..In the early Drosophila embryo, AJ assembly depends on Bazooka (Baz; PAR-3), but it is unclear how Baz affects AJ assembly and what precursors are involved...
  57. ncbi Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts
    Sarah E Siegrist
    Institutes of Neuroscience and Molecular Biology, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Development 133:529-36. 2006
    ..This ensures the proper coordination between neuroblast cell polarity and CNS tissue polarity...
  58. doi PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts
    Michael P Krahn
    Abteilung Stammzellbiologie, DFG Research Center for Molecular Physiology of the Brain, Georg August Universitat Gottingen, Gottingen, Germany
    Dev Cell 16:901-8. 2009
    b>Bazooka/Par-3 (Baz) is a key regulator of cell polarity in epithelial cells and neuroblasts (NBs)...
  59. ncbi Apicobasal polarization: epithelial form and function
    Matthew C Gibson
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston MA 02115, USA
    Curr Opin Cell Biol 15:747-52. 2003
    ..Recent findings show that segregation of ligand and receptor with one on each side of this barrier can be a crucial regulator of cell-cell signaling events...
  60. ncbi Composition and formation of intercellular junctions in epithelial cells
    Elisabeth Knust
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Science 298:1955-9. 2002
    ..Comparisons between fly, worm, and vertebrate epithelia reveal marked similarities with respect to the molecules used, and pronounced differences in the organization of the junctions themselves...
  61. ncbi Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts
    Y Hong
    Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California San Francisco, San Francisco, California 94143 0725, USA
    Nature 414:634-8. 2001
    ..Initially discovered in the landmark genetic screen for Drosophila developmental mutants, bazooka, crumbs, shotgun and stardust mutants exhibit severe disruption in apicobasal polarity in embryonic epithelia, ..
  62. ncbi Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila
    Wu Min Deng
    Department of Biochemistry, Box 357350, University of Washington, Seattle, WA 98195, USA
    Development 130:173-84. 2003
    ..These data suggest that the primary function of Dystroglycan in oogenesis is to organize cellular polarity; and this study sets the stage for analyzing the Dystroglycan complex by using the power of Drosophila molecular genetics...
  63. ncbi Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation
    Richard Benton
    The Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, CB2 1QR, Cambridge, United Kingdom
    Dev Cell 3:659-71. 2002
    ..The C. elegans 14-3-3 protein, PAR-5, is also required for A-P polarization, suggesting that this is a conserved mechanism by which PAR-1 establishes cellular asymmetries...
  64. ncbi Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity
    A Bachmann
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Germany
    Nature 414:638-43. 2001
    ..The Stardust proteins represent versatile candidates as structural and possibly regulatory constituents of the SAC, a crucial element in the control of epithelial cell polarity...
  65. ncbi Establishing cell polarity in development
    Andreas Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstr 1, 40225 Dusseldorf, Germany
    Nat Cell Biol 4:E39-44. 2002
    ..There is growing evidence that the proteins encoded by these genes interact with key regulators of both the actin and the microtubule cytoskeletons...
  66. ncbi PARsing embryonic polarity
    K Kemphues
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Cell 101:345-8. 2000
  67. ncbi Asymmetric cell division: fly neuroblast meets worm zygote
    C Q Doe
    Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, 1254 University of Oregon, Eugene, Oregon 97403, USA
    Curr Opin Cell Biol 13:68-75. 2001
    ..Mammalian epithelia also use this complex to regulate apical/basal polarity. Recent results have allowed us to compare the mechanisms regulating asymmetric cell division in Drosophila neuroblasts and the C. elegans zygote...
  68. ncbi The fusome and microtubules enrich Par-1 in the oocyte, where it effects polarization in conjunction with Par-3, BicD, Egl, and dynein
    Thomas Vaccari
    Developmental Biology Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Curr Biol 12:1524-8. 2002
    ..This polarization requires Par-1 kinase and the PDZ-containing Par-3 homolog, Bazooka (Baz). Par-1 has been observed on the fusome, which degenerates before the onset of oocyte polarization...
  69. ncbi Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast
    T Ohshiro
    CREST, Japan Science and Technology Corporation, Sendai
    Nature 408:593-6. 2000
    ..Prospero and Numb, localize to the basal cortex, from which the ganglion mother cell buds off; Inscuteable and Bazooka, which regulate spindle orientation, localize apically...
  70. ncbi The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts
    C Y Peng
    Howard Hughes Medical Institute, University of Oregon, Eugene 97403, USA
    Nature 408:596-600. 2000
    ..We conclude that Dlg and Lgl promote, and myosin II inhibits, actomyosin-dependent basal protein targeting in neuroblasts...
  71. ncbi Asymmetric division of Drosophila neural progenitors
    William Chia
    MRC Centre for Developmental Neurobiology, King s College London, 4th Floor, New Hunts House, Guy s Hospital Campus, London, UK
    Curr Opin Genet Dev 12:459-64. 2002
    ..Recent findings also suggest possible mechanisms by which the processes of cell-cycle progression, neuronal lineage development and asymmetric divisions may be integrated...
  72. ncbi Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization
    Guy Tanentzapf
    Department of Zoology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    Nat Cell Biol 5:46-52. 2003
    ..We find that bazooka (baz) functions redundantly with crb/sdt to support apical polarity at mid- to late-embryogenesis...
  73. ncbi Integrated activity of PDZ protein complexes regulates epithelial polarity
    David Bilder
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 5:53-8. 2003
    ..embryos have identified three complexes, each containing one of the PDZ domain proteins--Stardust (Sdt), Bazooka (Baz) and Scribble (Scrib)--that control epithelial polarity and formation of zonula adherens...
  74. ncbi Drosophila pod-1 crosslinks both actin and microtubules and controls the targeting of axons
    Michael E Rothenberg
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuron 39:779-91. 2003
    ..Taken together, these results reveal novel activities for pod-1 and show that proper levels of Dpod1, an actin/MT crosslinker, must be maintained in the growth cone for correct axon guidance...
  75. ncbi A conserved oligomerization domain in drosophila Bazooka/PAR-3 is important for apical localization and epithelial polarity
    Richard Benton
    The Wellcome Trust Cancer Research UK Institute, Tennis Court Road, CB2 1QR, Cambridge, United Kingdom
    Curr Biol 13:1330-4. 2003
    ..We show that CR1 of the Drosophila homolog, Bazooka (BAZ), mediates oligomerization in vitro and in vivo...
  76. ncbi Spindles cotton on to junctions, APC and EB1
    M Bienz
    Nat Cell Biol 3:E67-8. 2001
  77. ncbi Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions
    Naoyuki Fuse
    Laboratory for Cell Asymmetry, Center for Developmental Biology, RIKEN, Chuou ku, Kobe 650 0047, Japan
    Curr Biol 13:947-54. 2003
    ..Furthermore, the multiple equal cleavages of G beta mutant neuroblasts accompany neural defects; this finding suggests indispensable roles of eccentric division in assuring the stem cell properties of neuroblasts...
  78. ncbi Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system
    M Schaefer
    Research Institute of Molecular Pathology I M P, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Cell 107:183-94. 2001
    ..Thus, asymmetric activation of heterotrimeric G proteins by a receptor-independent mechanism may orient asymmetric cell divisions in different cell types...
  79. ncbi Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia
    Salim Abdelilah-Seyfried
    Max Delbruck Center for Molecular Medicine MDC Berlin Buch, Robert Rossle Strasse 10, D 13125 Berlin Buch, Germany
    Development 130:1927-35. 2003
    Drosophila Bazooka and atypical protein kinase C are essential for epithelial polarity and adhesion...
  80. ncbi The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl
    Jörg Betschinger
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, 1030 Vienna, Austria
    Nature 422:326-30. 2003
    ..Lgl promotes cortical localization of Miranda, and we propose that phosphorylation of Lgl by aPKC at the apical neuroblast cortex restricts Lgl activity and Miranda localization to the opposite, basal side of the cell...
  81. ncbi Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions
    Yu Cai
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore
    Cell 112:51-62. 2003
    ..we show that mitotic spindle geometry and unequal daughter cell size are controlled by two parallel pathways (Bazooka/DaPKC and Pins/G alpha i) within the apical complex...
  82. ncbi Control of cell polarity and mitotic spindle positioning in animal cells
    Julie Ahringer
    Wellcome Trust Cancer Research UK Institute, Tennis Court Road, Cambridge CB2 1QR, UK
    Curr Opin Cell Biol 15:73-81. 2003
    ..Microtubules and conserved PAR proteins are essential mediators of cell polarity, and mitotic spindle positioning depends on heterotrimeric G protein signalling and the microtubule motor protein dynein...
  83. ncbi Isoform-specific interaction of Flamingo/Starry Night with excess Bazooka affects planar cell polarity in the Drosophila wing
    Isabel Wasserscheid
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Dev Dyn 236:1064-71. 2007
    ..Here, we show that overexpression of Bazooka, a PDZ-domain protein essential for apicobasal polarity in the embryo, perturbs development of PCP, but has no ..
  84. ncbi Tumour-suppressor genes prosper during asymmetric division
    S Greaves
    Nat Cell Biol 3:E11. 2001
  85. ncbi X-linked loci of Drosophila melanogaster causing defects in the morphology of the embryonic salivary glands
    U Lammel
    Humboldt Universitaet zu Berlin, Institut fuer Biologie Abteilung Zytogenetik, Chausseestrasse 117, 10115 Berlin, Germany
    Dev Genes Evol 210:525-35. 2000
    ..From these, 39 lines could be assigned to nine complementation groups: armadillo, brinker, folded gastrulation, giant, hindsight, Notch, runt, stardust and twisted gastrulation...
  86. ncbi Cell polarity: the PARty expands
    C Q Doe
    Institute of Molecular Biology and the Institute of Neuroscience, HHMI, University of Oregon, Eugene, Oregon 97403, USA
    Nat Cell Biol 3:E7-9. 2001
    ..This common cell-polarity mechanism is used in cell-specific ways, as highlighted by the recent finding that at least two different types of asymmetric division are observed in Drosophila neural precursors...
  87. pmc Characterization of X-linked recessive lethal mutations affecting embryonic morphogenesis in Drosophila melanogaster
    D F Eberl
    Department of Molecular Biology and Genetics, University of Guelph, Ontario, Canada
    Genetics 118:109-20. 1988
    ..Nevertheless, saturation of the X chromosome for genes important for embryonic morphogenesis is probably incomplete...
  88. ncbi Epithelial differentiation in Drosophila
    U Tepass
    Department of Zoology, University of Toronto, Ontario, Canada
    Bioessays 19:673-82. 1997
    ..The combination of embryological and genetic/molecular tools in Drosophila will help us to elucidate the complex events that determine epithelial cell structure and how they relate to morphogenesis and other developmental processes...
  89. ncbi Drosophila: flying high in Zürich
    A S Wilkins
    BioEssays Editorial Office, 10 11 Tredgold Lane, Napier St, Cambridge CB1 1HN, UK
    Bioessays 22:305-7. 2000
  90. ncbi Cell biology. Which way is up?
    M Peifer
    Nature 403:611-2. 2000
  91. ncbi Cell polarity: Nailing Crumbs to the scaffold
    P Rashbass
    Developmental Genetics Programme, Krebs Institute, University of Sheffield, Sheffield, S10 2TN, UK
    Curr Biol 10:R234-6. 2000
    ..The isolation of a human Crumbs homologue required for normal vision revives questions about the role of Crumbs in cell-cell interactions...
  92. ncbi Protein-protein interactions define specificity in signal transduction
    T Pawson
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Genes Dev 14:1027-47. 2000
  93. ncbi Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates
    P Y Cheah
    Institute of Molecular and Cell Biology, National University of Singapore Campus, Singapore 117609
    Development 127:3325-35. 2000
    ..Our results suggest that in addition to the correct formation of an apical complex, transcription mediated by Jumu is also necessary to facilitate the correct asymmetric localisation and segregation of Pon/Numb...
  94. ncbi Cell polarity: Scaffold proteins par excellence
    D P Brazil
    Friedrich Miescher Institute, Basel, Switzerland
    Curr Biol 10:R592-4. 2000
    ..Recent studies have identified one of these proteins, Par6, as a key regulator of cell polarity and transformation via its interactions with small GTPases and atypical forms of protein kinase C...
  95. pmc The ups and downs of life in an epithelium
    H Kramer
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Cell Biol 151:F15-8. 2000
  96. ncbi Asymmetric cell division: plane but not simple
    P N Adler
    University of Virginia, Department of Biology and Cancer Center, Charlottesville, Virginia 22903, USA
    Curr Biol 11:R233-6. 2001
    ..The orientation of these divisions is under the control of the Frizzled pathway that generates planar polarity in a number of cell types...
  97. ncbi The Scribble and Par complexes in polarity and migration: friends or foes?
    Patrick O Humbert
    Cell Cycle and Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC 3002, Australia
    Trends Cell Biol 16:622-30. 2006
    The Par complex [consisting of Bazooka (also called Par3), Par6 and aPKC] is a well-described regulator of cell polarity whose role in many aspects of cell morphogenesis is under intense investigation...
  98. ncbi Lethal giant larvae acts together with numb in notch inhibition and cell fate specification in the Drosophila adult sensory organ precursor lineage
    Nicholas Justice
    Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143 0725, USA
    Curr Biol 13:778-83. 2003
    ..These findings uncover a previously unknown function of Lgl in the inhibition of Notch and reveal different modes of action by which Lgl can influence cell fate in the neuroblast and SOP lineages...
  99. ncbi LKB1 tumor suppressor protein: PARtaker in cell polarity
    Annette F Baas
    Hubrecht Laboratory, Center for Biomedical Genetics, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Trends Cell Biol 14:312-9. 2004
    ..In this article, we summarize the findings regarding LKB1 over the past six years. In addition, we discuss LKB1 in polarity in the context of both the other PAR proteins and its tumor suppressive activities...
  100. ncbi Role of the Crumbs complex in the regulation of junction formation in Drosophila and mammalian epithelial cells
    Emmanuelle Médina
    NMDA IBDM, UMR 6156, Campus de Luminy, Universite de la Mediterranee, Case 907, 13288 Marseille Cedex 09, France
    Biol Cell 94:305-13. 2002
    ..Finding an answer to these questions will help to find new therapies for Retinitis pigmentosa and other retina degeneration in which CRB1, the human homologue of crb, has been involved...
  101. pmc Distinct roles of Bazooka and Stardust in the specification of Drosophila photoreceptor membrane architecture
    Yang Hong
    Howard Hughes Medical Institute, and Departments of Physiology and Biochemistry, University of California San Francisco, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 100:12712-7. 2003
    ..cellular structures involves two distinct processes: the establishment of apical-basal polarity that requires Bazooka (Baz), and the regionalization of apical membrane into stalk membranes and rhabdomeres that requires Stardust (..

Research Grants68

  1. Physiological regulation and function of asymmetric stem cell division
    Yukiko Yamashita; Fiscal Year: 2011
    ..Understanding of such mechanisms may allow us to manipulate stem cell behavior;for example, normal stem cells can be expanded in culture for transplantation, or we can inhibit the expansion of cancerous stem cells. ..
  2. PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTION
    Richard Carthew; Fiscal Year: 2005
    ..abstract_text> ..
  3. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2005
    ..For one of these genes we will determine the relative importance of adhesion versus signal transduction for the mutant phenotype. ..
  4. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2005
    ..The information obtained should help understand the role of RPE in a variety of blinding diseases, such as age-related macular degeneration and diabetic retinopathy. ..
  5. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2009
    ..This information is essential to understand RPE's roles in the physiology of the retina and in blinding diseases, and may help in devising improved gene therapy strategies for their treatment. ..
  6. Molecular Mechanisms of Gene Silencing by RNAi
    Richard W Carthew; Fiscal Year: 2010
    ..Moreover, RNAi has been used experimentally to probe gene function and holds great promise as a therapeutic model, making its basic understanding an important biomedical research goal. ..
  7. Tight Junction Proteins and Epithelial Polarity
    Benjamin Margolis; Fiscal Year: 2009
    ..We have also found that PALS1 directly interacts with a common polarity cassette consisting of three proteins Par3/Par6/atypical Protein Kinase C...
  8. GENETIC AND MOLECULAR STUDIES OF NEUROGENESIS
    Chris Doe; Fiscal Year: 2009
    ..Thus, we propose to continue our investigation of temporal patterning in the Drosophila CNS, with the goal of providing insight into the mechanisms regulating temporal patterning during mammalian neurogenesis. ..
  9. Molecular Mechanisms of Gene Silencing by RNAi
    Richard Carthew; Fiscal Year: 2007
    ..Moreover, RNAi has been used experimentally to probe gene function and holds great promise as a therapeutic model, making its basic understanding an important biomedical research goal. ..
  10. RETINA: REVERSED POLARITY AND MORPHOGENESIS OF RPE
    Enrique Rodriguez Boulan; Fiscal Year: 2007
    ..This information is essential to understand RPE's roles in the physiology of the retina and in blinding diseases, and may help in devising improved gene therapy strategies for their treatment. ..
  11. GENETIC AND MOLECULAR STUDIES OF NEUROGENESIS
    Chris Q Doe; Fiscal Year: 2010
    ..Thus, we propose to continue our investigation of temporal patterning in the Drosophila CMS,with the goal of providing insight into the mechanisms regulating temporal patterning during mammalian neurogenesis. ..
  12. PREDOCTORAL TRAINING IN GENETICS AND DEVELOPMENT
    Kenneth Kemphues; Fiscal Year: 2007
    ..Currently there are 56 predoctoral students training in the graduate program and we are seeking support for nine trainees. ..
  13. PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTION
    Richard Carthew; Fiscal Year: 2001
    ....
  14. SORTING OF PLASMA MEMBRANE PROTEINS IN EPITHELIAL CELLS
    Enrique Rodriguez Boulan; Fiscal Year: 1993
    ..It is expected that these studies will contribute fundamental information to the process of epithelial cell organization and differentiation...
  15. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  16. GENETIC CONTROL OF TISSUE POLARITY
    Paul Adler; Fiscal Year: 2001
    ..We will also carry out experiments designed to distinguish between models proposed to explain the function of the fz signaling/signal transduction pathway in the development of tissue polarity. ..
  17. DISCS-LOST IN APICAL CELL JUNCTIONS IN DROSOPHILA EYE
    Kwang Wook Choi; Fiscal Year: 2002
    ..Vertebrate protein sequences similar to Dlt have been found. These studies on Dlt and Notch signaling proteins will provide useful insights into the function of vertebrate homologs in cell-cell interaction and signaling. ..
  18. Tri-Institutional Training in Vision Research
    Enrique Rodriguez Boulan; Fiscal Year: 2007
    ..The request for NIH support of a proposed Tri-Institutional Training Program in Vision Research builds on major commitments by the participating institutions of faculty, funds and research space devoted to vision research. ..