baz

Summary

Gene Symbol: baz
Description: bazooka
Alias: BAZ, Baz, Baz/Par-3, Baz/Par3, Bazooka, CG5055, D-Par3, D-par3, Dmel\CG5055, PAR-3, PAR3, Par-3, Par3, dPar-3, l(1)G0484, par-3, par3, bazooka, Bazooka-Par3, Bazooka/Par-3, Bazooka/Par3, CG5055-PA, CG5055-PB, CG5055-PC, CG5055-PD, baz-PA, baz-PB, baz-PC, baz-PD, par-3
Species: fruit fly

Top Publications

  1. Bellaiche Y, Radovic A, Woods D, Hough C, Parmentier M, O Kane C, et al. The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila. Cell. 2001;106:355-66 pubmed
    ..The Discs-large (Dlg) and Partner of Inscuteable (Pins) proteins accumulate at the anterior cortex, while Bazooka (Baz) relocalizes to the posterior cortex...
  2. Leibfried A, Fricke R, Morgan M, Bogdan S, Bellaiche Y. Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis. Curr Biol. 2008;18:1639-48 pubmed publisher
    ..Altogether our results show that Cdc42 functions with Par6 and aPKC to regulate E-Cad endocytosis and define Cip4 and WASp as regulators of the early E-Cad endocytic events in epithelial tissue. ..
  3. Shao W, Wu J, Chen J, Lee D, Tishkina A, Harris T. A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium. PLoS ONE. 2010;5:e9938 pubmed publisher
    The development and homeostasis of multicellular organisms depends on sheets of epithelial cells. Bazooka (Baz; PAR-3) localizes to the apical circumference of epithelial cells and is a key hub in the protein interaction network ..
  4. Sawyer J, Choi W, Jung K, He L, Harris N, Peifer M. A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. Mol Biol Cell. 2011;22:2491-508 pubmed publisher
    ..subtly enhances AJ planar polarity and dramatically increases planar polarity of the apical polarity proteins Bazooka/Par3 and atypical protein kinase C. Changes in Bazooka localization parallel retraction of the actomyosin network...
  5. McKim K, Dahmus J, Hawley R. Cloning of the Drosophila melanogaster meiotic recombination gene mei-218: a genetic and molecular analysis of interval 15E. Genetics. 1996;144:215-28 pubmed
    ..The mei-218 gene is predicted to produce an 1186-amino acid protein that has no significant similarities to any known proteins. ..
  6. Wang Y, Riechmann V. The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesis. Curr Biol. 2007;17:1349-55 pubmed
    ..Myosin is activated at the apical cortex by localized Rho kinase and inhibited at the basolateral cortex by PP1beta9C. In addition, our data indicate that active myosin is apically anchored by the Baz/Par-6/aPKC complex.
  7. Yu C, Harris T. Interactions between the PDZ domains of Bazooka (Par-3) and phosphatidic acid: in vitro characterization and role in epithelial development. Mol Biol Cell. 2012;23:3743-53 pubmed publisher
    b>Bazooka (Par-3) is a conserved polarity regulator that organizes molecular networks in a wide range of cell types. In epithelia, it functions as a plasma membrane landmark to organize the apical domain...
  8. Tamada M, Farrell D, Zallen J. Abl regulates planar polarized junctional dynamics through ?-catenin tyrosine phosphorylation. Dev Cell. 2012;22:309-19 pubmed publisher
    ..These results demonstrate that the asymmetrically localized Abl tyrosine kinase directs planar polarized junctional remodeling during Drosophila axis elongation through the tyrosine phosphorylation of ?-catenin...
  9. Roeth J, Sawyer J, Wilner D, Peifer M. Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm. PLoS ONE. 2009;4:e7634 pubmed publisher
    ..Tissue morphogenesis and organogenesis require that cells retain stable cell-cell adhesion while changing shape and moving. One mechanism to accommodate this plasticity in cell adhesion involves regulated trafficking of junctional proteins...
  10. Becalska A, Gavis E. Bazooka regulates microtubule organization and spatial restriction of germ plasm assembly in the Drosophila oocyte. Dev Biol. 2010;340:528-38 pubmed publisher
    ..In this study, we identify a novel allele of bazooka (baz), the Drosophila homolog of Par-3, which has allowed the analysis of baz function throughout oogenesis...

Detail Information

Publications97

  1. Bellaiche Y, Radovic A, Woods D, Hough C, Parmentier M, O Kane C, et al. The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in Drosophila. Cell. 2001;106:355-66 pubmed
    ..The Discs-large (Dlg) and Partner of Inscuteable (Pins) proteins accumulate at the anterior cortex, while Bazooka (Baz) relocalizes to the posterior cortex...
  2. Leibfried A, Fricke R, Morgan M, Bogdan S, Bellaiche Y. Drosophila Cip4 and WASp define a branch of the Cdc42-Par6-aPKC pathway regulating E-cadherin endocytosis. Curr Biol. 2008;18:1639-48 pubmed publisher
    ..Altogether our results show that Cdc42 functions with Par6 and aPKC to regulate E-Cad endocytosis and define Cip4 and WASp as regulators of the early E-Cad endocytic events in epithelial tissue. ..
  3. Shao W, Wu J, Chen J, Lee D, Tishkina A, Harris T. A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium. PLoS ONE. 2010;5:e9938 pubmed publisher
    The development and homeostasis of multicellular organisms depends on sheets of epithelial cells. Bazooka (Baz; PAR-3) localizes to the apical circumference of epithelial cells and is a key hub in the protein interaction network ..
  4. Sawyer J, Choi W, Jung K, He L, Harris N, Peifer M. A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. Mol Biol Cell. 2011;22:2491-508 pubmed publisher
    ..subtly enhances AJ planar polarity and dramatically increases planar polarity of the apical polarity proteins Bazooka/Par3 and atypical protein kinase C. Changes in Bazooka localization parallel retraction of the actomyosin network...
  5. McKim K, Dahmus J, Hawley R. Cloning of the Drosophila melanogaster meiotic recombination gene mei-218: a genetic and molecular analysis of interval 15E. Genetics. 1996;144:215-28 pubmed
    ..The mei-218 gene is predicted to produce an 1186-amino acid protein that has no significant similarities to any known proteins. ..
  6. Wang Y, Riechmann V. The role of the actomyosin cytoskeleton in coordination of tissue growth during Drosophila oogenesis. Curr Biol. 2007;17:1349-55 pubmed
    ..Myosin is activated at the apical cortex by localized Rho kinase and inhibited at the basolateral cortex by PP1beta9C. In addition, our data indicate that active myosin is apically anchored by the Baz/Par-6/aPKC complex.
  7. Yu C, Harris T. Interactions between the PDZ domains of Bazooka (Par-3) and phosphatidic acid: in vitro characterization and role in epithelial development. Mol Biol Cell. 2012;23:3743-53 pubmed publisher
    b>Bazooka (Par-3) is a conserved polarity regulator that organizes molecular networks in a wide range of cell types. In epithelia, it functions as a plasma membrane landmark to organize the apical domain...
  8. Tamada M, Farrell D, Zallen J. Abl regulates planar polarized junctional dynamics through ?-catenin tyrosine phosphorylation. Dev Cell. 2012;22:309-19 pubmed publisher
    ..These results demonstrate that the asymmetrically localized Abl tyrosine kinase directs planar polarized junctional remodeling during Drosophila axis elongation through the tyrosine phosphorylation of ?-catenin...
  9. Roeth J, Sawyer J, Wilner D, Peifer M. Rab11 helps maintain apical crumbs and adherens junctions in the Drosophila embryonic ectoderm. PLoS ONE. 2009;4:e7634 pubmed publisher
    ..Tissue morphogenesis and organogenesis require that cells retain stable cell-cell adhesion while changing shape and moving. One mechanism to accommodate this plasticity in cell adhesion involves regulated trafficking of junctional proteins...
  10. Becalska A, Gavis E. Bazooka regulates microtubule organization and spatial restriction of germ plasm assembly in the Drosophila oocyte. Dev Biol. 2010;340:528-38 pubmed publisher
    ..In this study, we identify a novel allele of bazooka (baz), the Drosophila homolog of Par-3, which has allowed the analysis of baz function throughout oogenesis...
  11. Cabernard C, Doe C. Apical/basal spindle orientation is required for neuroblast homeostasis and neuronal differentiation in Drosophila. Dev Cell. 2009;17:134-41 pubmed publisher
    ..We conclude that the ratio of apical/basal determinants specifies neuroblast/GMC identity, and that apical/basal spindle orientation is required for neuroblast homeostasis and neuronal differentiation. ..
  12. Wei S, Escudero L, Yu F, Chang L, Chen L, Ho Y, et al. Echinoid is a component of adherens junctions that cooperates with DE-Cadherin to mediate cell adhesion. Dev Cell. 2005;8:493-504 pubmed
    ..beta-catenin (a DE-Cadherin interacting protein) each possess a C-terminal PDZ domain binding motif that binds to Bazooka/PAR-3; these motifs redundantly position Bazooka to adherens junctions...
  13. Nam S, Mukhopadhyay B, Choi K. Antagonistic functions of Par-1 kinase and protein phosphatase 2A are required for localization of Bazooka and photoreceptor morphogenesis in Drosophila. Dev Biol. 2007;306:624-35 pubmed
    ..b>Bazooka (Baz), a component of the Par-6 complex, plays important roles in cell polarity in diverse cell types including ..
  14. Hutterer A, Betschinger J, Petronczki M, Knoblich J. Sequential roles of Cdc42, Par-6, aPKC, and Lgl in the establishment of epithelial polarity during Drosophila embryogenesis. Dev Cell. 2004;6:845-54 pubmed
    ..On the basolateral side, Lgl is active and excludes Par-6 from the cell cortex, suggesting that complementary cortical domains are maintained by mutual inhibition of aPKC and Lgl on opposite sides of an epithelial cell. ..
  15. Siegrist S, Doe C. Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts. Cell. 2005;123:1323-35 pubmed
    ..These results identify a role for microtubules in polarizing the neuroblast cortex, a fundamental step for generating cell diversity through asymmetric cell division. ..
  16. Franz A, Riechmann V. Stepwise polarisation of the Drosophila follicular epithelium. Dev Biol. 2010;338:136-47 pubmed publisher
    ..Thus, our data elucidate the genetic mechanisms leading to the stepwise polarisation of an epithelium with a mesenchymal origin. ..
  17. Lecuit T. Junctions and vesicular trafficking during Drosophila cellularization. J Cell Sci. 2004;117:3427-33 pubmed
    ..The novel proteins Nullo and Slam, which are specifically induced during cellularization, represent developmental regulators of membrane growth during cellularization. ..
  18. Atwood S, Chabu C, Penkert R, Doe C, Prehoda K. Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC. J Cell Sci. 2007;120:3200-6 pubmed
    ..polarity and asymmetric cell division, we show that Cdc42 colocalizes with Par-6-aPKC at the apical cortex in a Bazooka-dependent manner, and is required for Par-6-aPKC localization...
  19. Ruiz Canada C, Ashley J, Moeckel Cole S, Drier E, Yin J, Budnik V. New synaptic bouton formation is disrupted by misregulation of microtubule stability in aPKC mutants. Neuron. 2004;42:567-80 pubmed
    The Baz/Par-3-Par-6-aPKC complex is an evolutionarily conserved cassette critical for the development of polarity in epithelial cells, neuroblasts, and oocytes...
  20. Zallen J, Wieschaus E. Patterned gene expression directs bipolar planar polarity in Drosophila. Dev Cell. 2004;6:343-55 pubmed
    ..This polarity consists of an enrichment of nonmuscle myosin II at A-P cell borders and Bazooka/PAR-3 protein at the reciprocal D-V cell borders. Moreover, bazooka mutants are defective for germband extension...
  21. Pagliarini R, Xu T. A genetic screen in Drosophila for metastatic behavior. Science. 2003;302:1227-31 pubmed
    ..These findings suggest that the oncogenic background of tissues makes a distinct contribution toward metastatic development. ..
  22. Sotillos S, Diaz Meco M, Caminero E, Moscat J, Campuzano S. DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol. 2004;166:549-57 pubmed
    ..These results provide a mechanistic framework for the functional interaction between the Par-3-Par-6-aPKC and Crumbs-Sdt-Patj complexes based in the posttranslational modification of Crb by DaPKC. ..
  23. Betschinger J, Mechtler K, Knoblich J. The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl. Nature. 2003;422:326-30 pubmed
    ..Lgl promotes cortical localization of Miranda, and we propose that phosphorylation of Lgl by aPKC at the apical neuroblast cortex restricts Lgl activity and Miranda localization to the opposite, basal side of the cell. ..
  24. Fuse N, Hisata K, Katzen A, Matsuzaki F. Heterotrimeric G proteins regulate daughter cell size asymmetry in Drosophila neuroblast divisions. Curr Biol. 2003;13:947-54 pubmed
    ..Furthermore, the multiple equal cleavages of G beta mutant neuroblasts accompany neural defects; this finding suggests indispensable roles of eccentric division in assuring the stem cell properties of neuroblasts. ..
  25. Gervais L, Claret S, Januschke J, Roth S, Guichet A. PIP5K-dependent production of PIP2 sustains microtubule organization to establish polarized transport in the Drosophila oocyte. Development. 2008;135:3829-38 pubmed publisher
    ..Furthermore, we provide evidence that Skittles, by controlling the localization of Bazooka, Par-1 and Lgl, but not Lkb1, to the cell membrane, regulates PAR polarity proteins and the maintenance of ..
  26. Sanchez Soriano N, Bottenberg W, Fiala A, Haessler U, Kerassoviti A, Knust E, et al. Are dendrites in Drosophila homologous to vertebrate dendrites?. Dev Biol. 2005;288:126-38 pubmed
    ..Implications of these findings for studies of dendrite development, neuronal polarity, transport and evolution are discussed. ..
  27. Chandraratna D, Lawrence N, Welchman D, Sanson B. An in vivo model of apoptosis: linking cell behaviours and caspase substrates in embryos lacking DIAP1. J Cell Sci. 2007;120:2594-608 pubmed
    ..Next, we analyse the dynamic changes in the localisation of actomyosin, Discs large, Bazooka and DE-cadherin in the course of apoptosis...
  28. Robertson F, Pinal N, Fichelson P, Pichaud F. Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis. Development. 2012;139:3432-41 pubmed publisher
    ..It also sheds new light on the interplay between Ato, EGFR-dependent transcription and AJ remodelling in a system in which neurogenesis is coupled with cell shape changes and regulated steps of cell intercalation...
  29. Wirtz Peitz F, Nishimura T, Knoblich J. Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization. Cell. 2008;135:161-73 pubmed publisher
    ..Phosphorylated Lgl is released from aPKC and thereby allows the PDZ domain protein Bazooka to enter the complex...
  30. Baas A, Smit L, Clevers H. LKB1 tumor suppressor protein: PARtaker in cell polarity. Trends Cell Biol. 2004;14:312-9 pubmed
    ..In this article, we summarize the findings regarding LKB1 over the past six years. In addition, we discuss LKB1 in polarity in the context of both the other PAR proteins and its tumor suppressive activities. ..
  31. Georgiou M, Marinari E, Burden J, Baum B. Cdc42, Par6, and aPKC regulate Arp2/3-mediated endocytosis to control local adherens junction stability. Curr Biol. 2008;18:1631-8 pubmed publisher
    ..regulation of junctional stability was found to be independent of several well-known targets of Cdc42-aPKC-Par6: Baz, Lgl, Rac, and SCAR...
  32. Betschinger J, Knoblich J. Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr Biol. 2004;14:R674-85 pubmed
    ..Here, we outline the steps and factors that are involved in this process in Drosophila and C. elegans and discuss their potential conservation in vertebrates. ..
  33. Lee C, Robinson K, Doe C. Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature. 2006;439:594-8 pubmed
    ..We conclude that cortical aPKC kinase activity is a potent inducer of neuroblast self-renewal. ..
  34. Bergstralh D, Haack T, St Johnston D. Epithelial polarity and spindle orientation: intersecting pathways. Philos Trans R Soc Lond B Biol Sci. 2013;368:20130291 pubmed publisher
    ..In this review, we examine several factors implicated in both processes, namely Canoe, Bazooka, aPKC and Discs large, and consider the implications of this work on how the spindle is oriented during ..
  35. Matsuzaki F. Asymmetric division of Drosophila neural stem cells: a basis for neural diversity. Curr Opin Neurobiol. 2000;10:38-44 pubmed
    ..Our understanding now extends to the molecular nature of the cell polarity that underlies asymmetric divisions. This polarity is conserved among neural stem cells, epithelial cells and fertilized eggs. ..
  36. Bonaccorsi S, Mottier V, Giansanti M, Bolkan B, Williams B, Goldberg M, et al. The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division. Development. 2007;134:2183-93 pubmed
    ..division of larval neuroblasts (NBs); they suppress unequal cytokinesis, abrogate proper localization of Bazooka, Par-6, DaPKC and Miranda, but affect neither Pins/Galphai localization nor spindle rotation...
  37. Knust E. Control of epithelial cell shape and polarity. Curr Opin Genet Dev. 2000;10:471-5 pubmed
    ..Recent data have provided new insights into the molecular nature of these cues and the mechanisms by which they may be translated into a polarised phenotype. ..
  38. Peng C, Manning L, Albertson R, Doe C. The tumour-suppressor genes lgl and dlg regulate basal protein targeting in Drosophila neuroblasts. Nature. 2000;408:596-600 pubmed
    ..We conclude that Dlg and Lgl promote, and myosin II inhibits, actomyosin-dependent basal protein targeting in neuroblasts. ..
  39. Wang Y, Khan Z, Kaschube M, Wieschaus E. Differential positioning of adherens junctions is associated with initiation of epithelial folding. Nature. 2012;484:390-3 pubmed publisher
    ..Junctional positioning in the dorsal epithelium depends on the polarity proteins Bazooka and Par-1...
  40. Guilgur L, Prudêncio P, Ferreira T, Pimenta Marques A, Martinho R. Drosophila aPKC is required for mitotic spindle orientation during symmetric division of epithelial cells. Development. 2012;139:503-13 pubmed publisher
  41. Siegrist S, Doe C. Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts. Development. 2006;133:529-36 pubmed
    ..This ensures the proper coordination between neuroblast cell polarity and CNS tissue polarity. ..
  42. Szafranski P, Goode S. Basolateral junctions are sufficient to suppress epithelial invasion during Drosophila oogenesis. Dev Dyn. 2007;236:364-73 pubmed
    ..Our results demonstrate that spatiotemporal patterns of basolateral junction activity directly suppress epithelial invasion by organizing the cooperative activity of distinct polarity and motility pathways. ..
  43. Schaefer M, Shevchenko A, Knoblich J. A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in Drosophila. Curr Biol. 2000;10:353-62 pubmed
    ..Asymmetric localisation of Inscuteable is initiated during neuroblast delamination by direct binding to Bazooka, an apically localised protein that contains protein-interaction motifs known as PDZ domains...
  44. Schaefer M, Petronczki M, Dorner D, Forte M, Knoblich J. Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous system. Cell. 2001;107:183-94 pubmed
    ..Thus, asymmetric activation of heterotrimeric G proteins by a receptor-independent mechanism may orient asymmetric cell divisions in different cell types. ..
  45. Pilot F, Philippe J, Lemmers C, Lecuit T. Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz. Nature. 2006;442:580-4 pubmed
    ..These results provide a mechanism for the spatial order of actin organization underlying junction stabilization in primary embryonic epithelia. ..
  46. Blankenship J, Backovic S, Sanny J, Weitz O, Zallen J. Multicellular rosette formation links planar cell polarity to tissue morphogenesis. Dev Cell. 2006;11:459-70 pubmed
    ..We propose that the generation of higher-order rosette structures links local cell interactions to global tissue reorganization during morphogenesis. ..
  47. McGill M, McKinley R, Harris T. Independent cadherin-catenin and Bazooka clusters interact to assemble adherens junctions. J Cell Biol. 2009;185:787-96 pubmed publisher
    ..In the early Drosophila embryo, AJ assembly depends on Bazooka (Baz; PAR-3), but it is unclear how Baz affects AJ assembly and what precursors are involved...
  48. Kemphues K. PARsing embryonic polarity. Cell. 2000;101:345-8 pubmed
  49. Krahn M, Bückers J, Kastrup L, Wodarz A. Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia. J Cell Biol. 2010;190:751-60 pubmed publisher
    ..on several evolutionarily conserved proteins that have been assigned to two distinct protein complexes: the Bazooka (Baz)-PAR-6 (partitioning defective 6)-atypical protein kinase C (aPKC) complex and the Crumbs (Crb)-Stardust (..
  50. McKinley R, Yu C, Harris T. Assembly of Bazooka polarity landmarks through a multifaceted membrane-association mechanism. J Cell Sci. 2012;125:1177-90 pubmed publisher
    Epithelial cell polarity is essential for animal development. The scaffold protein Bazooka (Baz/PAR-3) forms apical polarity landmarks to organize epithelial cells...
  51. Baffet A, Benoit B, Januschke J, Audo J, Gourhand V, Roth S, et al. Drosophila tubulin-binding cofactor B is required for microtubule network formation and for cell polarity. Mol Biol Cell. 2012;23:3591-601 pubmed publisher
    ..These results establish a developmental function for the dTBCB gene that is essential for viability and MT-dependent cell polarity, but not cell division. ..
  52. McKinley R, Harris T. Displacement of basolateral Bazooka/PAR-3 by regulated transport and dispersion during epithelial polarization in Drosophila. Mol Biol Cell. 2012;23:4465-71 pubmed publisher
    Polarity landmarks guide epithelial development. In the early Drosophila ectoderm, the scaffold protein Bazooka (Drosophila PAR-3) forms apicolateral landmarks to direct adherens junction assembly...
  53. Horne Badovinac S, Bilder D. Dynein regulates epithelial polarity and the apical localization of stardust A mRNA. PLoS Genet. 2008;4:e8 pubmed publisher
    ..Moreover, we introduce a unique mechanism in which alternative splicing of a coding exon is used to control mRNA localization during development. ..
  54. Muller H, Wieschaus E. armadillo, bazooka, and stardust are critical for early stages in formation of the zonula adherens and maintenance of the polarized blastoderm epithelium in Drosophila. J Cell Biol. 1996;134:149-63 pubmed
    ..We show that embryos mutant for both stardust (sdt) and bazooka (baz) fail to form a ZA...
  55. Nam S, Choi K. Domain-specific early and late function of Dpatj in Drosophila photoreceptor cells. Dev Dyn. 2006;235:1501-7 pubmed
    ..Our study provides evidence that Dpatj has domain-specific early and late functions in regulating the localization and stability of the Crb-Sdt complex in photoreceptor cells. ..
  56. Ataman B, Ashley J, Gorczyca D, Gorczyca M, Mathew D, Wichmann C, et al. Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP. Proc Natl Acad Sci U S A. 2006;103:7841-6 pubmed
    ..These results provide a mechanism by which DFz2 is transported from the postsynaptic membrane to the postsynaptic nucleus during synapse formation and implicate dGRIP as an essential molecule in the transport of this signal. ..
  57. Fernandez Gonzalez R, Simões S, Röper J, Eaton S, Zallen J. Myosin II dynamics are regulated by tension in intercalating cells. Dev Cell. 2009;17:736-43 pubmed publisher
    ..These results demonstrate that myosin II dynamics are regulated by tension in a positive feedback loop that leads to multicellular actomyosin cable formation and efficient tissue elongation. ..
  58. Wang H, Ng K, Qian H, Siderovski D, Chia W, Yu F. Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins. Nat Cell Biol. 2005;7:1091-8 pubmed
    ..In addition, Gbetagamma acts to restrict Galphai (and GoLoco proteins) to the apical cortex, where Galphai (and Pins) can mediate asymmetric spindle geometry. ..
  59. Benton R, St Johnston D. Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells. Cell. 2003;115:691-704 pubmed
    ..We show that PAR-1 phosphorylates Bazooka/PAR-3 on two conserved serines to generate 14-3-3 binding sites...
  60. Lee J, Koh H, Kim M, Kim Y, Lee S, Karess R, et al. Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature. 2007;447:1017-20 pubmed
    ..Taken together, our results demonstrate that AMPK has highly conserved roles across metazoan species not only in the control of metabolism, but also in the regulation of cellular structures. ..
  61. Li Z, Wang L, Hays T, Cai Y. Dynein-mediated apical localization of crumbs transcripts is required for Crumbs activity in epithelial polarity. J Cell Biol. 2008;180:31-8 pubmed publisher
  62. Wodarz A, Ramrath A, Kuchinke U, Knust E. Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts. Nature. 1999;402:544-7 pubmed
    ..Here we show that localization of Inscuteable depends on Bazooka, a protein containing three PDZ domains with overall sequence similarity to Par-3 of Caenorhabditis elegans...
  63. Ohshiro T, Yagami T, Zhang C, Matsuzaki F. Role of cortical tumour-suppressor proteins in asymmetric division of Drosophila neuroblast. Nature. 2000;408:593-6 pubmed
    ..Prospero and Numb, localize to the basal cortex, from which the ganglion mother cell buds off; Inscuteable and Bazooka, which regulate spindle orientation, localize apically...
  64. Abdelilah Seyfried S, Cox D, Jan Y. Bazooka is a permissive factor for the invasive behavior of discs large tumor cells in Drosophila ovarian follicular epithelia. Development. 2003;130:1927-35 pubmed
    Drosophila Bazooka and atypical protein kinase C are essential for epithelial polarity and adhesion...
  65. Doerflinger H, Vogt N, Torres I, Mirouse V, Koch I, NUSSLEIN VOLHARD C, et al. Bazooka is required for polarisation of the Drosophila anterior-posterior axis. Development. 2010;137:1765-73 pubmed publisher
    ..elegans, with a complex of Bazooka (Baz; Par-3), Par-6 and aPKC marking the anterior and lateral cortex, and Par-1 defining the posterior...
  66. Bayraktar J, Zygmunt D, Carthew R. Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo. J Cell Sci. 2006;119:711-21 pubmed
    ..Epistasis analysis indicates that Par-1 functions upstream of Notch and is critical for proper localization of the Notch ligand Delta. ..
  67. Krahn M, Egger Adam D, Wodarz A. PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts. Dev Cell. 2009;16:901-8 pubmed publisher
    b>Bazooka/Par-3 (Baz) is a key regulator of cell polarity in epithelial cells and neuroblasts (NBs)...
  68. Campbell K, Knust E, Skaer H. Crumbs stabilises epithelial polarity during tissue remodelling. J Cell Sci. 2009;122:2604-12 pubmed publisher
    ..Here we show that, whereas the Bazooka and Scribble protein groups are required for the establishment of tubule cell polarity, the key apical ..
  69. Izumi Y, Ohta N, Itoh Furuya A, Fuse N, Matsuzaki F. Differential functions of G protein and Baz-aPKC signaling pathways in Drosophila neuroblast asymmetric division. J Cell Biol. 2004;164:729-38 pubmed
    ..However, the other apical components, Bazooka-atypical PKC-Par6-Inscuteable, still remain polarized and responsible for asymmetric Miranda localization, ..
  70. Choi W, Harris N, Sumigray K, Peifer M. Rap1 and Canoe/afadin are essential for establishment of apical-basal polarity in the Drosophila embryo. Mol Biol Cell. 2013;24:945-63 pubmed publisher
    ..Drosophila embryos provide a superb model. In the current view, apically positioned Bazooka/Par3 is the initial polarity cue as cells form during cellularization...
  71. Cai Y, Yu F, Lin S, Chia W, Yang X. Apical complex genes control mitotic spindle geometry and relative size of daughter cells in Drosophila neuroblast and pI asymmetric divisions. Cell. 2003;112:51-62 pubmed
    ..we show that mitotic spindle geometry and unequal daughter cell size are controlled by two parallel pathways (Bazooka/DaPKC and Pins/G alpha i) within the apical complex...
  72. Yu F, Morin X, Cai Y, Yang X, Chia W. Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localization. Cell. 2000;100:399-409 pubmed
    ..pins function in neuroblasts reveal two distinct steps for Insc apical cortical localization: A pins-independent, bazooka-dependent initiation step during delamination (interphase) and a later maintenance step during which Baz, Pins, ..
  73. Vaccari T, Ephrussi A. The fusome and microtubules enrich Par-1 in the oocyte, where it effects polarization in conjunction with Par-3, BicD, Egl, and dynein. Curr Biol. 2002;12:1524-8 pubmed
    ..This polarization requires Par-1 kinase and the PDZ-containing Par-3 homolog, Bazooka (Baz). Par-1 has been observed on the fusome, which degenerates before the onset of oocyte polarization...
  74. Wodarz A, Ramrath A, Grimm A, Knust E. Drosophila atypical protein kinase C associates with Bazooka and controls polarity of epithelia and neuroblasts. J Cell Biol. 2000;150:1361-74 pubmed
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    ..The combination of embryological and genetic/molecular tools in Drosophila will help us to elucidate the complex events that determine epithelial cell structure and how they relate to morphogenesis and other developmental processes. ..
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    ..This common cell-polarity mechanism is used in cell-specific ways, as highlighted by the recent finding that at least two different types of asymmetric division are observed in Drosophila neural precursors. ..
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    ..This complex, composed of the proteins Par-6, Bazooka (Par-3), aPKC, and Cdc42, is best known for roles in asymmetric cell division and apical/basal polarity...
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    ..Adherens junctions (AJs) often direct this polarity, but we previously found that Bazooka (Baz) acts upstream of AJs as epithelial polarity is first established in Drosophila...
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    ..These data suggest that the primary function of Dystroglycan in oogenesis is to organize cellular polarity; and this study sets the stage for analyzing the Dystroglycan complex by using the power of Drosophila molecular genetics. ..
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    The Drosophila protein Bazooka is required for both apical-basal polarity in epithelial cells and directing asymmetric cell division in neuroblasts...
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    ..Thus, Loco can potentially regulate heterotrimeric G-protein signaling via two distinct modes of action during Drosophila neuroblast asymmetric divisions. ..
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    ..Single neuroblast clones lacking Prospero have a similar phenotype. We conclude that Brat suppresses neuroblast stem cell self-renewal and promotes neuronal differentiation. ..
  86. Harris T, Peifer M. aPKC controls microtubule organization to balance adherens junction symmetry and planar polarity during development. Dev Cell. 2007;12:727-38 pubmed
    ..aPKC apparently regulates this balance. Without aPKC, abnormally strong microtubule interactions break AJ symmetry and epithelial structure is lost. ..
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    ..We have analyzed the relationship between myosin and the polarity regulators Par-6, aPKC and Bazooka (Par-3) (the PAR complex) during amnioserosa apical constriction at Drosophila dorsal closure...
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    ..These results suggest that the interaction of Crb and Par-6 complexes is required for the organization and maintenance of apical membranes and AJs of photoreceptors. ..
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    ..Initially discovered in the landmark genetic screen for Drosophila developmental mutants, bazooka, crumbs, shotgun and stardust mutants exhibit severe disruption in apicobasal polarity in embryonic epithelia, ..
  91. Chabu C, Doe C. Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression. Development. 2008;135:2739-46 pubmed publisher
    ..We conclude that Dap160 positively regulates aPKC activity and localization to promote neuroblast cell polarity and cell cycle progression. ..
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    ..Additionally, we show that non-muscle Myosin II and the polarity proteins Discs large (Dlg) and Bazooka are enriched along cell interfaces in a complex but reproducible pattern that suggests their involvement in ..
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    Par-3/Baz, Par-6, and aPKC are evolutionarily conserved regulators of cell polarity, and overexpression experiments implicate them as axon determinants in vertebrate hippocampal neurons...
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    ..localisation and segregation of Numb and the specification of distinct dMP2 and vMP2 identities require bazooka but not inscuteable...
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    ..Here, we show that the homologs of PAR-3 (Bazooka) and PAR-6 are also required to maintain oocyte fate...
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    ..Our data indicate that JNK-mediated cell engulfment could be an evolutionarily conserved intrinsic tumor-suppression mechanism that eliminates premalignant cells from epithelia. ..