Gene Symbol: Baldspot
Alias: CG 3971, CG3971, Dmel\CG3971, Elovl6, NEST:bs18f10, NEST:bs18g10, baldspot, blp, l(3)01895, l(3)02281, l(3)04106, l(3)neo21, l(3)neo22, noa, baldspot, Baldspot-PA, Baldspot-PB, CG3971-PA, CG3971-PB, neighbor of abl
Species: fruit fly
Szafer Glusman E, Giansanti M, Nishihama R, Bolival B, Pringle J, Gatti M, et al
. A role for very-long-chain fatty acids in furrow ingression during cytokinesis in Drosophila spermatocytes. Curr Biol. 2008;18:1426-31 pubmed publisher
..Our findings implicate very-long-chain fatty acids or their derivative complex lipids in allowing supple membrane deformation and the stable connection of cortical contractile components to the plasma membrane during cell division. ..
Jung A, Hollmann M, Schäfer M. The fatty acid elongase NOA is necessary for viability and has a somatic role in Drosophila sperm development. J Cell Sci. 2007;120:2924-34 pubmed
The essential gene noa (CG 3971; also known as Baldspot) encodes a very long chain fatty acid elongase which is most similar to the mammalian elongase ELOVL6...
Martin M, Ahern Djamali S, Hoffmann F, Saxton W. Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1. Mol Biol Cell. 2005;16:4225-30 pubmed
..A concomitant reduction in ena dosage rescued those defects. These results suggest that Ena/VASP, when not inhibited by the Abl pathway, can bind Khc and reduce its transport activity in axons. ..
Bausek N, Zeidler M. G?73B is a downstream effector of JAK/STAT signalling and a regulator of Rho1 in Drosophila haematopoiesis. J Cell Sci. 2014;127:101-10 pubmed publisher
..As such, we suggest a mechanism by which JAK/STAT pathway signalling may promote metastasis. ..
Shen L, Lai C, Feng X, Parnell L, Wan J, Wang J, et al
. Drosophila lacks C20 and C22 PUFAs. J Lipid Res. 2010;51:2985-92 pubmed publisher
..These findings demonstrate that Drosophila lacks the capability to synthesize the biologically important C20 and C22 PUFAs, and thereby argue that Drosophila is not a valid model for the study of lipid metabolism and related diseases. ..
Senyilmaz D, Virtue S, Xu X, Tan C, Griffin J, Miller A, et al
. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature. 2015;525:124-8 pubmed publisher
..This work identifies the metabolite C18:0 as a signalling molecule regulating mitochondrial function in response to diet. ..
Doiguchi M, Nakagawa T, Imamura Y, Yoneda M, Higashi M, Kubota K, et al
. SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation. Sci Rep. 2016;6:20179 pubmed publisher
..The interplay between the remodeling activity of SMARCAD1 and histone acetylation by CBP sheds light on the function of chromatin and the genome-integrity network. ..