Gene Symbol: baf
Description: barrier to autointegration factor
Alias: BAF, CG7380, Dmel\CG7380, anon-WO0172774.178, dBAF, barrier to autointegration factor, Barrier-to-autointegration factor, CG7380-PA, CG7380-PB, baf-PA, baf-PB
Species: fruit fly

Top Publications

  1. Lancaster O, Cullen C, Ohkura H. NHK-1 phosphorylates BAF to allow karyosome formation in the Drosophila oocyte nucleus. J Cell Biol. 2007;179:817-24 pubmed
    ..In this study, we report that phosphorylation of barrier to autointegration factor (BAF) by the conserved kinase nucleosomal histone kinase-1 (NHK-1; Drosophila Vrk1) has a critical ..
  2. Pinto B, Wilmington S, Hornick E, Wallrath L, Geyer P. Tissue-specific defects are caused by loss of the Drosophila MAN1 LEM domain protein. Genetics. 2008;180:133-45 pubmed publisher
    ..In addition to dBAF, dMAN1 associates with lamins, the LEM-D protein Bocksbeutel, and the receptor-regulated Smads, demonstrating ..
  3. Furukawa K, Sugiyama S, Osouda S, Goto H, Inagaki M, Horigome T, et al. Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila. J Cell Sci. 2003;116:3811-23 pubmed
    Barrier-to-autointegration factor (BAF) is potentially a DNA-bridging protein, which directly associates with inner nuclear membrane proteins carrying LEM domains...
  4. Wagner N, Schmitt J, Krohne G. Two novel LEM-domain proteins are splice products of the annotated Drosophila melanogaster gene CG9424 (Bocksbeutel). Eur J Cell Biol. 2004;82:605-16 pubmed
    ..This evolutionary conserved sequence motif can mediate via the interaction with the small protein BAF the binding of LEM-domain proteins to DNA...
  5. Furukawa K, Aida T, Nonaka Y, Osoda S, Juarez C, Horigome T, et al. BAF as a caspase-dependent mediator of nuclear apoptosis in Drosophila. J Struct Biol. 2007;160:125-34 pubmed
    b>BAF is a double-stranded DNA binding protein required for proper nuclear morphology and function in Drosophila development...
  6. Schulze S, Curio Penny B, Speese S, Dialynas G, Cryderman D, McDonough C, et al. A comparative study of Drosophila and human A-type lamins. PLoS ONE. 2009;4:e7564 pubmed publisher
    ..These studies provide new insights on the role of lamins in nuclear biology and support Drosophila as a model for studies of human laminopathies involving muscle dysfunction. ..
  7. Wagner N, Weyhersmüller A, Blauth A, Schuhmann T, Heckmann M, Krohne G, et al. The Drosophila LEM-domain protein MAN1 antagonizes BMP signaling at the neuromuscular junction and the wing crossveins. Dev Biol. 2010;339:1-13 pubmed publisher
    ..Genetic interaction experiments suggest that MAN1 is a BMP signaling antagonist both at the NMJ and during CV formation. ..
  8. Kadir R, Bakhrat A, Tokarsky R, Abdu U. Localization of the Drosophila Rad9 protein to the nuclear membrane is regulated by the C-terminal region and is affected in the meiotic checkpoint. PLoS ONE. 2012;7:e38010 pubmed publisher
    ..meiotic chromosomes to the oocyte nuclear envelope upon ectopic expression of non-phosphorylatable Barrier to Autointegration Factor (BAF) dramatically affects DmRad9A localization...
  9. Milon B, Cheng H, Tselebrovsky M, Lavrov S, Nenasheva V, Mikhaleva E, et al. Role of histone deacetylases in gene regulation at nuclear lamina. PLoS ONE. 2012;7:e49692 pubmed publisher
    ..These findings demonstrate the manifold and central involvement of class I HDACs in regulation of lamina-associated genes, illuminating a mechanism by which these enzymes can orchestrate normal and pathological development...

More Information


  1. Nikalayevich E, Ohkura H. The NuRD nucleosome remodelling complex and NHK-1 kinase are required for chromosome condensation in oocytes. J Cell Sci. 2015;128:566-75 pubmed that the main role of NHK-1 in chromosome condensation is to phosphorylate Barrier-to-autointegration factor (BAF) and suppress its activity in linking chromosomes to nuclear envelope proteins...