Gene Symbol: bab2
Description: bric a brac 2
Alias: BAB, BAB2, BTB-II, Bab2, BtbII, CG13911, CG9102, Dmel\CG9102, bab, bab-II, bric a brac 2, BTB-protein-II, Bric-a-brac 2, CG9102-PA, CG9102-PB, bab2-PA, bab2-PB, bric a brac, bric a brac II, bric-a-brac, bric-a-brac-2, bric-a-brac2
Species: fruit fly

Top Publications

  1. Delon I, Payre F. Evolution of larval morphology in flies: get in shape with shavenbaby. Trends Genet. 2004;20:305-13 pubmed
  2. Williams T, Selegue J, Werner T, Gompel N, Kopp A, Carroll S. The regulation and evolution of a genetic switch controlling sexually dimorphic traits in Drosophila. Cell. 2008;134:610-23 pubmed publisher
    ..male-specific abdominal pigmentation of Drosophila melanogaster, which is repressed in females by the Bric-à-brac (Bab) proteins...
  3. Kopp A, Duncan I, Godt D, Carroll S. Genetic control and evolution of sexually dimorphic characters in Drosophila. Nature. 2000;408:553-9 pubmed
    ..Here we show that these traits are controlled by the bric à brac [corrected] (bab) gene, which integrates regulatory inputs from the homeotic and sex-determination pathways...
  4. Pointud J, Larsson J, Dastugue B, Couderc J. The BTB/POZ domain of the regulatory proteins Bric à brac 1 (BAB1) and Bric à brac 2 (BAB2) interacts with the novel Drosophila TAF(II) factor BIP2/dTAF(II)155. Dev Biol. 2001;237:368-80 pubmed
    ..The Drosophila BTB/POZ proteins Bric à brac 1 (BAB1) and Bric à brac 2 (BAB2) are developmentally regulated transcription factors which are involved in pattern formation along the proximo-..
  5. de Celis Ibeas J, Bray S. Bowl is required downstream of Notch for elaboration of distal limb patterning. Development. 2003;130:5943-52 pubmed
    ..This mechanism might be important in the diversification of arthropod limbs, because it explains how segmented tarsomeres could have arisen from an ancestral limb with an unsegmented tarsus. ..
  6. Lours C, Bardot O, Godt D, Laski F, Couderc J. The Drosophila melanogaster BTB proteins bric à brac bind DNA through a composite DNA binding domain containing a pipsqueak and an AT-Hook motif. Nucleic Acids Res. 2003;31:5389-98 pubmed
    The bric à brac (bab) locus is composed of two paralogous genes, bab1 and bab2, in Drosophila melanogaster...
  7. Godt D, Couderc J, Cramton S, Laski F. Pattern formation in the limbs of Drosophila: bric à brac is expressed in both a gradient and a wave-like pattern and is required for specification and proper segmentation of the tarsus. Development. 1993;119:799-812 pubmed
    ..The graded requirement for bric à brac correlates with its graded expression pattern, suggesting that the concentration of BRIC A BRAC protein specifies segment identity in the tarsus.
  8. Bickel R, Schackwitz W, Pennacchio L, Nuzhdin S, Kopp A. Contrasting patterns of sequence evolution at the functionally redundant bric à brac paralogs in Drosophila melanogaster. J Mol Evol. 2009;69:194-202 pubmed publisher
    ..This locus is composed of two anciently duplicated paralogs, bab1 and bab2, which are involved in patterning the adult abdomen, legs, and ovaries...
  9. Jeong S, Rokas A, Carroll S. Regulation of body pigmentation by the Abdominal-B Hox protein and its gain and loss in Drosophila evolution. Cell. 2006;125:1387-99 pubmed
    ..These results demonstrate how Hox regulation of traits and target genes is gained and lost at the species level and have general implications for the evolution of body form at higher taxonomic levels. ..

More Information


  1. Gibert J, Karch F, Schlotterer C. Segregating variation in the polycomb group gene cramped alters the effect of temperature on multiple traits. PLoS Genet. 2011;7:e1001280 pubmed publisher
    ..Interestingly, traits modulated by crm natural variants can differ markedly between Drosophila species, suggesting that temperature adaptation facilitates their evolution. ..
  2. Gompel N, Carroll S. Genetic mechanisms and constraints governing the evolution of correlated traits in drosophilid flies. Nature. 2003;424:931-5 pubmed the same locus, by comparing abdominal pigmentation and trichome patterns and the expression of Bric-à-brac2 (Bab2), which regulates both traits in D...
  3. Bardot O, Godt D, Laski F, Couderc J. Expressing UAS-bab1 and UAS-bab2: a comparative study of gain-of-function effects and the potential to rescue the bric à brac mutant phenotype. Genesis. 2002;34:66-70 pubmed
  4. Chu J, Dong P, Panganiban G. Limb type-specific regulation of bric a brac contributes to morphological diversity. Development. 2002;129:695-704 pubmed
    ..We propose that this is due in part to the variations in the regulation of bric a brac. bric a brac is required for joint formation, and loss of bric a brac function leads to fusion of distal ..
  5. Wittkopp P, Carroll S, Kopp A. Evolution in black and white: genetic control of pigment patterns in Drosophila. Trends Genet. 2003;19:495-504 pubmed publisher
  6. Greenberg L, Hatini V. Essential roles for lines in mediating leg and antennal proximodistal patterning and generating a stable Notch signaling interface at segment borders. Dev Biol. 2009;330:93-104 pubmed publisher
    ..the opposing expression landscapes of the leg gap gene dachshund (dac) and the tarsal PD genes, bric-a-brac 2 (bab), apterous (ap) and BarH1 (Bar)...
  7. Galindo M, Bishop S, Greig S, Couso J. Leg patterning driven by proximal-distal interactions and EGFR signaling. Science. 2002;297:256-9 pubmed
    ..Our results uncover a mechanism for appendage patterning directed by genes expressed in proximal-distal domains and possibly conserved in other arthropods and vertebrates. ..
  8. Couderc J, Godt D, Zollman S, Chen J, Li M, Tiong S, et al. The bric à brac locus consists of two paralogous genes encoding BTB/POZ domain proteins and acts as a homeotic and morphogenetic regulator of imaginal development in Drosophila. Development. 2002;129:2419-33 pubmed
    ..It consists of two structurally and functionally related genes, bab1 and bab2, each of which encodes a single nuclear protein...
  9. Barmina O, Kopp A. Sex-specific expression of a HOX gene associated with rapid morphological evolution. Dev Biol. 2007;311:277-86 pubmed
    ..This is the first example of a sex-specific regulation of a HOX gene contributing to the development and evolution of a secondary sexual trait. ..
  10. Bickel R, Kopp A, Nuzhdin S. Composite effects of polymorphisms near multiple regulatory elements create a major-effect QTL. PLoS Genet. 2011;7:e1001275 pubmed publisher
    ..These findings have important design and conceptual implications for basic and medical genomics. ..
  11. Gibert J, Peronnet F, Schlotterer C. Phenotypic plasticity in Drosophila pigmentation caused by temperature sensitivity of a chromatin regulator network. PLoS Genet. 2007;3:e30 pubmed modulating a chromatin regulator network, interacting genetically with the transcription factor bric-à-brac (bab), a target of Abd-B and Hsp83, encoding the chaperone Hsp90...
  12. Godt D, Laski F. Mechanisms of cell rearrangement and cell recruitment in Drosophila ovary morphogenesis and the requirement of bric à brac. Development. 1995;121:173-87 pubmed
    ..Disruption of terminal filament formation, together with defects of basal and interfollicular stalk development, leads to disruption of ovariole formation and female sterility in bric à brac mutants. ..
  13. Kopp A, Graze R, Xu S, Carroll S, Nuzhdin S. Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanogaster. Genetics. 2003;163:771-87 pubmed
    ..melanogaster. Using quantitative complementation tests, we demonstrate that this QTL is allelic to the bric a brac gene, whose expression has previously been shown to correlate with interspecific differences in pigmentation...
  14. Randsholt N, Santamaria P. How Drosophila change their combs: the Hox gene Sex combs reduced and sex comb variation among Sophophora species. Evol Dev. 2008;10:121-33 pubmed publisher
  15. Chen J, Godt D, Gunsalus K, Kiss I, Goldberg M, Laski F. Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis. Nat Cell Biol. 2001;3:204-9 pubmed
    ..It is also required for the migration of border cells during oogenesis. These results show that cofilin/ADF is an important regulator of actin-based cell motility during Drosophila development. ..
  16. Campbell G, Tomlinson A. The roles of the homeobox genes aristaless and Distal-less in patterning the legs and wings of Drosophila. Development. 1998;125:4483-93 pubmed
    ..Dll is also required for the normal development of the wing, primarily for the differentiation of the wing margin. ..
  17. Zollman S, Godt D, Prive G, Couderc J, Laski F. The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. Proc Natl Acad Sci U S A. 1994;91:10717-21 pubmed
    ..The BTB domain defines a gene family with an estimated 40 members in Drosophila. This domain is found primarily at the N terminus of zinc finger proteins and is evolutionarily conserved from Drosophila to mammals. ..
  18. Liu Y, Ge Q, Chan B, Liu H, Singh S, Manley J, et al. Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila. Nat Commun. 2016;7:12149 pubmed publisher
    ..We also find that mitosis/cytokinesis proteins are especially important for male GSC maintenance. Our findings provide valuable insights and resources for studying stem cell regulation at the organismal level. ..
  19. Chiang Y, Tan K, Chung H, Lavrynenko O, Shevchenko A, Yew J. Steroid Hormone Signaling Is Essential for Pheromone Production and Oenocyte Survival. PLoS Genet. 2016;12:e1006126 pubmed publisher
    ..Taken together, these results identify a novel regulator of pheromone synthesis and reveal that ecdysteroid signaling is essential for the maintenance of cuticular lipids and oenocytes throughout adulthood. ..
  20. Pueyo J, Couso J. Tarsal-less peptides control Notch signalling through the Shavenbaby transcription factor. Dev Biol. 2011;355:183-93 pubmed publisher
  21. Zeng J, Kirk B, Gou Y, Wang Q, Ma J. Genome-wide polycomb target gene prediction in Drosophila melanogaster. Nucleic Acids Res. 2012;40:5848-63 pubmed publisher
    ..From a computational standpoint, our strategy of modelling transcription factor interaction with a non-linear kernel is original, effective and transferable to many other applications. ..
  22. Devi T, Amruthavalli C, Shyamala B. Evolution of sex comb from the primitive bristle pattern in Drosophila is associated with modification in the developmental regulatory protein Dachshund. Genesis. 2013;51:97-109 pubmed publisher
    ..Sex combs reduced (Scr), dachshund (dac), and bric-a-brac (bab) gene expression were studied...
  23. Burtis K. Development. Doublesex in the middle. Science. 2002;297:1135-6 pubmed
  24. Hatini V, Green R, Lengyel J, Bray S, Dinardo S. The Drumstick/Lines/Bowl regulatory pathway links antagonistic Hedgehog and Wingless signaling inputs to epidermal cell differentiation. Genes Dev. 2005;19:709-18 pubmed
    ..Thus, in all these developmental contexts, including the embryonic epidermis, the novel molecular regulatory pathway defined here is deployed in order to elaborate pattern across a field of cells. ..
  25. Boube M, Hudry B, Immarigeon C, Carrier Y, Bernat Fabre S, Merabet S, et al. Drosophila melanogaster Hox transcription factors access the RNA polymerase II machinery through direct homeodomain binding to a conserved motif of mediator subunit Med19. PLoS Genet. 2014;10:e1004303 pubmed publisher
    ..They support a role for Med19 as a PolII holoenzyme-embedded "co-factor" that acts together with Hox proteins through their homeodomains in regulated developmental transcription. ..
  26. Baanannou A, Mojica Vázquez L, Darras G, Couderc J, Cribbs D, Boube M, et al. Drosophila distal-less and Rotund bind a single enhancer ensuring reliable and robust bric-a-brac2 expression in distinct limb morphogenetic fields. PLoS Genet. 2013;9:e1003581 pubmed publisher
    ..A fine-tuned spatio-temporal expression of bric-a-brac2 (bab2) along concentric rings is essential for proper proximo-distal (P-D) differentiation of legs and antennae...
  27. Haag Liautard C, Dorris M, Maside X, Macaskill S, Halligan D, Houle D, et al. Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila. Nature. 2007;445:82-5 pubmed
    ..2 per diploid genome. This high rate suggests that selection against deleterious mutations may have a key role in explaining patterns of genetic variation in the genome, and help to maintain recombination and sexual reproduction. ..
  28. Panganiban G, Rubenstein J. Developmental functions of the Distal-less/Dlx homeobox genes. Development. 2002;129:4371-86 pubmed
    ..We review what is known about the invertebrate and vertebrate Dll/Dlx genes and their varied roles during development. We propose revising the vertebrate nomenclature to reflect phylogenetic relationships among the Dlx genes. ..
  29. Kennell J, Cadigan K, Shakhmantsir I, Waldron E. The microRNA miR-8 is a positive regulator of pigmentation and eclosion in Drosophila. Dev Dyn. 2012;241:161-8 pubmed publisher
    ..Together, these data suggest that miR-8 acts as a buffer to stabilize gene expression patterns in the midst of environmental variation. ..
  30. Li Y, Danzer J, Alvarez P, Belmont A, Wallrath L. Effects of tethering HP1 to euchromatic regions of the Drosophila genome. Development. 2003;130:1817-24 pubmed
    ..Silencing was not dependent on SU(VAR)3-9 dosage, suggesting a bypass of the requirement for histone methylation...
  31. Ebacher D, Todi S, Eberl D, Boekhoff Falk G. Cut mutant Drosophila auditory organs differentiate abnormally and degenerate. Fly (Austin). 2007;1:86-94 pubmed
    ..We speculate that Cut functions in conjunction with these factors to regulate transcription of as yet unidentified targets...
  32. Salomone J, Rogers W, Rebeiz M, Williams T. The evolution of Bab paralog expression and abdominal pigmentation among Sophophora fruit fly species. Evol Dev. 2013;15:442-57 pubmed publisher
    ..melanogaster, dimorphic pigmentation is controlled by the dimorphic expression of the paralogous Bab1 and Bab2 transcription factors that repress pigmentation...
  33. Christiansen A, Keisman E, Ahmad S, Baker B. Sex comes in from the cold: the integration of sex and pattern. Trends Genet. 2002;18:510-6 pubmed
    ..the activities of well-known signaling molecules (FGF, Wnt and TGF beta proteins) and transcription factors (BAB and DAC) to direct various sex-specific aspects of growth and differentiation...
  34. Rogers W, Salomone J, Tacy D, Camino E, Davis K, Rebeiz M, et al. Recurrent modification of a conserved cis-regulatory element underlies fruit fly pigmentation diversity. PLoS Genet. 2013;9:e1003740 pubmed publisher
    ..In Drosophila melanogaster fruit flies, the Bric-à-brac (Bab) transcription factors control the development of a suite of sexually dimorphic traits on the posterior abdomen...
  35. Green D, Extavour C. Convergent evolution of a reproductive trait through distinct developmental mechanisms in Drosophila. Dev Biol. 2012;372:120-30 pubmed publisher
    ..InR) alter SGP cell number but not ovarian morphogenesis, while targeted loss of function of bric-à-brac 2 (bab2) affects morphogenesis without changing SGP cell number...
  36. Li Q, Barish S, Okuwa S, Maciejewski A, Brandt A, Reinhold D, et al. A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity. PLoS Genet. 2016;12:e1005780 pubmed publisher
    ..Here, we show that Rn, along with BarH1/H2 (Bar), Bric-à-brac (Bab), Apterous (Ap) and Dachshund (Dac), constitutes a transcription factor (TF) network that patterns the developing ..
  37. Bartoletti M, Rubin T, Chalvet F, Netter S, Dos Santos N, Poisot E, et al. Genetic basis for developmental homeostasis of germline stem cell niche number: a network of Tramtrack-Group nuclear BTB factors. PLoS ONE. 2012;7:e49958 pubmed publisher
    ..Here we show that pipsqueak, Trithorax-like, batman and the bric-à-brac (bab) locus, all encoding nuclear BTB/POZ factors of the Tramtrack Group, are involved in limiting the number of ..
  38. Wei H, Shu H, Price J. Functional genomic analysis of the 61D-61F region of the third chromosome of Drosophila melanogaster. Genome. 2003;46:1049-58 pubmed
    ..One hundred sixteen mutations were identified by their failure to complement both Df(3L)bab-PG and Df(3L)3C7. These alleles were assigned to 14 complementation groups and 9 deficiency intervals...
  39. Dey B, Zhao X, Popo Ola E, Campos A. Mutual regulation of the Drosophila disconnected (disco) and Distal-less (Dll) genes contributes to proximal-distal patterning of antenna and leg. Cell Tissue Res. 2009;338:227-40 pubmed publisher
    ..These observations demonstrate that disco plays a fundamental role in the Dll-dependent patterning of antenna and leg, perhaps as a regulator of Dll gene expression. ..
  40. Loncle N, Boube M, Joulia L, Boschiero C, Werner M, Cribbs D, et al. Distinct roles for Mediator Cdk8 module subunits in Drosophila development. EMBO J. 2007;26:1045-54 pubmed
    ..These data reveal functional attributes of the Cdk8 module, apart from its regulated kinase activity, that may contribute to the diversification of genetic programs. ..