Gene Symbol: Awh
Description: Arrowhead
Alias: CG1072, Dmel\CG1072, awh, l(3)63Ea, l(3)63Ea/Awh, l(3)64Ea, l(3)SH9, l63Ea, arrowhead, Awh-PA, Awh-PB, Awh-PC, Awh-PD, CG1072-PA, CG1072-PB, CG1072-PC, CG1072-PD, lethal(3)63Ea
Species: fruit fly

Top Publications

  1. Curtiss J, Heilig J. Arrowhead encodes a LIM homeodomain protein that distinguishes subsets of Drosophila imaginal cells. Dev Biol. 1997;190:129-41 pubmed
    The Arrowhead gene encodes a LIM-homeodomain transcription factor required for establishment of a subset of imaginal tissues: the abdominal histoblasts and the salivary gland imaginal rings...
  2. Curtiss J, Heilig J. Establishment of Drosophila imaginal precursor cells is controlled by the Arrowhead gene. Development. 1995;121:3819-28 pubmed
    ..The imaginal primordia are established during embryonic stages and are quiescent for much of larval life. The Arrowhead gene is necessary for establishment of proper numbers of cells within a subset of imaginal precursor tissues...
  3. Harrison S, Solomon N, Rubin G. A genetic analysis of the 63E-64A genomic region of Drosophila melanogaster: identification of mutations in a replication factor C subunit. Genetics. 1995;139:1701-9 pubmed
    ..In addition we have isolated 11 new mutant alleles of the disembodied gene. ..
  4. Glazov E, Pheasant M, McGraw E, Bejerano G, Mattick J. Ultraconserved elements in insect genomes: a highly conserved intronic sequence implicated in the control of homothorax mRNA splicing. Genome Res. 2005;15:800-8 pubmed
  5. Choo S, White R, Russell S. Genome-wide analysis of the binding of the Hox protein Ultrabithorax and the Hox cofactor Homothorax in Drosophila. PLoS ONE. 2011;6:e14778 pubmed publisher
    ..Overall, we define a set of direct Ubx targets in the haltere imaginal disc and suggest that chromatin accessibility has important implications for Hox target selection and for transcription factor binding in general. ..
  6. Weasner B, Kumar J. Competition among gene regulatory networks imposes order within the eye-antennal disc of Drosophila. Development. 2013;140:205-15 pubmed publisher
    ..We propose that GRNs simultaneously promote primary fates, inhibit alternative fates and establish cell proliferation states. ..
  7. Wohlwill A, Bonner J. Genetic analysis of chromosome region 63 of Drosophila melanogaster. Genetics. 1991;128:763-75 pubmed
    ..Four loci, including the Minute gene, are candidates for hsp82 mutations by cytogenetic mapping. These loci were tested for complementation with a P element carrying the hsp82 gene. However, none of the mutations was rescued...
  8. Hawkins N, Thorpe J, Schupbach T. Encore, a gene required for the regulation of germ line mitosis and oocyte differentiation during Drosophila oogenesis. Development. 1996;122:281-90 pubmed
    ..We argue that these two phenotypes produced by mutations in encore represent two independent requirements for encore during oogenesis. ..
  9. Hobert O, Westphal H. Functions of LIM-homeobox genes. Trends Genet. 2000;16:75-83 pubmed
    ..Here, we summarize the recent findings on LIM-homeobox gene function, compare the function of these genes from different organisms and describe specific co-factor requirements. ..

More Information


  1. Vaskova M, Bentley A, Marshall S, Reid P, Thummel C, Andres A. Genetic analysis of the Drosophila 63F early puff. Characterization of mutations in E63-1 and maggie, a putative Tom22. Genetics. 2000;156:229-44 pubmed
    ..We show that mge mutations lead to first-instar larval lethality and that Mge protein is similar to the Tom22 mitochondrial import proteins of fungi, suggesting that it has a role in mitochondrial function. ..
  2. Komiyama T, Luo L. Intrinsic control of precise dendritic targeting by an ensemble of transcription factors. Curr Biol. 2007;17:278-85 pubmed
    ..These results begin to provide insights into the global strategy of how an ensemble of TFs regulates wiring specificity of a large number of neurons constituting a neural circuit. ..
  3. Zhai Z, Stein M, Lohmann I. Expression of the apoptosis gene reaper in homeotic, segmentation and other mutants in Drosophila. Gene Expr Patterns. 2009;9:357-63 pubmed publisher
  4. Zhai Z, Fuchs A, Lohmann I. Cellular analysis of newly identified Hox downstream genes in Drosophila. Eur J Cell Biol. 2010;89:273-8 pubmed publisher
  5. Roignant J, Legent K, Janody F, Treisman J. The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila. Development. 2010;137:273-81 pubmed publisher
    ..We show that two LIM-homeodomain proteins, Arrowhead and Lim1, are expressed in the region of the eye-antennal disc affected in Chip mutants, and that both require ..
  6. Sato A, Shibuya H. WNK signaling is involved in neural development via Lhx8/Awh expression. PLoS ONE. 2013;8:e55301 pubmed publisher
    ..Here, we identify a new target gene in WNK signaling, Arrowhead and Lhx8, which is a mammalian homologue of Drosophila Arrowhead...