aurB

Summary

Gene Symbol: aurB
Description: aurora B
Alias: ABK, Aur B, AurB, Aurora B, Aurora-B, CG6620, DmAIRK2, DmAurB, DmAuroraB, Dmel\CG6620, IAL, IAL1, Ial, ial, ial/AurB, aurora B, AURORA-like, CG6620-PA, DmAuroraB, IplI-aurora-like kinase, aurB-PA, aurora, aurora B kinase, aurora-B, auroraB, dAurora B
Species: fruit fly
Products:     aurB

Top Publications

  1. Giet R, Glover D. Drosophila aurora B kinase is required for histone H3 phosphorylation and condensin recruitment during chromosome condensation and to organize the central spindle during cytokinesis. J Cell Biol. 2001;152:669-82 pubmed
    ..We now show that depleting Aurora B kinase using double-stranded RNA interference in cultured Drosophila cells results in polyploidy...
  2. Perrimon N, Mathey Prevot B. Applications of high-throughput RNA interference screens to problems in cell and developmental biology. Genetics. 2007;175:7-16 pubmed
    ..Finally, we discuss emerging technological advances that will extend RNAi-based screening methods. ..
  3. Colombié N, Cullen C, Brittle A, Jang J, Earnshaw W, Carmena M, et al. Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis. Development. 2008;135:3239-46 pubmed publisher
    ..Here, we report two crucial roles of Incenp, an essential subunit of the chromosomal passenger complex (the Aurora B complex), in centrosome-independent spindle formation in Drosophila female meiosis...
  4. D Avino P, Savoian M, Glover D. Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy. J Cell Sci. 2005;118:1549-58 pubmed
    ..The same mechanism might be conserved in other organisms. ..
  5. Eggert U, Kiger A, Richter C, Perlman Z, Perrimon N, Mitchison T, et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004;2:e379 pubmed
    ..By comparing small molecule and RNAi phenotypes, we identified a small molecule that inhibits the Aurora B kinase pathway...
  6. Resnick T, Satinover D, MacIsaac F, Stukenberg P, Earnshaw W, Orr Weaver T, et al. INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila. Dev Cell. 2006;11:57-68 pubmed
    ..INCENP binds to the cohesion protector protein MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase. A MEI-S332 mutant that is only poorly phosphorylated by Aurora B is defective in localization to centromeres...
  7. Giet R, Prigent C. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. J Cell Sci. 1999;112 ( Pt 21):3591-601 pubmed
    ..A Drosophila melanogaster homologue, aurora, was the first to be isolated from a multicellular organism...
  8. Cesario J, Jang J, Redding B, Shah N, Rahman T, McKim K. Kinesin 6 family member Subito participates in mitotic spindle assembly and interacts with mitotic regulators. J Cell Sci. 2006;119:4770-80 pubmed
    ..Subito localizes to the spindle midzone at anaphase and is required for the localization of Polo, Incenp and Aurora B. Genetic evidence suggested that the effects of subito mutants are attenuated as a result of redundant mechanisms ..
  9. Bucciarelli E, Giansanti M, Bonaccorsi S, Gatti M. Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. J Cell Biol. 2003;160:993-9 pubmed
    ..In addition, chromosome-free spindles normally accumulate the Aurora B kinase at their midzones...

More Information

Publications68

  1. Gilliland W, Hughes S, Cotitta J, Takeo S, Xiang Y, Hawley R. The multiple roles of mps1 in Drosophila female meiosis. PLoS Genet. 2007;3:e113 pubmed
    ..cells, also contain the outer kinetochore protein kinase Polo, but not the inner kinetochore proteins Incenp or Aurora-B...
  2. Carmena M, Pinson X, Platani M, Salloum Z, Xu Z, Clark A, et al. The chromosomal passenger complex activates Polo kinase at centromeres. PLoS Biol. 2012;10:e1001250 pubmed publisher
    ..We show that INCENP, a key scaffolding subunit of the chromosomal passenger complex (CPC), which consists of Aurora B kinase, INCENP, Survivin, and Borealin/Dasra B, also interacts with Polo kinase in Drosophila cells...
  3. Inoue Y, Savoian M, Suzuki T, Mathe E, Yamamoto M, Glover D. Mutations in orbit/mast reveal that the central spindle is comprised of two microtubule populations, those that initiate cleavage and those that propagate furrow ingression. J Cell Biol. 2004;166:49-60 pubmed
    ..peripheral MTs still probe the cortex and form regions of overlap that recruit the Pav-KLP motor and Aurora B kinase. orbit mutants have disorganized or incomplete anillin and actin rings, and although cleavage furrows ..
  4. Hanson K, Kelley A, Bienz M. Loss of Drosophila borealin causes polyploidy, delayed apoptosis and abnormal tissue development. Development. 2005;132:4777-87 pubmed
    ..Like its mammalian counterpart, Borr colocalises with the CPC components Aurora B kinase and Incenp in mitotic Drosophila cells, and is required for their localisation to the mitotic spindle...
  5. Chang C, Goulding S, Earnshaw W, Carmena M. RNAi analysis reveals an unexpected role for topoisomerase II in chromosome arm congression to a metaphase plate. J Cell Sci. 2003;116:4715-26 pubmed
    ..This is not kinetochore-based movement, as the centromere of the affected chromosome is located on the plate. This observation raises the possibility that further unexpected functions for Topo II may remain to be discovered. ..
  6. Adams R, Maiato H, Earnshaw W, Carmena M. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J Cell Biol. 2001;153:865-80 pubmed
    ..RNAi) analysis of the role of two chromosomal passenger proteins, inner centromere protein (INCENP) and aurora B kinase, in cultured cells of Drosophila melanogaster. INCENP and aurora B function is tightly interlinked...
  7. Reich A, Yanai A, Mesilaty Gross S, Chen Moses A, Wides R, Motro B. Cloning, mapping, and expression of ial, a novel Drosophila member of the Ipl1/aurora mitotic control kinase family. DNA Cell Biol. 1999;18:593-603 pubmed
    The members of the Ipl1-aurora like kinase (IARK) subfamily are conserved serine/threonine kinases that play a key role in the control of chromosome segregation, centrosome separation, and cytokinesis from yeast to mammals...
  8. D Avino P, Savoian M, Glover D. Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. J Cell Biol. 2004;166:61-71 pubmed
    ..Similar genetic evidence indicates that RacGAP50C inhibits Rac during cytokinesis. We discuss that antagonism between Rho and Rac pathways may control contractile ring dynamics during cytokinesis. ..
  9. Cane S, Ye A, Luks Morgan S, Maresca T. Elevated polar ejection forces stabilize kinetochore-microtubule attachments. J Cell Biol. 2013;200:203-18 pubmed publisher
    ..NOD stabilized syntelic kt-MT attachments in a dose- and motor-dependent manner by overwhelming the ability of Aurora B to mediate error correction...
  10. D Avino P, Archambault V, Przewloka M, Zhang W, Laue E, Glover D. Isolation of protein complexes involved in mitosis and cytokinesis from Drosophila cultured cells. Methods Mol Biol. 2009;545:99-112 pubmed publisher
    ..Although this method has proven very successful in isolating mitotic and cytokinetic complexes, it can also be used to characterise protein complexes involved in many other cellular processes. ..
  11. Moutinho Santos T, Conde C, Sunkel C. POLO ensures chromosome bi-orientation by preventing and correcting erroneous chromosome-spindle attachments. J Cell Sci. 2012;125:576-83 pubmed publisher
    ..Abnormal chromosome-spindle interactions do occur but are corrected through the activity of Aurora B, which destabilizes erroneous attachments...
  12. Capalbo L, Montembault E, Takeda T, Bassi Z, Glover D, D Avino P. The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. Open Biol. 2012;2:120070 pubmed publisher
    ..Moreover, we find that the CPC's catalytic subunit, Aurora B kinase, phosphorylates one of the three human Snf7 paralogues-CHMP4C-in its C-terminal tail, a region known to ..
  13. Jang J, Rahman T, McKim K. The kinesinlike protein Subito contributes to central spindle assembly and organization of the meiotic spindle in Drosophila oocytes. Mol Biol Cell. 2005;16:4684-94 pubmed
    ..The meiotic central spindle appears during prometaphase and includes passenger complex proteins such as AurB and Incenp. Unlike mitotic cells, the passenger proteins do not associate with centromeres before anaphase...
  14. Prigent C, Glover D, Giet R. Drosophila Nek2 protein kinase knockdown leads to centrosome maturation defects while overexpression causes centrosome fragmentation and cytokinesis failure. Exp Cell Res. 2005;303:1-13 pubmed
    ..We discuss potential roles for DmNek2 in maintaining centrosome integrity in mitosis, during cytokinesis, and consequently for the fidelity of chromosome segregation. ..
  15. Bell G, Fletcher G, Brain R, Thompson B. Aurora kinases phosphorylate Lgl to induce mitotic spindle orientation in Drosophila epithelia. Curr Biol. 2015;25:61-8 pubmed publisher
    ..The Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization, whereas aPKC kinase activity is ..
  16. Nogueira C, Kashevsky H, Pinto B, Clarke A, Orr Weaver T. Regulation of centromere localization of the Drosophila Shugoshin MEI-S332 and sister-chromatid cohesion in meiosis. G3 (Bethesda). 2014;4:1849-58 pubmed publisher
    ..Although many Sgo members require Aurora B kinase to localize to the centromere, factors controlling delocalization are poorly understood and diverse...
  17. Terada Y, Uetake Y, Kuriyama R. Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells. J Cell Biol. 2003;162:757-63 pubmed
    A mitosis-specific Aurora-A kinase has been implicated in microtubule organization and spindle assembly in diverse organisms. However, exactly how Aurora-A controls the microtubule nucleation onto centrosomes is unknown...
  18. McCleland M, Shermoen A, O Farrell P. DNA replication times the cell cycle and contributes to the mid-blastula transition in Drosophila embryos. J Cell Biol. 2009;187:7-14 pubmed publisher
    ..We conclude that normal S phase and replication checkpoint activities are important timers of the undisturbed cell cycle before, but not after, the MBT...
  19. Chang C, Goulding S, Adams R, Earnshaw W, Carmena M. Drosophila Incenp is required for cytokinesis and asymmetric cell division during development of the nervous system. J Cell Sci. 2006;119:1144-53 pubmed
    ..The inner centromere protein (Incenp; a subunit of this complex) is thought to regulate the Aurora B kinase and target it to its substrates...
  20. Archambault V, D Avino P, Deery M, Lilley K, Glover D. Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis. Genes Dev. 2008;22:2707-20 pubmed publisher
    ..We propose that Map205-dependent targeting of Polo to microtubules provides a stable reservoir of Polo that can be rapidly mobilized by the activity of Cdk1 at mitotic entry. ..
  21. Carvalho C, Moreira S, Ventura G, Sunkel C, Morais de Sá E. Aurora A triggers Lgl cortical release during symmetric division to control planar spindle orientation. Curr Biol. 2015;25:53-60 pubmed publisher
    ..Lgl redistribution during epithelial mitosis is reminiscent of asymmetric cell division, where it is proposed that Aurora A promotes aPKC activation to control the localization of Lgl and cell-fate determinants...
  22. Nikalayevich E, Ohkura H. The NuRD nucleosome remodelling complex and NHK-1 kinase are required for chromosome condensation in oocytes. J Cell Sci. 2015;128:566-75 pubmed
    ..We further show that NHK-1 is important for chromosome condensation during mitosis as well as in oocytes. ..
  23. Lange B, Rebollo E, Herold A, Gonzalez C. Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes. EMBO J. 2002;21:5364-74 pubmed
    ..mitosis and male meiosis, and that these phenotypes closely resemble those brought about by the inactivation of Aurora B. We provide evidence that Aurora B interacts with and requires the Cdc37/Hsp90 complex for its stability...
  24. Carmena M, Lombardía M, Ogawa H, Earnshaw W. Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster. Open Biol. 2014;4:140162 pubmed publisher
    ..We have previously shown that Aurora B activates Polo kinase at the centromere in mitosis, and that the interaction between Polo and the chromosomal ..
  25. Royou A, Gagou M, Karess R, Sullivan W. BubR1- and Polo-coated DNA tethers facilitate poleward segregation of acentric chromatids. Cell. 2010;140:235-45 pubmed publisher
    ..The acentric chromatid poleward movement is mediated through DNA tethers decorated with BubR1, Polo, INCENP, and Aurora-B...
  26. Radford S, Hoang T, GÅ‚uszek A, Ohkura H, McKim K. Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes. PLoS Genet. 2015;11:e1005605 pubmed publisher
    ..Together, these results demonstrate that, in oocytes, kinetochore-dependent and -independent chromosome-microtubule attachments work together to promote the accurate segregation of chromosomes. ..
  27. Lenhart K, Dinardo S. Somatic cell encystment promotes abscission in germline stem cells following a regulated block in cytokinesis. Dev Cell. 2015;34:192-205 pubmed publisher
    ..The duration of this block is controlled by Aurora B kinase. Additionally, we have identified a requirement for somatic cell encystment of the germline in promoting GSC ..
  28. Cane S, McGilvray P, Maresca T. Insights from an erroneous kinetochore-microtubule attachment state. Bioarchitecture. 2013;3:69-76 pubmed publisher
    ..Our force-related studies are also discussed in the context of current models for tension-dependent stabilization of kt-MT interactions. ..
  29. Mathieu J, Cauvin C, Moch C, Radford S, Sampaio P, Perdigoto C, et al. Aurora B and cyclin B have opposite effects on the timing of cytokinesis abscission in Drosophila germ cells and in vertebrate somatic cells. Dev Cell. 2013;26:250-65 pubmed publisher
    ..Here, we show that Aurora B and Survivin regulate the number of germ cells in each Drosophila egg chamber by inhibiting abscission during ..
  30. Parry D, Hickson G, O Farrell P. Cyclin B destruction triggers changes in kinetochore behavior essential for successful anaphase. Curr Biol. 2003;13:647-53 pubmed
    ..Given its established role in destabilizing kinetochore-microtubule interactions [3], Aurora B dissociation is likely to be key to the change in kinetochore behavior...
  31. Brittle A, Nanba Y, Ito T, Ohkura H. Concerted action of Aurora B, Polo and NHK-1 kinases in centromere-specific histone 2A phosphorylation. Exp Cell Res. 2007;313:2780-5 pubmed
    ..We found that the Aurora B kinase complex is essential for this phosphorylation at centromeres, while Polo kinase is required to down-regulate ..
  32. Szafer Glusman E, Fuller M, Giansanti M. Role of Survivin in cytokinesis revealed by a separation-of-function allele. Mol Biol Cell. 2011;22:3779-90 pubmed publisher
    The chromosomal passenger complex (CPC), containing Aurora B kinase, Inner Centromere Protein, Survivin, and Borealin, regulates chromosome condensation and interaction between kinetochores and microtubules at metaphase, then relocalizes ..
  33. Mesilaty Gross S, Reich A, Motro B, Wides R. The Drosophila STAM gene homolog is in a tight gene cluster, and its expression correlates to that of the adjacent gene ial. Gene. 1999;231:173-86 pubmed
    ..By comparison to cDNAs isolated and characterized, this region contains four tightly clustered genes: ial, mitochondrial porin, and the two newly discovered genes, STAM and DNZ1...
  34. Afonso O, Matos I, Pereira A, Aguiar P, Lampson M, Maiato H. Feedback control of chromosome separation by a midzone Aurora B gradient. Science. 2014;345:332-336 pubmed publisher
    ..A midzone-associated Aurora B gradient was found to monitor chromosome position along the division axis and to prevent premature chromosome ..
  35. Hediger F, Gasser S. Heterochromatin protein 1: don't judge the book by its cover!. Curr Opin Genet Dev. 2006;16:143-50 pubmed
    ..Not only do HP1 isoforms have specific binding sites in both heterochromatic and euchromatic domains but they might also participate in the repression and activation of transcription in both compartments. ..
  36. Kachaner D, Pinson X, El Kadhi K, Normandin K, Talje L, Lavoie H, et al. Interdomain allosteric regulation of Polo kinase by Aurora B and Map205 is required for cytokinesis. J Cell Biol. 2014;207:201-11 pubmed publisher
    ..How Plks are regulated in cytokinesis is poorly understood. Here we show that phosphorylation of Polo by Aurora B is required for cytokinesis...
  37. Karg T, Warecki B, Sullivan W. Aurora B-mediated localized delays in nuclear envelope formation facilitate inclusion of late-segregating chromosome fragments. Mol Biol Cell. 2015;26:2227-41 pubmed publisher
    ..Localized delays of nuclear envelope reassembly require Aurora B kinase activity...
  38. Yin Z, Zhou X, Bakal C, Li F, Sun Y, Perrimon N, et al. Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. BMC Bioinformatics. 2008;9:264 pubmed publisher
    ..In our findings, the proposed method is suitable for online phenotype discovery in diverse high-throughput image-based genetic and chemical screens. ..
  39. Orr B, Sunkel C. Drosophila CENP-C is essential for centromere identity. Chromosoma. 2011;120:83-96 pubmed publisher
    ..We suggest that CENP-C might fulfill the structural roles of the human centromere-associated proteins not identified in Drosophila. ..
  40. Coelho P, Queiroz Machado J, Carmo A, Moutinho Pereira S, Maiato H, Sunkel C. Dual role of topoisomerase II in centromere resolution and aurora B activity. PLoS Biol. 2008;6:e207 pubmed publisher
    ..Codepletion of BubR1 in S2 cells restores Aurora B kinase activity, and consequently, most syntelic attachments are released...
  41. Hughes S, Gilliland W, Cotitta J, Takeo S, Collins K, Hawley R. Heterochromatic threads connect oscillating chromosomes during prometaphase I in Drosophila oocytes. PLoS Genet. 2009;5:e1000348 pubmed publisher
    ..Additionally, the passenger complex proteins Incenp and Aurora B appeared to localize to these heterochromatic threads...
  42. Crest J, Concha Moore K, Sullivan W. RhoGEF and positioning of rappaport-like furrows in the early Drosophila embryo. Curr Biol. 2012;22:2037-41 pubmed publisher
    ..We propose that the shift to the latter is driven by a corresponding shift from RhoGEF2 to Pebble in controlling furrow formation. ..
  43. Chanut Delalande H, Jung A, Lin L, Baer M, Bilstein A, Cabernard C, et al. A genetic mosaic analysis with a repressible cell marker screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis. Genetics. 2007;176:2177-87 pubmed
    ..Three of the mutants were mapped to either the Mhc or the stam complementation groups. Further experiments confirmed that these genes are required for cell migration in the tracheal air sac primordium. ..
  44. Sánchez Alvarez M, Zhang Q, Finger F, Wakelam M, Bakal C. Cell cycle progression is an essential regulatory component of phospholipid metabolism and membrane homeostasis. Open Biol. 2015;5:150093 pubmed publisher
    ..We propose that coupling lipid metabolism to cell cycle progression is a means by which cells have evolved to coordinate proliferation with cell and organelle growth. ..
  45. Kondo S, Booker M, Perrimon N. Cross-species RNAi rescue platform in Drosophila melanogaster. Genetics. 2009;183:1165-73 pubmed publisher
    ..melanogaster, both in cell culture and in vivo. Altogether, the tools and method that we have developed provide a gold standard for validation of Drosophila RNAi experiments. ..
  46. Bucciarelli E, Pellacani C, Naim V, Palena A, Gatti M, Somma M. Drosophila Dgt6 interacts with Ndc80, Msps/XMAP215, and gamma-tubulin to promote kinetochore-driven MT formation. Curr Biol. 2009;19:1839-45 pubmed publisher
    ..Dgt6 may also promote elongation of kinetochore-driven k-fibers through its interaction with gamma-tubulin and Msps. ..
  47. Zavortink M, Contreras N, Addy T, Bejsovec A, Saint R. Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster. J Cell Sci. 2005;118:5381-92 pubmed
    ..cells lacking Tum do not form furrows and fail to localise the key cytokinetic components Pebble (a RhoGEF), Aurora B kinase, Diaphanous, Pav-KLP and Anillin...
  48. Vale R, Spudich J, Griffis E. Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells. J Cell Biol. 2009;186:727-38 pubmed publisher
    ..These results suggest models for how Kinesin-6 might define the position of cortical myosin during cytokinesis. ..
  49. Conde C, Osswald M, Barbosa J, Moutinho Santos T, Pinheiro D, Guimaraes S, et al. Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation. EMBO J. 2013;32:1761-77 pubmed publisher
    ..We demonstrate that Polo and Aurora B functional interdependency comprises a positive feedback loop that promotes Mps1 kinetochore localization and ..
  50. Gao S, Giansanti M, Buttrick G, Ramasubramanyan S, Auton A, Gatti M, et al. Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis. J Cell Biol. 2008;180:521-35 pubmed publisher
    The chromosomal passenger complex (CPC), which is composed of conserved proteins aurora B, inner centromere protein (INCENP), survivin, and Borealin/DASRA, localizes to chromatin, kinetochores, microtubules, and the cell cortex in a cell ..
  51. Matias N, Mathieu J, Huynh J. Abscission is regulated by the ESCRT-III protein shrub in Drosophila germline stem cells. PLoS Genet. 2015;11:e1004653 pubmed publisher
    ..In addition, our results indicate a negative regulation of Shrub by the Aurora B kinase during GSC abscission...
  52. Radford S, Jang J, McKim K. The chromosomal passenger complex is required for meiotic acentrosomal spindle assembly and chromosome biorientation. Genetics. 2012;192:417-29 pubmed publisher
    ..central spindle kinesin-6 protein Subito, which is required for spindle bipolarity, depend on the CPC components Aurora B and Incenp...
  53. Oliveira R, Hamilton R, Pauli A, Davis I, Nasmyth K. Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. Nat Cell Biol. 2010;12:185-92 pubmed publisher
    ..We conclude that only two key events, opening of cohesin rings and downregulation of Cdk1, are sufficient to drive proper segregation of chromosomes in anaphase. ..
  54. Salemi J, McGilvray P, Maresca T. Development of a Drosophila cell-based error correction assay. Front Oncol. 2013;3:187 pubmed publisher
    ..Importantly, error correction in Eg5-expressing S2 cells was dependent on the well-established error correction kinase Aurora B. This system provides a powerful new cell-based platform for studying error correction and CIN.
  55. Jang J, Rahman T, Kober V, Cesario J, McKim K. Misregulation of the kinesin-like protein Subito induces meiotic spindle formation in the absence of chromosomes and centrosomes. Genetics. 2007;177:267-80 pubmed
    ..Instead of the chromosomes directly capturing microtubules, signals released upon nuclear envelope breakdown may activate proteins like Subito, which in turn bundles together microtubules. ..
  56. Wang Y, Antunes M, Anderson A, Kadrmas J, Jacinto A, Galko M. Integrin Adhesions Suppress Syncytium Formation in the Drosophila Larval Epidermis. Curr Biol. 2015;25:2215-27 pubmed publisher
    ..Our results reveal a novel and unexpected role for proper integrin-based adhesion in suppressing larval epidermal cell-cell fusion--a role that may be conserved in other epithelia. ..
  57. Mirkovic M, Hutter L, Novák B, Oliveira R. Premature Sister Chromatid Separation Is Poorly Detected by the Spindle Assembly Checkpoint as a Result of System-Level Feedback. Cell Rep. 2015;13:469-478 pubmed publisher
    ..Our findings explain how cohesion defects may escape SAC surveillance. ..
  58. Delcros J, Prigent C, Giet R. Dynactin targets Pavarotti-KLP to the central spindle during anaphase and facilitates cytokinesis in Drosophila S2 cells. J Cell Sci. 2006;119:4431-41 pubmed
    ..Although cyclin B was degraded in these anaphase cells, Aurora B, MEI-S322 and BubR1 were not released from the non-segregating chromosomes...
  59. Smurnyy Y, Toms A, Hickson G, Eck M, Eggert U. Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis. ACS Chem Biol. 2010;5:1015-20 pubmed publisher
    ..We report that Binucleine 2 is a highly isoform-specific inhibitor of Drosophila Aurora B kinase, and we identify a single residue within the kinase active site that confers specificity for Aurora B...