Gene Symbol: ATPCL
Description: ATP citrate lyase
Alias: ACL, BcDNA:LD21334, CG8322, DmATPCL, Dmel\CG8322, anon-WO0140519.179, dATPCL, l(2)01466, l(2)k09217, n(2)k09217, ATP citrate lyase, ATP-citrate lyase, ATPCL-PD, ATPCL-PE, ATPCL-PF, ATPCL-PG, CG8322-PD, CG8322-PE, CG8322-PF, CG8322-PG
Species: fruit fly
Sassu E, McDermott J, Keys B, Esmaeili M, Keene A, Birnbaum M, et al
. Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. Biochem Biophys Res Commun. 2012;426:43-8 pubmed publisher
..Together, these data implicate a role for Mio in controlling fat accumulation in Drosophila and suggests that it may act as a nutrient sensor in the fat body to coordinate feeding behavior with nutrient availability. ..
Seegmiller A, Dobrosotskaya I, Goldstein J, Ho Y, Brown M, Rawson R. The SREBP pathway in Drosophila: regulation by palmitate, not sterols. Dev Cell. 2002;2:229-38 pubmed
..Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis. ..
Lim H, Wang W, Wessells R, Ocorr K, Bodmer R. Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. Genes Dev. 2011;25:189-200 pubmed publisher
..These findings suggest that dysregulated phospholipid signaling that alters SREBP activity contributes to the progression of impaired heart function in flies and identifies a potential link to lipotoxic cardiac diseases in humans. ..
Chang Y, Hung W, Chang Y, Chang H, Wu C, Chiang A, et al
. Pathogenic VCP/TER94 alleles are dominant actives and contribute to neurodegeneration by altering cellular ATP level in a Drosophila IBMPFD model. PLoS Genet. 2011;7:e1001288 pubmed publisher
..Taken together, our analyses have defined the nature of IBMPFD-causing VCP mutations and made an unexpected link between cellular ATP level and IBMPFD pathogenesis...
Kim G, Lee Y, Lee G, Cho Y, Lee Y, Jang Y, et al
. Overexpression of malic enzyme in the larval stage extends Drosophila lifespan. Biochem Biophys Res Commun. 2015;456:676-82 pubmed publisher
..Our results suggest that metabolic changes mediated by Men during development might be related to the control of ROS tolerance and the longevity of Drosophila. ..
Peleg S, Feller C, Forne I, Schiller E, SÃ©vin D, Schauer T, et al
. Life span extension by targeting a link between metabolism and histone acetylation in Drosophila. EMBO Rep. 2016;17:455-69 pubmed publisher
..Based on these observations, we decreased the activity of the acetyl-CoA-synthesizing enzyme ATP citrate lyase (ATPCL) or the levels of the histone H4 K12-specific acetyltransferase Chameau...
Bi J, Wang W, Liu Z, Huang X, Jiang Q, Liu G, et al
. Seipin promotes adipose tissue fat storage through the ER Ca²?-ATPase SERCA. Cell Metab. 2014;19:861-71 pubmed publisher
..Our results reveal that Seipin promotes adipose tissue fat storage by regulating intracellular calcium homeostasis. ..