ATPase

Summary

Gene Symbol: ATPase
Description: Vacuolar H[+] ATPase 14kD subunit 1
Alias: ATP6V1F, ATPase, CG8210, Dmel\CG8210, VAF1_DROME, Vha14, l(2)SH1248, l(2)SH2 1248, vha14, vha14-1, vacuolar H[+] ATPase 14kD subunit 1, CG8210-PA, F subunit, V-ATPase 14kD subunit, V-ATPase proton pump, Vha14-1-PA, lethal (2) SH1248, vacuolar H[+] ATPase 14kD subunit, vacuolar H[+] ATPase subunit 14-1
Species: fruit fly

Top Publications

  1. Dow J, Davies S, Guo Y, Graham S, Finbow M, Kaiser K. Molecular genetic analysis of V-ATPase function in Drosophila melanogaster. J Exp Biol. 1997;200:237-45 pubmed
    ..While yeast is the model of choice for the rapid generation and identification of V-ATPase mutants, it does not allow their analysis in a plasma membrane context...
  2. Sessions O, Barrows N, Souza Neto J, Robinson T, Hershey C, Rodgers M, et al. Discovery of insect and human dengue virus host factors. Nature. 2009;458:1047-50 pubmed publisher
    ..This indicates notable conservation of required factors between dipteran and human hosts. This work suggests new approaches to control infection in the insect vector and the mammalian host. ..
  3. Adamson A, Chohan K, Swenson J, Lajeunesse D. A Drosophila model for genetic analysis of influenza viral/host interactions. Genetics. 2011;189:495-506 pubmed publisher
    ..In a candidate gene screen we identified mutations in components of the vacuolar V1V0 ATPase that modify the UAS-M2 phenotype...
  4. Dow J. The multifunctional Drosophila melanogaster V-ATPase is encoded by a multigene family. J Bioenerg Biomembr. 1999;31:75-83 pubmed
    ..Recently, the first animal "knockouts" of a V-ATPase were described in Drosophila...
  5. Wakabayashi Ito N, Belvin M, Bluestein D, Anderson K. fusilli, an essential gene with a maternal role in Drosophila embryonic dorsal-ventral patterning. Dev Biol. 2001;229:44-54 pubmed
  6. Mauvezin C, Nagy P, Juhász G, Neufeld T. Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification. Nat Commun. 2015;6:7007 pubmed publisher
    The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity...
  7. Guo Y, Kaiser K, Wieczorek H, Dow J. The Drosophila melanogaster gene vha14 encoding a 14-kDa F-subunit of the vacuolar ATPase. Gene. 1996;172:239-43 pubmed
    A Drosophila melanogaster (Dm) cDNA (vha14) encoding the 14-kDa F-subunit of the vacuolar H(+)-ATPase (V-ATPase) has been cloned via homology with the corresponding Manduca sexta (Ms) gene...
  8. Guo Y, Gillan A, Torok T, Kiss I, Dow J, Kaiser K. Site-selected mutagenesis of the Drosophila second chromosome via plasmid rescue of lethal P-element insertions. Genome Res. 1996;6:972-9 pubmed
    ..The success rate was better than one in four. This rate would undoubtedly be improved by the use of genomic DNA probes. ..