Gene Symbol: Atf6
Alias: ATF6, CG3136, DM15, Dmel\CG3136, atf6, Atf6, Atf6-PA, Atf6-PB, Atf6-PC, CG3136-PA, CG3136-PB, CG3136-PC
Species: fruit fly
Ryoo H, Steller H. Unfolded protein response in Drosophila: why another model can make it fly. Cell Cycle. 2007;6:830-5 pubmed
..Here, we review the molecular components of the Drosophila UPR as well as the disease models that may be affected by this signaling pathway. ..
Kang M, Chung J, Ryoo H. CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model. Nat Cell Biol. 2012;14:409-15 pubmed publisher
..These findings establish a previously unrecognized branch of ER-stress response signalling involved in degenerative diseases. ..
Ryoo H. Drosophila as a model for unfolded protein response research. BMB Rep. 2015;48:445-53 pubmed
..The fact that the basic UPR pathways are conserved, together with the availability of many human disease models in this organism, makes Drosophila a powerful tool for studying human disease mechanisms. ..
Haag Liautard C, Dorris M, Maside X, Macaskill S, Halligan D, Houle D, et al
. Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila. Nature. 2007;445:82-5 pubmed
..2 per diploid genome. This high rate suggests that selection against deleterious mutations may have a key role in explaining patterns of genetic variation in the genome, and help to maintain recombination and sexual reproduction. ..
Coulthard A, Alm C, Cealiac I, Sinclair D, Honda B, Rossi F, et al
. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Genetics. 2010;185:479-95 pubmed publisher
..existence of eight novel essential loci in 2Rh: CG17665, CG17683, CG17684, CG17883, CG40127, CG41265, CG42595, and Atf6. Two of these essential loci, CG41265 and CG42595, are synonymous with the previously characterized loci l(2)41Ab ..
Dimitriadi M, Sleigh J, Walker A, Chang H, Sen A, Kalloo G, et al
. Conserved genes act as modifiers of invertebrate SMN loss of function defects. PLoS Genet. 2010;6:e1001172 pubmed publisher
Wang L, Ryoo H, Qi Y, Jasper H. PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress. PLoS Genet. 2015;11:e1005220 pubmed publisher
..Our studies highlight the significance of the PERK branch of the unfolded protein response of the ER (UPRER) in intestinal homeostasis and provide a viable strategy to improve organismal health- and lifespan. ..
LindstrÃ¶m R, Lindholm P, KallijÃ¤rvi J, Palgi M, Saarma M, Heino T. Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster. PLoS ONE. 2016;11:e0151550 pubmed publisher
..Our data suggest a role for Manf in the regulation of Drosophila UPR. ..