Gene Symbol: Atf3
Description: Activating transcription factor 3
Alias: A3-3, ATF3, CG11405, DM11, Dmel\CG11405, EG:33C11.1, atf3, dATF3, activating transcription factor 3, A3-3, Atf3-PA, Atf3-PB, Atf3-PC, CG11405-PA, CG11405-PB, CG11405-PC
Species: fruit fly
Rynes J, Donohoe C, Frommolt P, Brodesser S, Jindra M, Uhlirova M. Activating transcription factor 3 regulates immune and metabolic homeostasis. Mol Cell Biol. 2012;32:3949-62 pubmed publisher
..Here, we show that the Drosophila melanogaster activating transcription factor 3 (Atf3) safeguards metabolic and immune system homeostasis...
Sekyrova P, Bohmann D, Jindra M, Uhlirova M. Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. Development. 2010;137:141-50 pubmed publisher
..Here, we implicate Drosophila Activating transcription factor 3 (Atf3), the single ortholog of human ATF3 and JDP2 bZIP proteins, in abdominal morphogenesis...
Koizumi K, Higashida H, Yoo S, Islam M, Ivanov A, Guo V, et al
. RNA interference screen to identify genes required for Drosophila embryonic nervous system development. Proc Natl Acad Sci U S A. 2007;104:5626-31 pubmed
..The total number of dsRNAs that we have tested for an RNAi-induced phenotype affecting the embryonic nervous system, including our previous study, is 7,312, which corresponds to approximately 50% of the genes in the Drosophila genome. ..
Chakrabarti S, Poidevin M, Lemaitre B. The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine. PLoS Genet. 2014;10:e1004659 pubmed publisher
..The role of p38c in lipid metabolism is mediated by the Atf3 transcription factor...
Busser B, Lin Y, Yang Y, Zhu J, Chen G, Michelson A. An Orthologous Epigenetic Gene Expression Signature Derived from Differentiating Embryonic Stem Cells Identifies Regulators of Cardiogenesis. PLoS ONE. 2015;10:e0141066 pubmed publisher
..Collectively, these results show that orthologous gene expression signatures can be used to identify conserved cardiogenic pathways. ..
Castillo D, Mell J, Box K, Blumenstiel J. Molecular evolution under increasing transposable element burden in Drosophila: a speed limit on the evolutionary arms race. BMC Evol Biol. 2011;11:258 pubmed publisher
..Third, we test whether increasing TE abundance is correlated with greater codon bias in genes of the piRNA machinery. This is predicted if increasing TE abundance selects for increased efficiency in the machinery of genome defense...
Douglas A. The molecular basis of bacterial-insect symbiosis. J Mol Biol. 2014;426:3830-7 pubmed publisher
Bhat S, Jones W. An accelerated miRNA-based screen implicates Atf-3 in Drosophila odorant receptor expression. Sci Rep. 2016;6:20109 pubmed publisher
..Here we describe such a screen that uncovers a role for Atf3 in the expression of the odorant receptor Or47b.
LindstrÃ¶m R, Lindholm P, KallijÃ¤rvi J, Palgi M, Saarma M, Heino T. Exploring the Conserved Role of MANF in the Unfolded Protein Response in Drosophila melanogaster. PLoS ONE. 2016;11:e0151550 pubmed publisher
..Our data suggest a role for Manf in the regulation of Drosophila UPR. ..