Gene Symbol: AstA-R1
Description: Allatostatin A receptor 1
Alias: ASR, AST-R, AlstR, CG2872, D.AlstR1, DAR-1, DAR1, DGR, Dmel\CG2872, EG:121E7.2, allatostatin A receptor 1, ASA-receptor, AlstR, AstA-R1-PB, AstA-R1-PD, CG2872-PB, CG2872-PD, allatostatin receptor, galanin receptor
Species: fruit fly
Products:     AstA-R1

Top Publications

  1. Birgul N, Weise C, Kreienkamp H, Richter D. Reverse physiology in drosophila: identification of a novel allatostatin-like neuropeptide and its cognate receptor structurally related to the mammalian somatostatin/galanin/opioid receptor family. EMBO J. 1999;18:5892-900 pubmed
    ..of the synthesized octapeptide activated the cognate receptor response mediated through GIRK1, indicating that we have isolated the 394-amino-acid Drosophila allatostatin receptor which is coupled to the Gi/Go class of G proteins.
  2. Lenz C, Søndergaard L, Grimmelikhuijzen C. Molecular cloning and genomic organization of a novel receptor from Drosophila melanogaster structurally related to mammalian galanin receptors. Biochem Biophys Res Commun. 2000;269:91-6 pubmed
    ..has most amino acid sequence identity with the three mammalian galanin receptors (37% identity with the rat galanin receptor type-1, 32% identity with type-2, and 29% identity with type-3)...
  3. Lenz C, Williamson M, Grimmelikhuijzen C. Molecular cloning and genomic organization of a second probable allatostatin receptor from Drosophila melanogaster. Biochem Biophys Res Commun. 2000;273:571-7 pubmed
    ..47% identity in the overall sequence) and that is, therefore, most likely to be a second Drosophila allatostatin receptor (named DAR-2). The DAR-2 gene has three introns and four exons...
  4. Marina N, Abdala A, Trapp S, Li A, Nattie E, Hewinson J, et al. Essential role of Phox2b-expressing ventrolateral brainstem neurons in the chemosensory control of inspiration and expiration. J Neurosci. 2010;30:12466-73 pubmed publisher
    ..following transduction with a lentiviral construct to express the G-protein-coupled Drosophila allatostatin receptor. Selective inhibition of the Phox2b-expressing neurons in the ventrolateral brainstem, including the RTN, ..
  5. Larsen M, Burton K, Zantello M, Smith V, Lowery D, Kubiak T. Type A allatostatins from Drosophila melanogaster and Diplotera puncata activate two Drosophila allatostatin receptors, DAR-1 and DAR-2, expressed in CHO cells. Biochem Biophys Res Commun. 2001;286:895-901 pubmed
  6. Macdonald S, Long A. Fine scale structural variants distinguish the genomes of Drosophila melanogaster and D. pseudoobscura. Genome Biol. 2006;7:R67 pubmed
    ..Further examination of other Drosophila genome sequences will likely identify an array of novel microinversion events. ..
  7. Zhou Y, Won J, Karlsson M, Zhou M, Rogerson T, Balaji J, et al. CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala. Nat Neurosci. 2009;12:1438-43 pubmed publisher
    ..HSV) and reversibly inactivated transfected neurons with the Drosophila allatostatin G protein-coupled receptor (AlstR)/ligand system...
  8. Wang C, Zhang J, Tobe S, Bendena W. Defining the contribution of select neuropeptides and their receptors in regulating sesquiterpenoid biosynthesis by Drosophila melanogaster ring gland/corpus allatum through RNAi analysis. Gen Comp Endocrinol. 2012;176:347-53 pubmed publisher
    ..Reduction in the neuropeptide Y receptor (NepYr) or neuropeptide F receptor (NPF-R) inhibited JHIII and JHB(3) production in 3rd instars but only reduction in NepYr resulted in JHB(3) reduction in adults. ..
  9. Mastitskaya S, Marina N, Gourine A, Gilbey M, Spyer K, Teschemacher A, et al. Cardioprotection evoked by remote ischaemic preconditioning is critically dependent on the activity of vagal pre-ganglionic neurones. Cardiovasc Res. 2012;95:487-94 pubmed publisher
    ..dorsal motor nucleus of the vagus nerve (DVMN) were targeted using viral vectors to express a Drosophila allatostatin receptor (AlstR) or light-sensitive fast channelrhodopsin variant (ChIEF), respectively...

More Information


  1. Steele L, Coates B, Valero M, Sun W, Seong K, Muir W, et al. Selective sweep analysis in the genomes of the 91-R and 91-C Drosophila melanogaster strains reveals few of the 'usual suspects' in dichlorodiphenyltrichloroethane (DDT) resistance. PLoS ONE. 2015;10:e0123066 pubmed publisher
    ..These results suggest hitherto unknown mechanisms of DDT resistance, most of which have been overlooked in previous transcriptional studies, with some genes having orthologs in mammals. ..
  2. Kreienkamp H, Larusson H, Witte I, Roeder T, Birgul N, Honck H, et al. Functional annotation of two orphan G-protein-coupled receptors, Drostar1 and -2, from Drosophila melanogaster and their ligands by reverse pharmacology. J Biol Chem. 2002;277:39937-43 pubmed
    ..Localization of receptor transcripts identifies a role of the new transmitter system in visual information processing as well as endocrine regulation. ..
  3. Ye B, Kim J, Yang L, McLachlan I, Younger S, Jan L, et al. Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1. J Neurosci. 2011;31:3309-19 pubmed publisher
    ..and axonal development, we conducted a genetic screen in Drosophila and isolated the dendritic arbor reduction 1 (dar1) mutants, which display defects in dendritic but not axonal growth...
  4. Wang C, Chin Sang I, Bendena W. The FGLamide-allatostatins influence foraging behavior in Drosophila melanogaster. PLoS ONE. 2012;7:e36059 pubmed publisher
    ..Associated with the foraging defect in C. elegans npr-9 mutants is accumulation of intestinal lipid. Lipid accumulation was not a phenotype associated with the FGLa/AST and Dar-1 RNAi lines. ..
  5. Farhan A, Gulati J, Groβe Wilde E, Vogel H, Hansson B, Knaden M. The CCHamide 1 receptor modulates sensory perception and olfactory behavior in starved Drosophila. Sci Rep. 2013;3:2765 pubmed publisher
    ..In addition it revealed that the CCHamide-1 receptor is another important factor governing starvation-induced olfactory modifications. ..
  6. Bergland A, Tobler R, González J, Schmidt P, Petrov D. Secondary contact and local adaptation contribute to genome-wide patterns of clinal variation in Drosophila melanogaster. Mol Ecol. 2016;25:1157-74 pubmed publisher
    ..melanogaster and provide a context for future studies seeking to identify loci contributing to local adaptation in a wide variety of organisms, including other invasive species as well as temperate endemics. ..
  7. McPartland J, Matias I, Di Marzo V, Glass M. Evolutionary origins of the endocannabinoid system. Gene. 2006;370:64-74 pubmed
    ..Our methods identified fewer orthologs than did automated annotation systems, such as HomoloGene. Phylogenetic profiles, nonorthologous gene displacement, functional convergence, and coevolution are discussed. ..