Gene Symbol: ASPP
Description: Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein
Alias: CG18375, Dmel\CG18375, dASPP, Ankyrin-repeat, SH3-domain, and Proline-rich-region containing protein, ASPP-PA, ASPP-PB, ASPP-PC, Ankyrin-repeat, SH3-domain and Proline-rich-region containing protein, CG18375-PA, CG18375-PB, CG18375-PC
Species: fruit fly
Langton P, Colombani J, Aerne B, Tapon N. Drosophila ASPP regulates C-terminal Src kinase activity. Dev Cell. 2007;13:773-82 pubmed
..We have identified Drosophila Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein (dASPP) as a regulator of Drosophila Csk (dCsk) activity...
Langton P, Colombani J, Chan E, Wepf A, Gstaiger M, Tapon N. The dASPP-dRASSF8 complex regulates cell-cell adhesion during Drosophila retinal morphogenesis. Curr Biol. 2009;19:1969-78 pubmed publisher
..We previously identified dASPP as a positive regulator of dCsk (Drosophila C-terminal Src kinase)...
Bothma J, Magliocco J, Levine M. The snail repressor inhibits release, not elongation, of paused Pol II in the Drosophila embryo. Curr Biol. 2011;21:1571-7 pubmed publisher
Chen P, Lee C, Weng Y, Tarn W, Tsao Y, Kuo P, et al
. BCAS2 is essential for Drosophila viability and functions in pre-mRNA splicing. RNA. 2013;19:208-18 pubmed publisher
..In summary, Drosophila and human BCAS2 share a similar function in RNA splicing, which affects cell viability. ..
Zaessinger S, Zhou Y, Bray S, Tapon N, Djiane A. Drosophila MAGI interacts with RASSF8 to regulate E-Cadherin-based adherens junctions in the developing eye. Development. 2015;142:1102-12 pubmed publisher
..domain protein RASSF8 through a WW domain-PPxY motif binding, and show that apical Magi recruits the RASSF8-ASPP complex during AJ remodeling in IOCs...
Dimitriadi M, Sleigh J, Walker A, Chang H, Sen A, Kalloo G, et al
. Conserved genes act as modifiers of invertebrate SMN loss of function defects. PLoS Genet. 2010;6:e1001172 pubmed publisher
Zhang W, Cohen S. The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth. Biol Open. 2013;2:822-8 pubmed publisher
..These findings provide evidence that the Hippo pathway acts via several distinct routes to limit proliferation-induced apoptosis. ..